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Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023 edition)

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Chinese Herbal Medicines 2024年第1期16卷 3-12页

作者： Qing Zhao Tong Wang Hongbin Wang Peng Cao Chengyu jiang Hongzhi Qiao Lihua Peng Xingdong Lin Yunyao jiang Honglei Jin Huantian Zhang Shengpeng Wang Yang Wang Ying Wang Xi Chen Junbing Fan Bo Li Geng Li Bifeng Liu Zhiyang Li Suhua Qi Mingzhen Zhang Jianjian Zheng Jiuyao Zhou Lei Zheng kewei Zhao Guangdong Engineering Research Center of Chinese Herbal Vesicles The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Institute of Life and Health Engineering the First Affiliated HospitalJinan UniversityGuangzhou 510630China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Institute of Basic Medicine Chinese Academy of Medical SciencesBeijing 100005China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310030China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of Bone and Joint Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAomen 999078China Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233China School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515China School of Life Sciences Nanjing UniversityNanjing 210008China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Laboratory Animal Center Guangzhou University of Chinese MedicineGuangzhou 510405China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Nanjing 210008China School of Medical and Technology Xuzhou Medical UniversityXuzhou 221004China School of Basic Medical Sciences Xi’an Jiaotong UniversityXi’an 710065China The First Affiliated Hospital of Wenzhou Medical University WenZhou 325035China

To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization,led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles,research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles,Professional Committee on Extracellular Vesicle Research and Application,Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles.Based on the collation of relevant literature,we have adopted the Delphi method,the consensus meeting method combined with the nominal group method to form a discussion draft of“Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023)”.The first draft was discussed in online and offline meetings on October 12,14,November 2,2022 and April and May 2023 on the current status of research,nomenclature,isolation methods,quality standards and research applications of extracellular vesicles of Chinese herbal medicines,and 13 consensus opinions were finally formed.At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles,held on May 26,2023,kewei Zhao,convenor of the consensus,presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles.The consensus highlights the characteristics and advantages of Chinese medicine,inherits the essence,and keeps the righteousness and innovation,aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad,decode the mystery behind Chinese herbal vesicles together,establish a safe,effective and controllable accurate Chinese herbal vesicle prevention and treatment system,and build a bridge for Chinese medicine to the world.

关键词： Chinese herbal medicine extracellular vesicles research application consensus

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甲状旁腺术中识别技术及临床应用和研究现况

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西安交通大学学报（医学版） 2024年第1期45卷 49-54页

作者：贺晨宇姜可伟北京大学人民医院胃肠外科北京100442 北京大学人民医院外科肿瘤研究室、结直肠癌诊疗研究北京市重点实验室北京100442

甲状旁腺在机体钙磷代谢中有重要作用,颈部手术中完整保留甲状旁腺对避免术后甲状旁腺功能减退和术后低钙血症至关重要。目前大多数甲状腺手术中仍依赖传统肉眼识别方式或通过术中冰冻辨认甲状旁腺,前者依赖于术者经验,后者所消耗的时... 详细信息

甲状旁腺在机体钙磷代谢中有重要作用,颈部手术中完整保留甲状旁腺对避免术后甲状旁腺功能减退和术后低钙血症至关重要。目前大多数甲状腺手术中仍依赖传统肉眼识别方式或通过术中冰冻辨认甲状旁腺,前者依赖于术者经验,后者所消耗的时间和费用较高。近年,国内外学者对术中有助于识别甲状旁腺的染色技术和基于荧光的成像技术进行了相关研究,如亚甲蓝、纳米炭、近红外自体荧光、吲哚菁绿血管造影技术、激光散斑对比成像等,均可显著提高对甲状旁腺的识别与保护。本文将对甲状旁腺术中识别技术的临床研究进展情况作一综述。

关键词：甲状腺癌根治术甲状旁腺保护术中识别

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基于双线性频率分离的梁类结构呼吸裂纹定位方法

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现代制造工程 2024年第3期 140-147页

作者：蒋阳鲁志文冯科伟武汉科技大学机械自动化学院武汉430081

针对梁类结构早期呼吸裂纹定位问题,基于含呼吸裂纹梁不同测点位置双线性程度的差异,提出了一种双线性频率分离的梁类结构呼吸裂纹定位方法。利用零点搜索、信号分割等技术将不同空间位置的结构响应,分解为双线性效应对应的正响应和负... 详细信息

针对梁类结构早期呼吸裂纹定位问题,基于含呼吸裂纹梁不同测点位置双线性程度的差异,提出了一种双线性频率分离的梁类结构呼吸裂纹定位方法。利用零点搜索、信号分割等技术将不同空间位置的结构响应,分解为双线性效应对应的正响应和负响应分量,分别反映了结构在裂纹张开状态及闭合状态下的动力学行为。不同测点分裂分量频率成分的差异与裂纹位置及深度有关,为此构造了双线性频率成分间的距离损伤指标,实现裂纹的定位。通过对裂纹位置、裂纹深度、激励频率和幅值、固有结构形状及噪声等影响因素的数值研究,表明了方法的有效性,可为实际工程应用提供理论依据。

关键词：裂纹定位双线性特性零点搜索呼吸裂纹信号分割

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A biodegradable magnesium surgical staple for colonic anastomosis: In vitro and in vivo evaluation

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Bioactive Materials 2023年第4期22卷 225-238页

作者： Yue Zhang Jian Cao Mengmeng Lu Yi Shao kewei jiang Xiaodong Yang Xiaoyu Xiong Shan Wang Chenglin Chu Feng Xue Yingjiang Ye Jing Bai jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing211189China Institute of Biomedical Devices(Suzhou) Southeast UniversitySuzhou215163China Department of Gastroenterological Surgery Peking University People’s HospitalBeijing100044China Department of Oral Implantology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing210029China jiangsu Key Laboratory for Light Metal Alloys Nanjing211212China

Staplers have been widely used in the clinical treatment of gastrointestinal reconstruction.However,the current titanium(Ti)staple will remain in the human body permanently,resulting in some adverse effects.In this study,we developed a type of biodegradable staple for colonic anastomosis using 0.3 mm diameter magnesium(Mg)alloy wires.The wire surface was modified by micro-arc oxidation treatment(MAO)and then coated with poly-L-lactic acid(PLLA)to achieve a moderate degradation rate matching the tissue healing process.The results of tensile tests on isolated porcine colon tissue anastomosed by Mg and Ti staples showed that the anastomotic property of Mg staples was almost equal to that of Ti staples.The in vitro degradation tests indicated the dual-layer coating effectively enhanced the corrosion resistance and maintained the tensile force of the coated staple stable after 14-day immersion in the simulated colonic fluid(SCF).Furthermore,24 beagle dogs were employed to conduct a comparison experiment using Mg-based and clinical Ti staples for 90-day implantation by ent-to-side anastomosis of the colon.The integrated structure of Mg-based staples was observed after 7 days and completely degraded after 90 days.All animals did not have anastomotic leakage and stenosis,and 12 dogs with Mg-based staples fully recovered after 90 days without differences in visceral ion levels and other side effects.The favorable performance makes this Mg-based anastomotic staple an ideal candidate for colon reconstruction.

关键词： Gastrointestinal tract Degradation Bursting pressure Anastomotic stoma Colon reconstruction

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深度强化学习及其在军事领域中的应用综述

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系统工程与电子技术 2024年第4期46卷 1297-1308页

作者：张梦钰豆亚杰陈子夷姜江杨克巍葛冰峰国防科技大学系统工程学院湖南长沙410003

随着大数据、云计算、物联网等一系列新兴技术的大量涌现,人工智能技术不断取得突破性进展。深度强化学习(deep reinforcement learning,DRL)技术作为人工智能的最新成果之一,正被逐渐引入军事领域中,促使军事领域走向信息化和智能化。... 详细信息

随着大数据、云计算、物联网等一系列新兴技术的大量涌现,人工智能技术不断取得突破性进展。深度强化学习(deep reinforcement learning,DRL)技术作为人工智能的最新成果之一,正被逐渐引入军事领域中,促使军事领域走向信息化和智能化。在未来战争作战模式及军队发展建设中,网络化、信息化、智能化和无人化形成重要特征,已经成为不可逆转的趋势。因此,在回顾了DRL基本原理和主要算法的基础上,对当前DRL在武器装备、网络安全、无人机(unmanned aerial vehicle,UAV)编队、智能决策与博弈等方面的应用现状进行了系统的梳理与总结。最后,针对实际推进DRL技术在军事领域应用落地所面临的一系列问题和挑战,提供了未来进一步研究的思路。

关键词：深度强化学习军事应用智能决策发展趋势

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重视原发性甲状腺机能亢进患者合并甲状腺癌的规范化诊治

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西安交通大学学报（医学版） 2024年第1期45卷 35-38页

作者：王晨一贺晨宇姜可伟北京大学人民医院胃肠外科北京100442 北京大学人民医院外科肿瘤研究室、结直肠癌诊疗研究北京市重点实验室北京100442

原发性甲状腺机能亢进与甲状腺癌通常被视为相互独立的疾病,但近年来,越来越多的研究表明,这两种疾病可能存在共同的发病机制。本文旨在规范原发性甲状腺机能亢进患者合并甲状腺癌的诊治,通过综合分析国内外相关研究,为临床医师在面对... 详细信息

原发性甲状腺机能亢进与甲状腺癌通常被视为相互独立的疾病,但近年来,越来越多的研究表明,这两种疾病可能存在共同的发病机制。本文旨在规范原发性甲状腺机能亢进患者合并甲状腺癌的诊治,通过综合分析国内外相关研究,为临床医师在面对甲状腺机能亢进合并甲状腺癌患者时提供有益的参考和指导,进一步提高诊治水平。

关键词：甲状腺功能亢进症甲状腺肿瘤格雷夫斯病甲状腺疾病

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Salt effect on MUCT system performance of nitrogen and phosphorus removal

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Green Energy & Environment 2021年第5期6卷 670-677页

作者： Huining Zhang Zhuowei Zhang kewei jiang Zhili Li Kefeng Zhang Jianqing Ma Yongxing Qian NingboTech University Ningbo315100China College of Water Sciences Beijing Normal UniversityBeijing100875China Ningbo Research Institute Zhejiang UniversityNingbo315100China Ningbo Key Laboratory of Urban and Rural Water Pollution Control Technology Ningbo315100China

The effect of salinity on biological nitrogen and denitrifying phosphorus removal was investigated in a Modified University of Cape Town(MUCT)system.Removal rates of COD,NH_(4)^(+)-N,NO_(3)^(-)-N,NO_(2)^(-)-N,phosphorus and the sludge characteristics at salt concentrations(0.0,3.2,6.4,11.2 and 16.0 g L^(-1))were analyzed.With the salt concentration increasing,all the COD,NH_(4)^(+)-N,TN and TP removal rates exhibited a trend of decline,and exhibited an initial reduction and subsequent increase at every stage of salt concentration.NH_(4)^(+)-N,TN and TP removal rates were 92.7%,51.5%and 67.2%in 16 g L^(-1) salt concentration,respectively.And they were outperformed the literature reported and acceptable in practical applications.When the salinity of wastewater changed from 0.0 to 16.0 g L^(-1),the biomass yield coefficients increased from 0.0794 to 0.126 g VSS/g COD.Increased salinity had a detrimental effect on phosphorus-accumulating organisms(PAOs)and denitrifying PAOs(DPAOs)(especially DPAOs).Therefore,phosphorus removal gradually depended on PAO.The simultaneous nitrification and denitrification(SND)rate and nitrogen removal rate(including nitrification rate,denitrification rate,and total nitrogen removal rate)gradually decreased with the increased salinity.

关键词： Aquaculture wastewater Denitrifying phosphorus removal MUCT process TP SND rate

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Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing

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Chinese Journal of Cancer Research 2021年第2期33卷 271-288页

作者： Quan Wang Zhu Wang Zhen Zhang Wei Zhang Mengmeng Zhang Zhanlong Shen Yingjiang Ye kewei jiang Shan Wang Department of Gastroenterological Surgery Peking University People’s HospitalBeijing 100044China Laboratory of Surgical Oncology Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People’s HospitalBeijing 100044China Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitisassociated cancer(CAC)and to reveal a potential evolutionary trajectory from ulcerative colitis(UC)to CAC at the single-cell level.Methods:Fresh samples of tumor tissues and adjacent UC tissues from a CAC patient with pT3N1M0 stage cancer were examined by single-cell RNA sequencing(scRNA-seq).Data from The Cancer Genome Atlas(TCGA)and The Human Protein Atlas were used to confirm the different expression levels in normal and tumor tissues and to determine their relationships with patient prognosis.Results:Ultimately,4,777 single-cell transcriptomes(1,220 genes per cell)were examined,of which 2,250(47%)and 2,527(53%)originated from tumor and adjacent UC tissues,respectively.We defined the composition of cancer-associated stromal cells and identified six cell clusters,including myeloid,T and B cells,fibroblasts,endothelial and epithelial cells.Notable pathways and transcription factors involved in these cell clusters were analyzed and described.Moreover,the precise cellular composition and developmental trajectory from UC to UCassociated colon cancer were graphed,and it was predicted that CD74,CLCA1,and DPEP1 played a potential role in disease progression.Conclusions:scRNA-seq technology revealed intra-tumor cell heterogeneity in UC-associated colon cancer,and might provide a promising direction to identify novel potential therapeutic targets in the evolution from UC to CAC.

关键词： Ulcerative colitis-associated colon cancer single-cell RNA sequencing cell heterogeneity evolutionary trajectory

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基于复杂适应性理论的无人机作战试验交互协作问题研究

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舰船电子工程 2024年第4期44卷 6-10,27页

作者：胡景博杨克巍蒋平姜江国防科技大学系统工程学院长沙410073 中国人民解放军63969部队南京211113

复杂适应性系统理论(简称CAS)是研究复杂性巨系统的有效方法。针对无人机装备特性和开展作战试验时的复杂特征,从无人机作战试验的主体、特征、机制三个方面阐述了无人机作战试验中交互协作与复杂适应性系统的一致性,说明了无人机作战... 详细信息

复杂适应性系统理论(简称CAS)是研究复杂性巨系统的有效方法。针对无人机装备特性和开展作战试验时的复杂特征,从无人机作战试验的主体、特征、机制三个方面阐述了无人机作战试验中交互协作与复杂适应性系统的一致性,说明了无人机作战试验是典型的复杂适应性系统。基于复杂适应系统理论,分析参试单位在开展无人机作战试验过程中的聚集、非线性、流、多样性特征以及标识、内部模型和积木机制,为不同专业领域和思维层次的人员进行有效交互协作,顺畅试验进程最终涌现出结论性成果,提出优化试验方法和管理水平的实施策略。

关键词：复杂适应系统理论无人机作战试验交互协作

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基于GA-BP神经网络的转子轴承系统轴承等效刚度辨识

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组合机床与自动化加工技术 2024年第5期 126-130页

作者：冯科伟李锋鲁志文周多龙蒋阳武汉科技大学冶金装备及其控制省部共建教育部重点实验室武汉430081 武汉重型机床集团有限公司武汉430081

针对转子-轴承系统的力学模型中轴承等效刚度难以确定的问题,提出了基于GA-BP代理模型的转子系统轴承参数辨识的方法。首先,建立转子-轴承系统有限元模型并进行模型的静态和动态验证;其次,搭建试验台进行模态锤击试验,得到其前四阶弯曲... 详细信息

针对转子-轴承系统的力学模型中轴承等效刚度难以确定的问题,提出了基于GA-BP代理模型的转子系统轴承参数辨识的方法。首先,建立转子-轴承系统有限元模型并进行模型的静态和动态验证;其次,搭建试验台进行模态锤击试验,得到其前四阶弯曲固有频率;最后,基于转子系统仿真模型生成GA-BP神经网络代理模型完成轴承等效刚度的辨识并做误差分析。结果表明,采用该方法可有效的识别轴承的等效刚度,并且GA-BP神经网络的识别效果优于传统的BP神经网络,其最大误差为1.52%,证明了该方法的可行性。

关键词：转子-轴承系统参数识别模态分析 ANSYS GA-BP神经网络

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