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Journal of Cancer Therapy 2018年第1期9卷 55-63页

作者： Anwar Tawfik Amin khalid M. rezk Haisam Atta Department of Surgical Oncology South Egypt Cancer Institute Assiut University Assiut Egypt Department of Diagnostic Radiology South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Lateral neck dissection is risky and should be performed only as a therapeutic intervention for known disease. Aim of the Study: This study aims at finding predictors which help in selecting patients who have high risk of lymph node metastasis. Methods: All the patients with well differentiated thyroid cancer underwent thyroidectomy with lateral lymph nodes (LNs) dissection with available pathology report and sufficient data have been included in the study. Results: Sixty nine patients have been included in this study. In multivariate analysis, the most reliable and significant factors for detecting L.N. involvement were the clinical picture and the U/S appearance of the Neck with P value of (0.008) and (0.001) respectively. Conclusion: Clinical and U/S examinations are the most independent and reliable factors to detect lateral neck lymph nodes involvement.

关键词： Thyroid Cervical Lymphadenectomy Thyroid Carcinoma Neck Ultrasonography

Complications of Parotid Surgery—10 Years’ Experience

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Journal of Cancer Therapy 2020年第5期11卷 306-323页

作者： Ali Zedan khalid rezk Anwar A. Elshenawy Ola Nabih Haisam Atta Department of Surgical Oncology South Egypt Cancer Institute Assiut University Assiut Egypt Department of Surgical Oncology Aswan University Assiut Egypt Department of Clinical Oncology Assiut University Assiut Egypt Department of Diagnostic Radiology South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Parotid surgery with dissection of the facial nerve branches is a technically challenging surgery. Even in experienced hands, parotidectomy has well-documented post-operative complications. We aim to evaluate complications following parotid surgery. Methods: We retrospectively reviewed the charts of 187 patients who underwent parotidectomy from January 2010 to January 2020 performed in surgical oncology department South Egypt Cancer Institute, Assiut University, from patients (57.3% males and 42.7% females, average age 42.96 years). Results: 78.4% Patients had benign tumors, the most frequent being pleomorphic adenoma 55.1% followed by Warthin’s tumour 16.9%, and 21.6% malignant tumors, mucoepidermoid carcinoma being the most frequent. Superficial parotidectomy was the most common surgery 40.4% performed followed by 25.3%, total conservative parotidectomy, while 1.1%, underwent radical parotidectomy, (extended radical parotidectomy was performed 2.2%), and revision total parotidectomy (Recurrence 6.7%, and parotidectomy with modified radical neck dissection (MRND) 7.9%. The most common complication following parotidectomy was transient facial nerve palsy 21.3%. Permanent facial nerve paresis was observed in 3.9%, sensory deficit in 20.2%, sialocele in 6.7%, hematoma formation 3.4% and wound infection in 7.3%, and recurrence 7.3%. Frey’s syndrome occurred in 7.3% and salivary fistula 5.1%. Conclusion: Parotidectomy is safe procedure causing minimal complications. Transient facial palsy is the most common postoperative complication.

关键词： Pleomorphic Adenoma Major Salivary Gland Painless Swelling

Capecitabine and Oxaliplatin versus 5-Fluorouracil in the Neoadjuvant Chemoradiation for Patients with Locally Advanced Rectal Carcinoma: A Comparative Study

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Journal of Cancer Therapy 2018年第10期9卷 767-779页

作者： Amal Rayan Hosam A. Hasan Asmaa M. Zahran Ahmed Soliman khalid rezk Clinical Oncology Department Faculty of Medicine Assiut University Assiut Egypt Diagnostic Radiology Department Faculty of Medicine Assiut University Assiut Egypt Clinical Pathology Department South Egypt Cancer Institute Assiut University Assiut General Surgery Departments Faculty of medicine Assiut University Assiut Egypt Surgical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt

Aim of work: This study aimed to evaluate the resectability rate, rate of conservative surgery, toxicity, local control, and disease free survival for oxaliplatin and capecitabine based chemoradiation compared to standard 5-FU based chemoradiation in locally advanced cancer rectum. Patients and methods: 65 patients were eligible;33 patients received oxaliplatin and capecitabine based chemoradiation (arm I) and 32 patients received 5-FU based chemoradiation (arm II). Results: The overall response rate in arms I and II were 78.7% and 87.5% respectively. Conservative surgery was done in 81.81% and 53.13% of patients with arms I and II, pathologic complete response (pCR) rate was significantly better in arm I than arm II (30.3% vs. 21.9%, P < 0.01). 3-year recurrence rates were 54.5% and 56.2% in arms I, II respectively;the median disease free survival (DFS) were 30 months and 15 months in arms I and II respectively. Grade III anemia, grade IV diarrhea and severe proctitis were developed in a significantly large number of patients with arm I;in addition deep venous thrombosis (DVT) was developed in 15.15% of patients with arm I but none in arm II. Conclusion: The addition of oxaliplatin to the preoperative chemo radiation increased the response rate mainly pCR rate which was considered a target goal in the neoadjuvant treatment, but it was not recommended because of higher toxicity and no significant effect on DFS in different response groups of arm I when compared to arm II, but longer follow up may be needed to evaluate the overall survival.

关键词： Neoadjuvant Concurrent Chemoradiation Oxaliplatin Capecitabine Locally Advanced Cancer Rectum

Preoperative Conformal Radiotherapy Concurrently with Paclitaxel/Carboplatin in Gastric Cancer

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Journal of Cancer Therapy 2018年第6期9卷 503-515页

作者： Shimaa Ahmed Mayada Fawzy khalid rezk Wessam Elshrif Mohamed Alaa Mohamed M. H. Abd Ellah Radiation Oncology South Egypt Cancer Institute Assuit University Assiut Egypt Medical Oncology South Egypt Cancer Institute Assuit University Assiut Egypt Surgical Oncology South Egypt Cancer Institute Assuit University Assiut Egypt Clinical Oncology Cairo University Cairo Egypt Clinical Oncology Assuit University Assiut Egypt Diagnostic Radiology South Egypt Cancer Institute Assuit University Assiut Egypt

Background and objectives: Surgery is the primary therapy for localized gastric cancer, but even with the best results only 40% 5-year survival can be achieved with the use of postoperative adjuvant chemoradiotherapy. Preoperative therapy might help increase the R0 resection rate, which is an independent predictor of 5-year OS. Our study hypothesized that the concurrent combination of carboplatin-paclitaxel with radiation therapy would result in a pathological CR rate, which will be in turn associated with OAS and DFS benefits. Patients and methods: prospective phase II study included 32 patients with locally advanced gastric adenocarcinoma including gastroesophageal junction who received a combination of neoadjuvant conformal radiotherapy concurrently with carboplatin-paclitaxel followed by surgery. Results: Pathological CR and R0 resection rates were 18.8% and 75% respectively. With a median follow up of 24 months, 2 years disease-free survival was 28.1% and overall survival was 51.3%. The regimen was tolerated with neither grade 4 toxicities nor deaths. Conclusion: Neoadjuvant radiotherapy concomitant with carboplatin-paclitaxel chemotherapy is a well-tolerated approach for patients with locally advanced gastric adenocarcinoma resulting in significant pathological CR and R0 resection margins as reflected by the good DFS and OS.

关键词： Gastric Adenocarcinoma Neoadjuvant Paclitaxel-Carboplatin Chemoradiotherapy Pathologicalcr-R0

Effect of Ketamine Instillation on Acute and Chronic Post Mastectomy Pain, a Dose Finding Clinical Study

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Open Journal of Anesthesiology 2022年第4期12卷 146-159页

作者： Fatma El Sherif Hany Elmorabaa Khaled Mohamed Fares Sahar Abdel-Baky Mohamed Nourhan M. Elgalaly khalid rezk Moaaz Tohamy Department of Anesthesia ICU and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt Department of Anesthesia ICU and Pain Management Faculty of Medicine Assuit University Assiut Egypt

Background: Uncontrolled acute postoperative pain is considered a risk factor for the development of chronic pain afterward. Objectives: To explore the most effective dose of ketamine instillation (1 of 3 doses: 1, 2, or 3 mg/kg) for acute and chronic post mastectomy pain (PMP). Methods: Ninety female patients with cancer breast, aged (18 - 60 yrs), weighted (50 - 90 kg), scheduled for modified radical mastectomy, randomly allocated into 3 groups to receive ketamine instillation after surgical homeostasis before wound closure (1 of 3 doses;1, 2, or 3 mg/kg as A, B or C groups respectively) patients were followed up for 48 h for acute pain (total morphine consumption, the first request of analgesia and visual analog scale at rest and movement (VASR/M), chronic pain by Leeds assessment of neuropathic signs and symptoms (LANSS) for six-months, hemodynamics, and side effects. Results: Median total dose of morphine consumption was 8 mg (5 - 10) versus 6 mg (6 - 7) in A and B groups respectively in the first 48 h postoperatively. Lowest VASR/M was recorded in C then B and lastly A group (P = 0.037). No patients in the C group requested analgesia versus thirty (100%) and nine (30%) patients in the A and B groups respectively with the first request of analgesia was 12 h (5 - 36) in the A group versus 30 h (12 - 36) in the B group respectively (P Conclusion: Ketamine instillation effectively controlled acute post mastectomy pain (PMP) in a dose-dependent manner and reduced the incidence and severity of chronic pain in patients who undergoing a modified radical mastectomy.

关键词： Acute Pain Breast Cancer Chronic Pain Ketamine Instillation Modified Radical Mastectomy

Isolation, purification and structure elucidation of three newbioactive secondary metabolites from Streptomyces lividans AM

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BIOCELL 2021年第5期45卷 1263-1271页

作者： MOHAMMAD EL-METWALLY MAMDOUH ABDEL-MOGIB MANAL ELFEDAWY GAAD SOHSAH AHMED rezk MAHMOUD MOUSTAFA MOHAMED SHAABAN Botany and Microbiology Department Faculty of ScienceDamanhour UniversityDamanhour22511Egypt Chemistry Department Faculty of ScienceMansoura UniversityEl-Mansoura35516Egypt Bioprocess Development Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab CityAlexandria21934Egypt Biology Department College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Chemistry of Natural Compounds Department Division of Pharmaceutical IndustriesNational Research CentreDokki-Cairo12622Egypt Organic and Bioorganic Chemistry Department of ChemistryBielefeld UniversityBielefeld33615Germany

Microorganisms are a huge mine of bioactive metabolites,and actinomycetes are one of the very active groups in this *** this article,we are concerned about the full taxonomical characterization of Streptomyces lividans AM,isolated from Egyptian *** isolate produced three new bioactive metabolites,namely:1-Nona-decanoyl,4-oleyl disuccinate(1),filoboletic acid;(9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid(2),and sitosteryl-3β-D-glucoside(3).Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three ***,ten known compounds were also *** antimicrobial activity of the producing organism and newly reported compounds(1–3)was investigated against a selected group of pathogenic microorganisms.A full taxonomical characterization of the strain was described as well.

关键词： Bioactive metabolites Streptomyces sp. Taxonomy Biological activity