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Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells

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BIOCELL 2023年第8期47卷 1783-1791页

作者： YIFAN LI JING ZHANG YITAO FAN HANDAN XIAO kexin kang YALI ZHOU ZHIWEN ZHANG YUMIN LI MUZHOU TENG The Second Clinical Medical College of Lanzhou University Lanzhou University Second HospitalLanzhou730000China Department of Dermatology Lanzhou University Second HospitalLanzhou730000China Department of Dermatology and Venereology Guangdong Women’s and Children’s HospitalSouthern Medical UniversityGuangzhou510000China

Background:((1-triphenylaminebenzo[c][1,2,5]thiadiazole-4-yl)styryl)-1-methylpyridin methylpyridin-1-ium iodide salt(TBZPy)is a novel photosensitizer that displays excellent photodynamic ***,There are few reports on the mechanism of action of the TBZPy *** studies revealed that photodynamic therapy(PDT)could induce endoplasmic reticulum stress by acting on the endoplasmic ***,in this study,we investigated the effects of endoplasmic reticulum stress induced by TBZPy-PDT in treating High-risk human papillomavirus(HR-HPV)infection and their underlying ***:The human cervical cancer cell line HeLa(containing whole genome of HR-HPV18)was treated with *** migration,invasion,and colony-forming ability were evaluated using wound-healing,Transwell invasion,and colonyforming assays,*** western blot analysis,we determined the level of expression of the PI3K/AKT and PERK/eIF2αpathway proteins and the proteins associated with calcium trafficking and *** calcium levels in the cytoplasm were detected via flow ***:The result shows that TBZPy-PDT could inhibite the migration,invasion,and colony forming ability of infected HeLa cells by downregulating the PI3K/AKT pathway in *** we found that TBZPy-PDT induced endoplasmic reticulum stress-specific apoptosis via the PERK/eIF2α***,TBZPy-PDT increased the levels of calcium and calmodulin,while decreasing the levels of endoplasmic reticulum calcium-binding ***:TBZPy-PDT is effective on treating human papillomavirus-infected *** the PI3K/AKT and PERK/eIF2αpathways and the endoplasmic reticulum stress process may help improve the effects of TBZPy-PDT for treating high-risk human papillomavirus infection.

关键词： Photodynamic therapy Cervical intraepithelial neoplasia Cervical cancer Photosensitizer TBZPy

分光光度法测定皮革中甲醛含量的不确定度评价

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西部皮革 2024年第4期46卷 7-9页

作者：马迎辉张玉芳康克鑫刘志聪禹欣涛鲍春铭河南省产品质量检验技术研究院

为有效控制实验室的测量过程，提高检测结果的可靠性和准确性，根据日常检测情况，对皮革中甲醛含量检测项目的不确定度评定进行分析和评定，建立皮革中甲醛含量的不确定度评价方法。采用分光光度法，测定皮革中甲醛含量，通过建立测量... 详细信息

为有效控制实验室的测量过程，提高检测结果的可靠性和准确性，根据日常检测情况，对皮革中甲醛含量检测项目的不确定度评定进行分析和评定，建立皮革中甲醛含量的不确定度评价方法。采用分光光度法，测定皮革中甲醛含量，通过建立测量数学模型，结合不确定度评定规则，分别对甲醛含量测定过程中引入的相对不确定度分量进行计算评估，最终实现对检测结果的不确定度评价。试验得出，皮革中甲醛含量为16.96 mg/kg，扩展不确定度为0.69 mg/kg。在试验条件下，认为标准溶液本身和分光光度仪测量吸光度产生的不确定度是影响结果的主要因素。

关键词：皮革甲醛不确定度

The Exchange Attack and the Mixture Differential Attack Revisited: From the Perspective of Automatic Evaluation

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Chinese Journal of Electronics 2024年第1期33卷 19-29页

作者： kexin QIAO Zhiyu ZHANG Zhongfeng NIU Liehuang ZHU School of Cyberspace Science and Technology Beijing Institute of Technology State Key Laboratory of Cryptology Institute of Information Engineering Chinese Academy of Sciences School of Cryptography University of Chinese Academy of Sciences

Recent results show that the differential properties within quadruples boom as a new inspiration in cryptanalysis of Advanced Encryption Standard(AES)-like constructions. These methods include the exchange attack proposed in Asiacrypt’19, the mixture differential attack proposed in To SC’18, etc., where the essential properties are obtained by manually scrutinizing the structures of the AES-like constructions. This paper presents a novel framework and an automatic tool based on mixed integer linear programming to search for mixture differential distinguishers for general constructions. This framework considers what equality patterns among quadruples can make a distinguisher and traces how the patterns propagate through cipher components with accurate probability *** this tool, a 5-round AES distinguishing attack with lower complexity and more 6-round distinguishing attacks in the chosen plaintext scenarios are deduced. We prove that no exchange-type or mixture differential distinguisher exists for 7 and above rounds AES if the details of the Sbox and Mix Columns matrix are not taken into account.

关键词： Ciphers Estimation Encryption Mixed integer linear programming Complexity theory Standards

Inorganic ionic polymerization:From biomineralization to materials manufacturing

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Nano Research 2024年第2期17卷 550-569页

作者： Yanhua Sang kexin Qin Ruikang Tang Zhaoming Liu Department of Chemistry Zhejiang UniversityHangzhou 310058China

Biomineralization process regulates the growth of inorganic minerals by complex molecules,proteins,and cells,endowing bio-materials with marvels structures and excellent *** intricate structures and compositions found in biominerals have inspired scientists to design and synthesize numerous artificial biomimetic *** methodology for controlling the formation of inorganics plays a pivotal role in achieving biomimetic structures and ***,the current approach predominantly relies on the classical nucleation theory,which hinders the precise preparation of inorganic materials by replicating the biomineralization ***,the development of“inorganic ionic polymerization”strategy has enabled us to regulate the arrangement of inorganic ions from solution to solid phase,which establishes an artificial way to produce inorganic materials analogous to the biomineralization *** on inorganic ionic polymerization,a series of achievements have been realized for the biomimetic preparation,including moldable construction of inorganic materials,hard tissue regeneration,and high-performance biomimetic ***,the utilization of inorganic ionic polymerization has also facilitated the production of numerous advanced materials,including novel structures that exceed the current knowledge of materials *** inorganic ionic polymerization system provides new artificial strategies and methodologies for the controllable synthesis of inorganics,which mimics the biomineralization process,paving the way for the future development of more high-performance materials.

关键词： biomineralization inorganic ionic polymerization biomimetic materials crystal growth synthetic methodology

Hydrochemical insights on the signatures and genesis of water resources in a high-altitude city on the Qinghai-Xizang Plateau, South-west China

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 123-140页

作者： Jiutan Liu kexin Lou Zongjun Gao Menghan Tan College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Water resources have crucial implications for the steady development of the urban social *** study investigated the hydrochemical signatures and genesis of water resources in the urban area of Lhasa City(UALC).To this end,several analyses,such as ion ratio analysis and correlation analysis,were performed by comprehensively applying mathematical statistics and integrated hydrochemical *** results show relatively low concentrations of major ions in the groundwater and surface water(GSW)of the *** primary anions and cations are HCO3-and Ca2+,reflecting the HCOg-Ca water ***,groundwater exhibits higher concentrations of key chemical components compared to surface *** are weakly alkaline,with pH values of 7.78 and 7.61,respectively,and they have low salinity with average concentrations of total dissolved solids being 190.74 and 112.17 mg/L,*** inputs have minimal influence on the hydrochemical features of GSw,whereas rock weathering is the dominant controlling ***,cation *** a significant *** influencing their hydrochemical *** to the isotope analysis(H and 180),the primary source of recharge for GSW is atmospheric precipitation,with some input from melted ice and ***,GSW samples from the UALC show relatively similar 2H and 18O isotopic compositions,indicating the existence of a discernible hydraulic connection linking the two water *** research findings can serve as a valuable scientific reference and foundation for the sustainable development,effective utilization,and proper safeguarding of regional water resources in high-altitude areas.

关键词： Groundwater and surface water Hydrochemical features Genesis mechanism Water quality Urban area of Lhasa City

Neural-network-based fully distributed formation control for nonlinear multi-agent systems with event-triggered communication

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Science China(Technological Sciences) 2024年第1期67卷 209-220页

作者： ZHU GuoLiang LIU kexin GU HaiBo LÜJinHu School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Zhongguancun Laboratory Beijing 100094China

This paper investigates the consensus-based formation control problem for multi-agent systems with unknown nonlinear *** achieve the desired formation,we propose two formation controllers to achieve the desired formation,one based on system states and the other on system *** proposed controllers utilize adaptive gains to avoid global information and neural networks to estimate and compensate for *** proposed event-triggered schemes avoid continuous communication among agents and exclude the Zeno *** analysis reveals that formation errors are bounded,and numerical simulations are used to validate the effectiveness of the proposed approaches.

关键词： formation control neural network adaptive control event-triggered communication multi-agent systems

Understanding the Relationship Between Shrinking Cities and Land Prices:Spatial Pattern,Effectiveness,and Policy Implications

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Chinese Geographical Science 2024年第1期34卷 1-18页

作者： WANG Xiaohui PENG Li HUANG kexin DENG Wei College of Geography and Resources Sichuan Normal UniversityChengdu610101China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu610101China

Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and *** study focuses on 2851 county-level cities in China in 2005–2018(excluding Hong Kong,Macao,Taiwan,and‘no data’areas in Qinhai-Tibet Plateau)as the fundamental units of *** employing nighttime light(NTL)data to identify shrinking cities,the propensity score matching(PSM)model was used to quantitatively examine the impact of shrinking cities on land prices,and evaluate the magnitude of this *** findings demonstrate the following:1)there were 613 shrinking cities in China,with moderate shrinkage being the most prevalent and severe shrinkage being the least.2)Regional disparities are evident in the spatial distribution of shrinking cities,especially in areas with diverse terrain.3)The spatial pattern of land price exhibits a significant correlated to the economic and administrative levels.4)Shrinking cities significantly negatively impact on the overall land price(ATT=–0.1241,P<0.05).However,the extent of the effect varies significantly among different spatial *** study contributes novel insights into the investigation of land prices and shrinking cities,ultimately serving as a foundation for government efforts to promote the sustainable development of urban areas.

关键词： shrinking cities land price propensity score matching(PSM) relative effectiveness China

Effects of cement-enhanced soil on the ultimate lateral resistance of composite pile in clayey soil

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 183-191页

作者： Zhijun Yang kexin Chen Xudong Fu Zhiyan Zou School of Civil Engineering Wuhan UniversityWuhan430000China Changjiang Design Group Co. Ltd.Wuhan430000China Institute of Geotechnical Engineering College of Civil Engineering and ArchitectureMOE Key Laboratory of Soft Soils and Geoenvironmental EngineeringZhejiang UniversityHangzhou310000China

The composite pile consisting of core-pile and surrounding cement-enhanced soil is a promising pile foundation in recent ***,how and to what extent the cement-enhanced soil influences the ultimate lateral resistance has not been fully *** this paper,the ultimate lateral resistance of the composite pile was studied by finite element limit analysis(FELA)and theoretical upper-bound *** results of FELA and theoretical analysis revealed three failure modes of laterally loaded composite *** effects of the enhanced soil thickness,strength,and pile-enhanced soil interface characteristics on the ultimate lateral resistance were *** results show that increasing the enhanced soil thickness leads to a significant improvement on ultimate lateral resistance factor(N P),and there is a critical thickness beyond which the thickness no longer affects the N *** the enhanced soil strength induced 6.2%-232.6%increase of N ***,no noticeable impact was detected when the enhanced soil strength was eight times higher than that of the natural *** maximum increment of N P is only 30.5%caused by the increase of interface adhesion factor(a).An empirical model was developed to calculate the N P of the composite pile,and the results show excellent agreement with the analytical results.

关键词： Composite pile Ultimate soil resistance Finite element limit analysis(FELA) Plasticity theory Failure mode

A hybrid attention model based on first-order statistical features for smoke recognition

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Science China(Technological Sciences) 2024年第3期67卷 809-822页

作者： GUO Nan LIU JiaHui DI kexin GU Ke QIAO JunFei Beijing Laboratory of Smart Environmental Protection Beijing Key Laboratory of Computational Intelligence and Intelligent SystemBeijing Artificial Intelligence InstituteBeijing 100124China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China

Smoke and fire recognition are of great importance on foreseeing fire disasters and preventing environmental pollution by monitoring the burning process of objects(e.g., straw, fuels). However, since fire images suffer from problems like the variability of the features, complexity of scenarios, interference from background, changeable weather conditions as well as image quality problems, identifying smoke and fire accurately and promptly from a given image still remains a substantial challenge. Automatically learning the features of smoke images by CNNs has improved the target recognition ability compared to traditional approaches,nonetheless, convolutions and pooling operations in CNNs may cause severe information loss which may lead to *** tackle the above problems, this paper proposed a hybrid attention model based on the characteristics of smoke images. This model adopted multiple optimized attention mechanism in several stages to quickly and precisely capture the important features,achieving state-of-the-art performance on smoke and fire recognition in terms of accuracy and speed. Our proposed module mainly consists of two stages: pooling and attention. In the first stage, we conducted several newly proposed first-order pooling methods. Through traversing the data space in a larger scope, features are better reserved, thus constructing a more intact feature space of smoke and fire in an image. In the second stage, feature maps are aggregated together to perform channel and spatial attention. The channel and spatial dependencies allow us to quickly catch the important features presented in an image. By fully exploring the feature space and prominent salient features, characteristics of smoke and fire are better presented so as to obtain better smoke and fire detection results. Experiments have been conducted on public smoke detection dataset and new proposed fine-grained smoke and fire detection database. Experimental results revealed that the propose

关键词： hybrid attention first-order pooling smoke and fire detection deep convolutional neural networks