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Arabidopsis RNA polymerase Ⅱ C-terminal domain phosphatase-like 1 targets mitogen-activated protein kinase cascades to suppress plant immunity

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Journal of Integrative Plant Biology 2023年第10期65卷 2380-2394页

作者： Junjun Wei Wei Sun Xinhang Zheng Shanshan Qiu Shuangyu Jiao kevin babilonia Hisashi Koiwa Ping He Libo Shan Wenxian Sun Fuhao Cui Department of Plant Pathology and the Ministry of Agriculture Key Laboratory of Pest Monitoring and Green Management China Agricultural UniversityBeijing 100193China Department of Biochemistry and Biophysics Texas A&M UniversityCollege StationTX 77843USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843USA

Mitogen-activated protein kinase(MAPK) cascades play pivotal roles in plant defense against phytopathogens downstream of immune receptor complexes. The amplitude and duration of MAPK activation must be strictly controlled, but the underlying mechanism remains unclear. Here, we identified Arabidopsis CPL1(C-terminal domain phosphatase-like 1)as a negative regulator of microbe-associated molecular pattern(MAMP)-triggered immunity via a forward-genetic screen. Disruption of CPL1 significantly enhanced plant resistance to Pseudomonas pathogens induced by the bacterial peptide fg22. Furthermore, fg22-induced MPK3/MPK4/MPK6 phosphorylation was dramatically elevated in cpl1 mutants but severely impaired in CPL1 overexpression lines, suggesting that CPL1 might interfere with fg22-induced MAPK activation. Indeed, CPL1 directly interacted with MPK3 and MPK6, as well as the upstream MKK4 and MKK5. A firefy luciferase-based complementation assay indicated that the interaction between MKK4/MKK5 and MPK3/MPK6 was significantly reduced in the presence of CPL1. These results suggest that CPL1 plays a novel regulatory role in suppressing MAMP-induced MAPK cascade activation and MAMP-triggered immunity to bacterial pathogens.

关键词： Arabidopsis C-terminal domain(CTD)phosphatase-like 1(CPL1) microbe-associated molecular pattern(MAMP) mitogen-activated protein kinase(MAPK) pattern-triggered immunity(PTI)

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