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Emerging role of galectin 3 in neuroinflammation and neurodegeneration

Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian M.Lozinski khanh ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

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Nutritional status of Vietnamese infants assessed by Fenton growth chart and related factors:A cross-sectional study

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Pediatric Investigation 2023年第4期7卷 254-262页

作者： Lieu Thu Thi Nguyen Cuong Danh Tran Ha Thu Thi Nguyen Hai Thanh Phan Linh Thuy Nguyen Huong Lan Thi Nguyen Anh Hoai Thi ta Chau Quynh Thi Pho khanh Nam Do Anh Kim Dang Huong Thi Le School of Preventive Medicine and Public Health Hanoi Medical UniversityHanoiVietnam Department of Nutrition National Hospital of Obstetrics and GynecologyHanoiVietnam Department of General Obstetrics National Hospital of Obstetrics and GynecologyHanoiVietnam Department of Nutrition and Dietetics Hanoi Medical University HospitalHanoiVietnam Queensland Alliance for Environmental Health Sciences(QAEHS) The University of QueenslandBrisbaneAustralia

Importance:Nutritional status of infants,measured by birth weight and length,is an essential factor in neonatal *** in newborns may lead to a higher risk of mortality,neurological and cognitive impairment,and poor language ***:This study aims to assess the nutritional status of infants and related factors regarding maternal anthropometric characteristics and medical ***:A cross-sectional study was conducted at the National Hospital of Obstetrics and Gynecology,Vietnam from May 2021 to May 2022 on 340 infants and *** birth weight was defined following the Intergrowth-21 *** was evaluated using the Fenton growth chart when the length was below the 10%percentile line of the gestational *** regression models were applied to identify factors associated with the nutritional status of ***:We found that 12.4%and 14.1%of infants in our study fell into stunted and underweight categories,*** of mothers over 35 years old,having a height lower than 150 cm or experiencing anemia during pregnancy were more likely to be stunted or have low birth *** albumin deficiency during pregnancy was strongly associated with the infant being underweight(odds ratio[OR]=2.8,95%confidence interval[95%CI]1.1–7.3).Newborns were more likely to be stunted if their mothers had a history of preterm birth(OR=3.3,95%CI 1.1–10.2).Interpretation:Maternal nutritional status is closely related to infant malnutrition,particularly in preterm *** the understanding of mothers regarding prenatal care,reproductive healthcare,adequate nutritional diet,and multi-micronutrient supplements during pregnancy is therefore important.

关键词： Fenton chart Infant Low birth weight Stunting Underweight

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