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Comparison of Cognitive Registration Transrectal Ultrasound-Guided Targeted Biopsy of Prostate to Systematic 12-Core Biopsy: A Retrospective, Multicentre Study

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Open Journal of Urology 2024年第7期14卷 381-390页

作者： kevin chang Yue Wei Lee Say Bob Devindran Manoharan Liong Men Long Teoh Sze Yong Teo Rui Ling Chua Zi Wei Department of Urology Hospital Pulau Pinang George Town Malaysia Department of Urology Georgetown Specialist Hospital George Town Malaysia Department of Radiology Hospital Pulau Pinang George Town Malaysia Department of Radiology Georgetown Specialist Hospital George Town Malaysia

Introduction: Prostate cancer (PCa) is the third most prevalent cancer among Malaysian males, often diagnosed at advanced stages, leading to suboptimal outcomes. While transrectal ultrasound-guided systematic biopsy (TRUS-SB) is the primary diagnostic method, prebiopsy multiparametric magnetic resonance imaging (mpMRI) is gaining popularity in identifying suspicious lesions. This study addresses the lack of comprehensive investigations into the efficacy of cognitive registration TRUS targeted biopsy (COG-TB) compared to conventional TRUS-SB, considering the resource limitations of the Malaysian healthcare system. Materials and Methods: A retrospective cohort study was conducted in two Malaysian healthcare facilities. 116 adult patients with a prostate-specific antigen (PSA) level of more than 4 ng/mL who underwent both COG-TB and TRUS-SB between October 2020 and March 2022 were included. Primary outcomes were cancer detection rate and histopathological outcomes, including Gleason score. Results: COG-TB showed a higher overall cancer detection rate (50%) compared to TRUS-SB (44%). Clinically significant cancer detection rates were similar between COG-TB and TRUS-SB (37.1%). Further analysis revealed that both COG-TB and TRUS-SB detected clinically significant cancer in 30.2% of patients, did not detect it in 56.0%, and had conflicting findings in 16 patients (p Conclusion: COG-TB and TRUS-SB have comparable detection rates for clinically significant prostate cancer, with COG-TB showing a higher tendency to detect insignificant prostate cancer. Further studies comparing these methods are warranted.

关键词： Prostate Cancer Multiparametric MRI Targeted Biopsy Cognitive Fusion Transrectal Ultrasound-Guided Biopsy

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Comparison of Cognitive Registration Transrectal Ultrasound-Guided Targeted Biopsy of Prostate to Systematic 12-Core Biopsy: A Retrospective, Multicentre Study

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Open Journal of Urology（泌尿学期刊） 2024年第7期 381页

作者： kevin chang Yue Wei Lee Say Bob Devindran Manoharan Liong Men Long Teoh Sze Yong Teo Rui Ling Chua Zi Wei

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Generalizations of the Feline and Texas Chainsaw Josephus Problems

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Open Journal of Discrete Mathematics 2019年第4期9卷 144-158页

作者： David Ariyibi kevin chang Pamela E. Harris Department of Mathematics and Statistics Williams College Williamstown MA USA

We define and study the Extended Feline Josephus Game, a game in which n players, each with ℓlives, stand in a circle. The game proceeds by alternating between hitting k consecutive players—each of whom will consequently lose a life—and skipping s consecutive players. This cycle continues until every player except one loses all of their lives. Given the nonnegative integer parameters n, k, s and ℓ, the goal of the game is to identify the surviving player. In this paper, we show how the defining parameters n, k, s, and ℓaffect the survivor of games with specific constraints on those parameters and our main results provide new closed formulas to determine the survivor of these Extended Feline Josephus Games. Moreover, for cases where these formulas do not apply, we provide recursive formulas for reducing the initial game to other games with smaller parameter values. For the interested reader, we present a variety of directions for future work in this area, including an extension which considers players lying on a general graph, rather than on a circle.

关键词： Josephus Game Feline Josephus Game Texas Chainsaw Josephus Game

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Microfacies and diagenetic alteration in a semi-deep to deep lacustrine shale: The Yanchang Formation in the Ordos Basin, China

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Petroleum Science 2024年第3期21卷 1524-1538页

作者： Bin Bai Jing-Yue Hao Ling Fu Yu-Xi Liu Jian-Peng Wang Lan Wang kevin GTaylor Lin Ma PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Department of Earth and Environmental Sciences University of ManchesterM139PLUK College of Earth Sciences Jilin UniversityChangchun130061jilinChina Department of Chemical Engineering University of ManchesterM139PLUK

The mineralogical development and diagenetic sequence of lacustrine shales in the chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this *** detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing *** main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale *** shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in *** shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of *** carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of *** shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon *** shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil *** findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.

关键词： Ordos Basin Yanchang Formation chang 7 Member Diagenesis Microfacies

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广州广商中心超高层偏置筒体复杂钢结构设计

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建筑结构 2019年第13期49卷 13-21页

作者：陈晋张凯任邓·朗奇海莉·阿特本马克思·库珀万天舒丁晗刘菀迪美国SOM建筑结构事务所芝加哥60604

广州广商中心塔楼的冠顶高度为375m,塔楼按偏置筒体布置,采用钢管混凝土巨柱外框、巨型钢斜撑、带状钢桁架和偏心支撑钢框架的复杂钢结构体系,建成后将成为中国最高的钢结构超高层。塔楼结构体系的主要特点包括:中部4根柱在第7层倾斜转... 详细信息

广州广商中心塔楼的冠顶高度为375m,塔楼按偏置筒体布置,采用钢管混凝土巨柱外框、巨型钢斜撑、带状钢桁架和偏心支撑钢框架的复杂钢结构体系,建成后将成为中国最高的钢结构超高层。塔楼结构体系的主要特点包括:中部4根柱在第7层倾斜转换到地面层、周边普通柱由两道带状桁架转换、外围抗弯框架和巨撑不在同一平面、楼板不连续等。结构中存在多项超限或者抗震不利的特征,设计过程中采用了基于性能的抗震设计思想。通过提高转换部位构件的性能目标、多轮风洞测试、优化节点设计、非线性施工模拟等措施,使整个结构体系高效而优化。另外,风致舒适度、施工可行性等方面的优化具有明显的综合经济效益,成功降低了结构总造价。

关键词：超高层结构钢结构巨柱巨撑偏心支撑转换偏置筒体

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Long-term improvements in water conservation functions at Qilian Mountain National Park, northwest China

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Journal of Mountain Science 2023年第10期20卷 2885-2897页

作者： GAO Xiang HUANG Xing-xing chang Shu-hang DANG Qian-wen WEN Rui-yang LO kevin LI Jie YAN An College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China Department of Geography Hong Kong Baptist UniversityHong Kong 999077China

Water conservation is one of the most important ecosystem *** study uses the InVEST model to examine the water conservation function of the Qilian Mountain National Park(QMNP),an important water supply area in northwest *** analyzed the spatiotemporal water conservation patterns of QMNP from 1988 to *** showed that the water conservation capacity in QMNP has increased over the past 32 years,reaching a peak of 6.495×108 m3 in *** area with an increased water conservation capacity is 12 times larger than the area with a reduced *** also examined how climatic,land-use,vegetation coverage,and topographical factors influence water conservation *** found that precipitation is the main climatic factor in water *** water conservation function also varies with land-cover type,with forests having the highest capacity,followed by ***,topographical factors,including altitude and slope,also shape the spatial patterns of water conservation functions in QMNP.

关键词： Water conservation function Ecosystem services InVEST model Qilian Mountain National Park Northwest China

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Colonic diverticulitis with comorbid diseases may require elective colectomy

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World Journal of Gastroenterology 2013年第39期19卷 6613-6617页

作者： kevin CW Hsiao Joseph G Wann Chien-Sheng Lin chang-Chieh Wu Shu-Wen Jao Ming-Hsin Yang Department of Surgery Tri-Service General HospitalNational Defense Medical Center Department of Physiology College of MedicineNational Taiwan University Department of Emergency and Critical Care Medicine Cheng Hsin Rehabilitation Medical Center Department of Emergency Tri-Service General HospitalNational Defense Medical Center

AIM:To investigate the comorbid disease could be the predictors for the elective colectomy in colonic ***:A retrospective chart review of 246 patients with colonic diverticulitis admitted between 2000and 2008 was conducted,and 19 patients received emergent operation were identified and *** were collected with regard to age,sex,albumin level on admission,left or right inflammation site,the history of recurrent diverticulitis,preoperative comorbidity,smoking habits,medication,treatment policy,morbidity,and *** comorbid diseases included cardiovascular disease,diabetes,pulmonary disease,peptic ulcer disease,gouty arthritis,and *** in use included non-steroidal anti-inflammatory drugs,acetylsalicylic acid(Aspirin),and *** and multivariate logistic regression analyses were performed to identify the relevant risk factors correlating to ***:The mean age of the 246 patients was 69.5years(range,24-94 years).Most diverticulitis could be managed with conservative treatment(n=227,92.3%),and urgent colectomy was performed in 19patients(7.7%).There were three deaths in the surgical group and four deaths in the nonsurgical *** overall mortality rate in the study was 1.7%among patients with conservative treatment and 15.7%among patients undergoing urgent *** logistic regression analysis indicated that comorbidities were risk factors for urgent colectomy for ***:To avoid high mortality and morbidity related to urgent colectomy,we suggest that patients with colonic diverticulitis and comorbid diseases may require elective colectomy.

关键词： Colonic diverticulitis Colectomy Comorbid disease

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Fungal community succession on decomposing leaf litter across five phylogenetically related tree species in a subtropical forest

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Fungal Diversity 2022年第4期115卷 73-103页

作者： Danushka S.Tennakoon chang‑Hsin Kuo Witoon Purahong Eleni Gentekaki Chayakorn Pumas Itthayakorn Promputtha kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Department of Soil Ecology UFZ-Helmholtz Centre for Environmental ResearchTheodor-Lieser-Str.406120 Halle(Saale)Germany Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand

Fungi are an essential component of the *** play an integral role in the decomposition of leaf litter and return nutrients to the ecosystem through nutrient *** are considered as the“key players”in leaf litter decomposition,because of their ability to produce a wide range of extracellular ***-related changes of fungal communities during leaf litter decomposition have been relatively ***,it has not been established how the tree species,tree phylogeny,and leaf litter chemistry influence fungal communities during *** direct observations and a culturing approach,this study compiles fungi found in freshly collected leaf litter from five phylogenetically related,native tree species in Taiwan:Celtis formosana(CF),Ficus ampelas(FA),Ficus septica(FS),Macaranga tanarius(MT),and Morus australis(MA).We investigated(i)the effects of tree species(including tree phylogeny)and leaf litter chemistry on fungal community succession,and(ii)specific patterns of fungal succession(including diversity and taxonomic community assembly)on decomposing leaf litter across the selected tree *** hypothesized that host species and leaf litter chemistry significantly affect fungal community succession.A total of 1325 leaves(CF:275,FA:275,FS:275,MT:275 and MA:225)were collected and 236 fungal taxa were recorded(CF:48,FA:46,FS:64,MT:42 and MA:36).Tree species relationships had variable associations on the fungal communities,as even closely related tree species had strongly differing communities during decomposition.A high number of species were unique to a single tree species and may indicate‘host-specificity’to a particular leaf *** overlap of microfungal species in pair wise comparisons of tree species was low(7–16%),and only 1–2%of microfungal species were observed in leaves of all tree *** percentage of occurrences of fungal communities using Hierarchical Cluster Analyses(HCA)showed that there were at least f

关键词： Fungal diversity Ecology Leaf litter decomposition Percentage of occurrences Taxonomy

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Converting lateral scanning into axial focusing to speed up three-dimensional microscopy

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Light(Science & Applications) 2020年第1期9卷 429-440页

作者： Tonmoy Chakraborty Bingying Chen Stephan Daetwyler Bo-Jui chang Oliver Vanderpoorten Etai Sapoznik Clemens F.Kaminski Tuomas P.J.Knowles kevin M.Dean Reto Fiolka Department of Cell Biology UT Southwestern Medical CenterDallasTXUSA Department of Physics and Astronomy University of New MexicoAlbuquerqueNMUSA Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB30ASUK Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUK Lyda Hill Department of Bioinformatics UT Southwestern Medical CenterDallasTXUSA

In optical microscopy,the slow axial scanning rate of the objective or the sample has traditionally limited the speed of volumetric ***,by conjugating either a movable mirror to the image plane in a remote-focusing geometry or an electrically tuneable lens(ETL)to the back focal plane,rapid axial scanning has been ***,mechanical actuation of a mirror limits the axial scanning rate(usually only 10–100 Hz for piezoelectric or voice coil-based actuators),while ETLs introduce spherical and higher-order aberrations that prevent high-resolution *** an effort to overcome these limitations,we introduce a novel optical design that transforms a lateral-scan motion into a spherical aberration-free axial scan that can be used for high-resolution *** a galvanometric mirror,we scan a laser beam laterally in a remote-focusing arm,which is then back-reflected from different heights of a mirror in the image *** characterize the optical performance of this remote-focusing technique and use it to accelerate axially swept light-sheet microscopy by an order of magnitude,allowing the quantification of rapid vesicular dynamics in three *** also demonstrate resonant remote focusing at 12 kHz with a two-photon raster-scanning microscope,which allows rapid imaging of brain tissues and zebrafish cardiac dynamics with diffraction-limited resolution.

关键词： mirror axial image

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Effect of weekend admission on geriatric hip fractures

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World Journal of Orthopedics 2020年第9期11卷 391-399页

作者： Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph chang Ronald J Simon kevin K Kang Department of Orthopaedic Surgery Maimonides Medical CenterBrooklynNY 11219United States Department of Trauma Surgery Maimonides Medical CenterBrooklynNY 11219United States

BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well *** respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care *** was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a *** To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical *** A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was *** cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a *** outcome measures included mortality rate,complication rate,transfusion rate,and length of *** outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to *** There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday *** rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients

关键词： Hip fracture Weekend admission Time to surgery Morbidity Mortality Complication

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