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The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

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Biosafety and Health 2024年第4期6卷 216-224页

作者： Yihui He Yang Zhang Jiaxin Zhen Guangqiang Sun Zhen Li Bo Yang Bin Yang keyi chang Xue Chen Yulin Zhang Caiping Guo Wen Wang Ping Wu Tong Zhang Lei Wang Postgraduate Union Training Base of Jinzhou Medical University PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Neurology PLA Rocket Force Characteristic Medical CenterBeijing 100088China Center for Infectious Disease Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Key Laboratory for HIV/AIDS Research Beijing 100069China Beijing Institute for Sexually Transmitted Disease Control Beijing 100069China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders and National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China The Second Hospital of Beijing Beijing 100031China Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Key Discipline for Neuroscience of the Ministry of Education Department of NeurobiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Integrase strand transfer inhibitors(INSTIs)have emerged as the first‐line choice for treating human immunodeficiency virus(HIV)infection due to their superior efficacy and ***,the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV(PLWH)is not fully understood due to limited *** this study,we conducted a cross‐sectional examination of PLWH receiving antiretroviral therapy,with a specific focus on HIV‐positive men who have sex with men(MSM)on INSTI‐based regimens(n=61)and efavirenz(EFV)‐based regimens(n=28).Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging(MRI)scans,including T1‐weighted images and resting‐state functional *** to the EFV group,the INSTI group exhibited primarily reduced gray matter volume(GMV)in the right superior parietal gyrus,higher regional homogeneity(ReHo)in the left postcentral gyrus,lower ReHo in the right orbital part of the inferior frontal gyrus,and increased voxel‐wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right ***,the analysis revealed a main effect of antiretroviral drugs on GMV changes,but no main effect of neuropsychiatric disorders or their *** repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group,validating the initial *** study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI‐based regimens compared to those on EFV‐based *** neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI‐based regimens。

关键词： Human immunodeficiency virus(HIV) Multimodal magnetic resonance imaging(MRI) Integrase strand transfer inhibitors(INSTIs) Efavirenz(EFV)

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HIV感染者/AIDS患者参与同伴支持体验质性研究的Meta整合

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中华护理杂志 2024年第1期59卷 108-116页

作者：常可意吴杨峰单锶楷韩舒羽全晓丽韩佳凝吴冬霞张莉莉首都医科大学附属北京佑安医院感染与免疫医学科北京市100069 首都医科大学附属北京佑安医院护理部北京市100069 北京大学护理学院

目的系统评价和整合HIV感染者/AIDS患者参与同伴支持的体验,为完善对HIV感染者/AIDS患者的同伴支持提供参考和建议。方法计算机检索PubMed、CINAHL、Web of Science Core Collection、ProQuest、中国知网、万方数据库等中英文数据库,搜... 详细信息

目的系统评价和整合HIV感染者/AIDS患者参与同伴支持的体验,为完善对HIV感染者/AIDS患者的同伴支持提供参考和建议。方法计算机检索PubMed、CINAHL、Web of Science Core Collection、ProQuest、中国知网、万方数据库等中英文数据库,搜集有关HIV感染者/AIDS患者参与同伴支持体验的质性研究,检索时限为1996年1月—2022年9月。采用澳大利亚乔安娜布里格斯研究所质性研究质量评价标准(2020版)对纳入文献进行方法学质量评价,采用汇集性整合方法对原始研究结果进行整合,按照提高定性研究合成报告透明度的指南撰写论文。结果共纳入7篇质性研究,提取出26个原始研究结果,归纳为12个类别,综合为4个整合结果,分别是同伴支持为患者提供信息支持,帮助患者建立和维持健康生活方式;患者在同伴支持中获得心理和情感支持;患者在同伴支持中获得社会支持;开展同伴支持的客观要求及情景。结论同伴支持对AIDS防治工作有积极作用,对解决HIV感染者/AIDS患者实际需求具有重要意义。AIDS同伴支持的实践需要进一步的理论支持及科学指导,构建AIDS同伴支持模式,对AIDS同伴进行系统的培训和专业的指导,有利于提升AIDS同伴支持行为的准确性,促进AIDS同伴支持活动的开展,优化HIV感染者/AIDS患者同伴支持的有效性和可持续性。

关键词：获得性免疫缺陷综合征同伴支持 Meta整合循证护理学

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大型阅兵训练期间女兵心理健康状况调查

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护理研究 2021年第24期35卷 4509-4512页

作者：常可意王斌全山西医科大学山西030001 山西医科大学第一医院

目的:了解女兵在阅兵训练过程中心理健康水平及变化情况,为开展受阅女兵心理健康监测和维护提供参考依据。方法:随机抽取参加"十一"国庆阅兵女兵140名,分别在进入阅兵村前1个月和入村后1个月,采用症状自评量表(SCL-90)、简易应对方式问... 详细信息

目的:了解女兵在阅兵训练过程中心理健康水平及变化情况,为开展受阅女兵心理健康监测和维护提供参考依据。方法:随机抽取参加"十一"国庆阅兵女兵140名,分别在进入阅兵村前1个月和入村后1个月,采用症状自评量表(SCL-90)、简易应对方式问卷、心理弹性量表进行测评,采用Spearman秩相关分析心理健康水平与应对方式、心理弹性的相关性,并将心理健康水平与中国成人常模、中国女军人常模比较。结果:参加阅兵训练的女兵入村前后在SCL-90总分、阳性数、体重、人际关系敏感、抑郁、焦虑、恐怖、偏执和精神病性方面差异有统计学意义(P<0.05);入村后各因子得分均小于入村前;女兵心理健康状况与其心理弹性有关;入村前后女兵各项得分均低于中国常模和女军人常模(P<0.05)。结论:受阅女兵心理健康状况总体良好,入阅兵村后的心理健康状况好于入村前,需关注个别女兵并进行个体化的心理干预与治疗。

关键词：女兵心理健康 SCL-90 心理弹性应对方式影响因素

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Effect of heat treatment on microstructure and mechanical properties of selective laser-melted PH13-8Mo stainless steel

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Journal of Iron and Steel Research International 2024年第4期31卷 945-955页

作者： Yuan Zhang Xiang Liu chang-jun Wang chang Liu School of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research Institute Co. Ltd.Beijing 100081China

PH13-8Mo stainless steel powder with high sphericity and well fluidity was prepared by the plasma rotating electrode *** formed parts with ultra-high purity were manufactured by selective laser *** tensile and impact mechanical properties of the printed parts under three heat treatment regimes were compared to those without heat *** microstructure,grain orientation and phase composition were characterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** characterization results reveal that the addition of heat treatment makes the grains enlarge,and after different heat treatments,the average grain size from 1.51μm in the printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,the NiAl and M23C precipitates form,which are the major strengthening phases of PH13-8Mo stainless *** optimal heat treatment process is 925℃×1 h water cooling(WC)+0℃×2 h air cooling(AC)+540℃×4 h *** this heat treatment process,PH13-8Mo formed parts have the optimal comprehensive mechanical properties:the tensile strength,yield strength and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strengthening and toughening via heat treatment are mainly attributed to dislocation strengthening,the formation of NiAl and M23Co precipitates and the change of volume fraction of the retained austenite.

关键词： High-strength stainless steel-Selective laser melting-Heat treatment Microstructure Mechanical property

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Inverse-time Backup Protection Based on Unified Characteristic Equation for Distribution Networks with High Proportion of Distributed Generations

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 202-212页

作者： Nana chang Guobing Song Zhongxue chang Yuping Zheng Xingang Yang the School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina State Key Laboratory of Smart Grid Protection and Control NARI Group CorporationNanjingChina Electric Power Research Institute of State Grid Shanghai Electric Power Company ShanghaiChina

The setting work of backup protection using steady-state current is tedious,and mismatches occasionally occur due to the increased proportion of distributed generations(DGs)connected to the power ***,there is a practical need to study a backup protection technology that does not require step-by-step setting and can be adaptively *** paper proposes an action sequence adaptive to fault positions that uses only positive sequence fault component(PSFC)*** the influence of DGs,the unified time dial setting can be obtained by selecting specific *** protection performance is improved by using the adjacent upstream and downstream protections to meet the coordination time interval in the case of metallic faults at the near-and far-ends of the ***,the expression and implementation scheme for inverse-time backup protection(ITBP)based on the unified characteristic equation is *** results show that this scheme can adapt to DG penetration scenarios and can realize the adaptive coordination of multi-level relays.

关键词： Inverse-time backup protection(ITBP) distributed generation(DG) positive sequence fault component(PSFC)voltage unified characteristic equation adaptive coordination

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Polymeric piezoelectric accelerometers with high sensitivity,broad bandwidth,and low noise density for organic electronics and wearable microsystems

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Microsystems & Nanoengineering 2024年第3期10卷 63-74页

作者： chang Ge Edmond Cretu The Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBCCanada

Piezoelectric accelerometers excel in vibration *** the emerging trend of fully organic electronic microsystems,polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals,such as vocal vibrations in wearable speaking assistants for those with speaking ***,high-performance polymeric piezoelectric accelerometers suitable for such applications are *** organic compounds such as PVDF have inferior properties to their inorganic counterparts such as ***,most existing polymeric piezoelectric accelerometers have very unbalanced performance *** often sacrifice resonance frequency and bandwidth for a flat-band sensitivity comparable to those of PZT-based accelerometers,leading to increased noise density and limited application *** this study,a new polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is *** new design aims to simultaneously achieve high sensitivity,broad bandwidth,and low *** samples were manufactured and characterized,demonstrating an average sensitivity of 29.45 pC/g within a±10 g input range,a 5%flat band of 160 Hz,and an in-band noise density of 1.4μg/√*** results surpass those of many PZT-based piezoelectric accelerometers,showing the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.

关键词： piezoelectric polymeric overcome

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Recent Progresses of the DAMPE Mission

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空间科学学报 2024年第4期44卷 633-642页

作者： chang Jin Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033 School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026

The DArk Matter Particle Explorer(DAMPE)is a space high-energy particle andγ-ray detector whose major scientific goals are the indirect detection of dark matter particles,the origin of cosmic rays and highenergyγ-ray *** its successful launch in December 2015,the DAMPE has been operated smoothly in orbit for more than 8 *** direct measurements of the boron-to-carbon and boron-to-oxygen flux ratios,and the proton+Helium spectrum up to 316 TeV have been obtained,revealing new spectral features with very high *** search results ofγ-ray spectral line and fractionally charged particles indicate a good potential of DAMPE for indirect dark matter detection and new physical discovery in *** DAMPE measurements are expected to significantly advance our understanding of the fundamental problems in astroparticle physics.

关键词： DAMPE Dark matter Indirect detection Cosmic rays

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Preface to the Special Issue:Additive Manufacturing—Expanding Production Horizon

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 1-2页

作者： Lai-chang Zhang Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

Additive manufacturing(AM),commonly known as 3D printing,has become a transformative technology that has a profound impact on various industrial *** encompasses a set of techniques for building objects layer by layer from digital *** conventional subtractive manufacturing methods that involve removing material from large blocks,AM adds material incrementally,providing unprecedented design flexibility and efficiency.

关键词： removing printing Expanding

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Breakthrough in Li-mediated continuous electrosynthesis of ammonia

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Science China Chemistry 2024年第10期67卷 3191-3192页

作者： Fei Zhan chang Yu State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

Ammonia(NH3)ranks among the manufactured chemicals,with an annual production surpassing 182 million tons[1],which is an indispensable raw material for fertilizer industry and has been recognized as a promising carbon-... 详细信息

关键词： ammonia Ammonia suppl

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An interview with *** Zhang

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High Power Laser Science and Engineering 2024年第3期12卷 122-125页

作者： Guoqing chang Institute of Physics Chinese Academy of SciencesBeijingChina

*** Zhang,a distinguished physicist,has made significant contributions in the fields of high-energy-density physics and inertial confinement *** of these,he was elected academician of the Chinese Academy of Sciences in 2003,academician of the German National Academy of Sciences in 2007,Fellow of the Academy of Sciences for the Developing World(TWAS)in 2008,foreign member of the Royal Academy of Engineering in the United Kingdom in 2011 and foreign associate of the National Academy of Sciences in the United States in *** 2015,he was awarded the prestigious Edward Teller Medal,the most important international award in inertial confinement fusion and high-energy-density *** 2021,he was awarded the Future Science Prize in Physical Sciences.

关键词： interview award Jie

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