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罗非昔布和依他昔布在妇科小手术中的预先性镇痛效果

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中国医学科学院学报 2004年第6期26卷 666-670页

作者：刘薇 Loo CC Tan hm 叶铁虎任洪智中国医学科学院中国协和医科大学北京协和医院麻醉科 Anesthesia Department(O&G) Singapore KK Women's and Children's HospitalSingapore 229899

目的比较环氧化酶-2(COX-2)抑制剂罗非昔布和依他昔布应用于妇科小手术的预先性镇痛效果。方法采用随机、双盲、安慰剂对照研究,选取在日间病房行妇科人工流产吸宫术的60例患者,将其随机分成3组,每组20例,分别在术前口服安慰剂、或罗非... 详细信息

目的比较环氧化酶-2(COX-2)抑制剂罗非昔布和依他昔布应用于妇科小手术的预先性镇痛效果。方法采用随机、双盲、安慰剂对照研究,选取在日间病房行妇科人工流产吸宫术的60例患者,将其随机分成3组,每组20例,分别在术前口服安慰剂、或罗非昔布50mg、或依他昔布120mg。术后15、30、60min及出院时,出院后6、24h分别记录患者的视觉模拟评分(VAS),对于镇痛不足的患者予以芬太尼(恢复室内)和扑热息痛(回家后),并记录其用量。术后24h评估患者对镇痛治疗的满意度。结果在术后60min,依他昔布组VAS低于罗非昔布组(P<0.05);术后6h罗非昔布组和依他昔布组VAS评分显著低于安慰剂组(P<0.05,P<0.01)。术后24h罗非昔布组和依他昔布组均无患者主诉腹痛。其他时间点各组间VAS差异无显著性。各组患者在恢复室内芬太尼用量无差异,但患者回家后扑热息痛的用量罗非昔布组(0.2g/人)和依他昔布组(0.05g/人)明显低于安慰剂组(1.21g/人)(P<0.01),且依他昔布组用量低于罗非昔布组(P<0.05)。各组患者的恢复过程差异无显著性。术后24h依他昔布组镇痛满意度(96±7)显著高于其他两组(P<0.01)。结论在人工流产吸宫术患者术前应用罗非昔布和依他昔布可以降低术后6h的VAS,并减少其他镇痛药物的用量,二者之间依他昔布的效果更加明显。

关键词：罗非昔布依他昔布预先性镇痛

Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study

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Chinese Journal of Chemical Engineering 2018年第1期26卷 159-167页

作者： Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana Malik Abdul Rub Mohammad A.Halim Mohammed Abdullah khan Farida Akhtar Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Division of Quantum Chemistry BICCBThe Red-Green Computing Centre218 Elephant RoadDhaka 1205Bangladesh Institut Lumière Matière Université Lyon 1-CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 *** drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed *** decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the *** ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the *** values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and *** thermodynamic properties of transfer for the micellization were also evaluated and discussed in *** dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and *** water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the *** hydrophobic core region is highly conserved and *** addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions.

关键词： Ciprofloxacin hydrochloride Cetyltrimethylammonium bromide Molecular dynamics Flydrophobic interaction Salt effect

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减轻左心室肥厚的好处

国外医学（心血管疾病分册） 1993年第6期20卷 337-338页

作者： Franz hm 解玉水

流行病学研究显示左心室肥厚(LVH)是心脏病发作、猝死、充血性心力衰竭和其它心血管意外发生率和死亡率的强力危险因子。特异性的降压治疗可减轻LVH,并改善LVH引起的病理生理变化。

关键词：心室肥厚左

CD45McAb通过LFA－1和ICAM－1诱导外周血单个核细胞粘附反应

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国际免疫学杂志 1994年第2期17卷 109-110页

作者： Lorenz-hm 及和照

ＣＤ４５ＭｃＡｂ通过ＬＦＡ－１和ＩＣＡＭ－１诱导外周血单个核细胞粘附反应〔英〕／ＬｏｒｅｎｚＨＭ…／／ＣｅｌｌＩｍｍｕｎｏｌ。─１９９３，１４７．─１１０～１２８ＣＤ４５是白细胞的共同抗原，是唯一表达于所有白细胞表面... 详细信息

ＣＤ４５ＭｃＡｂ通过ＬＦＡ－１和ＩＣＡＭ－１诱导外周血单个核细胞粘附反应〔英〕／ＬｏｒｅｎｚＨＭ…／／ＣｅｌｌＩｍｍｕｎｏｌ。─１９９３，１４７．─１１０～１２８ＣＤ４５是白细胞的共同抗原，是唯一表达于所有白细胞表面的一种含量最丰富的跨膜蛋白质，但是...

关键词：粘附介导簇集 ICAM LFA CD45McAb 外周血单个核细胞反应

血中羊种布氏菌的快速诊断：BACT／ALERT系统的一些操作特征

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地方病译丛 1994年第2期15卷 18-19页

作者： Solo.,hm 杨发莲

第五病(传染性红斑)的童年期、成年期和妊娠期感染

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国外医学（流行病学．传染病学分册） 1990年第5期17卷 222-224页

作者： Feder hm 胡林华

第五病(传染性红斑)由细小病毒引起,在童年期、成年期及妊娠期均可受其感染。本文简述第五病的有关近况。

关键词：传染性红斑童年成年妊娠感染

水介质中药物-AOT混合物的温度依赖的混合胶束化行为(英文)

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物理化学学报 2014年第4期30卷 699-707页

作者： RUB Malik Abdul ASIRI Abdullah M KUMAR Dileep AZUM Naved khan Farah Chemistry Department King Abdulaziz University Center of Excellence for Advanced Materials Research King Abdulaziz University Department of Chemistry Aligarh Muslim University

The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride(AMT)in the presence of the conventional anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate(AOT)was studied at five different temperatures and compositions by the conductometric *** critical micelle concentration(cmc)and critical micelle concentration at the ideal state(cmcid)values show mixed micelle formation between the components(i.e.,drug and AOT).The micellar mole fractions of the AOT(X1)values calculated using the Rubingh,Motomura,and Rodenas models show a higher contribution of AOT in the mixed *** interaction parameter(β)is negative at all temperatures and the compositions show attractive interactions between the *** activity coefficients(f1and f2)calculated using the different proposed models are always less than unity indicating non-ideality in the ***ΔGmΘ values were found to be negative for all the binary mixed ***,ΔhmΘ values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures(293.15-303.15 K)and positive at higher temperatures(308.15 K and above).TheΔSmΘ values are positive at all temperatures but their magnitude was higher at T=308.15 K and *** excess free energy of mixing(ΔGex)determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug(AMT)and surfactant micelles.

关键词：抗抑郁药物临床分析药物治疗浓度

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控制高温蒸汽泡沫流度的表面活剂

油气田开发工程译丛 1991年第1期 12-19页

作者： Muij.,hm 赵以文

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光学双稳定性

光学工程 1990年第36期 27-30页

作者： Gibbs,hm 林枝煌