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Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang mu kevin m.mcBride Taiping Chen Department of Epigenetics and molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and mZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse Igm’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse Igm’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now

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World Journal of Diabetes 2024年第5期15卷 797-809页

作者： Joseph m Pappachan Cornelius James Fernandez Ambika P Ashraf Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology&metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of Pediatric Endocrinology and Diabetes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic *** has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and *** looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most *** there is a collective global effort to curb the devastation caused by the situation,the impact is poised to be pro-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this *** article delves into the current epidemiological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.

关键词： Childhood obesity Diabesity Type 2 diabetes mellitus Adolescence Cardiovascular disease Pharmacotherapy

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陶瓷部件的浆料打印快速成型(英文)

硅酸盐学报 2001年第4期29卷 344-349页

作者：王树海 Jang J H Schulze W A pilgrim S m 山东工业陶瓷研究设计院山东淄博255031 NYS College of Ceramics

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实... 详细信息

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实验表明 ,虽然偶联剂的加入可以降低石蜡介质浆料的粘度 ,但是粘度足够低的可打印浆料的固相含量太低 [约 3 % (involume)以下 ] ,打印成型后不能完全烧结 ,因此 ,要通过打印成型出可完全烧结的陶瓷部件便只能采用挥发性液体作为浆料介质。

关键词：陶瓷部件浆料打印成型烧结四打印头快速成型机

WHAT DOES ACCESS TO JUSTICE REQUIRE？ -- OVERCOmING BARRIERS TO INVOKE THE UNITED NATIONS CONVENTION ON THE RIGHTS OF PERSONS WITH DISABILITIES

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Frontiers of Law in China-Selected Publications from Chinese Universities 2016年第2期11卷 280-322页

作者： kevin m. Cremin Columbia Law School mFY Legal Services Inc. New York US

Persons with disabilities have a right to effective access to justice under the United Nations Convention on the Rights of Persons with Disabilities （UNCRPD）. This article provides insights on the parameters of that right, including a close examination of the history and text of Article 13, which directly addresses access to justice and other relevant UNCRPD provisions. In addition to the UNCRPD, this article discusses implementation guidance from the Committee on the Rights of Persons with Disabilities, including its guidelines for State Party reports and jurisprudence. The initial reports by eleven States Parties -- Argentina, Azerbaijan, China, Costa Rica, Croatia, Dominican Republic, Ecuador, Hungary, mexico, Peru and Turkmenistan - are also considered. The Committee＇s feedback regarding implementation of Article 13 by these eleven States parties is critiqued for being limited and inconsistent. This article then attempts to clarify what effective access to justice actually requires. It does so by focusing on the insights that can be drawn from implementation of Article 13 since the UNCRPD was adopted as well as implementation guidance from the Conference of States Parties, the International Disability Alliance, the World Network of Users and Survivors of Psychiatry and the National Center for Access to Justice. This article concludes with recommendations on how the Committee can improve its guidance on access to justice to help ensure that equal rights will not be illusory for persons with disabilities.

关键词： access to justice Convention on the Rights of Persons with Disabilities right tocounsel Committee on the Rights of Persons with Disabilities

Elements of disturbance that affect epiphyte vitality in a temperate rainforest:an experimental approach

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Journal of Plant Ecology 2019年第2期12卷 306-313页

作者： Nalini m.Nadkarni kevin D.Kohl Department of Biology University of Utah257 South 1400 EastSalt Lake CityUT 84112USA Department of Biological Sciences University of Pittsburgh403B Clapp Hall4249 Fifth AvenuePittsburghPA 115260USA

Aims Epiphytes are an abundant and diverse component of many wet temperate forests and have significant roles in ecosystem *** is known about the processes and rates of their death and decomposition when they fall from the canopy,which limits our understanding of their role in forest carbon sequestration and nutri-ent *** the temperate rainforest of the Quinault River Valley,Washington State,our aim was to test hypotheses regarding four elements of disturbance that might contribute to their *** We established set of experiments in which we placed samples of canopy epiphytes and their branch segments:(i)in the canopy versus forest floor microenvironment(stratum);(ii)attached to live versus dead branch substrates;(iii)subjected to physical disruption and‘jarring’;and(iv)in direct versus indirect con-tact with the forest *** the 2-year study,we assigned a non-destructive‘vitality index’(based on color and appar-ent mortality and dryness)to each sample every 2-3 months to compare effects of the experimental treatments and analyzed with a statistical model and post hoc pairwise comparisons of *** Findings The canopy versus ground stratum and live/dead branch status sig-nificantly affected epiphyte *** of physical disruption and ground contact were not *** were seasonal effects(low vitality during the sampling times in the summer,revitalization upon sampling times in the winter)for all treatments except samples in contact with the *** implication of these results relates to effects of climate change,which is predicted to shift to hotter,drier summers and wetter *** change may affect forest dynamics and nutrient cycling in unpredictable *** also point to future experiments to understand biotic and abiotic effects on epiphyte disturbance and dynamics.

关键词： disturbance epiphytes forest canopy forest dynamics moss Olympic rainforest

Capacitance,charge dynamics,and electrolyte-surface interactions in functionalized carbide-derived carbon electrodes

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Progress in Natural Science:materials International 2015年第6期25卷 631-641页

作者： Boris Dyatkin Eugene mamontov kevin m.Cook Yury Gogotsi Department of materials Science & Engineering and A.J.Drexel Nanomaterials Institute Drexel University Spallation Neutron Source Oak Ridge National Laboratory materials Engineering Division Naval Air Systems Command

This study analyzed the dynamics of ionic liquid electrolyte inside of defunctionalized,hydrogenated,and aminated pores of carbide-derived carbon supercapacitor *** approach tailors surface functionalities and tunes nanoporous structures to decouple the influence of pore wall composition on capacitance,ionic resistance,and long-term ***-elastic neutron scattering probes the self-diffusion properties and electrode-ion interactions of electrolyte molecules confined in functionalized ***-temperature ionic liquid interactions in confined pores are strongest when the hydrogen-containing groups are present on the *** property translates into higher capacitance and greater ion transport through pores during electrochemical *** hydrogenated pores,aminated pores do not favorably interact with ionic liquid ions and,subsequently,are outperformed by defunctionalized surfaces.

关键词： Supercapacitor Carbide-derived carbon Neutron scattering Energy storage Porous materials Surface chemistry

Rapid flood inundation mapping by differencing water indices from pre-and post-flood Landsat images

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Frontiers of Earth Science 2021年第1期15卷 1-11页

作者： Ramesh SIVANPILLAI kevin m.JACOBS Chloe m.mATTILIO Ela V.PISKORSKI Wyoming Geographic Information Science Center University of WyomingLaramieWY 82071USA Department of Ecosystem Science&management University of WyomingLaramieWY 82071USA Haub School of Environment&Natural Resources University of WyomingLaramieWY 82071USA Department of Plant Sciences University of WyomingLaramieWY 82071USA

Following flooding disasters,satellite images provide valuable information required for generating flood inundation *** or optical imagery can be used for generating flood maps when the inundated areas are not covered by *** propose a rapid mapping method for identifying inundated areas based on the increase in the water index value between the pre-and post-flood satellite *** of the Normalized Difference Water Index(NDWI)and modified NDWI(mNDWI)will be higher in the post-flood image for flooded areas compared to the pre-flood *** on a threshold value,pixels corresponding to the flooded areas can be separated from non-flooded *** maps derived from differencing mNDWI values accurately captured the flooded *** the output image will be influenced by the choice of the pre-flood image,hence analysts have to avoid selecting pre-flood images acquired in drought or earlier flood *** the inundation maps generated using this method have to be overlaid on the post-flood satellite image in order to orient personnel to landscape *** of the proposed technique are that flood impacted areas can be identified rapidly,and that the pre-existing water bodies can be excluded from the inundation *** pairs of other satellite data,several maps can be generated within a single flood which would enable emergency response agencies to focus on newly flooded areas.

关键词： Rapid Flood mapping(RFm) inundation maps Satellite data NDWI mNDWI

ezQTL:A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 541-548页

作者： Tongwu Zhang Alyssa Klein Jian Sang Jiyeon Choi kevin m.Brown Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892USA

Genome-wide association studies(GWAS)have identified thousands of genomic loci associated with complex diseases and traits,including *** vast majority of common traitassociated variants identified via GWAS fall in non-coding regions of the genome,posing a challenge in elucidating the causal variants,genes,and mechanisms *** quantitative trait locus(eQTL)and other molecular QTL studies have been valuable resources in identifying candidate causal genes from GWAS loci through statistical colocalization *** QTL colocalization is becoming a standard analysis in post-GWAS investigation,an easy web tool for users to perform formal colocalization analyses with either user-provided or public GWAS and eQTL datasets has been ***,we present ezQTL,a web-based bioinformatic application to interactively visualize and analyze genetic association data such as GWAS loci and molecular QTLs under different linkage disequilibrium(LD)patterns(1000 Genomes Project,UK Biobank,or user-provided data).This application allows users to perform data quality control for variants matched between different datasets,LD visualization,and two-trait colocalization analyses using two state-of-the-art methodologies(eCAVIAR and HyPrColoc),including batch *** is a free and publicly available cross-platform web tool,which can be accessed online at https://***/ezqtl.

关键词： Genome-wide association study Expression quantitative trait locus Colocalization Linkage disequilibrium Visualization

metabolic-associated fatty liver disease and sarcopenia:A double whammy

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World Journal of Hepatology 2024年第2期16卷 152-163页

作者： Aditya Viswanath Sherouk Fouda Cornelius James Fernandez Joseph m Pappachan School of medicine Leicester UniversityLeicester LE17RHUnited Kingdom School of Health and Biomedical Sciences Rmit UniversityMelbourne VICAustralia Department of Endocrinology and metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

The prevalence of metabolic-associated fatty liver disease(mAFLD)has increased substantially in recent years because of the global obesity ***,now recognized as the number one cause of chronic liver disease in the world,not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease,type 2 diabetes mellitus,obstructive sleep apnoea,lipid disorders and *** the interplay between mAFLD and these comorbidities is important to design optimal therapeutic *** can be either part of the disease process that results in mAFLD(e.g.,obesity or adiposity)or a consequence of mAFLD,especially in the advanced stages such as fibrosis and *** can also worsen mAFLD by reducing exercise capacity and by the production of various muscle-related chemical ***,it is crucial to thoroughly understand how we deal with these diseases,especially when they *** explore the pathobiological interlinks between mAFLD and sarcopenia in this comprehensive clinical update review article and propose evidence-based therapeutic strategies to enhance patient care.

关键词： metabolic-associated fatty liver disease Sarcopenia Sarcopenic obesity Lean metabolic-associated fatty liver disease Cardiovascular disease Liver-muscle axis