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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason Lynch Christopher E.Stevens Christopher Munley Chentao Li jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen kevin Li Arka Majumdar Pjames Schuck Aditya Mohite Hayk Harutyunyan joshua R.Hendrickson Deep jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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FEARCF a multidimensional free energy method for investigating conformational landscapes and chemical reaction mechanisms

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Science China Chemistry 2011年第12期54卷 1962-1973页

作者： NAIDOO kevin j. Scientific Computing Research Unit and Department of Chemistry University of Cape Town

The development and implementation of a computational method able to produce free energies in multiple dimensions,descriptively named the free energies from adaptive reaction coordinate forces(FEARCF) method is described in this *** the method can be used to calculate free energies of association,conformation and reactivity here it is shown in the context of chemical reaction landscapes.A reaction free energy surface for the Claisen rearrangement of chorismate to prephenate is used as an illustration of the method's efficient *** simulations are shown to achieve flat histograms for complex multidimensional free energy *** sampling efficiency by which it produces multidimensional free energies is demonstrated on the complex puckering of a pyranose ring,that is described by a three dimensional W(θ1,θ2,θ3) potential of mean force.

关键词： free energy calculations reaction dynamics reaction surfaces multidimensional free energy surfaces

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Discrete element modelling of the quasi-static uniaxial compression of individual infant formula agglomerates

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Particuology 2012年第5期10卷 523-531页

作者： kevin j.Hanley Catherine O'Sullivan Edmond P.Byrne kevin Cronin Department of Process and Chemical Engineering University College CorkCorkIreland Department of Civil and Environmental Engineering Skempton BuildingImperial College LondonLondon SW7 2AZ United Kingdom

Infant formula is usually produced in an agglomerated powder form. These agglomerates are subjected to many transient forces following their manufacture. These can be difficult to quantify experimentally because of their small magnitudes and short durations, Numerical models have the potential to address this gap in the experimental data. The objective of the research described here was to calibrate a discrete element model for these agglomerates using experimental data obtained for quasi-static loading, and to use this model to study the mechanics of the particle response in detail. The Taguchi method was previously proposed as a viable calibration approach for discrete element models. In this work, the method was assessed for calibration of the model parameters （e.g., bond stiffnesses and strengths） considering three responses： the force at failure, strain at failure and agglomerate stiffness. The Weibull moduli for the simulation results and the experimental data were almost identical following calibration and the 37% characteristic stresses were similar. An analysis of the energy terms in the model provided useful insight into the model response. The bond energy and the normal force exerted on the platens were strongly correlated, and bond breakage events coincided with the highest energy dissipation rates.

关键词： Discrete element modellingUniaxial compressionQuasi-static crushingSimulationGranular materialsTaguchi methods

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Image-Based Lifelogging: User Emotion Perspective

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Computers, Materials & Continua 2021年第5期67卷 1963-1977页

作者： junghyun Bum Hyunseung choo joyce jiyoung Whang College of Computing Sungkyunkwan UniversitySuwon16417Korea School of Computing KAISTDaejeon34141Korea

Lifelog is a digital record of an individual’s daily *** collects,records,and archives a large amount of unstructured data;therefore,techniques are required to organize and summarize those data for easy *** has been utilized for diverse applications including healthcare,self-tracking,and entertainment,among *** regard to the imagebased lifelogging,even though most users prefer to present photos with facial expressions that allow us to infer their emotions,there have been few studies on lifelogging techniques that focus upon users’*** this paper,we develop a system that extracts users’own photos from their smartphones and congures their lifelogs with a focus on their *** design an emotion classier based on convolutional neural networks(CNN)to predict the users’*** train the model,we create a new dataset by collecting facial images from the CelebFaces Attributes(CelebA)dataset and labeling their facial emotion expressions,and by integrating parts of the Radboud Faces Database(RaFD).Our dataset consists of 4,715 high-resolution *** propose Representative Emotional Data Extraction Scheme(REDES)to select representative photos based on inferring users’emotions from their facial *** addition,we develop a system that allows users to easily congure diaries for a special day and summaize their *** experimental results show that our method is able to effectively incorporate emotions into lifelog,allowing an enriched experience.

关键词： Lifelog facial expression emotion emotion classier transfer learning

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Non-uniqueness of critical solid fraction considering boundary conditions and strain-rate effects

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Particuology 2021年第1期19卷 37-49页

作者： Mingze Xu Zixin Zhang Xin Huang kevin j.Hanley Department of Geotechnical Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Geotechnical Engineering Ministry of EducationTongji UniversityShanghai 200092China School of Engineering Institute for Infrastructure and EnvironmentThe University of EdinburghEdinburgh EH93JLUnited Kingdom

The critical solid fraction(ϕj),which marks the transition between the solid and liquid phases in the jamming diagram,is influenced by several *** this study,the dependency ofϕj on strain rate and boundary conditions is examined through discrete element method simulations considering a frictionless polydisperse granular *** approaches are used to determineϕ*** observed boundary effect is due to the nonuniform solid fraction distribution induced by the clustering of particles close to rigid-wall boundaries at high compression *** solid fraction distribution within the sample in the rigid-wall simulations approaches that in the periodic-boundary simulations as the compression rate *** increasing compression rate,the major force transmission network contains fewer mechanically stable particles and a less stable force transmission *** causes jamming of the granular assembly at a lower solid *** force transmission networks,however,are fragile and disintegrate quickly upon relaxation.

关键词： jamming transition jamming density Strain rate dependency Boundary effects

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The effects of sun exposure on carotenoid accumulation and oxidative stress in the retina of the House Finch(Haemorhous mexicanus)

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Chinese Birds 2016年第1期7卷 56-67页

作者： Matthew B.Toomey kevin j.McGraw School of Life Sciences Arizona State University Department of Pathology and Immunology Washington University Medical School

Background: Diet-derived carotenoid pigments are concentrated in the retinas of birds and serve a variety of functions, including photoprotection. In domesticated bird species(e.g., chickens and quail), retinal carotenoid pigmentation has been shown to respond to large manipulations in light exposure and provide protection against photodamage. However, it is not known if or how wild birds respond to ecologically relevant variation in sun ***: We manipulated the duration of natural sunlight exposure and dietary carotenoid levels in wild-caught captive House Finches(Haemorhous mexicanus), then measured carotenoid accumulation and oxidative stress in the ***: We found no significant effects of sun exposure on retinal levels of carotenoids or lipid peroxidation, in replicate experiments, in winter(jan–Mar) and spring/summer(May–june). Dietary carotenoid supplementation in the spring/summer experiment led to significantly higher retinal carotenoid levels, but did not affect lipid peroxidation. Carotenoid levels differed significantly between the winter and spring/summer experiments, with higher retinal and lower plasma carotenoid levels in birds from the later ***: Our results suggest that variation in the duration of exposure to direct sunlight have limited influence on intraspecific variation in retinal carotenoid accumulation, but that accumulation may track other seasonal–environmental cues and physiological processes.

关键词： Carotenoids Haemorhous mexicanus House Finch Photostress Vision

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A systematic literature review of blockchain cyber security

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Digital Communications and Networks 2020年第2期6卷 147-156页

作者： Paul j.Taylor Tooska Dargahi Ali Dehghantanha Reza M.Parizi Kim-Kwang Raymond choo School of Computing Science&EngineeringUniversity of SalfordManchesterUK Cyber Science Lab School of Computer ScienceUniversity of GuelphOntarioCanada Department of Software Engineering and Game Development Kennesaw State UniversityMariettaGA30060USA Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Since the publication of Satoshi Nakamoto's white paper on Bitcoin in 2008,blockchain has(slowly)become one of the most frequently discussed methods for securing data storage and transfer through decentralized,trustless,peer-to-peer *** research identifies peer-reviewed literature that seeks to utilize blockchain for cyber security purposes and presents a systematic analysis of the most frequently adopted blockchain security *** findings show that the Internet of Things(IoT)lends itself well to novel blockchain applications,as do networks and machine visualization,public-key cryptography,web applications,certification schemes and the secure storage of Personally Identifiable Information(PII).This timely systematic review also sheds light on future directions of research,education and practices in the blockchain and cyber security space,such as security of blockchain in IoT,security of blockchain for AI data,and sidechain security.

关键词： Blockchain Smart contracts Cyber security Distributed ledger technology IoT Cryptocurrency Bitcoin

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Overcoming the limitations of gallium oxide through heterogeneous integration

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 118-119页

作者： Yuhao Zhang kevin jChen Center for Power Electronics Systems Virginia Polytechnic and State UniversityBlacksburgVA24060USA Departmnet of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina

Power electronics,processing over 50%of world's electric energy,enables very efficient electric energy conversion for a wide range of applications such as electric vehicles,data centers,autonomous driving,robotics and smart *** availability of low-cost,efficient,and reliable power semiconductor devices that can conduct high current,block high voltage,and switch at high frequencies are key to improving the performance of power electronics systems.

关键词： integration enable autonomous

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FEARCF a multidimensional free energy method for investigating conformational landscapes and chemical reaction mechanisms

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中国科学：化学 2012年第1期42卷 119-120页

作者： NAIDOO kevin j. Scientific Computing Research Unit and Department of Chemistry. University of Cape Town. South Africa 7701

关键词：化学反应机理自由能景观多维能量法适应性反应反应势能面采样效率

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