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小鼠Rad1基因剔除引发皮肤肿瘤易感性

小鼠Rad1基因剔除引发皮肤肿瘤易感性

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者：韩璐胡志上刘宇恒王向远 kevin m.hopkins Howard B. Lieberman 杭海英中国科学院国家大分子重点实验室中国科学院系统中心实验室生物物理研究所 Department of Genetics&Development and Obstetrics&Gynecology and The Institute for Human Nutritionand Herbert Irving Comprehensive Cancer Center Columbia University Medical Center Center for Radiological Research Columbia UniversityCollege of Physicians and Surgeons Department of Environmental Health Sciences Columbia UniversityMailman School of Public Health

＜正＞生物时刻都面对着细胞内源自由基和环境污染物及辐射等DNA损伤因素。DNA复制过程中也会产生DNA损伤。生物经过长期进化,发展出高精度的细胞周期监控点与

关键词： mrad1 mrad9 基因打靶肿瘤发生 DNA损伤

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小鼠Rad1基因剔除引发皮肤肿瘤易感性

生物物理学报 2009年第S1期25卷 452-452页

作者：韩璐胡志上刘宇恒王向远 kevin m.hopkins Howard B.Lieberman 杭海英国家大分子重点实验室生物物理研究所中国科学院系统中心实验室生物物理研究所中国科学院 Department of Genetics & Development and Obstetrics & Gynecology and The Institute for Human Nutritionand Herbert Irving Comprehensive Cancer CenterColumbia University Medical Center1130St.Nicholas AvenueRoom311BNew YorkNY10032 Center for Radiological Research Columbia UniversityCollege of Physicians and Surgeons630W.168th St.New YorkNY10032 Department of Environmental Health Sciences Columbia UniversityMailman School of Public Health60Haven AvenueSuite B1New YorkNY10032

生物时刻都面对着细胞内源自由基和环境污染物及辐射等 DNA 损伤因素。DNA 复制过程中也会产生 DNA 损伤。生物经过长期进化。

关键词： mrad1 mrad9 基因打靶肿瘤发生 DNA损伤

Rad9基因的小鼠角质细胞条件基因敲出增加遗传毒性致癌率

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Rad9基因的小鼠角质细胞条件基因敲出增加遗传毒性致癌率

Poisoning effect of polyvinyl chloride on the catalytic pyrolysis of mixed plastics over zeolites

中国科学技术协会第十届年会21分会场环境因素、遗传毒性与肿瘤学术会议

作者：胡志上刘宇恒张春波赵云何伟韩璐杨蕾蕾 kevin m.hopkins 杨晓 Howard B.Lieberman 杭海英中国科学院生物物理研究所生物大分子重点实验室中国科学院生物物理研究所感染与免于中心首都师范大学生命学院军事医学科学院生物技术研究所遗传发育疾病研究室 Center for Radiological Research College of Physicians and Surgeons Columbia UniversityMailman School of Public HealthNew YorkNew York Department of Environmental Health Sciences Columbia UniversityMailman School of Public HealthNew YorkNew York

生物每天都面对着细胞内源白由基和环境辐射等各种各样的DNA损伤因素,它们依靠高度保守的DNA修复机制抵抗内外源物质的损伤效应,维持细胞基因组的稳定性。在真核生物中,有细胞周期监控点。细胞周期监控点参与DNA损伤修复过程。一个生物...

生物每天都面对着细胞内源白由基和环境辐射等各种各样的DNA损伤因素,它们依靠高度保守的DNA修复机制抵抗内外源物质的损伤效应,维持细胞基因组的稳定性。在真核生物中,有细胞周期监控点。细胞周期监控点参与DNA损伤修复过程。一个生物体受到多大的伤害和其细胞如何应对这种伤害很大程度上决定了他是否会患癌症。Rad9是一个进化上从酵母到人都高度保守的基因,在参与DNA修复和细胞周期监控点调控、维持基因组稳定性中起重要作用。但是,Rad9基因在肿瘤发生中的具体作用还不太清晰。因此,我们建立了基因敲除小鼠模型来研究这个问题。由于将小鼠Rad9基因全身剔除会导致其胚胎致死,所以我们构建了特异地只在角质细胞中剔除Rad9基因的小鼠,来研究该基因在肿瘤发生中的作用。在正常饲养的情况下,杂合和敲除型的Rad9条件剔除小鼠与野生小鼠表型无明显差异。但在小鼠背部皮肤上涂抹DNA损伤药物DmBA后,发现Rad9基因敲除的小鼠比对照鼠显著地易诱导发生皮肤肿瘤,同时易产生皮肤衰老。检测DNA损伤响应基因p21,p53和Rad9的同源基因mrad9B发现敲除小鼠皮肤中的这些基因与野生小鼠相比表达升高。体外分离培养原代角质细胞发现Rad9基因敲除的细胞与野生细胞相比,其自发DNA损伤以及DmBA诱导的DNA双链断裂均明显增加。若在培养过程中加入抗氧化剂EGCG可以减少这种损伤,提示空气中的氧可导致皮肤角质细胞中DNA损伤,而Rad9有抗这种DNA损伤的作用。综合上述数据可知,基因组不稳定性应是本研究中小鼠皮肤肿瘤诱导发生的关键原因,而Rad9基因在维持角质细胞基因组稳定性和防止皮肤肿瘤发生方面有重要作用。我们利用组织特异性剔除Rad9基因的小鼠第一次从体内水平证明了Rad9是抑癌基因。由此我们有理由关注人体内的mrad9同源基因是否起到抑癌作用,是否有癌症患者体内存在Rad9突变。我们的工作将有益于对人类肿瘤发生机制的深入探索和发展新的临床检测及治疗方法。

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Science China Chemistry 2024年第7期67卷 2265-2273页

作者： Jiangchun Yuan Wenjie Wang Weixiao Sun Zhirong Yang Yueqiang Cao Wenyao Chen Xiaohu Ge Gang Qian Xiang Feng Xuezhi Duan Xinggui Zhou kevin m.Van Geem Jing Zhang State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Laboratory for Chemical Technology(LCT) Department of MaterialsTextiles and Chemical EngineeringFaculty of Engineering&ArchitectureGhent UniversityZwijnaarde B-9052Belgium State Key Lab of Heavy Oil Processing China University of PetroleumQingdao 266580China

Nowadays,the chemical recycling is applied for only 1%of total waste plastics,largely due to contaminants in plastic waste and difficulty in product *** the major contaminant,polyvinyl chloride(PVC)often forms corrosive hydrogen chloride(HCl)during the chemical recycling,which may cause severe catalyst deactivation and equipment ***,the investigation on catalytic pyrolysis(the major route for plastics chemical recycling)of the PVC containing mixed plastics has been rarely ***,catalytic co-pyrolysis of PVC and polyethylene(PE)was studied over an aromatization catalyst,Pt/ZSm-5,since the basic building block aromatics are desired products from plastics chemical *** poisoning effect of PVC vapor on the catalyst stability was explored by collective efforts of thorough product analysis and catalyst *** was found that the HCl evolving from PVC has an autocatalytic effect that promotes the scission of dehydrochlorinated PVC,resulting in the high yield of benzene and acetylene from *** the other hand,the presence of PVC suppressed the aromatics formation from PE,largely due to the poisoning effect of PVC-derived HCl on the Pt/*** deactivation is irreversible as evidenced by the decreased zeolite crystallinity and the loss of strong acid sites that are key to the aromatization,possibly due to the removal of framework Al upon the interaction with *** modification with octadecylphosphonic acid only slightly alleviated the PVC poisoning *** insights on the PVC poisoning of zeolite catalysts provided in this work may guide the process design of chemical recycling of PVC containing waste plastics.

关键词： polyvinyl chloride polyethylene zeolite aromatics deactivation

Implementation and evaluation of Exercise is medicine in primary care clinics within a large academic health system

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Family medicine and Community Health 2024年第1期12卷 16-27页

作者： John kevin Ong Dayao Caroline E L Duffy Amalia m Cristiano Gene'Rusty'Kallenberg Sarah E Linke University of California San Diego School of medicine La JollaCaliforniaUSA milken Institute of Public Health The George Washington UniversityWashingtonDistrict of ColumbiaUSA The University of Texas medical Branch at Galveston School of medicine GalvestonTexasUSA Scripps Family medicine Residency Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA Herbert Wertheim School of Public Health&Human Longevity Science University of California San DiegoLa JollaCaliforniaUSA Department of Family medicine University of California San DiegoLa JollaCaliforniaUSA Omada Health San FranciscoCaliforniaUSA

Objective Exercise is medicine(EIm)is a global initiative encouraging healthcare providers to routinely assess and promote physical activity(PA)among *** objective of this study was to evaluate the feasibility,adoption,implementation and effectiveness of EIm from patient,clinician and healthcare staff perspectives using a combination of electronic health record(EHR),survey and interview *** This study used a combination of the Practical Robust Implementation and Sustainability model(PRISm)and the Learning Evaluation model to implement *** captured from the EHR,including Physical Activity Vital Sign(PAVS)scores,and data collected from qualitative surveys and interviews were used to evaluate the programme’s Reach,Effectiveness,Adoption,Implementation,maintenance(RE-AIm,which is embedded within PRISm)from provider,staff and patient *** Five primary care clinics within a large academic health *** A total of 24443 patients from all participating clinics had at least one PAVS score during the study period.A total of 17 clinicians completed surveys,and 4 clinicians,8 medical assistants and 9 patients completed *** Implementation fidelity metrics varied widely between components and across clinics but were generally consistent over time,indicating a high degree of programme *** was highest during the first 6 months of the COVID-19 pandemic when most visits were *** PAVS scores increased from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min per week at 6 months for patients not meeting PA guidelines at baseline and decreased from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min per week at 6 months for patients meeting PA guidelines at *** EIm implementation,clinician-estimated time spent discussing PA with patients increased for 35%of providers and stayed the same for 53%.Conclusion Overall,this study established EIm’s feasibility,adoption,implementation

关键词： routine qualitative completed

Genetic analyses of ancient tea trees provide insights into the breeding history and dissemination of Chinese Assam tea(Camellia sinensis ***)

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Plant Diversity 2024年第2期46卷 229-237页

作者： miao-miao Li muditha K.meegahakumbura moses C.Wambulwa kevin S.Burgess michael möller Zong-Fang Shen De-Zhu Li Lian-ming Gao CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming650201YunnanChina Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla90000Sri Lanka Department of Life Sciences School of Science and ComputingSouth Eastern Kenya University170-90200KituiKenya Department of Biology Columbus State UniversityUniversity System of GeorgiaColumbusGA31907-5645USA Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburghEH35LRScotlandUK Lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100YunnanChina

Chinese Assam tea(Camellia sinensis ***)is an important tea crop with a long history of cultivation in Yunnan,*** its potential value as a genetic resource,its genetic diversity and domestication/breeding history remain *** address this issue,we genotyped 469 ancient tea plant trees representing 26 *** *** populations,plus two of its wild relatives(six and three populations of *** and ***,respectively)using 16 nuclear microsatellite *** showed that Chinese Assam tea has a relatively high,but comparatively lower gene diversity(H_(S)=0.638)than the wild relative ***(H_S=0.658).Clustering in STRUCTURE indicated that Chinese Assam tea and its two wild relatives formed distinct genetic groups,with considerable interspecific *** Chinese Assam tea accessions clustered into three gene pools,corresponding well with their geographic ***,New Hybrids analysis indicated that 68.48%of ancient Chinese Assam tea plants from Xishuangbanna were genetic intermediates between the Puer and Lincang gene *** addition,10%of the ancient Chinese Assam tea individuals were found to be hybrids between Chinese Assam tea and *** results suggest that Chinese Assam tea was domesticated separately in three gene pools(Puer,Lincang and Xishuangbanna)in the mekong River valley and that the hybrids were subsequently selected during the domestication *** the domestication history of Chinese Assam tea in southwestern Yunnan remains complex,our results will help to identify valuable genetic resources that may be useful in future tea breeding programs.

关键词： Tea plant Hybrid origin Genetic diversity Domestication history Camellia sinensis var.assamica Camellia taliensis

Speed and surface steepness affect internal tibial loading during running

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Journal of Sport and Health Science 2024年第1期13卷 118-124页

作者： Hannah Rice markus Kurz Patrick mai Leon Robertz kevin Bill Timothy R.Derrick Steffen Willwacher Department of Physical Performance Norwegian School of Sport SciencesOslo 0806Norway Sports Tech Research Centre Mid Sweden UniversityÖstersund SE-83125Sweden Department of mechanical and Process Engineering Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Orthopaedics German Sport University CologneCologne 50933Germany Department of Kinesiology Iowa State UniversityAmesIA 50011USA

Background:Internal tibial loading is influenced by modifiable factors with implications for the risk of stress *** encounter varied surface steepness(gradients)when running outdoors and may adapt their speed according to the *** study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different ***:Twenty recreational runners ran on a treadmill at 3 different speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gradients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).Force and marker data were collected synchronously *** moments were estimated at the distal third centroid of the tibia about the medial-lateral axis by ensuring static equilibrium at each 1%of *** was derived from bending moments at the anterior and posterior peripheries by modeling the tibia as a hollow ***-way repeated-measures analysis of variance were conducted using both functional and discrete statistical ***:There were significant main effects for running speed and gradient on peak bending moments and peak anterior and posterior *** running speeds resulted in greater tibial *** uphill at+10%and+15%resulted in greater tibial loading than level *** downhill at-10%and-15%resulted in reduced tibial loading compared to level *** was no difference between+5%or-5%and level ***:Running at faster speeds and uphill on gradients≥+10%increased internal tibial loading,whereas slower running and downhill running on gradients≥-10%reduced internal *** running speed according to the gradient could be a protective mechanism,providing runners with a strategy to minimize the risk of tibial stress injuries.

关键词： Bending moments Gradient musculoskeletal modeling Overuse injury Tibial stress Training factors

Cognitive function among military veterans with STEm occupations

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military medical Research 2024年第2期11卷 308-310页

作者： Justin T.mcDaniel kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda m.Weidhuner Harvey Henson David L.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEm Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEm)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEm) Animal fluency test Dementia

microfacies and diagenetic alteration in a semi-deep to deep lacustrine shale: The Yanchang Formation in the Ordos Basin, China

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Petroleum Science 2024年第3期21卷 1524-1538页

作者： Bin Bai Jing-Yue Hao Ling Fu Yu-Xi Liu Jian-Peng Wang Lan Wang kevin GTaylor Lin ma PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Department of Earth and Environmental Sciences University of ManchesterM139PLUK College of Earth Sciences Jilin UniversityChangchun130061jilinChina Department of Chemical Engineering University of ManchesterM139PLUK

The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this *** detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing *** main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale *** shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in *** shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of *** carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of *** shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon *** shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil *** findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.

关键词： Ordos Basin Yanchang Formation Chang 7 member Diagenesis microfacies