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Behavior of advanced gastrointestinal stromal tumor in a patient with von-Recklinghausen disease: Case report

World Journal of Clinical Oncology 2013年第3期4卷 70-74页

作者： Samer Sawalhi khalid al-harbi Zakaria Raghib Abdelrahman I Abdelrahman Ahmed al-Hujaily Department of Surgery Permanent researcher in the Centre of Genetics and Inherited DiseasesCollege of Medicine-Taibah UniversityAl-Madina 30001Saudi Arabia Center of Genetics and Inherited Diseases College of MedicineTaibah UniversityAl-Madina 30001Saudi Arabia Department of Surgery King Fahd HospitalAl-Madina 42351Saudi Arabia Department of Radiology King Fahd HospitalAl-Madina 42351Saudi Arabia Department of Pathology King Fahd HospitalAl-Madina 42351Saudi Arabia

Gastrointestinal stromal tumors(GISTs)represent a malignant gastrointestinal tumor of neurofibromatosis type 1(NF1)Von Recklinghausen *** the current case,we report a 27-year-old woman with NF1,who presented with a lower abdominal mass,symptomatic anaemia,and significant weight *** employed multiple approaches to assess the tumor behavior,including computed tomography(CT)scan,surgical tumor resection,histological and immunohistochemical analysis and gene ***,the patient was given Imatinib mesylate(Gleevec)as adjuvant *** scan delineated a large thick wall cavity lesion connecting to the small bowel *** of the tumor yielded a mass of 17 cm×13 cm with achievement of safety *** diagnosis was GIST,confirmed by immunohistochemical expression of CD117,CD34,and *** revealed no mutations in either KIT or platelet-derived growth factor receptor-alpha,genes which are mutated in over 85%of sporadic GIST ***,there was no evidence of recurrence,metastasis or metachronous GIST for over three years in our *** our analyses,we believe selective genotyping is advisable for high risk patients to predict potential tumor behavior.

关键词： KIT Gastrointestinal stromal tumor Imatinib Neurofibromatosis type-1 Platelet-derived growth factor receptor-alpha

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Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children &Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)

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Journal of Cancer Therapy 2015年第4期6卷 299-314页

作者： Nahla ali Mobark Suha A. Tashkandi Wafa al Shakweer khalid al Saidi Suha A. Fataftah Mohammed M. al Nemer Awatif alanazi Mohammed Rayis Walid Ballourah Othman Mosleh Zaheer Ullah Fahad El Manjomi Musa al harbi Department of Pediatric Hematology and Oncology Comprehensive Cancer Centre KFMC Riyadh Saudi Arabia Department of Cytogenetic and Molecular Cytogenetic Laboratory KFMC Riyadh Saudi Arabia Department of Anatomical Pathology KFMC Riyadh Saudi Arabia

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8;1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8;14) (q24;q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and hi

关键词： Non-Hodgkin Lymphoma Disease Patients Children and Adolescents

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