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HISP-1 Inhibits HSv-1 Infection in Cultured vero Cells

Advances in Bioscience and Biotechnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams kevin T. Bilyk Modukuri v. Ramani Gottumukkala v. Subbaraju Department of Biology Montclair State University Montclair USA Department of Chemistry Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSv-1) remains a leading cause of viral disease worldwide and is spread by direct contact with infected lesions. There is no vaccine against HSv-1 infections and there remains a need to identify therapeutics that could reduce the spread. In this study various hispolon compounds were analyzed to determine their antiviral potential against HSv-1 infections in cultured vero cells. To determine the effects on infectivity and possible mechanisms of inhibition, the following assays were conducted. In vitro cytotoxicity assays were conducted to determine the effect of the compounds on cell viability and the maximum non-cytotoxic concentrations. Antiviral assays measured cell viability, percent inhibition of infection following treatment with the compounds, and the effect on the viral infection cycle. These effects were visualized using inverted light and fluorescent microscopy. Of the 24 hispolons tested, only hispolon pyrazole-1 (HISP-1) demonstrated antiviral effects. HISP-1 was demonstrated to effect early stages in HSv-1 infection in cultured vero cells (attachment, penetration, and post-penetration). In silico modeling analyses were conducted to analyze the interactions between HISP-1 and viral glycoprotein D (gD). HISP-1 is safe at concentrations tested and is effective in inhibiting infection of HSv-1 in cultured cells. HISP-1 has potential for therapeutic use as an antiviral against HSv-1 infection, could work in synergy with other antivirals that work be a different modality, and could be developed as a component of a topical agent to reduce the spread of HSv-1 infections.

关键词： Hispolon Herpes Simplex virus-1 Antiviral Curcumin

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Source of metals related to gold occurrences in Cameroon, Central African Belt

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Acta Geochimica 2024年第2期43卷 308-324页

作者： kevin Igor Azeuda Ndonfack Jinlin Zhang Yuling Xie NSamiratou Yaya Emmanuel Archelaus Afanga Basua JCHX Mining Management Co. LtdBeijing 101500People’s Republic of China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037People’s Republic of China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Department of Earth Science University of BamendaBamendaRepublic of Cameroon

Suites of granitic and metamorphic rocks form a perfect geological environment in which to investigate the source of metals related to gold *** the East Province of Cameroon,the source of metals-related gold(grade~4.6 g/t)that occurs within metamorphic and granitic rocks remains *** host rocks were subjected to XRF and ICP-MS whole-rock geochemistry and BSE/EDS mineral analyses to investigate the source(s)of metals related to gold in the ***,chalcopyrite-pyrite and magnetite-ilmenite are the main sulfi des and oxides of granites,*** low-grade metamorphic rocks are sulfi de-rich consisting of arsenopyrite,chalcopyrite,pyrite,and sphalerite,and oxides include magnetite,ilmenite,hematite,and ***,Ni,Co,Sb,Sc,and Zn concentrations depleted in high-grade metamorphic rocks and granites compared to low-grade metamorphic *** well,Bi,Cd,Co,Cu,Ni,Sb,v,W,and Zn concentrations decrease with increasing temperatures from low-grade rocks to high-grade rocks and *** suite of depleted elements in high-grade rocks and granites is almost identical to those enriched in gold *** conclude that metals(Bi,Cd,Co,Cu,Ni,Sb,and Zn)related to gold mineralization in the East Province of Cameroon likely originated from metal-rich low-grade metamorphic rocks during prograde metamorphic processes prior to partial melting.

关键词： East Province of Cameroon Metamorphic rocks Granites Oxide–sulﬁdes Metal and gold Geochemistry

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Potential transformation of organic matter by microbes in cryoconite,Tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1978-1989页

作者： Bixi GUO Yongqin LIU kevin Xu ZHONG Quan SHI Chen HE Qiang ZHENG Ruanhong CAI State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for the Pan-Third Pole Environment Lanzhou UniversityLanzhou 730000China Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouverBC V6T 1Z4Canada State Key Laboratory of Heavy Oil Processing Petroleum Molecules Engineering Center(PMEC)China University of PetroleumBeijing 102249China State Key Laboratory for Marine Environmental Science Collage of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361005China

Microorganisms play an essential role in the glacier carbon cycle;how they transform organic matter in mountain glacial cryoconite remains to be ***,we applied ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)and deep sequencing of 16S rRNA gene,to investigate the temporal microbial transformation of dissolved organic matter(DOM)of the Tibetan Plateau *** the 60-day incubation,we found that DOM in cryoconite underwent a three-stage transformation,with decreasing bioavailability over *** microbial community did not change much in the first week while degrading DOM molecules that were associated with higher H/C_(wa)and lower O/C_(wa).During days 15-30,DOM composition remained stable while microbial diversity *** day 60,the DOM was microbially converted into a higher state of recalcitrance,with higher values of aromatic index,O/C_(wa),and lower H/C_(wa),which contained molecules containing more *** among various microbial taxa,like Cyanobacteria,Bacteroidota,Gammaproteobacteria,Firmicutes,and Actinobacteriota,drove the DOM transformation in *** study sheds light on the in-situ transformation of DOM composition meditated by microbial populations in cryoconite at a temporal scale,providing new insights into understanding the microbial roles in the glacier organic carbon transformation.

关键词： Cryoconite Dissolved organic matter Biodegradation Microbial community Temporal variation

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Gene Copy number variation and associated polymorphisms of complement component C4 in human SLE

Gene Copy number variation and associated polymorphisms of c...

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The 8th International Congress on SLE

作者： Erwin K Chung Yee Ling Wu Stephanie Savelli Haikady N Nagaraja Maddie Hebert Karla Jones Kathryn Kitzmiller Carol A Blanchong NatalieJacobsen-Longman Kim McBride Gloria C Higgins Robert M Rennebohm Robert R Rice kevin v hackshaw Robert A Roubey Jennifer M Grossman Betty P Tsao Daniel J Birmingham Brad H Rovin Lee A Hebert C Yung Yu Columbus Children’s Research Institute College of Medicine and Public HealthThe Ohio State UniversityColumbusOhioUSA Division of Rheumatology Allergy and ImmunologyThe University of North Carolina at Chapel HillChapel Hill.NC.USA Department of Internal Medicine University of California.Los AngelesCaliforniaUSA

＜正＞Purpose:To determine the inter-individual gene copy number variation（GCNv）of complement C4 and its associated polymorphisms in gene size（long and short）and protein isotypes（C4A and C4B）in human SLE. Method...

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Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John v.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose v.Apostol Beatriz M.Prieto Department of Ophthalmology and visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pvisayas(Pved by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

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Waste fly ash-ZnO as a novel sunlight-responsive photocatalyst for dye discoloration

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Water Science and Engineering 2023年第1期16卷 76-82页

作者： Leena v.Bora Sonal P.Thakkar kevin S.vadaliya Nisha v.Bora Nirma University AhmedabadGujarat 382481India Government Engineering College ModasaGujarat 383315India

Treating waste with a waste material using freely available solar energy is the most effective way towards sustainable *** this study,a novel photocatalyst,partly derived from waste material from the coal industry,was *** ash hybridized with ZnO(FAeZn)was synthesized as a potential photocatalyst for dye *** synthesized photocatalyst was characterized by X-ray diffraction,scanning electron microscopy,transmission electron microscopy,and ultravioletevisible/near infra-red *** photocatalytic activity was examined with the discoloration of methylene blue used as synthetic dye *** the experiments were performed in direct *** photocatalytic performance of FAeZn was found to be better than that of ZnO and the conventionally popular *** LangmuireHinshelwood model rate constant values of ZnO,TiO2,and FAeZn were found to be 0.016 min1,0.017 min1,and 0.020 min1,*** were two reasons for this:(1)FAeZn was able to utilize both ultraviolet and visible parts of the solar spectrum,and(2)its BrunauereEmmetteTeller surface area and porosity were significantly *** led to increased photon absorption and dye adsorption,thus exhibiting an energy-efficient ***,FAeZn,partly derived from waste,can serve as a suitable material for environmental remediation and practical solar energy applications.

关键词： Photocatalyst ZnO Fly ash Geopolymer Wastewater treatment Methylene blue

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Designing high-TC superconductors with BCS-inspired screening,density functional theory,and deep-learning

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npj Computational Materials 2022年第1期8卷 2331-2342页

作者： Kamal Choudhary kevin Garrity Material Measurement Laboratory GaithersburgMD20899USA National Institute of Standards and Technology GaithersburgMD20899USA Theiss Research La JollaCA92037USA

We develop a multi-step workflow for the discovery of conventional superconductors,starting with a Bardeen–Cooper–Schrieffer inspired pre-screening of 1736 materials with high Debye temperature and electronic density of ***,we perform electron-phonon coupling calculations for 1058 of them to establish a large and systematic database of BCS superconducting *** the McMillan-Allen-Dynes formula,we identify 105 dynamically stable materials with transition temperatures,TC≥5 ***,we analyze trends in our dataset and individual materials including MoN,vC,vTe,KB_(6),Ru_(3)NbC,v_(3)Pt,ScN,LaN_(2),RuO_(2),and *** demonstrate that deep-learning(DL)models can predict superconductor properties faster than direct first-principles ***,we find that by predicting the Eliashberg function as an intermediate quantity,we can improve model performance versus a direct DL prediction of *** apply the trained models on the crystallographic open database and pre-screen candidates for further DFT calculations.

关键词： database BCS faster

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Enhanced recovery after surgery protocols for outpatient operations in otolaryngology:Review of literature

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 96-106页

作者： kevin Chorath Sara Hobday Neeraj v.Suresh Beatrice Go Alvaro Moreira Karthik Rajasekaran Department of Otorhinolaryngology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Pediatrics University of Texas Health-San AntonioSan AntonioTexasUSA Leonard Davis Institute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Enhanced recovery after surgery(ERAS)protocols are patient-centered,evidence-based pathways designed to reduce complications,promote recovery,and improve outcomes following *** protocols have been successfully applied for the management of head and neck cancer,but relatively few studies have investigated the applicability of these pathways for other outpatient procedures in *** goal was to perform a systematic review of available evidence reporting the utility of ERAS protocols for the management of patients undergoing outpatient otolaryngology ***:A systematic literature review was conducted using MEDLINE,EMBASE,SCOPUS,and gray *** identified studies that evaluated ERAS protocols among patients undergoing otologic,laryngeal,nasal/sinus,pediatric,and general otolaryngology *** assessed the outcomes and ERAS components across protocols as well as the study design and ***:A total of eight studies fulfilled the inclusion criteria and were included in the *** of procedures evaluated with ERAS protocols included tonsillectomy and adenoidectomy,functional endoscopic sinus surgery,tympanoplasty and mastoidectomy,and septoplasty.A reduction in postoperative length of stay and hospital costs was reported in two and three studies,*** studies between ERAS and control groups showed persistent improvement in pre-and postoperative anxiety and pain levels,without an increase in postoperative complications and readmission ***:A limited number of studies discuss implementation of ERAS protocols for outpatient operations in *** clinical pathways appear promising for these procedures as they may reduce length of stay,decrease costs,and improve pain and anxiety postoperatively.

关键词： enhanced recovery after surgery otolaryngology outpatient surgery patient safety PSQI

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Control systems and data management for high-power laser facilities

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High Power Laser Science and Engineering 2023年第5期11卷 51-75页

作者： Scott Feister kevin Cassou Stephen Dann Andreas Döpp Philippe Gauron Anthony J.Gonsalves Archis Joglekar victoria Marshall Olivier Neveu Hans-Peter Schlenvoigt Matthew J.v.Streeter Charlotte A.J.Palmer California State University Channel Islands CamarilloCaliforniaUSA UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Ludwig–Maximilians–Universität München GarchingGermany BELLA Center Lawrence Berkeley National LaboratoryBerkeleyCaliforniaUSA Department of Nuclear Engineering and Radiological Sciences University of MichiganAnn ArborMichiganUSA Ergodic LLC San FranciscoCaliforniaUSA Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Queen’s University Belfast BelfastUK

The next generation of high-power lasers enables repetition of experiments at orders of magnitude higher frequency than what was possible using the prior *** requiring human intervention between laser repetitions need to adapt in order to keep pace with the new laser technology.A distributed networked control system can enable laboratory-wide automation and feedback control *** higher-repetition-rate experiments will create enormous quantities of data.A consistent approach to managing data can increase data accessibility,reduce repetitive data-software development and mitigate poorly organized *** opportunity arises to share knowledge of improvements to control and data infrastructure currently being *** compare platforms and approaches to state-of-the-art control systems and data management at high-power laser facilities,and we illustrate these topics with case studies from our community.

关键词： big data community organization control systems data management feedback loops high-power lasers high repetition rate metadata stabilization standards

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Functionalized Hydrogels for Articular Cartilage Tissue Engineering

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Engineering 2022年第6期8卷 71-90页

作者： Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.v.M.van Osch kevin Ki-Wai Ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and Sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

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