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Updated bone mineral density status in Saudi patients with inflammatory bowel disease

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World Journal of Gastroenterology 2020年第35期26卷 5343-5353页

作者： Mohammed Ewid Nawaf Al Mutiri khalid Al omar Amal N Shamsan Awais A Rathore Nazmus Saquib Anas Salaas omar Al Sarraj Yaman Nasri Ahmed Attal Abdulrahman Tawfiq Hossam Sherif Internal Medicine Department College of MedicineSulaiman Al Rajhi UniversityBukairyah 51941Al-QassimSaudi Arabia Internal Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Gastroenterology Department King Fahad Specialist HospitalBuraidah 52366Al-QassimSaudi Arabia Epidemiology Department College of MedicineSulaiman Al Rajhi UniversityBukairyah 51941Al-QassimSaudi Arabia Medical students College of MedicineSulaiman Al Rajhi UniversityBukairyah 51941Al-QassimSaudi Arabia Critical Care Medicine Department College of MedicineSulaiman Al Rajhi UniversityBukairyah 51941Al-QassimSaudi Arabia Critical Care Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND Little is known about inflammatory bowel disease(IBD)burden and its impact on bone mineral density(BMD)among adult patients in Saudi *** the best of our knowledge,our study is the only study to give an update about this health problem in adult Saudi patients with *** is a great risk factor for reduced BMD due to its associated chronic inflammation,malabsorption,weight loss and medication side ***,screening for reduced BMD among patients with IBD is of utmost importance to curb and control anticipated morbidity and mortality among those *** To assess the relationship between IBD and BMD in a sample of adult Saudi patients with *** Ninety adult patients with IBD-62 Crohn’s disease(CD)and 28 ulcerative colitis(UC)-were recruited from King Fahad Specialist Hospital gastroenterology clinics in Buraidah,*** enrolled patients were interviewed for their demographic information and for IBD-and BMD-related clinical *** patients had the necessary laboratory markers and dual-energy x-ray absorptiometry scans to evaluate their BMD *** were divided into two groups(CD and UC)to explore their clinical characteristics and possible risk factors for reduced *** The CD group was significantly more prone to osteopenia and osteoporosis compared to the UC group;44%of the CD patients had normal BMD,19%had osteopenia,and 37%had osteoporosis,while 78%of the UC patients had normal BMD,7%had osteopenia,and 25%had osteoporosis(P value<0.05).In the CD group,the lowest t-score showed a statistically significant correlation with body mass index(BMI)(r=0.45,P<0.001),lumbar z-score(r=0.77,P<0.05)and femur z-score(r=0.85,P<0.05).In the UC group,the lowest t-score showed only statistically significant correlation with the lumbar z-score(r=0.82,P<0.05)and femur z-score(r=0.80,P<0.05).The ROC-curve showed that low BMI could predict the lowest t-score in the CD group with the best cut-off value at≤23.43(m/kg2);area

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Bone mineral density Osteoporosis Fracture risk

Secure and Reliable Routing in the Internet of Vehicles Network:AODV-RL with BHA Attack Defense

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 633-659页

作者： Nadeem Ahmed khalid Mohammadani Ali Kashif Bashir Marwan omar Angel Jones Fayaz Hassan School of Electronic Science Beijing University of Post and TelecommunicationBeijing100086China Department of Computer Science Huanggang Normal UniversityHuanggangChina Department of Computing and Mathematics Manchester Metropolitan UniversityManchesterUK Woxsen School of Business Woxsen UniversityHyderabad502345India Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Information Technology and Management Illinois Institute of TechnologyChicagoUSA College of Computing Capital Technology UniversityLaurelUSA

Wireless technology is transforming the future of transportation through the development of the Internet of Vehicles(IoV).However,intricate security challenges are intertwinedwith technological progress:Vehicular ad hoc Networks(VANETs),a core component of IoV,face security issues,particularly the Black Hole Attack(BHA).This malicious attack disrupts the seamless flow of data and threatens the network’s overall reliability;also,BHA strategically disrupts communication pathways by dropping data packets from legitimate nodes *** the importance of this challenge,we have introduced a new solution called ad hoc On-Demand Distance Vector-Reputation-based mechanism Local Outlier Factor(AODV-RL).The significance of AODVRL lies in its unique approach:it verifies and confirms the trustworthiness of network components,providing robust protection against *** additional safety layer is established by implementing the Local Outlier Factor(LOF),which detects and addresses abnormal network *** testing of our solution has revealed its remarkable ability to enhance communication in ***,Our experimental results achieve message delivery ratios of up to 94.25%andminimal packet loss ratios of just 0.297%.Based on our experimental results,the proposedmechanismsignificantly improves VANET communication reliability and *** results promise a more secure and dependable future for IoV,capable of transforming transportation safety and efficiency.

关键词： Black hole attack IoV vehicular ad hoc network AODV routing protocol

Advances in Zika virus vaccines and therapeutics:A systematic review

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 97-109页

作者： Shiza Malik khalid Muhammad omar Ahsan Muhammad Tahir Khan Ranjit Sah Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Department of Biology College of SciencesUAE University15551Al AinUnited Arab Emirates Department of Medicine Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan INTI International University Persiaran Perdana BBN Putra Nilai71800 NilaiNegeri SembilanMalaysia Institute of Molecular Biology and Biotechnology the University of LahoreKM Defence RoadLahore 58810Pakistan Zhongjing Research and Industrialization Institute of Chinese Medicine Zhongguancun Scientific ParkNanyang 473006China Department of Microbiology Tribhuvan University Teaching HospitalInstitute of MedicineKathmandu 44600Nepal Department of Microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon

Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults *** wide transmission route and alarming spread rates are of great concern to the scientific *** trials have been conducted to develop treatment options for ZIKV *** review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic *** results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based *** addition,approved anti-ZIKV drugs that can reduce the global burden are *** many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to *** issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

关键词： Zika virus Infection Therapeutics Antiviral agents Vaccines Therapies Treatment Novel therapeutic Clinical management

Application of Stork Optimization Algorithm for Solving Sustainable Lot Size Optimization

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Computers, Materials & Continua 2024年第8期80卷 2005-2030页

作者： Tareq Hamadneh khalid Kaabneh omar Alssayed Gulnara Bektemyssova Galymzhan Shaikemelev Dauren Umutkulov Zoubida Benmamoun Zeinab Monrazeri Mohammad Dehghani Department of Mathematics Al Zaytoonah University of JordanAmman11733Jordan Faculty of Information Technology Al-Ahliyya Amman UniversityAmman19328Jordan Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Faculty of Engineering Liwa CollegeAbu Dhabi41009United Arab Emirates Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran

The efficiency of businesses is often hindered by the challenges encountered in traditional Supply Chain Manage-ment(SCM),which is characterized by elevated risks due to inadequate accountability and *** address these challenges and improve operations in green manufacturing,optimization algorithms play a crucial role in supporting decision-making *** this study,we propose a solution to the green lot size optimization issue by leveraging bio-inspired algorithms,notably the Stork Optimization Algorithm(SOA).The SOA draws inspiration from the hunting and winter migration strategies employed by storks in *** theoretical framework of SOA is elaborated and mathematically modeled through two distinct phases:exploration,based on migration simulation,and exploitation,based on hunting strategy *** tackle the green lot size optimization issue,our methodology involved gathering real-world data,which was then transformed into a simplified function with multiple constraints aimed at optimizing total costs and minimizing CO_(2) *** function served as input for the SOA ***,the SOA model was applied to identify the optimal lot size that strikes a balance between cost-effectiveness and *** extensive experimentation,we compared the performance of SOA with twelve established metaheuristic algorithms,consistently demonstrating that SOA outperformed the *** study’s contribution lies in providing an effective solution to the sustainable lot-size optimization dilemma,thereby reducing environmental impact and enhancing supply chain *** simulation findings underscore that SOA consistently achieves superior outcomes compared to existing optimization methodologies,making it a promising approach for green manufacturing and sustainable supply chain management.

关键词： Optimization supply chain management sustainable lot size optimization bio-inspired metaheuristic stork

Nutritional Status of Mothers and Its Determinants in Alemtidad Area, Khartoum

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Food and Nutrition Sciences 2014年第22期5卷 2203-2208页

作者： Waled Amen Mohammed Ahmed Eiman Abdalla Ahmed khalid Ahmad omar Arafa Ehab Ibrahim Salih El-Amin Ziad M. Alostaz khalid Eltahir khalid Nursing Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Altaiseer Medical Complex Khartoum Sudan Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Basic Sciences Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia

Background: Nutritional status of mothers is considered one of the major problems facing mothers in the world. The nutrition plays a major role in mothers and child health. Objective: This study aims to assess mothers’ nutritional status and its determinants in Alemtidad area, Khartoum. Methods: A descriptive community based survey was conducted in the Alemtidad area of Khartoum between November 2012 and December 2012. One hundred and eighty mothers were selected by simple randomization. Data were collected by using structured designed questionnaire which was then analyzed by (SPSS) program version 20. Results: The study conducted among mothers in Alemtidad area;their age ranged between 19 and 86 years with the mean age 38 ± 12 years. From those mothers about half were unemployed, and having mainly primary and secondary educational level. 81.1% of mothers were not able to select the proper food according to age and nutrients and about 71.1% of mothers took two meals per day and 23.3% one meals per day, and only 5.6 take three meals per day. The Body Mass Index (BMI) was calculated to measure the nutrition status of mothers;this study shows that mothers in Alemtidad are mainly overweight and obese, 45.6% and 18% respectively and only 35% within normal range of Body Mass Index (BMI). Conclusion: The study concludes that mothers are either overweight or obese (45.6%, 17.7% respectively). Compared to national and international statistics the findings of this study reflect high Body Mass Index (BMI) of mothers in Alemtidad.

关键词： Nutritional Status Determinant of Nutritional Status Food Consumption Mothers

Towards hepatitis C virus elimination:Egyptian experience,achievements and limitations

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World Journal of Gastroenterology 2018年第38期24卷 4330-4340页

作者： Dalia Omran Mohamed Alboraie Rania A Zayed Mohamed-Naguib Wifi Mervat Naguib Mohamed Eltabbakh Mohamed Abdellah Ahmed Fouad Sherief Sahar Maklad Heba Hamdy Eldemellawy omar khalid Saad Doaa Mohamed Khamiss Mohamed El Kassas Department of Endemic Medicine and Hepatology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11599Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11651Egypt Department of Clinical and Chemical Pathology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11599Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11566Egypt National Hepatology and Tropical Medicine Research Institute Cairo 11599Egypt Department of Internal Medicine Faculty of MedicineBeni-Suef UniversityBeni-Suef 62511Egypt Faculty of Medicine Ain Shams UniversityCairo 11566Egypt Department of Clinical and Chemical Pathology El-monera hospitalMinistry of HealthCairo 11562Egypt

Worldwide, more than one million people die each year from hepatitis C virus(HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients. Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014. Yet, with the development of highly-effective direct acting antivirals(DAAs) for HCV, elimination of viral hepatitis has become a real possibility. The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs. Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV. This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols. Also, it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV.

关键词： Hepatitis C virus Egypt Direct acting antivirals screening elimination Limitations

Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-<i>d</i>]pyrimidines

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International Journal of Organic Chemistry 2013年第2期3卷 110-118页

作者： Hend Nagah Hafez omar khalid Al-Duaij Abdel-Rhman Barakat A. El-Gazzar Chemistry Department Faculty of Science Al-Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh KSA Photochemistry Department National Research Centre Cairo Egypt

During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.

关键词： Spirobenzothienopyrimidine Triazolopyrimidine Pyrazolopyrimidine Analgesic Anti-inflammatory Ulcerogenic Effect

Burden of routine orthopedic implant removal a single center retrospective study

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World Journal of Orthopedics 2024年第2期15卷 139-146页

作者： Ammar K AlOmran Nader Alosaimi Ahmed A Alshaikhi omar M Bakhurji khalid J Alzahrani Basil Ziyad Salloot Tamim omar Alabduladhem Ahmed I AlMulhim Arwa Alumran Department of Orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Health Information Management and Technology Department Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACKGROUND Open reduction and internal fixation represent prevalent orthopedic procedures,sparking ongoing discourse over whether to retain or remove asymptomatic *** consensus on this matter is paramount for orthopedic *** study aims to quantify the impact of routine implant removal on patients and healthcare facilities.A retrospective analysis of implant removal cases from 2016 to 2022 at King Fahad Hospital of the University(KFHU)was conducted and subjected to statistical *** these cases,44%necessitated hospitalization exceeding one day,while 56%required only a single *** exhibited a 55%need for extended hospital stays,contrasting with 22.8%among the pediatric *** complication rate was 6%,with all patients experiencing at least one ***,34.1%required sick leave and 4.8%exceeded 14 *** anesthesia was predominant(88%).Routine implant removal introduces unwarranted complications,particularly in adults,potentially prolonging *** procedure strains hospital resources,tying up the operating room that could otherwise accommodate critical *** defined institutional guidelines are imperative to regulate this *** To measure the burden of routine implant removal on the patients and *** This is a retrospective analysis study of 167 routine implant removal cases treated at KFHU,a tertiary hospital in Saudi *** were collected in the orthopedic department at KFHU from February 2016 to August 2022,which includes routine asymptomatic implant removal cases across all age *** indications such as infection,pain,implant failure,malunion,nonunion,restricted range of motion,and prominent hardware were *** who had external fixators removed or joints replaced were also *** Between February 2016 and August 2022,360 implants were retrieved;however,only 167 of those who met the inclusion criteria were included in this

关键词： Implant removal Healed fracture Orthopedic implant Complications Healthcare system

Stoichiometry and Stability Constant Values for Copper (II) Chelates with Ethylene Diamine in Deep Eutectic Solvents (DES) (Ethaline) Solutions

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Open Journal of Applied Sciences 2024年第9期14卷 2592-2609页

作者： khalid El Ttaib Abdolhadi Benhmid Rifat Hasan omar Chemistry Department Faculty of Science University of Benghazi Benghazi Libya

In this study we used the deep eutectic solvents (ionic liquids) to investigate the reaction between copper (II) with ethylene diamine (en). Two of the existing methods for analyzing spectrophotometric measurements have been applied for establishing, the stoichiometry and whenever possible, the stability constants of the chelates formed. The method of continuous variations was necessary to determine first whether, the metal ion and the ligand ethylene diamine form one or more than one chelate, when more than one chelate formed, the results obtained depend on the wavelength and for meaningful conclusions the wavelengths were carefully selected. The empirical formulae of the chelates were further substantiated by the molar ratio method. The effect of time and temperature on the formation and stability of these chelates in solution is also studied. The stability constants, K1 and K2 for the copper (II) chelates were calculated, though reliable, and are comparable to literature values.

关键词： Cu(II) Ethylene Diamine (en) Deep Eutectic Solvents Job’s Method Ionic Liquids and Stability Constant