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Aortic valve stenosis： treatments options in elderly high-risk patients

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Journal of Geriatric Cardiology 2016年第6期13卷 473-474页

作者： khalil Fattouch Sebastiano Castrovinci Patrizia Carita Cardiovascular Department Maria Eleonora Hospital Palermo Italy

In the last decades, a trend towards a worldwide aging has been reported and diseases which are common in the elderly people would have important implications in clinical practice. Aortic stenosis （AS） is perhaps the most common and most often cause of sudden death among valvular heart diseases. Its prevalence is low among adults aged 〈 60 years, but increases to almost 10% in adults ≥ 80 years.[2] Since the degenerative calcific disease represents the lead- ing cause of AS in developed countries, the improved understanding on its pathogenesis （atherosclerotic processes and/or skeleton key） may offer potentially new targets for preventing and inhibiting AS development and progres- sion.[3] Patients with AS are generally asymptomatic for a prolonged period and the development of symptoms is a critical point in the natural history. Indeed, the prognosis changes dramatically with the onset of symptoms of angina,

关键词： Aortic valve stenosis Elderly patients Minimaly invasive surgery Risck stratification Transcatheter aortic valve implantation

Performance Analysis of Intrusion Detection System in the IoT Environment Using Feature Selection Technique

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Intelligent Automation & Soft Computing 2023年第6期36卷 3709-3724页

作者： Moody Alhanaya khalil Hamdi Ateyeh Al-Shqeerat Department of Computer Science College of ComputerQassim UniversitySaudi Arabia

The increasing number of security holes in the Internet of Things(IoT)networks creates a question about the reliability of existing network intrusion detection *** problem has led to the developing of a research area focused on improving network-based intrusion detection system(NIDS)*** to the analysis of different businesses,most researchers focus on improving the classification results of NIDS datasets by combining machine learning and feature reduction ***,these techniques are not suitable for every type of *** light of this,whether the optimal algorithm and feature reduction techniques can be generalized across various datasets for IoT networks *** paper aims to analyze the methods used in this research and whether they can be generalized to other *** ML models were used in this study,namely,logistic regression(LR),decision trees(DT),Naive Bayes(NB),random forest(RF),K-nearest neighbors(KNN),and linear *** primary detection algorithms used in this study,Principal Component(PCA)and Gini Impurity-Based Weighted Forest(GIWRF)evaluated against three global ToN-IoT datasets,UNSW-NB15,and Bot-IoT *** optimal number of dimensions for each dataset was not studied by applying the PCA *** is stated in the paper that the selection of datasets affects the performance of the FE techniques and detection algorithms *** the efficiency of this research area requires a comprehensive standard feature set that can be used to improve quality over time.

关键词： Machine learning internet of things intrusion detection system feature selection technique

Microscopic study of binary mixtures between pyrrolidinium bis(triflorosulfonyl)imide and dimethyl sulfoxide/acetonitrile

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Science China Chemistry 2016年第5期59卷 578-586页

作者： Hamad Ashraf Yu Zhou Jing Xu khalil Ahmad Zhi-Wu Yu Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University

Molecular interactions of a representative pyrrolidinium-based ionic liquid 1-butyl-l-methyl-pyrrolidinium bis（triflorosulfonyl）- imide （[BMPyrr][TFSI]） with dimethyl sulfoxide （DMSO） and acetonitrile （AN） have been analyzed in this work. Attenuated total reflection Fourier transform infrared spectroscopy （ATR-FTIR） and density functional theory （DFT） calculations are used in the investigation, while excess infrared spectra and two-dimensional correlation spectroscopy are used to explore the data in detail. It has been found that the molecular solvents can interact with TFSI- （mainly with S=O and weakly with S-N-S group）. AN interacts feebly with BMPyrr＋ as compared with the strong interaction of DMSO. The strength of the interactions depends on the electron donating ability of the solvent. Upon mixing, hydrogen bonds regarding C-Hs in cation and S-N-S in anion are weakened, while that regarding S=O in anion is strengthened. Among the C-Hs which are connected directly with the N of the cation, Cl-H is the main interaction site for both DMSO and AN. This means that Cl-H is the most acidic hydrogen in pyrrolidinium cation.

关键词： ATR-FTIR DFT calculations excess infrared spectrum two-dimensional correlation spectroscopy ionic liquid,hydrogen bond

Application of a validated HPLC-PDA method for the determination of melatonin content and its release from poly(lactic acid)nanoparticles

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Journal of Pharmaceutical Analysis 2017年第6期7卷 388-393页

作者： Leiziani Gnatkowski Martins Najeh Maissar khalil Rubiana Mara Mainardes Department of Pharmacy Universidade Estadual do Centro-Oeste/UNICENTRORua Simeao Camargo Varela de Sd 0385040-080 GuarapuavaPRBrazil

Melatonin is a natural hormone and with the advancement of age its production declines and thereby may result in some neurological disorders. Exogenous administration of melatonin has been suggested as a neuroprotective agent. Due to its low oral bioavailability, the loading of melatonin in polymeric nanoparticles could be an important tool to effectively use exogenous melatonin. The quantification of the incorporated drug within polymeric nanoparticles is an important step in nanoparticles characterization. An analytical method using high performance liquid chromatography equipped with photodiode array detector （HPLC-PDA） was developed and validated for melatonin determination in poly （lactic acid） nanoparticles obtained by a single emulsion-solvent evaporation technique. The melatonin in vitro release profile also was determined by the HPLC method. Mobile phase consisted of acetonitrile： water （65：35, v/v） pumped at a flow rate of 0.9 mL/min, in the isocratic mode and PDA detector was set at 220 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. Analytical curve was linear over the concentration range of 10-100 ~tg/mL, and limits of detection and quantification were 25.9 ng/mL and 78.7 ng/mL, respectively. The mean recovery for melatonin was 100.47% （RSD = 1.25%, n = 9）. In the intra- and inter- assay, the coefficient of variation was less than 2%. Robustness was proved performing changes in mobile phase, column temperature and flow rate. The method was suitable for the determination of melatonin encapsulation efficiency in poly（lactic acid） nanopartieles and for the evaluation of melatonin in vitro release profile.

关键词： High-performance liquid chromatography Validation Melatonin Polymeric nanoparticles

New Class of Doubt Bipolar Fuzzy Sub Measure Algebra

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Computer Modeling in Engineering & Sciences 2023年第4期135卷 293-300页

作者： Shadia Majeed Noori Abd Ghafur Ahmad Shuker Mahmood khalil Department of Mathematical Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi Selangor43600Malaysia Department of Mathematics College of Education for Pure ScienceUniversity of TikritTikrit34001Iraq Department of Mathematics College of ScienceUniversity BasrahBasrah61004Iraq

The ideas of ambiguous bipolar skepticism under algebra and closed skepticism ambiguous bipolar ideals and related features have been *** fuzzy measure ideal is described in terms of bipolar ambiguous measure algebra and bipolar skepticism,and the linkages between bipolar fuzzy measure algebra are determined.A bipolar misty ideal’s skepticism is *** andBCL-measure algebra,homogeneous ideas and dubious pictures of fuzzy bipolar measure ideas are ***,we gave the relationship between these ***,it is given the perfect terms for an occult bipolar doubt to be a measure of ideal fuzzy bipolar closed doubt.

关键词： Fuzzy measure algebra fuzzy measure BCW-idials BCF-ideals

Terlipressin and hepatorenal syndrome: What is important for nephrologists and hepatologists

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World Journal of Gastroenterology 2010年第41期16卷 5139-5147页

作者： Ahmed A Magan Atif A khalil Mohamed H Ahmed Department of Surgery Cambridge Uni-versity Hospital NHS foundation Trust Hills Road Cambridge CB2 0QQ United Kingdom Department of Nephrology Royal Liverpool and Broadgreen University Hospitals Liverpool L7 8XP United Kingdom Division of Acute Medicine James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom

Hepatorenal syndrome (HRS) is a reversible form of functional renal failure that occurs with advanced hepatic cirrhosis and liver failure. Despite mounting research in HRS, its etiology and medical therapy has not been resolved. HRS encompasses 2 distinct types. Type 1 is characterized by the rapid development of renal failure that occurs within 2 wk and involves a doubling of initial serum creatinine. Type 2 has a more insidious onset and is often associated with ascites. Animal studies have shown that both forms, in particular type 1 HRS, are often precipitated by bacterial infections and cir-culatory changes. The prognosis for HRS remains very poor. Type 1 and 2 both have an expected survival time of 2 wk and 6 mo, respectively. Progression of liver cir-rhosis and the resultant portal hypertension leads to the pooling of blood in the splanchnic vascular bed. The ensuing hyperdynamic circulation causes an ineffective circulatory volume which subsequently activates neuro-hormonal systems. Primarily the sympathetic nervoussystem and the renin angiotensin system are activated, which, in the early stages of HRS, maintain adequate circulation. Both advanced cirrhosis and prolonged ac-tivation of neurohormonal mechanisms result in fatal complications. Locally produced nitric oxide may have the potential to induce a deleterious vasodilatory effect on the splanchnic circulation. Currently medical therapy is aimed at reducing splanchnic vasodilation to resolve the ineffective circulation and maintain good renal per-fusion pressure. Terlipressin, a vasopressin analogue, has shown potential benefit in the treatment of HRS. It prolongs both survival time and has the ability to re-verse HRS in the majority of patients. In this review we aim to focus on the pathogenesis of HRS and its treatment with terlipressin vs other drugs.

关键词： Heptorenal syndrome Terlipressin Kidney Liver

Experimental investigation of the application of Eucalyptus bark to prevent lost circulation in pay zones with acid dissolution capability

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Petroleum 2021年第2期7卷 152-159页

作者： Mostafa Sedaghatzadeh khalil Shahbazi Peyman Pourafshary Seyed Ali Razavi National Iranian Drilling Company Ahvaz90161635Iran Petroleum University of Technology Abadan***Iran School of Mining and Geoscience Nazarbayev UniversityNur-Sultan010000Kazakhstan

Loss of drilling fluid is a common problem during the drilling of wells and it restricts the appropriate functionality of *** fluid loss significantly increases drilling costs and non-productive time as well as the drilling operation *** investigations have been carried out in order to find appropriate mud additives that either block fractures and pores or reduce fluid loss by improving the fluid ***,environmentally friendly and effective additives are still required by the drilling ***,the application of available materials in each region,to produce appropriate additives,is a challenge for the oil *** this study,Eucalyptus Camaldulensis(EUC)bark powder has been chosen as a new,fibrous,cheap,environmentally friendly and available material to control fluid loss,particularly in southern *** characterization tests,such as acid dissolution and fluid loss control,were carried out to study the performance of the new proposed *** by hydrochloric acid and sulfuric acid were studied at various acid concentrations and *** fluid loss was also measured at different EUC *** study showed that EUC powder can reduce the final fluid loss by 88-97%,the initial fluid loss by 45-66%,and the total loss by 87e94%,which is a satisfactory level.

关键词： Eucalyptus bark Lost circulation Acid solubility Drilling mud Fluid loss

Antifungal, phytotoxic and hemagglutination activity of methanolic extracts of Ocimum basilicum

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Journal of Traditional Chinese Medicine 2016年第6期36卷 794-798页

作者： Kafeel Ahmad Ali talha khalil Yusra Ramla Somayya Centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE: To report some of the pharmacological features of the medicinal plant Ocimum ***: In the current studies, Antifungal activity of crude methanolic fraction of Ocimum basilicum was determined against eight pathogenic fungal strains using tube dilution assay. The methanolic fraction was also investigated for phytotoxic and hemagglutination ***: Of the eight strains investigated only Candida albicans and Curvilaria lunata were found to be least affected by plant extract while the rest were significantly inhibited. Moderate phytotoxic activity was observed against lemna minor. Hemagglutination activity showed absence of phytolectins and hence no agglutination of ***: The crude extract of Ocimum basilicum has significant properties against fungi and phytotoxic substances.

关键词： Plants,toxic Antifungal agents Pathogenicity Ocimum basilicum

Computational Analysis of Heat and Mass Transfer in Magnetized Darcy-Forchheimer Hybrid Nanofluid Flow with Porous Medium and Slip Effects

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2311-2330页

作者： Nosheen Fatima Nabeela Kousar khalil Ur Rehman Wasfi Shatanawi Faculty of Basic and Applied Sciences Department of MathematicsAir UniversityPAF Complex E-9Islamabad44000Pakistan Department of Mathematics and Sciences College of Humanities and SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Mathematics Air UniversityPAF Complex E-9Islamabad44000Pakistan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402TaiwanChina Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O Box 330127Zarqa13133Jordan

A computational analysis of magnetized hybrid Darcy-Forchheimer nanofluid flow across a flat surface is presented in this *** the study of heat and mass transfer aspects viscous dissipation,activation energy,Joule heating,thermal radiation,and heat generation effects are *** suspension of nanoparticles singlewalled carbon nanotubes(SWCNTs)and multi-walled carbon nanotubes(MWCNTs)are created by hybrid ***,single-walled carbon nanotubes(SWCNTs)produce nanofluids,with water acting as conventional fluid,*** partial differential equations(PDEs)that describe the ultimate flow are converted to nonlinear ordinary differential equations(ODEs)using appropriate similarity *** ODEs are dealt with numerically by means of MATLAB’s inbuilt routine function ***,temperature,and concentration profiles are explained pictorially whereas Sherwood number,local skin friction coefficient,and Nusselt number values are represented through bar *** radiation and activation parameters shows direct impact on flow ***,hybrid nanofluid admits a higher magnitude of velocity and temperature than nanofluid,but the concentration profile exhibits the opposite *** notable findings of the present investigation have significant applications in heat combustion and cooling chambers,space technology,the ceramics industry,paint and conductive coatings,bio-sensors,and many more.

关键词： Heat transfer hybrid nanofluid MCNTs SCNTs MHD Darcy-Forchheimer joule heating activation energy