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Cary 3500多池紫外-可见分光光度计用于蛋白质分析的优势

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实验与分析 2019年第2期 32-34页

作者： kevin grant Matt Quinn 安捷伦科技公司澳大利亚

提高极小体积样品定性和定量测量的效率和重现性//紫外-可见分光光度计测量为样品的质量控制检查提供了一种快速可靠的方法。它们还可用于计算比活性或估算纯化后的产率,并鉴定含有蛋白质和氨基酸的组分。

关键词：紫外-可见分光光度计蛋白质分析质量控制检查定量测量重现性小体积比活性氨基酸

Unconventional routes to developing insect-resistant crops

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Molecular Plant 2021年第9期14卷 1439-1453页

作者： Laramy Enders kevin Begcy Purdue University Department of EntomologyWest LafayetteIN 47907USA University of Florida Environmental Horticulture DepartmentGainesvilleFL 32611USA

Concerns over widespread use of insecticides and heightened insect pest virulence under climate change continue to fuel the need for environmentally safe and sustainable control strategies. However, to develop such strategies, a better understanding of the molecular basis of plant-pest interactions is still needed. Despite decades of research investigating plant-insect interactions, few examples exist where underlying molecular mechanisms are well characterized, and even rarer are cases where this knowledge has been successfully applied to manage harmful agricultural pests. Consequently, the field appears to be static, urgently needing shifts in approaches to identify novel mechanisms by which insects colonize plants and plants avoid insect pressure. In this perspective, we outline necessary steps for advancing holistic methodologies that capture complex plant-insect molecular interactions. We highlight novel and underexploited approaches in plant-insect interaction research as essential routes to translate knowledge of underlying molecular mechanisms into durable pest control strategies, including embracing microbial partnerships, identifying what makes a plant an unsuitable host, capitalizing on tolerance of insect damage, and learning from cases where crop domestication and agronomic practices enhance pest virulence.

关键词： insects plants compatible and incompatible interaction host and non-host plant resista nee

High Resolution Global Modeling of the Atmospheric Circulation

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Advances in Atmospheric Sciences 2006年第6期23卷 842-856页

作者： kevin HAMILTON International Pacific Research Center University of Hawaii at Manoa HonoluluHawaii 96822USA

An informal review is presented of recent developments in numerical simulation of the global atmospheric circulation with very fine numerical resolution models, The focus is on results obtained recently with versions of the GFDL SKYHI model and the Atmospheric Model for the Earth Simulator （AFES） global atmospheric models. These models have been run with effective horizontal grid resolution of -10-40 km and fine vertical resolution. The results presented demonstrate the utility of such models for the study of a diverse range of phenomena, Specifically the models are shown to simulate the development of tropical cyclones with peak winds and minimum central pressures comparable to those of the most intense hurricanes actually observed, More fundamentally, the spectrum of energy content in the mesoscale in the flow can be reproduced by these models down to near the smallest explicitly-resolved horizontal scales, in the middle atmosphere it is shown that increasing horizontal resolution can lead to significantly improved overall simulation of the global-scale circulation, The application of the models to two specific problems requiring very fine resolution global will be discussed, The spatial and temporal variability of the vertical eddy flux of zonal momentum associated with gravity waves near the tropopause is evaluated in the very fine resolution AFES model, This is a subject of great importance for understanding and modelling the flow in the middle atmosphere, Then the simulation of the small scale variations of the semidiurnal surface pressure oscillation is analyzed, and the signature of significant topographic modulation of the semidiurnal atmospheric tide is identified.

关键词： general circulation model mesoscale simulation gravity waves atmospheric tides

Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases

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Infectious Diseases of Poverty 2014年第1期3卷 310-324页

作者： kevin Bardosh Centre of African Studies School of Social and Political ScienceCollege of Humanities and Social ScienceThe University of Edinburgh58 George SquareEdinburgh EH89LDUK Division of Pathway Medicine and Centre for Infectious Diseases School of Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUK

Neglected Tropical Diseases(NTDs)are both drivers and manifestations of poverty and social *** advocacy efforts since the mid-2000s have led to ambitious new control and elimination targets set for 2020 by the World Health *** these global aspirations represent significant policy momentum,there are multifaceted challenges in controlling infectious diseases in resource-poor local contexts that need to be acknowledged,understood and *** a number of recent publications have emphasised the“neglected”status of applied social science research on *** light of the 2020 targets,this paper explores the social science/NTD literature and unpacks some of the ways in which social inquiry can help support effective and sustainable *** priority areas are discussed,including on policy processes,health systems capacity,compliance and resistance to interventions,education and behaviour change,and community *** paper shows that despite the multifaceted value of having anthropological and sociological perspectives integrated into NTD programmes,contemporary efforts underutilise this *** is reflective of the dominance of top-down information flows and technocratic approaches in global *** counter this tendency,social research needs to be more than an afterthought;integrating social inquiry into the planning,monitoring and evaluating process will help ensure that flexibility and adaptability to local realities are built into *** emphasis on social science perspectives can also help link NTD control to broader social determinants of health,especially important given the major social and economic inequalities that continue to underpin transmission in endemic countries.

关键词： Neglected tropical diseases Applied social sciences Implementation research Social determinants Community participation Policy Global health Sociology Anthropology

Layer-layout-based heuristics for loading homogeneous items into a single container

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1944-1952页

作者： WANG Zhou-jing LI kevin W Department of Automation Xiamen University Xiamen 361005 China Odette School of Business University of Windsor Windsor Ontario N9B 3P4 Canada

The container loading problem (CLP) is a well-known NP-hard problem. Due to the computation complexity, heuristics is an often-sought approach. This article proposes two heuristics to pack homogeneous rectangular boxes into a single container. Both algorithms adopt the concept of building layers on one face of the container, but the first heuristic determines the layer face once for all, while the second treats the remaining container space as a reduced-sized container after one layer is loaded and, hence, selects the layer face dynamically. To handle the layout design problem at a layer's level, a block-based 2D packing procedure is also developed. Numerical studies demonstrate the efficiency of the heuristics.

关键词： Container loading problem (CLP) Heuristic Laver Packing. Optimization

A NOVEL APPROACH TO CHARACTERIZING HESITATIONS IN INTUITIONISTIC FUZZY NUMBERS

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Journal of Systems Science and Systems Engineering 2013年第3期22卷 283-294页

作者： Minji HUANG kevin W.LI Department of Automation Xiamen University Odette School of Business University of Windsor

Building upon the concept of Dα operator introduced by Atanassov （1989）, thin article proposes an improved objective approach and a hybrid approach to operationalize Dα so that the hesitation in an intuitionistic fuzzy number （IFN） can be further refined and characterized. Numerical experiments are carried out to demonstrate the features and novelty of the proposed approach compared to existing methods in the literature. The aim is to furnish an effective way to refine hesitations in intuitionistic fuzzy assessments for more reliable and confident decision aids.

关键词： Intuitionistic fuzzy numbers fuzzy numbers hesitation Dα operator

Epidemiologic investigation of pediatric distal humerus fractures: An American insurance claims database study

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World Journal of Orthopedics 2024年第1期15卷 52-60页

作者： Kyle Jay Klahs Jake E Dertinger grant T Mello kevin Thapa Alexis B Sandler E'Stephan J Jesus Garcia Nata Parnes Department of Orthopaedic Surgery Texas Tech University Health Sciences-El PasoEl PasoTX 79905United States Medical School California Health Sciences University College of Osteopathic MedicineClovisCA 93611United States Undergraduate School Binghampton UniversityVestalNY 13902United States Department of Orthopaedic Surgery William Beaumont Army Medical CenterFort BlissTX 79918United States Department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)*** To evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and ME)from an American insurance claims *** A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and ME fractures based on the IBM Truven MarketScan®Commercial and IBM Truven MarketScan Medicare Supplemental *** from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and *** A total of 1133 SC,154 LC,and 124 ME fractures were *** fractures had the highest percentage of operation at 83%,followed by LC(78%)and ME fractures(41%).Male patients were,on average,older than female patients for both SC and ME *** In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally ME *** was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with ME *** peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.

关键词： Supracondylar humerus fracture Lateral condyle fracture Medial epicondyle fracture Pediatric elbow Truven Epidemiology

Neuron-to-astrocyte proteostatic stress signaling in response to tau pathology

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Neural Regeneration Research 2024年第3期19卷 505-506页

作者： kevin Llewelyn Batenburg Wiep Scheper Amsterdam UMC location Vrije Universiteit Amsterdam Department of Human GeneticsAmsterdam Neuroscience-NeurodegenerationAmsterdamThe Netherlands Department of Functional Genomics Center for Neurogenomics and Cognitive ResearchVrije Universiteit AmsterdamAmsterdam Neuroscience-NeurodegenerationAmsterdamThe Netherlands

Maintenance of protein homeostasis or“proteostasis”is essential for the functioning and viability of *** is in particular the case for cells like neurons that cannot self-renew and acquire unique functional properties during their *** proteostatic stress responses are in place to protect cells from damage in case of proteostatic *** integrated stress response(ISR)is one of the key proteostatic stress responses in the cell(Costa-Mattioli and Walter,2020).The ISR is the downstream convergence point for the four stress-induced eIF2αkinases(EIF2AK1-4)that control stress-regulated protein translation via phosphorylation of the translation factor eIF2α.ISR activation results in a transient reduction of global translation while it concomitantly enhances the translation of specific mRNAs,including that encoding the activating transcription factor 4(ATF4).Together,the translational control mediated by the ISR results in a temporary reduction of the overall protein load and the selectively increased expression of proteins that contribute to restoration of the proteostatic balance.

关键词： translation stress Together

NOTES ON “MULTICRITERIA FUZZY DECISION-MAKING METHOD BASED ON A NOVEL ACCURACY FUNCTION UNDER INTERVAL-VALUED INTUITIONISTIC FUZZY ENVIRONMENT”

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Journal of Systems Science and Systems Engineering 2010年第4期19卷 504-508页

作者： kevin W. LI Zhoujing WANG Odette School of Business University of Windsor Windsor Ontario N9B 3P4 Canada School of Computer Science and Engineering Beihang University Beijing 100083 China Department of Automation Xiamen University Xiamen Fujian 361005 China

This note points outs the inappropriateness of an accuracy function introduced by Ye [Ye, J. （2009）. Multicriteria fuzzy decision-making method based on a novel accuracy function under interval-valued intuitionistic fuzzy environment. Expert Systems with Applications, 36 （3）： 6899-6902] and its misleading use for comparing two interval-valued intuitionistic fuzzy numbers.

关键词： Interval-valued intuitionistic fuzzy set accuracy function score function multicriteria decision-making