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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik shah Mona Al Hammad Fatima ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

Intrusion Detection System for Smart Industrial Environments with Ensemble Feature Selection and Deep Convolutional Neural Networks

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Intelligent Automation & Soft Computing 2024年第3期39卷 545-566页

作者： Asad Raza shahzad Memon Muhammad ali Nizamani Mahmood Hussain shah Dr.AHS Bukhari Postgraduate Centre of Information and Communication Technology Faculty of Engineering and TechnologyUniversity of SindhJamshoro76060Pakistan Newcastle Business School Northumbria UniversityNewcastleNE1UK

Smart Industrial environments use the Industrial Internet of Things(IIoT)for their routine operations and transform their industrial operations with intelligent and driven ***,IIoT devices are vulnerable to cyber threats and exploits due to their connectivity with the *** signature-based IDS are effective in detecting known attacks,but they are unable to detect unknown emerging ***,there is the need for an IDS which can learn from data and detect new *** Machine Learning(ML)and individual Deep Learning(DL)based IDS have been developed,and these individual models achieved low accuracy;however,their performance can be improved with the ensemble stacking *** this paper,we have proposed a Deep Stacked Neural Network(DSNN)based IDS,which consists of two stacked Convolutional Neural Network(CNN)models as base learners and Extreme Gradient Boosting(XGB)as the meta *** proposed DSNN model was trained and evaluated with the next-generation dataset,TON_*** pre-processing techniques were applied to prepare a dataset for the model,including ensemble feature selection and the SMOTE ***,precision,recall,F1-score,and false positive rates were used to evaluate the performance of the proposed ensemble *** experimental results showed that the accuracy for binary classification is 99.61%,which is better than in the baseline individual DL and ML *** addition,the model proposed for IDS has been compared with similar *** proposed DSNN achieved better performance metrics than the other *** proposed DSNN model will be used to develop enhanced IDS for threat mitigation in smart industrial environments.

关键词： Industrial internet of things smart industrial environment cyber-attacks convolutional neural network ensemble learning

Role of fecal microbiota transplant in management of hepatic encephalopathy: Current trends and future directions

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World Journal of Hepatology 2024年第1期16卷 17-32页

作者： Yash R shah Hassam ali Angad Tiwari David Guevara-Lazo Natalia Nombera-Aznaran Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Harishankar Gopakumar Amir H Sohail SriLakshmiDevi Kanumilli Ernesto Calderon-Martinez Geetha Krishnamoorthy Nimish Thakral Dushyant Singh Dahiya Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Maharani Laxmi Bai Medical CollegeJhansi 284001India Faculty of Medicine Universidad Peruana Cayetano HerediaLima 15102Peru Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology University of Illinois College of Medicine at PeoriaPeoriaIL 61605United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine GSL Medical CollegeRajamahendravaram 533296India Department of Internal Medicine Universidad Nacional Autonoma de MexicoCiudad De Mexico 04510Mexico Department of Digestive Diseases and Nutrition University of KentuckyLexingtonKY 40536United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States

Fecal microbiota transplantation(FMT)offers a potential treatment avenue for hepatic encephalopathy(HE)by leveraging beneficial bacterial displacement to restore a balanced gut *** prevalence of HE varies with liver disease severity and *** pathogenesis involves ammonia toxicity,gut-brain communication disruption,and *** aims to restore gut microbiota balance,addressing these ***'s efficacy has been explored in various conditions,including *** suggest that FMT can modulate gut microbiota,reduce ammonia levels,and alleviate *** has shown promise in alcohol-associated,hepatitis B and C-associated,and non-alcoholic fatty liver *** include improved liver function,cognitive function,and the slowing of disease ***,larger,controlled studies are needed to validate its effectiveness in these *** have shown cognitive improvements through FMT,with potential benefits in cirrhotic ***,trials have demonstrated reduced serious adverse events and cognitive enhancements in FMT arms compared to the standard of *** evidence is promising,challenges remain:Limited patient numbers,varied dosages,administration routes,and donor *** large-scale,controlled trials are essential to establish standardized guidelines and ensure FMT's clinical applications and *** FMT holds potential for HE management,ongoing research is needed to address these challenges,optimize protocols,and expand its availability as a therapeutic option for diverse hepatic conditions.

关键词： Hepatic encephalopathy Fecal microbiota transplant Cognitive impairment Liver cirrhosis Chronic liver disease

Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Hassam ali Sahib Singh Yash R shah Daksh Ahluwalia Mihir Prakash shah Saurabh Chandan Neil R Sharma Shyam Thakkar Department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States Department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical Endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(Pality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden

Towards Improving the Quality of Requirement and Testing Process in Agile Software Development:An Empirical Study

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Computers, Materials & Continua 2024年第9期80卷 3761-3784页

作者： Irum Ilays Yaser Hafeez Nabil Almashfi Sadia ali Mamoona Humayun Muhammad Aqib Ghadah Alwakid University Institute of Information Technology Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Software Engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia School of Arts Humanities and Social Sciences University of RoehamptonLondonSW155PJUK Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia

Software testing is a critical phase due to misconceptions about ambiguities in the requirements during specification,which affect the testing ***,it is difficult to identify all faults in *** requirement changes continuously,it increases the irrelevancy and redundancy during *** to these challenges;fault detection capability decreases and there arises a need to improve the testing process,which is based on changes in requirements *** this research,we have developed a model to resolve testing challenges through requirement prioritization and prediction in an agile-based *** research objective is to identify the most relevant and meaningful requirements through semantic analysis for correct change *** compute the similarity of requirements through case-based reasoning,which predicted the requirements for reuse and restricted to error-based ***,the apriori algorithm mapped out requirement frequency to select relevant test cases based on frequently reused or not reused test cases to increase the fault detection ***,the proposed model was evaluated by conducting *** results showed that requirement redundancy and irrelevancy improved due to semantic analysis,which correctly predicted the requirements,increasing the fault detection rate and resulting in high user *** predicted requirements are mapped into test cases,increasing the fault detection rate after changes to achieve higher user ***,the model improves the redundancy and irrelevancy of requirements by more than 90%compared to other clustering methods and the analytical hierarchical process,achieving an 80%fault detection rate at an earlier ***,it provides guidelines for practitioners and researchers in the modern *** the future,we will provide the working prototype of this model for proof of concept.

关键词： Requirement prediction software testing agile software development semantic analysis case-based reasoning

Enhancing Secure Development in Globally Distributed Software Product Lines: A Machine Learning-Powered Framework for Cyber-Resilient Ecosystems

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Computers, Materials & Continua 2024年第6期79卷 5031-5049页

作者： Marya Iqbal Yaser Hafeez Nabil Almashfi Amjad Alsirhani Faeiz Alserhani Sadia ali Mamoona Humayun Muhammad Jamal University Institute of Information Technology PMAS-Arid Agriculture UniversityRawalpindiPakistan Department of Software Engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Engineering&Networks College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72388Saudi Arabia Department of Mathematics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

Embracing software product lines(SPLs)is pivotal in the dynamic landscape of contemporary software ***,the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability,underscoring the critical importance of robust cybersecurity *** paper advocates for leveraging machine learning(ML)to address variability management issues and fortify the security of *** the context of the broader special issue theme on innovative cybersecurity approaches,our proposed ML-based framework offers an interdisciplinary perspective,blending insights from computing,social sciences,and ***,it employs ML for demand analysis,dynamic feature extraction,and enhanced feature selection in distributed settings,contributing to cyber-resilient *** experiments demonstrate the framework’s superiority,emphasizing its potential to boost productivity and security in *** digital threats evolve,this research catalyzes interdisciplinary collaborations,aligning with the special issue’s goal of breaking down academic barriers to strengthen digital ecosystems against sophisticated attacks while upholding ethics,privacy,and human values.

关键词： Machine Learning variability management cybersecurity digital ecosystems cyber-resilience

Clinical Insights:Prevalence of β-Thalassemia Mutations(IVSI-5,FSC8/9,and CD41/42)in the Swat District

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Journal of Bio-X Research 2024年第1期7卷 1-7页

作者： Sumaia Saif shah Lila Gulalai Ghani Murad ali Rahat Akhtar Rasool Muhammad Israr Department of Forensic Sciences University of SwatKhyber PakhtunkhwaPakistan Centre for Animal Sciences and Fisheries University of SwatKhyber PakhtunkhwaPakistan

Background:Thalassemia is a prevalent condition characterized by decreased production or absence of hemoglobin globin *** are 2 types of thalassemia,alpha thalassemia and beta thalassemia(β-thalassemia),classified according to defects in the alpha or beta protein chain.β-Thalassemia results from a diverse range of mutations in theβsubunit of the hemoglobin gene(HBB).This results in severe reductions in erythrocyte and hemoglobin ***,more than 40,000 babies are born withβ-thalassemia *** are approximately 80 millionβ-thalassemia *** Pakistan,the annual birth rate ofβ-thalassemia major carriers is approximately 6,000,and 50,000 to 100,000 patients suffer from this common inherited ***-1,IVSI-5(G>C),Fr 8/9(+G),Fr 41/42(-TTCT),and del 619 are the 5 most common mutations that account for 90%ofβ-thalassemia cases in *** study aimed to investigate the prevalence ofβ-thalassemia mutations(IVSI-5,Fr 41/42,and Fr 8/9)in the Swat district and to analyze the blood morphology of different mutant thalassemia blood ***:A cross-sectional study was performed at the Forensic Research Lab University of Swat from December 2021 to March *** study included a total of 150 blood *** analysis of blood morphology through microscopy was carried out on samples from patients with differentβ-thalassemia mutations and normal *** DNA extraction was performed according to the Sambrook protocol,and DNA was quantified via agarose gel *** mutations were detected by amplification refractory mutation system(ARMS)-polymerase chain reaction(PCR).The frequencies of differentβ-thalassemia mutations were ***:Thalassemia blood cells were more hypochromic and microcytic than normal blood cells,although no differences were detected in the morphology of IVSI-5,Fr 8/9,or CD41/42 mutant blood *** IVSI-5,Fr 8/9,and CD41/42 mutations were analyzed through agarose ge

关键词： Thalassemia annually Pakistan

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氯化铵溶液加速水泥基材料钙溶蚀的最佳浓度

常州大学学报（自然科学版） 2024年第5期36卷 71-77页

作者：王少伟高文龙肖焰钰吴佳雯 SYED Piyar ali shah 常州大学城市建设学院江苏常州213164

选取0.2~6.0 mol/L的NH_(4)Cl溶液作为溶蚀介质,使用全浸泡法对纯水泥净浆试件开展加速溶蚀试验,研究不同浓度NH_(4)Cl溶液浸泡下试件的溶蚀深度、钙溶蚀量以及孔隙率随溶蚀时间的变化规律,并通过X射线衍射分析进行微观机理解释。结果发... 详细信息

选取0.2~6.0 mol/L的NH_(4)Cl溶液作为溶蚀介质,使用全浸泡法对纯水泥净浆试件开展加速溶蚀试验,研究不同浓度NH_(4)Cl溶液浸泡下试件的溶蚀深度、钙溶蚀量以及孔隙率随溶蚀时间的变化规律,并通过X射线衍射分析进行微观机理解释。结果发现,随着NH_(4)Cl溶液浓度的升高,其对溶蚀深度和钙溶蚀量的时间变化规律拟合所得Fick扩散定律比例系数分别呈先线性增大、后线性降低和负指数函数增长的演变规律,浸泡81 d后的试件溶蚀区相同深度处的CaCO_(3)衍射峰呈先降低、后增大的趋势。NH_(4)Cl溶液浓度过高,将导致溶蚀环境下固相含钙水化物的溶解-扩散过程明显偏离自然浸水环境下水泥基材料的钙溶蚀机理,NH_(4)Cl浸泡液浓度以3 mol/L为最佳。

关键词：水泥基材料钙溶蚀 NH 4Cl溶液浸泡法最佳浓度

A Review and Bibliometric Analysis of the Current Studies for the 6G Networks

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2165-2206页

作者： Qusay M.Salih Md.Arafatur Rahman Ahmad Firdaus Mohammed Rajih Jassim Hasan Kahtan Jasni Mohamad Zain Ahmed Hussein ali Faculty of Computing Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)PekanPahang26600Malaysia Department of Medical Equipment Technology Engineering Al Salam University CollegeBaghdadIraq School of Mathematics and Computer Science University of WolverhamptonWolverhampton01902UK Department of Production Engineering and Metallurgy University of TechnologyBaghdadIraq Cardiff School of Technologies Cardiff Metropolitan UniversityCardiffCF52YBUK Institute for Big Data Analytics and Artificial Intelligence(IBDAAI) Kompleks Al-KhawarizmiUniversiti Teknologi MARAShah AlamSelangor40450Malaysia Department Computer Science Al-Salam University CollegeBaghdadIraq

The race to develop the next generation of wireless networks,known as Sixth Generation(6G)wireless,which will be operational in 2030,has already *** realize its full potential over the next decade,6G will undoubtedly necessitate additional improvements that integrate existing solutions with cutting-edge ***,the studies about 6G are mainly limited and scattered,whereas no bibliometric study covers the 6G ***,this study aims to review,examine,and summarize existing studies and research activities in *** study has examined the Scopus database through a bibliometric analysis of more than 1,000 papers published between 2017 and ***,we applied the bibliometric analysis methods by including(1)document type,(2)subject area,(3)author,and(4)country of *** study’s results reflect the research 6G community’s trends,highlight important research challenges,and elucidate potential directions for future research in this interesting area.

关键词： 6G bibliometric wireless networks review