检索结果-南通市图书馆

2023年度金属材料学科国家自然科学基金管理工作综述

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金属学报 2024年第4期60卷 417-424页

作者：陈克新张龙国家自然科学基金委员会工程与材料科学部北京100085 中国科学院金属研究所沈阳110016

本文统计和分析了2023年度国家自然科学基金委员会工程与材料科学部金属材料(E01)学科基金项目的申请、受理、评审和资助情况;介绍了E01学科基金项目的进展、中期与结题管理情况;阐述了学科在落实科学基金改革与加强人才培养方面的举措... 详细信息

本文统计和分析了2023年度国家自然科学基金委员会工程与材料科学部金属材料(E01)学科基金项目的申请、受理、评审和资助情况;介绍了E01学科基金项目的进展、中期与结题管理情况;阐述了学科在落实科学基金改革与加强人才培养方面的举措;并对学科下一步的工作进行了展望。

关键词：金属材料学科国家自然科学基金科学基金改革 E01基金项目管理

Potassium transporter OsHAK9 regulates seed germination under salt stress by preventing gibberellin degradation through mediating OsGA2ox7 in rice

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第4期66卷 731-748页

作者： Peng Zeng Ting Xie Jiaxin Shen Taokai Liang Lu Yin kexin Liu Ying He Mingming Chen Haijuan Tang Sunlu Chen Sergey Shabala Hongsheng Zhang Jinping Cheng National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Jiangsu Collaborative Innovation Center for Modern Crop ProductionHainan Yazhou Bay Seed LabJiangsu Province Engineering Research Center of Seed Industry Science and TechnologyNanjing Agricultural UniversityNanjing 210095China International Research Center for Environmental Membrane Biology Foshan UniversityFoshan 528000China School of Biological Sciences University of Western AustraliaCrawley WA 6009Australia

Soil salinity has a major impact on rice seed germination,severely limiting rice ***,a rice germination defective mutant under salt stress(gdss)was identified by using chemical *** GDSS gene was detected via MutMap and shown to encode potassium transporter *** analysis of complementation and mutant lines demonstrated that OsHAK9 was an essential regulator responsible for seed germination under salt ***9 is highly expressed in germinating seed *** contents and non-invasive micro-test technology results showed that OsHAK9 restricted K^(+)efflux in salt-exposed germinating seeds for the balance of K^(+)/Na^(+).Disruption of OsHAK9 significantly reduced gibberellin 4(GA4)levels,and the germination defective phenotype of oshak9a was partly rescued by exogenous GA_(3)treatment under salt *** sequencing(RNA-seq)and real-time quantitative polymerase chain reaction analysis demonstrated that the disruption of OsHAK9 improved the GA-deactivated gene OsGA2ox7 expression in germinating seeds under salt stress,and the expression of OsGA2ox7 was significantly inhibited by salt *** mutants of OsGA2ox7 created using clustered,regularly interspaced,short palindromic repeat(CRISPR)/CRISPR-associated nuclease 9 approach displayed a dramatically increased seed germination ability under salt ***,our results highlight that OsHAK9 regulates seed germination performance under salt stress involving preventing GA degradation by mediating OsGA2ox7,which provides a novel clue about the relationship between GA and OsHAKs in rice.

关键词： GDSS gibberellins potassium transporter rice salt tolerance seed germination

APIR:Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 171-187页

作者： Yiling Elaine Chen Xinzhou Ge Kyla Woyshner MeiLu McDermott Antigoni Manousopoulou Scott B.Ficarro Jarrod A.Marto kexin Li Leo David Wang Jingyi Jessica Li Department of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Quantitative and Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA Department of Cancer Biology and Blais Proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Department of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Interdepartmental Program University of CaliforniaLos AngelesCA 90095USA Department of Human Genetics University of CaliforniaLos AngelesCA 90095USA Department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA Department of Biostatistics University of CaliforniaLos AngelesCA 90095USA

Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide–spectrum matches(PSMs),which convert mass spectra to peptide *** database search algorithms use distinct search strategies and thus may identify unique ***,no existing approaches can aggregate all user-specified database search algorithms with a guaranteed increase in the number of identified peptides and a control on the false discovery rate(FDR).To fill in this gap,we proposed a statistical framework,Aggregation of Peptide Identification Results(APIR),that is universally compatible with all database search ***,under an FDR threshold,APIR is guaranteed to identify at least as many,if not more,peptides as individual database search algorithms *** of APIR on a complex proteomics standard dataset showed that APIR outpowers individual database search algorithms and empirically controls the *** data studies showed that APIR can identify disease-related proteins and post-translational modifications missed by some individual database search *** APIR framework is easily extendable to aggregating discoveries made by multiple algorithms in other high-throughput biomedical data analysis,e.g.,differential gene expression analysis on RNA sequencing *** APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteomics Peptide–spectrum match Peptide identification Aggregation of lists FDR control

The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第3期7卷 388-395页

作者： Meng Li Panpan Wei kexin Li Haole Liu Naqash Alam Haiwen Hou Jie Deng Baohui Xu Enqi Liu Sihai Zhao Yankui Li Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Intimal hyperplasia(IH)is a negative vascular remodeling after arterial *** occasionally occurs in elastase-induced abdominal aortic aneurysm(AAA)mouse *** study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastaseinduced mouse AAA *** IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were *** 42 elastase-induced AAA mouse models,10 mice developed mild IH(24%)and severe IH was found in only 2 mice(5%).The outer diameters of the AAA segments in mice with and without IH did not show significant *** mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH *** was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe ***,only a lower numbers of T cells and B cells were found in the IH *** cell-secreted matrix metalloproteinases(MMP)2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe *** conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastaseinduced mouse AAA *** will help researchers better understand this model,and optimize it for use in AAA-related research.

关键词： abdominal aortic aneurysms animal model histology intimal hyperplasia

Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri:intraspecific and interspecific patterns

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第5期13卷 2799-2812页

作者： Chunxiu Lin Yuxing Zheng Bo Zhang Guopeng Lin kexin Shang Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China

Lactobacillus rhamnosus(Rh)and Lactobacillus reuteri(Re)are well-known probiotic species in inflammatory bowel disease(IBD)*** variations between these species’efficacy against colitis,and their model of action in this regard,are intriguing and enable treatment to be individually tailored to *** this study,four strains each of Rh and Re were isolated from fecal samples and their draft genomes were *** anti-colitis activities of both strains involved various aspects of intestinal immune,physical,chemical,and biological barrier ***,the tested strains exhibited considerable interspecies and intraspecies specificity in colitis *** strains significantly outperformed Re strains in terms of short-chain fatty acid ***,Re strains were more effective than Rh strains in inhibiting production of inflammatory factors;promoting production of intestinal mucus,antimicrobial peptides,and tight junction proteins;and supporting the stem cell *** accounts for the anti-colitis outcomes of Re strains being superior to those of Rh *** addition,the effective Rh and Re strains were found to express high concentrations of specific carbohydrate metabolism-and prophage-related genes,*** together,the results of this study could assist researchers in developing effective therapies for IBD.

关键词： Inflammatory bowel disease Anti-colitis Lactobacillus rhamnosus Lactobacillus reuteri Intestinal barrier function Short-chain fatty acids

Development and assessment of cutting-edge biotechnologies

在线全文

学校读者我要写书评

暂无评论

Journal of Biosafety and Biosecurity 2024年第1期6卷 51-63页

作者： Xiaofeng Hu Baichuan Xu Mingliang Chen kexin Li Yang Xiao Shengnan Liang Chuanfu Zhang Hui Ma Hongbin Song Chinese PLA Center for Disease Control and Prevention BeijingChina Army Medical University ChongqingChina Institute of Pathology and Southwest Cancer Centre Southwest HospitalArmy Medical UniversityChongqingChina Department of Chemical Defense Medicine School of Military Preventive MedicineArmy Medical UniversityChongqingChina Institute of Toxicology School of Military Preventive MedicineArmy Medical UniversityChongqingChina China Medical University ShenyangChina Chongqing University Cancer Hospital School of MedicineChongqing UniversityChongqingChina The Nursing Department of PLA General Hospital BeijingChina

The emergence of advanced biotechnologies has intensified in recent *** rapid development of these biotechnologies has had a wide and profound impact globally,with the majority on the frontier of biosecurity *** global biosecurity situation is currently highly challenging,with the characteristics of internationalization,extremely serious harm,and complex *** misuse and abuse of biotechnologies are common,which thereby endanger *** international community and governments have attached great importance to cutting-edge biotechnologies and are implementing laws and regulations to control and prevent biosecurity-related *** tracking the frontier progress of the new technologies generated from gene editing,gene drives,synthetic biology,and related cross-disciplines as applied in the biosecurity field,we analyzed the development trends in biotechnologies and their potential *** the one hand,this paper proposes that there is an urgent need for global cooperation to formulate management,control strategies,and measures for cutting-edge technologies in biosecurity to jointly promote their sound *** the other hand,the international community should jointly shoulder the responsibility for safeguarding biosecurity and restrict the biotechnologies to rational applications within legal and ethical *** paper aims to provide a reference for the prevention of misuse and abuse of biotechnologies and support global cooperation in biosecurity governance.

关键词： Biotechnology Gene drives Gene editing Synthetic biology

A closer look at the belief propagation algorithm in side-channel attack on CCA-secure PQC KEM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第11期67卷 317-334页

作者： kexin QIAO Zhaoyang WANG Heng CHANG Siwei SUN Zehan WU Junjie CHENG Changhai OU An WANG Liehuang ZHU School of Cyberspace Science and Technology Beijing Institute of Technology State Key Laboratory of Cryptology School of Cryptology University of Chinese Academy of Sciences School of Cyber Science and Engineering Wuhan University

The implementation security of post-quantum cryptography(PQC) algorithms has emerged as a critical concern with the PQC standardization process reaching its end. In a side-channel-assisted chosen-ciphertext attack, the attacker builds linear inequalities on secret key components and uses the belief propagation(BP) algorithm to solve. The number of inequalities leverages the query complexity of the attack, so the fewer the better. In this paper, we use the PQC standard algorithm CRYSTALS-KYBER as a study case to construct bilateral inequalities on key variables with substantially narrower intervals using a side-channel-assisted oracle. For KYBER512, KYBER768, and KYBER1024, the average Shannon entropy carried by such inequality is improved from the previous 0.6094, 0.4734, and 0.8544 to 0.6418, 0.4777, and 1.2007. The number of such inequalities required to recover the key utilizing the BP algorithm for KYBER512 and KYBER1024 is reduced by 5.32% and 40.53% in theory and experimentally the reduction is even *** query complexity is reduced by 43%, 37%, and 48% for KYBER512, 768, and 1024 assuming reasonably perfect reliability. Furthermore, we introduce a strategy aimed at further refining the interval of *** into the BP algorithm, we discover a measure metric named JSD(Jensen-Shannon distance)-metric that can gauge the tightness of an inequality. We then develop a machine learning-based strategy to utilize the JSD-metrics to contract boundaries of inequalities even with fewer inequalities given, thus improving the entropy carried by the system of linear inequalities. This contraction strategy is at the algorithmic level and has the potential to be employed in all attacks endeavoring to establish a system of inequalities concerning key variables.

关键词： Kyber chosen-ciphertext attack side-channel belief propagation contraction strategy machine learning

同方期刊数据库

Analysis of Aluminum Alloy Double-Pulse MIG Welding Arc Signal Characteristics Based on Broadband Mode Decomposition

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Research and Application 2024年第4期8卷 7-16页

作者： Yin Si Zixiong Xia Wei Liu kexin Zhang Xiangyu Song School of Information and Intelligent Engineering Guangzhou Xinhua UniversityGuangzhou 510000Guangdong ProvinceChina School of Mechanical and Electrical Engineering Guangdong Engineering PolytechnicQingyuan 511510Guangdong ProvinceChina

Welding voltage and current in arc signals are directly related to arc stability and welding *** experiments with different parameters were organized according to the orthogonal experimental design method by constructing an aluminum alloy double-pulse metal inert gas(MIG)welding arc electric signal test *** data acquisition system of the aluminum alloy MIG welding process was established to obtain real-time arc signal information reflecting the welding *** aluminum alloy’s collected double-pulse arc current signals are decomposed adaptively by broadband mode decomposition(BMD).The direct current(DC)signal,pulse signal,distortion signal,ripple signal,and noise signal are separated and extracted,and the composite multiscale fuzzy entropy(CMFE)is calculated for the component set of the electrical *** experimental results show that the current waveform obtained by the double-pulse MIG welding current signal is consistent with the corresponding weld forming ***,the composite multiscale fuzzy entropy is calculated for the arc characteristic *** rationality of matching process parameters and arc stability of aluminum alloy’s double-pulse MIG welding were evaluated.

关键词： Double-pulse MIG welding Electric arc signal Broadband mode decomposition Welding stability

平欧榛子副产物不同溶剂提取物的生物活性评价及超高效液相色谱-质谱分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

食品科学 2024年第1期45卷 32-41页

作者：苏可欣赵玉红东北林业大学生命科学学院黑龙江哈尔滨150040 黑龙江省森林食品资源利用重点实验室黑龙江哈尔滨150040

采用不同极性溶剂(水、甲醇、80%乙醇溶液和乙酸乙酯)对平欧榛子的副产物(叶、果苞、壳、枝条和种皮)进行酚类物质提取,对其体外抗氧化、降血糖、抗炎活性进行评估,并利用超高效液相色谱-质谱(ultra-high performance liquid chromatogr... 详细信息

采用不同极性溶剂(水、甲醇、80%乙醇溶液和乙酸乙酯)对平欧榛子的副产物(叶、果苞、壳、枝条和种皮)进行酚类物质提取,对其体外抗氧化、降血糖、抗炎活性进行评估,并利用超高效液相色谱-质谱(ultra-high performance liquid chromatography-mass spectrometry,UPLC-MS)联用技术对其多酚类物质进行鉴定。榛子叶和枝条提取物比果苞、壳和种皮提取物具有更强的体外抗氧化、降血糖和抗炎活性,主要与榛子副产物中的总酚和原花青素相关,其中榛子枝条的甲醇提取物中总酚(以干质量中没食子酸质量计)和原花青素(以干质量中原花青素质量计)含量最高,分别为(37.13±0.22)mg/g和(2.27±0.04)mg/g,榛子叶的80%乙醇溶液提取物中的总黄酮(以干质量中芦丁质量计)含量最高,为(18.21±1.37)mg/g。乙酸乙酯提取物的总酚、总黄酮和原花青素含量在相同部位提取物中最低,但是对α-淀粉酶活性和脂氧合酶活性具有显著抑制能力(P<0.05),其中果苞的乙酸乙酯提取物抑制α-淀粉酶的效果最好,叶的乙酸乙酯提取物对脂氧合酶的抑制作用最强。经UPLC-MS分析可知,平欧榛子副产物中的酚类物质以黄酮类化合物居多,另外还含有萜类、生物碱、木脂素和有机酸等多种活性物质。平欧榛子副产物中的活性成分具有应用于功能食品或药品中的潜能。

关键词：平欧榛子副产物酚类物质生物活性主成分分析相关性分析