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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei khine khin mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin khin Than Oo Myat Myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species

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Zoological Research 2020年第6期41卷 656-669页

作者： Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin khin mar yi Paing Soe Zin mar Hein margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Gene Bank of Primates German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Chances for Nature(CfN) Goettingen 37073Germany Australian Museum Research Institute Australian MuseumSydneyNew South Wales 2010Australia Natural History Museum London SW7 BDUK Wildlife Conservation Society(WCS)-Myanmar Program Yangon 11041Myanmar Fauna&Flora International(FFI)-Myanmar Programme Yangon 11201Myanmar Popa Mountain Park Nature and Wildlife Conservation DivisionForest DepartmentPopa 05242Myanmar World Wide Fund for Nature(WWF)-Myanmar Yangon 11191Myanmar Department of Zoology Jagannath UniversityDhaka 1100Bangladesh Primate Research and Conservation Division AaranyakGuwahatiAssam 781028India Department of Anthropology Emory UniversityAtlantaGA 30322USA Department of Anthropology Yale UniversityNew HavenCT 06511USA Department of Mammalogy American Museum of Natural HistoryNew YorkNY 10024USA Naturalis Biodiversity Center Leiden 2333 CRThe Netherlands Lee Kong Chian Natural History Museum National University of SingaporeSingapore 117377Singapore Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030USA Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China Cuc Phuong Commune Nho Quan DistrictNinh Binh ProvinceVietnam School of Life Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Center for Biodiversity Conservation and Endangered Species Ho-Chi-Minh CityVietnam Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany De

Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian *** several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly ***’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and ***,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of ***,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two *** analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the *** group branched first,followed by the *** group,and the *** and *** groups most *** four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within ***,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two *** the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the *** subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three ***,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of *** but the entire Trachypithecus genus as well.

关键词： Colobinae Integrative zoology Mitochondrial genome Museum specimens New species

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Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1869-1879页

作者： Li-Ming Chen Min Kang Jun-yi Wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou yi-Xin Wang Xu Chen Ping ying Hui Huang yi Shao Rui Wu Department of Rheumatology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First School of Clinical Medicine of Nanchang University Jiangxi Medical College of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200030China

AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal ***:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD *** 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control *** macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual *** densities of retinal microvascular(MIR),macrovascular(mar),and total microvascular(TMI)were calculated and *** in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson ***:The OCTA data demonstrated a statistically significant difference(Pmarked decreases in SL and IR in the deep retina(Pying the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation m

关键词： connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface retina

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Agglutination of Helicobacter pylori coccoids by lectins

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World Journal of Gastroenterology 2000年第2期6卷 202-209页

作者： mar mar khin Jie Song Hua Han Cong Ng Torkel Wadstrm Bow Ho Departments of Microbiology Faculty of MedicineNational University of Singapore5Science Drive 2Singapore 117597Republic of Singapore Department of Medical Microbiology Lund UniversitySolvegatan 23S 223 62 LundSweden

AIM To study the agglutination pattern ofHelicobacter pylori coccoid and spiral *** Assays of agglutination andagglutination inhibition were applied usingfifteen commercial *** Strong agglutination was observedwith mannose-specific Concanavalin A(Con A),fucose-specific Tetragonolobus purpureas(Lotus A)and N-acetyl glucosamine-specificTriticum vulgaris(WGA)*** andfucose specific lectins were reactive with allstrains of *** coccoids as compared to *** carbohydrates,glycoproteinsand mucin were shown to inhibit ***-agglutination ***-treatment ofthe bacterial cells with formalin and sulphuricacid did not alter the agglutination patterns ***,sodium periodate treatment ofbacterial cells were shown to inhibitagglutination reaction with Con A,Lotus A andWGA *** the contrary,enzymatictreatment of coccoids and spirals did not showmarked inhibition of ***,heating of *** cells at 60℃ for 1 hour was shown toaugment the agglutination with all of the *** The considerable differences inlectin agglutination patterns seen among the twodifferentiated forms of *** might beattributable to the structural changes during theevents of morphological transformation,resulting in exposing or masking some of the sugar residues on the cell *** ofvarious sugar residues on the cell wall of thecoccoids may allow them to bind to differentcarbohydrate receptors on gastric mucus andepithelial *** coccoids with adherencecharacteristics like the spirals could aid in thepathogenic process of Helicobacter *** may probably lead to different clinicaloutcome of *** associated gastroduodenaldisease.

关键词： Helicobacter pylori coccoids lectin gastric mucosa

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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期 549页

作者： Yan Zheng Ei Ei khine khin mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin khin Than Oo Myat Myat Moe San San Aye Weiren Wu

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Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants

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Journal of Integrative Medicine 2018年第5期16卷 358-366页

作者： The Su Moe Htet Htet Win Thin Thin Hlaing War War Lwin Zaw Min Htet khin mar Mya Pharmaceutical Research Laboratory Biotechnology Research DepartmentMinistry of EducationMandalay Division Department of Research and Innovation (DRI) Ministry of Education Cell Culture Laboratory Biotechnology Research DepartmentMinistry of EducationMandalay Division

Objective： Myanmar has a long history of using medicinal plants for treatment of various diseases. To the best of our knowledge there are no previous reports on antiglycation activities of medicinal plants from Myanmar. Therefore, this study was aimed to evaluate the antioxidant, antiglycation and antimicrobial properties of 20 ethanolic extracts from 17 medicinal plants indigenous to Myanmar. Methods： In vitro scavenging assays of 2,2-diphenyl-l-picrylhydrazyl （DPPH）, nitric oxide （NO）, superoxide （SO） radicals were used to determine the antioxidant activities. Folin-Ciocalteu＇s method was performed to determine the total phenolic content. Antiglycation and antimicrobial activities were detected by bovine serum albumin-fluorescent assay and agar well diffusion method. Results： Terminalia cbebula Retz. （Fruit）, containing the highest total phenolic content, showed high antioxidant activities with inhibition of 77.98% ± 0.92% 88.95% ± 2.42%, 88.56% ±1.87% and 70.74% ±2.57% for DPPH, NO, SO assays and antiglycation activity respectively. It also showed the antimicrobial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coil, Pseudomonas aeruginosa and Candida albicans with inhibition zone of 19, 18, 17, 25 and 15 ram, respectively. Garcinia mangostana Linn. showed the strongest activities for SO and antiglycation assays with inhibition of 93.68% ± 2.63% and 82.37%± 1.78%. Bark of Melia sp. was the best NO radical scavenger with inhibition rate of 89.39%± 0.60%. Conclusion： The results suggest that these plants are potential sources of antioxidants with free radical-scavenging and antiglycation activities and could be useful for decreasing the oxidative stress and glycation end-product formation in glycation-related diseases.

关键词： Medicinal plants Antiglycation Antioxidant2,2 -Diphenyl-1 -picrylhydrazyl Nitric oxide Superoxide Antimicrobial agents

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Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei (Blyth, 1847) and description of a new species

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动物学研究 2020年第6期

作者： Christian Roos Kristofer M. Helgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin khin mar yi Paing Soe Zin mar Hein margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh E. Grace Veatch Neil Duncan Pepijn Kamminga marcus A. H. Chua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg

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Helicobacter pylori acquisition of metronidazole resistance by natural transformation in vitro

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World Journal of Gastroenterology 1998年第5期4卷 22-24页

作者： HUA Jiesong 1, ZHENG Peng Yuan 1, Teo Keng Fong 1, khin mar mar 2 and HO Bow 1

AIM To study whether Helicobacter pylori is naturally transformable. METHODS Transformation was performed in BHI broth supplemented with horse serum and yeast extract. Genomic DNA extracted from a metronidazole resistant H. pylori strain was added to H. pylori broth culture. The mixture was incubated at microaerophilic atmosphere. The DNA treated cells were plated on blood agar containing 8mg/L metronidazole to select for transformants. Sterile distilled water was used as a negative DNA control. The DNA profiles of transformants were compared with that of their parent strains by randomly amplified polymorphic DNA (RAPD) fingerprinting. RESULTS Transformation of H. pylori with DNA from a metronidazole resistant strain as a marker was demonstrated. Out of the 12 strains of H. pylori tested, 9 (75%) strains were found to be transformable. The transformation frequencies ranged from 3 4×10 -6 to 2 4×10 -4 . By RAPD, DNA fingerprints of the transformants and their parent strains showed no change in DNA profiles though transformants were all resistant to metronidazole as compared with their metronidazole sensitive parent strains. CONCLUSION Helicobacter pylori is naturally transformable which might be one of the ways that H. pylori develops resistance to metronidazole.

关键词： Helicobacter pylori metronidazole drug resistance, microbial transformation, bacterial

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Human Perception of Group Synchronization Error in Remote Learning: Dependencies of Voice and Video Contents in One-Way Communication

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International Journal of Communications, Network and System Sciences 2022年第3期15卷 31-42页

作者： Hay mar Mo Mo Lwin Yutaka Ishibashi khin Than Mya Faculty of Computer Systems and Technologies University of Computer Studies Yangon Yangon Myanmar Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan

This paper examines dependencies of voice and video contents on human perception of group (or inter-destination) synchronization error in remote learning by Quality of Experience (QoE) assessment. In our assessment, we use two videos and three voices (two voices for one video and one voice for the other video). We also investigate influences of silence periods in the voices and temporal relations between the voices and videos (called the tightly-coupled and loosely-coupled contents here). The voices are spoken by a teacher according to the videos. Each subject as a student assesses the group synchronization quality by watching each lecture video and the corresponding explanation voice, and then the subject answers whether he/she perceives the group synchronization error or not. As a result, assessment results illustrate that silence periods mitigate the perception rate of the error, and we can also find that we can more easily perceive the error for tightly-coupled contents than loosely-coupled ones.

关键词： Remote Learning Voice Video Group Synchronization Error Human Perception QoE Assessment

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Challenges faced by community health nurses to achieve universal health coverage in Myanmar:A mixed methods study

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International Journal of Nursing Sciences 2021年第3期8卷 271-278,I0002,I0003页

作者： Sein Yaw May Naw Clara Ohn khin khin Win Win mar Aye Nandar Han Su Su Maw Community Health Nursing Department University of Nursing-YangonMyanmar

Objective:This study aimed to identify the challenges of community health nurses(CHNs)in delivering effective community health care to achieve universal health coverage(UHC)in ***:A total of 30 CHNs from township health centers in the northeastern,southern,and western parts of Myanmar were purposefully recruited for quantitative and qualitative *** data were processed using Microsoft Excel software,and qualitative data were analyzed using thematic *** study is registered with ***:Around the country,30 CHNs uncovered their hardships in implementing primary health care to achieve *** 90%of the participants agreed to the problem of inadequate health infrastructure,while half of them felt unmotivated when they encountered role conflicts among various cadres of healthcare providers and poor opportunities for career *** problems arose from the lack of standard professional education at the entry point to community settings because most CHNs did not achieve specialized training in providing public health *** are incapable of evaluating health services for policy-making and the inability to conduct health research to develop evidencebased *** work and living conditions,unsupportive community relationships,and undereducation in professional practices were supportive major themes explored by CHNs to achieve a deeper understanding of the barriers to *** only the health system itself but also the population and other geographical factors have contributed to many challenges to ***:Myanmar’s CHNs face many challenges in achieving *** challenges are not confined to the health *** situations,such as geographical barriers and transportation problems,remain persistent challenges for healthcare *** study highlights the fact that current health systems should be strengthened by qualified healthcare providers and sufficient infras

关键词： Community health nurses Community health services Health personnel Myanmar Primary health care Professional practice Social conditions Universal health coverage

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