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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew n.Lane kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRnAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRnA splicing CD8 T cells ARS2 PKM2

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Surgical Treatment of Osteonecrosis of the Femoral Head Using Minimally Invasive Surgical Drilling and Cancellous Grafting at Brazzaville University Hospital

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Open Journal of Orthopedics 2024年第2期14卷 122-132页

作者： kevin Parfait Bienvenu Bouhelo-Pam Marius Monka Arnauld Sledje Wilfrid Bilongo Bouyou Regis Perry Massouama Paul Yèlai Ikounga Roger Bertrand Sah Mbou Armand Moyikoua Department of Orthopaedic surgery and Traumatology University Hospital of Brazzaville Brazzaville Republic of the Congo Faculty of Health Sciences Marien N’GOUABI University Brazzaville Republic of the Congo

Introduction: Osteonecrosis of the femoral head (OnTF) is a debilitating condition. Several treatments have been proposed with controversial results. The aim of our study was to evaluate treatment by surgical drilling coupled with in situ cancellous grafting. Materials and methods: Our study was a case-control study conducted at Brazzaville University Hospital from 1st January 2018 to 31 December 2023. It compared two groups of patients with OnTF: non-operated (13 patients, 20 hips) and operated (22 patients, 35 hips). We used the visual digital scale (VDS) for pain assessment, the Merle D’Aubigne-Postel (MDP) scoring system for clinical and functional assessment, and the evolution of necrosis. Results: The group of non-operated patients had a mean age of 35.69 ± 3.4 years, no improvement in pain with an EVn above seven at the last recoil and a mean global MDP score falling from 12.7 before offloading to 10.13 at one year. The group of patients operated on had a mean age of 37.86 ± 7.02 years, a significant reduction in pain (p = 0.00004) and a significantly increased MDP score (p = 0.0034). A comparison of the two groups of patients showed significant stabilization of the necrotic lesions in the operated patients (p = 0.00067), with better satisfaction in the same group. Conclusion: Surgical drilling combined with grafting in the treatment of early-stage OnTF has improved progress in our series. The technique is reproducible and less invasive. It has made it possible to delay unfavorable progression and, consequently, hip replacement surgery.

关键词： Hip Osteonecrosis of the Femoral Head Conservative Treatment Surgical Drilling Bone Grafting

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White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment

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Stroke & Vascular neurology 2022年第4期7卷 364-366页

作者： Adam de Havenon kevin n Sheth Sharon D Yeatts Tanya n Turan Shyam Prabhakaran neurology Yale UniversityNew HavenConnecticutUSA Public Health Sciences MUSCCharlestonSouth CarolinaUSA neurology MUSCCharlestonSouth CarolinaUSA neurology University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk *** We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRInT MInD)*** primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from *** primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH *** secondary predictor was a binary WMH progression threshold(≥1.4 mL vsng the 433 included patients,33(7.6%)developed dementia/*** were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients withn(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRInT MInD,WMH progression over 48 months was associated with the development of probable dementia or MCI.

关键词： impairment Blood incident

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Unfoldomics of prostate cancer： on the abundance and roles of intrinsically disordered proteins in prostate cancer

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Asian Journal of Andrology 2016年第5期18卷 662-672页

作者： kevin S Landau Insung na Ryan O Schenck Vladimir n Uversky DepartmentofMolecularMedicine MorsaniCollegeofMedicineUniversityofSouthFloridaTampaFL33612USA USFHealthByrdAlzheimer'sResearchInstitute MorsaniCollegeofMedicineUniversityofSouthFloridaTampaFlorida33612USA LaboratoryofStructuralDynamics StabilityandFoldingofProteinsInstituteofCytologyRussianAcademyofSciencesStPetersburgRussia

Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.

关键词： intrinsical ly disordered proteins posttranslational mod ifications prostate cancer protein-protein interaction proteomics proteome unfoldome

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Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases

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neural Regeneration Research 2020年第9期15卷 1631-1638页

作者： kevin Puertas-neyra Ricardo Usategui-Martín Rosa MCoco Ivan Fernandez-Bueno Instituto Universitario de Oftalmobiologia Aplicada Universidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leon ValladolidSpain Red Tematica de Investigacion Cooperativa en Salud OftaredInstituto de Salud CarlosⅢValladolidSpain

Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients' daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.

关键词： clinical trials growth factors intraocular injection intravitreal injection neuroprotection paracrine properties photoreceptors preclinical models retinal diseases stem cells

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Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults

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Stroke & Vascular neurology 2023年第5期8卷 358-367页

作者： Julián n Acosta Stefan P Haider Cyprien Rivier Audrey C Leasure kevin n Sheth Guido J Falcone Seyedmehdi Payabvash Department of neurology Yale School of MedicineNew HavenConnecticutUSA Department of Radiology and Biomedical Imaging Yale School of MedicineNew HavenConnecticutUSA Department of Otorhinolaryngology Ludwig Maximilians University MunichMunchenGermany

Background and objectives We aimed to investigate the white matter(WM)microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure(SBP),and whether they mediate SBP effects on cognitive performance in middle-aged *** Using the UK Biobank study of community-dwelling volunteers aged 40-69 years,we included participants without a history of stroke,dementia,demyelinating disease or traumatic brain *** investigated the association of SBP with MRI diffusion metrics:fractional anisotropy(FA),mean diffusivity(MD),intracellular volume fraction(a measure of neurite density),isotropic(free)water volume fraction(ISOVF)and orientation dispersion across WM ***,we determined whether WM diffusion metrics mediated the effects of SBP on cognitive *** We analysed 31363 participants-mean age of 63.8 years(SD:7.7),and 16523(53%)*** SBP was associated with lower FA and neurite density,but higher MD and *** different WM tracts,diffusion metrics of the internal capsule anterior limb,external capsule,superior and posterior corona radiata were most affected by higher *** seven cognitive metrics,SBP levels were only associated with‘fluid intelligence’(adjusted pn mediation analysis,the averaged FA of external capsule,internal capsule anterior limb and superior cerebellar peduncle mediated 13%,9%and 13%of SBP effects on fluid intelligence,while the averaged MD of external capsule,internal capsule anterior and posterior limbs,and superior corona radiata mediated 5%,7%,7%and 6%of SBP effects on fluid intelligence,*** Among asymptomatic adults,higher SBP is associated with pervasive WM microstructure disintegrity,partially due to reduced neuronal count,which appears to mediate SBP adverse effects on fluid *** metrics of select WM tracts,which are most reflective of SBP-related parenchymal damage and cognitive impairment,may serve as imaging biomarkers to

关键词： capsule Blood impairment

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Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases

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Infectious Diseases of Poverty 2014年第1期3卷 310-324页

作者： kevin Bardosh Centre of African Studies School of Social and Political ScienceCollege of Humanities and Social ScienceThe University of Edinburgh58 George SquareEdinburgh EH89LDUK Division of Pathway Medicine and Centre for Infectious Diseases School of Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUK

neglected Tropical Diseases(nTDs)are both drivers and manifestations of poverty and social *** advocacy efforts since the mid-2000s have led to ambitious new control and elimination targets set for 2020 by the World Health *** these global aspirations represent significant policy momentum,there are multifaceted challenges in controlling infectious diseases in resource-poor local contexts that need to be acknowledged,understood and *** a number of recent publications have emphasised the“neglected”status of applied social science research on *** light of the 2020 targets,this paper explores the social science/nTD literature and unpacks some of the ways in which social inquiry can help support effective and sustainable *** priority areas are discussed,including on policy processes,health systems capacity,compliance and resistance to interventions,education and behaviour change,and community *** paper shows that despite the multifaceted value of having anthropological and sociological perspectives integrated into nTD programmes,contemporary efforts underutilise this *** is reflective of the dominance of top-down information flows and technocratic approaches in global *** counter this tendency,social research needs to be more than an afterthought;integrating social inquiry into the planning,monitoring and evaluating process will help ensure that flexibility and adaptability to local realities are built into *** emphasis on social science perspectives can also help link nTD control to broader social determinants of health,especially important given the major social and economic inequalities that continue to underpin transmission in endemic countries.

关键词： neglected tropical diseases Applied social sciences Implementation research Social determinants Community participation Policy Global health Sociology Anthropology

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Experimental study on modification of water-based filtercake to improve the bonding strength at the wellbore cement-formation interface

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Petroleum Research 2023年第4期8卷 531-540页

作者： kevin nsolloh Lichinga Department of Engineering Development Tanzania Industrial Research and Development Organization(TIRDO)PO Box 23235Dar es SalaamTanzania Department of Petroleum Engineering Faculty of Earth Resources for Oil Well Cement Research and TestingNo.388Lumo RoadHongshan DistrictWuhanChina University of GeosciencesWuhan430074PR China

The objective of this experimental study is to improve the cementing bond quality of sandstone oil-gas well along the wellbore cement-formation interface(WCFI),so as to ensure long-term zonal isolation throughout the lifecycle of the well by using nsO solution as filtercake modifier which was developed in the *** to designed experimental method and API RP 10,the effectiveness of filtercake modifier(nSO)on the bonding strength at the WCFI was assessed by using designed simulated wellbore as sandstone *** experimental results indicated that the samples which were treated with nsO solution had higher bond strength over untreated *** strength generally increased with curing period as for treated samples,0.198,0.374,0.433 and 0.473 MPa for 3,7,15,and 30 days respectively while for the untreated samples the bond strength were 0.050,0.070,0.81 and 0.100 MPa for the same *** water-based filtercake modification techniques had significantly enhanced the bonding strength of WCFI by increasing rates above 296%.Improvement of bond strength to the treated sample was due to filtercake modification as a result of formation of cementitious material as revealed in FTIR spectral such as Calcium-Silicate-Hydrate(C-S-H)and other geopolymers like Calcium-Aluminium-Silicate-Hydrate(C-A-S-H)and Sodium-Aluminium-Silicate-Hydrate(n-A-S-H)along the interface which filled the existed pores hence reducing porosity hence high strength of *** low transmittance value for the nsO treated samples revealed that there were more cementitious materials existing at the WCFI which led to improvement of bonding strength as compared to the untreated *** lower/poor bond strength for the untreated samples is due to existence of untreated,thick water-based filtercake films at WCFI,which prevented the complete hydration process between rock grains and cement slurry components to make chemical binder of cement slurry material and formation.2022 The Authors.P

关键词： Geopolymer Bond strength Water-based mud Wellbore cement-formation interface nSO

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The American Heart Association’s Get With the Guidelines(GWTG)-Stroke development and impact on stroke care

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Stroke & Vascular neurology 2017年第2期2卷 94-105页

作者： Cora H Ormseth kevin n Sheth Jeffrey L Saver Gregg C Fonarow Lee H Schwamm neurology Yale University School of MedicineNew HavenConnecticutUSA Department of neurology UCLA Medical CenterLos AngelesCaliforniaUSA Department of Cardiology UCLA Medical CenterLos AngelesCaliforniaUSA Department of neurology Massachusetts General HospitalBostonMassachusettsUSA

The American Heart Association’s Get With the Guidelines(GWTG)-Stroke programme has changed stroke care delivery in the USA since its establishment in *** is a voluntary registry and continuous quality improvement initiative that collects data on patient characteristics,hospital adherence to guidelines and inpatient *** of the programme saw increased provision of evidence-based care and improved patient *** review will describe the development of the programme and discuss the impact on stroke outcomes and transformation of stroke care delivery that followed its implementation.

关键词： impact programme

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