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Can we suppress excessive post-surgical scar formation:A case report

World Journal of Orthopedics 2023年第3期14卷 166-170页

作者： Mir Sadat-ali Sulaiman A al-Mousa khalid waleed al-tabash Mohamed M Abotaleb Fawaz M al-Anii Department of Orthopaedic Surgery Imam Abdulrahman Bin Faisal UniversityDammam 31142Saudi Arabia

BACKGROUND Hypertrophic scars(HSs)formation is a complication that occurs after wounds heal with secondary intention and sometimes after clean surgical *** treatments are in vogue now with varying *** the mechanism or mechanisms that cause a HS to form are not clearly understood,one thing that is clear is that once scar tissue matures,any intervention will not be *** this paper,we report on a case where a patient who was known to develop HS was treated with a new combination of ingredients(Phyto-chemicals+Silicone JUMI)to suppress HS *** SUMMARY A 68-year-old female of African descent presented a severe HS post total knee replacement(TKR),which the patient describes as itchy and *** to complications caused by the scar,she was apprehensive about undergoing TKR on her other ***,after the TKR of the contralateral side post-removal of skin clips,JUMI anti-scar cream(JASC)was used to suppress excessive scar *** JASC appears potent and efficacious at suppressing excessive scar *** believe that this warrants further studies on larger patient groups and on different surgical sites.

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Vancomycin flushing syndrome in orthopaedic practice:A case report

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World Journal of Orthopedics 2023年第10期14卷 771-775页

作者： Fawaz M al-Anii Mir Sadat-ali khalid waleed al-tabash Ahmad I alMulhim Sulaiman A alMousa Abdulaziz M alHawas Orthopaedic Surgery Imam AbdulRahman Bin Faisal University and King Fahd Hospital of the UniversityAlKhobar 31952Saudi Arabia

BACKGROUND Vancomycin flushing syndrome(VFS),also known as red man syndrome,is an allergic reaction to *** typically presents as a rash on the face,neck,and upper torso after intravenous administration of *** is blamed on rapid intravenous infusion of vancomycin during management and rarely happens after local use.A review of the literature showed that in the last 23 years,4 such cases have been ***,we add another case of VFS developed after slow local absorption of vancomycin in cement *** SUMMARY A 44-year-old male with a known case of hypertension,no history of allergies to medications,and a history of chronic osteomyelitis of the right tibia with discharging sinus over the anterolateral aspect of the *** pus culture grew Staphylococcus aureus,which was sensitive to clindamycin and *** patient underwent irrigation and debridement with the placement of vancomycin cement beads made from 4 g of vancomycin powder and 40 g of polymethyl *** hours postoperatively,the patient developed a pruritic,erythematous,macular rash predominantly on his face,neck,chest,and lower extremities and to a lesser extent his upper extremities.A diagnosis of VFS was made and was successfully treated with cetirizine(10 mg,oral)and methylprednisolone sodium succinate(125 mg,intravenous).The patient continued to have itching with a facial rash for 12 h with gradual improvement.A decision was made to not remove the beads as the patient continued to ***,the rash disappeared after 96 h with no further *** VFS can occur not only after rapid intravenous injection of vancomycin but also with local release,as in our *** orthopaedic surgeons routinely use vancomycin with polymethyl methacrylate in chronic osteomyelitis and revision arthroplasty,they should be aware of such a complication occurring.

关键词： Vancomycin Anaphylactic reactions Red man syndrome Vancomycin flushing syndrome Case report

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Deep Learning Based Efficient Crowd Counting System

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Computers, Materials & Continua 2024年第6期79卷 4001-4020页

作者： waleed khalid al-Ghanem Emad Ul Haq Qazi Muhammad Hamza Faheem Syed Shah Amanullah Quadri Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Centre of Excellence in Cybercrime and Digital Forensics Naif Arab University for Security SciencesRiyadh14812Saudi Arabia Center of Excellence for Information Assurance(COEIA) King Saud UniversityRiyadh12372Saudi Arabia

Estimation of crowd count is becoming crucial nowadays,as it can help in security surveillance,crowd monitoring,and management for different *** is challenging to determine the approximate crowd size from an image of the crowd’s *** in this research study,we proposed a multi-headed convolutional neural network architecture-based model for crowd counting,where we divided our proposed model into two main components:(i)the convolutional neural network,which extracts the feature across the whole image that is given to it as an input,and(ii)the multi-headed layers,which make it easier to evaluate density maps to estimate the number of people in the input image and determine their number in the *** employed the available public benchmark crowd-counting datasets UCF CC 50 and ShanghaiTech parts A and B for model training and testing to validate the model’s *** analyze the results,we used two metrics Mean Absolute Error(MAE)and Mean Square Error(MSE),and compared the results of the proposed systems with the state-of-art models of crowd *** results show the superiority of the proposed system.

关键词： Crowd counting EfficientNet multi-head attention convolutional neural network transfer learning

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheikh Prashant Kesharwani waleed H.almalki Salem Salman almujri Linxin Dai Zhe‑Sheng Chen Amirhossein Sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

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Extraction of cobalt(Ⅱ) from aqueous solution by N,N'-carbonyl difatty amides

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Chinese Chemical Letters 2011年第4期22卷 469-472页

作者： Emad A.Jaffar al-Mulla khalid waleed S.al-Janabi Department of Chemistry College of ScienceUniversity of KufaAnNajafIraq Department of Chemistry College of EducationBaghdad UniversityBaghdadIraq

The development of economic and environmentally friendly extractants to recover cobalt metal is required due to the increasing demand for this *** this study,solvent extraction of Co（Ⅱ） from aqueous solution using a mixture of N,N＇-carbonyl difatty amides（CDFAs） synthesised from palm oil as the extractant was carried *** effects of various parameters such as acid,contact time,extractant concentration,metal ion concentration and stripping agent and the separation of Co（Ⅱ） from other metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ） were *** was found that the extraction of Co（Ⅱ） into the organic phase involved the formation of 1：1 ***（Ⅱ） was successfully separated from commonly associated metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ）.Co（Ⅱ） stripping from the loaded organic phase was studied in aqueous *** results are useful to recover Co（Ⅱ） from aqueous solution utilising（CDFAs） as an extractant.

关键词： N N'-Carbonyl difatty amides Solvent extraction Co(Ⅱ)

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Automatic Data Clustering Based Mean Best Artificial Bee Colony algorithm

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Computers, Materials & Continua 2021年第8期68卷 1575-1593页

作者： Ayat alrosan waleed alomoush Mohammed alswaitti khalid alissa Shahnorbanun Sahran Sharif Naser Makhadmeh Kamal alieyan Deanship of Information and Communication Technology Imam Abdulrahman bin Faisal UniversityDammamSaudi Arabia Computer Department Imam Abdulrahman bin Faisal UniversityDammamSaudi Arabia School of Electrical and Computer Engineering Department of Information and Communication TechnologyXiamen University MalaysiaSepang43900Malaysia Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman bin Faisal UniversityDammamSaudi Arabia Center for Artificial Intelligence Technology(CAIT) Faculty of Information Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiMalaysia School of Computer Sciences Universiti Sains Malaysia11800PenangMalaysia Faculty of Computer Sciences and Informatics Amman Arab UniversityAmmanJordan

Fuzzy C-means(FCM)is a clustering method that falls under unsupervised machine *** main issues plaguing this clustering algorithm are the number of the unknown clusters within a particular dataset and initialization sensitivity of cluster *** Bee Colony(ABC)is a type of swarm algorithm that strives to improve the members’solution quality as an iterative process with the utilization of particular kinds of ***,ABC has some weaknesses,such as balancing exploration and *** improve the exploration process within the ABC algorithm,the mean artificial bee colony(MeanABC)by its modified search equation that depends on solutions of mean previous and global best is ***,to solve the main issues of FCM,Automatic clustering algorithm was proposed based on the mean artificial bee colony called(AC-MeanABC).It uses the MeanABC capability of balancing between exploration and exploitation and its capacity to explore the positive and negative directions in search space to find the best value of clusters number and centroids value.A few benchmark datasets and a set of natural images were used to evaluate the effectiveness of *** experimental findings are encouraging and indicate considerable improvements compared to other state-of-the-art approaches in the same domain.

关键词： Artificial bee colony automatic clustering natural images validity index number of clusters

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Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation

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World Journal of Hepatology 2023年第2期15卷 274-281页

作者： Saad alghamdi Shaden alamro Dhari alobaid Elwy Soliman ali albenmousa khalid Ibrahim Bzeizi Saleh alabbad Saleh A alqahtani Dieter Broering waleed al-Hamoudi Liver and Small Bowel Health Centre Department KFSHRCRiyadh 11211Saudi Arabia Department of Medicine KFSHRCRiyadh 11211Saudi Arabia Department of Internal Medicine Minia UniversityMinya 61519Egypt Division of Gastroenterology and Hepatology Johns Hopkins UniversityBaltimoreMD 21287United States Liver Disease Research Center Department of MedicineCollege of MedicineKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Non-alcoholic fatty liver disease is a global health care challenge and a leading indication of liver transplantation(LT).Hence,more patients with diabetes mellitus(DM)are undergoing LT,especially,above the age of *** To evaluate the impact of DM on short-term outcomes post-LT in patients over the age of *** We collected data of patients who underwent LT from January 2001 until December 2019 using our electronic medical *** assessed the impact of DM on short-term outcomes,one-year,post-LT based on the following variables:Survival at one year;acute cellular rejection(ACR)rates;intensive care unit(ICU)and hospital length of stay;and *** Total of 148 patients who are 65 year or older underwent LT during the study *** mean age is 68.5±3.3 years and 67.6%were *** median Model for End-stage Liver Disease score at time of transplantation was 22(6-39),39%of patients had hepatocellular carcinoma and 77.7%underwent living donor *** one-year survival was similar between DM patients and others,91%.ACR occurred in 13.5%of patients(P=0.902).The median ICU stay is 4.5-day P=*** rates of ICU and 90-d readmission were similar(P=0.821)and(P=0.194),*** The short-term outcome of elderly diabetic patients undergoing LT is similar to *** presence of DM in elderly LT candidates should not discourage physicians from transplant consideration in this cohort of patients.

关键词： Acute cellular rejection Diabetes mellitus Elderly Graft survival Liver transplantation

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Multidrug resistance Acinetobacter species at the intensive care unit,Aseer Central Hospital,Saudi Arabia:A one year analysis

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 881-885页

作者： ali al Bshabshe Martin R.P.Joseph ali al Hussein waleed Haimour Mohamed E.Hamid Department of Medicine College of MedicineKing Khalid University Department of Microbiology College of MedicineKing Khalid University Intensive Care Unit Aseer Central Hospital Microbiology Laboratories Aseer Central Hospital

Objective:To identify and to determine the antimicrobial susceptibility of Acinetobacter baumannii(***) clinical isolates from ICU at Aseer Central ***:The study was conducted in the Intensive Care Unit,Aseer Central Hospital,Saudi Arabia over 13 months period(2014-2015).Acinetobacter species(n= 105) were isolated from various clinical *** were identified using selected phenotypic criteria and confirmed using the Vitek 2 automated *** system was used to determine the susceptibilities of 21 antimicrobial ***,isolates and drug data were analyzed using the SPSS statistical software package to determine some epidemiological and microbiological ***:Of the 105 stains,*** accounted for 49(46.67%),*** complex,19(18.09%),***/haemolyticus 32(30.47),Acinetobacter haemolyticus 4(3.81%),Acinetobater lwoffii 1(0.95%) and unidentified Acinetobater species 2(1.3%).Of the 105 Acinetobacter strains,103(98.1%) were found multidrug resistant(MDR).*** strain were 100% sensitive to colistin and 74.5% to trimethoprim + *** remaining 19 antimicrobial agents revealed low or no sensitivities:amikacin 16.3%; ampicillin 7.7%; ceftazidime 7.3%.Distribution of similar sensitivities was shown by other Acinetobacter *** number of isolates from males and females indicates no statistical variation(P=0.867) whereas age groups showed significant differences(P= 0.008) as it is clear from the high percentage of infected individuals more than 60 years followed by those aged 20 to 29 years old(19.05%).Upper respiratory tract(30.48%),lower respiratory tract(47.65%) and subcutaneous tissue(9.5%) were the main sources of Acinetobacter *** mean numbers of isolates from these specimens indicate no discrepancy between specimens(P=0.731).Conclusions:Acinetobacterspecies including *** were found MDR(98.1%) according to the current Acinetobacter *** categorization.A

关键词： Acinetobacter spp. ICU Antimicrobials Aseer Central Hospital

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Modes of failure with fractional flow reserve guidewires:Insights from the manufacturer and user facility device experience database

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World Journal of Cardiology 2021年第7期13卷 223-229页

作者： Nauman khalid Yagya Pandey Umair khalid Hassan Kamran Jason P Wermers Lovely Chhabra Mahboob alam Hani Jneid waleed Tallat Kayani Department of Interventional Cardiology St.Francis Medical CenterMonroeLA 71201United States Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Interventional Cardiology Michael E.DeBakey VA Medical CenterHoustonTX 77030United States Department of Interventional Cardiology Baylor College of MedicineHoustonTX 77030United States Health Sciences University of Maryland Graduate SchoolBaltimoreMD 21201United States

BACKGROUND Fractional flow reserve(FFR)measurement is commonly used in the cardiac catheterization laboratory to assess the functional significance of coronary arterial *** real-world data on complications and modes of failure of FFR guidewires are *** To characterize these outcomes by analyzing the post-marketing surveillance data from the United States Food and Drug Administration Manufacturer and User Facility Device Experience(MAUDE)database for commonly used FFR *** The MAUDE database was queried from January 2010 through April 2020 for 3 FFR guidewires[PressureWireTM X(Abbott),CometTM(Boston Scientific),and VerrataTM(Philips)]by searching for the following events:“Injury”,“malfunction”,“death”,and“other”.This yielded 544 *** excluding incomplete reports,486 reports were *** Guidewire tip fracture was the most commonly reported mode of failure,in 174(35.8%)cases followed by guidewire kinking(n=152,31.3%),communication failure(n=141,29.0%),and shaft fracture(n=67,13.8%).In total,133(27.4%)device failures resulted in patient adverse *** most common adverse event was retained guidewire tip,in 71(53.4%)cases,followed by freshly deployed stent dislodgment(n=26,19.6%)and coronary artery dissection(n=23,17.3%).Seven deaths were *** FFR guidewire failures can occur because of various mechanisms and cause patient adverse *** MAUDE database serves as an important platform for improved collaboration among clinicians,device manufacturers,and regulators to improve device performance and optimize patient *** analysis provides mechanistic insights of FFR guidewire failure and associated adverse events but cannot verify causality or provide a comparison among different guidewires.

关键词： Fractional flow reserve Coronary guidewire Adverse events Modes of failure Food and Drug Administration Manufacturer and user facility device experience

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Sudden death in the southern region of Saudi Arabia:A retrospective study

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World Journal of Clinical Cases 2023年第20期11卷 4843-4851页

作者： Ahmed Mohamed Ahmed al-Emam Abdulrahman Dajam Mohammed alrajhi waleed alfaifi Mubarak al-Shraim Ahmed Mohamed Helaly Department of Pathology College of MedicineKing Khalid UniversityAsir 61421Saudi Arabia Forensic Medicine and Clinical Toxicology Mansoura UniversityMansoura 35516Egypt Medical School King Khalid UniversityAsir 61421Saudi Arabia Clinical Science Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGROUND Sudden death is unanticipated,non-violent death taking place within the first 24 h after the onset of *** is a major public health problem ***,the effects of living at moderate altitude on mortality are poorly *** To retrospectively report the frequency and the main causes of sudden deaths in relation to total deaths at Asir Central Hospital,2255 m above sea level,in the southern region of Saudi Arabia over a period of 4 years from 2013 to *** The medical records of 1821 deaths were examined and showed 353 cases(19.4%)of sudden *** The highest incidence of sudden death was among the elderly(51%),whereas,the lowest was among children and adolescents(6.5%).With regard to gender,the incidence of sudden death was higher in males(54.4%)compared to 45.6% in *** this study,we found that the most common direct causes of sudden death were cardiovascular diseases(29.2%),respiratory disease(22.7%),infectious disease(12.2%),cancer(9.4%)and hematological diseases(6.2%).With respect to seasonal variation,the highest incidence was during winter(31.32%)followed by summer(25.8%).CONCLUSION The results of this study will help emergency physicians and health care providers to exercise due care to reduce the incidence of sudden death and raise public awareness about the impact of sudden death.

关键词： Sudden death High altitude Cardiovascular Gender distribution Age Seasonal variation

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