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大陆集团总部

现代装饰 2024年第3期 32-41页

作者： Arsen Aliverdiev(设计) Michael Bertram(设计) kerstin El-Khawad(设计) Gunter Fleitz(设计) Eva Perez Fons(设计) Lisa Holler(设计) Leticia Hutchings(设计) Peter Ippolito(设计) Christiane Klinner(设计) Susann Kreplin(设计) Frank Lakmann(设计) Tim Lessmann(设计) Eleonora Mannisi(设计) Thomas Mura(设计) Maria Cristina Orizzonte(设计) Jana Stumpe(设计) Bradley Wheeler(设计) Elisabed Zautashvili(设计) Werner Huthmacher(摄影) Ippolito Fleitz Group(摄影) 不详

“The Future in Motion”是大陆集团的座右铭,而大陆集团的品牌“Continental”则代表着面向未来、可持续发展和团结协作的理念。由于原集团总部的面积不再能满足公司的未来发展,大陆集团决定在德国汉诺威毗邻城市森林的位置新建一座... 详细信息

“The Future in Motion”是大陆集团的座右铭,而大陆集团的品牌“Continental”则代表着面向未来、可持续发展和团结协作的理念。由于原集团总部的面积不再能满足公司的未来发展,大陆集团决定在德国汉诺威毗邻城市森林的位置新建一座总部。新总部的设计以共享办公为概念,可为多达2400名员工提供工作场所。新楼经过五年建设,于2023年12月投入使用。

关键词：集团总部德国汉诺威可持续发展团结协作大陆座右铭

The joint impact of bankruptcy costs, fire sales and cross-holdings on systemic risk in financial networks

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Probability, Uncertainty and Quantitative Risk 2017年第1期2卷 192-229页

作者： Stefan Weber kerstin Weske Institut fur Mathematische Stochastik Leibniz Universit¨at HannoverWelfengarten 130167 HannoverGermany

The paper presents a comprehensive model of a banking system that integrates network effects,bankruptcy costs,fire sales,and *** the integrated financial market we prove the existence of a price-payment equilibrium and design an algorithm for the computation of the greatest and the least *** number of defaults corresponding to the greatest price-payment equilibrium is analyzed in several comparative case *** illustrate the individual and joint impact of interbank liabilities,bankruptcy costs,fire sales and cross-holdings on systemic *** study policy implications and regulatory instruments,including central bank guarantees and quantitative easing,the significance of last wills of financial institutions,and capital requirements.

关键词： Systemic risk Financial contagion Financial network Cross-holdings Fire sales Bankruptcy costs

DNA identification of compromised samples with massive parallel sequencing

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Forensic Sciences Research 2019年第4期4卷 331-336页

作者： Andreas Tillmar Ida Grandell kerstin Montelius Department of Forensic Genetics and Forensic Toxicology National Board of Forensic MedicineLinköpingSweden Department of Clinical and Experimental Medicine Faculty of Health SciencesLinköping UniversityLinköpingSweden

Genetic profiling is a standard procedure for human identification,*** criminal cases and mass disasters,and has been proven to be an important part in the process in the repatriation of victims to their *** the event of a catastrophe whether it be a natural disaster,terror attack or accident,fatalities of many nationalities may be a consequence and international collaboration becomes *** DNA techniques used on a routine basis at forensic laboratories world-wide are very useful,and results reported from different labs are compared,making it possible to be matched in order to declare the identification of a *** calculations of possibilities of a random match are achievable since population data from many parts of the world are ***,decomposition and degradation of the remains are not uncommon in the aftermath of a catastrophe and hence it may be difficult to retrieve detailed DNA profiles from such *** parallel sequencing(MPS)is a technique capable of producing a vast amount of DNA sequence data in a high-through put manner,and panels of single nucleotide polymorphism(SNP)markers allow the amplification of small DNA fragments,often seen in compromised ***,we report the results from a set of 10 samples from missing person identification cases,analyzed with an MPS based method comprising 131 SNP markers and compared with direct reference material or buccal swab samples collected from relatives of the *** assess the weight of evidence of a match by statistical ***,we compare results reported on different platforms using different SNP panels,and conclude that more work has to be done if results from missing person identification cases analyzed on MPS with SNP panels at different laboratories are to be fully reliable and thus comparable.

关键词： Forensic science forensic genetics disaster victim identification massive parallel sequencing SNP mass disaster

Affairs happen---to whom？ A study on extrapair paternity in common nightingales

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Current Zoology 2017年第4期63卷 421-431页

作者： Conny LANDGRAF kerstin WILHELM Jutta WIRTH Michael WEISS Silke KIPPER Leibniz Institute for Zoo and Wildlife Research (IZW) Alfred-Kowalke-StraBe 17 10315 Berlin Germany Animal Behavior Group Free University of Berlin TakustraBe 6 14195 Berlin Germany Institute of Evolutionary Ecology and Conservation Genomics University of UIm Albert Einstein Allee 11 89069 UIm Germany Behavioural Ecology Group Department of Animal Sciences Wageningen University De Elst 1 6708 WD Wageningen The Netherlands Department of Exposition Unit Epidemiology Statistics and Mathematical Modelling Federal Institute for Risk Assessment (BfR) Max-Dohrn-Str. 8-10 10589 Berlin Germany Chair of Zoology School of Life Sciences Weihenstephan Technische Universitat Munchen LieseI-Beckmann-StraBe 4 85350 Freising Germany

Most birds engage in extrapair copulations despite great differences across and within species. Besides cost and benefit considerations of the two sex environmental factors have been found to alter mating strategies within or between populations and/or over time. For socially monogamous species, the main advantage that females might gain from mating with multiple males is probably increasing their offspring's genetic fitness. Since male (genetic) quality is mostly not directly measurable for female birds, (extrapair) mate choice is based on male secondary traits. In passerines male song is such a sexual ornament indicating male phenotypic and/or genetic quality and song repertoires seem to affect female mate choice in a number of species. Yet their role in extrapair mating behavior is not well understood. In this study, we investigated the proportion of extrapair paternity (EPP) in a population of common nightingales . We found that EPP rate was rather high (21.5% of all offspring tested) for a species without sexual dimorphism and high levels of paternal care. Furthermore, the occurrence of EPP was strongly related to the spatial distribution of male territories with males settling in densely occupied areas having higher proportions of extrapair young within their own brood. Also, song repertoire size affected EPP: here larger repertoires of social mates were negatively related to the probability of being cuckolded. When directly comparing repertoires sizes of social and extrapair mates, extrapair mates tended to have larger repertoires. We finally discuss our results as a hint for a flexible mating strategy in nightingales where several factors-including ecological as well as male song features-need to be considered when studying reproductive behavior in monogamous species with complex song.

关键词：亲子鉴定夜莺一夫一妻制交配策略 EPP 种内差异环境因素直接测量

In situ Raman imaging of high-temperature solid-state reactions in the CaSO4-SiO2 system

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International Journal of Coal Science & Technology 2019年第2期6卷 247-259页

作者： Nadine Bohme kerstin Hauke Manuela Neuroth Thorsten Geisler Institut fiir Geowissenschaften und Meteorologie Universitat Bonn Poppelsdorfer Schloss Meckenheimer Allee 169 53115 Bonn Germany RWE Power AG F und E Kraftwerk NiederauBem Bergheim Germany

The deposition of mineral phases on the heat transfer surfaces of brown coal power plants may have a negative effect on power plant boilers. The paragenesis of these deposits contains information about the actual temperature prevailed during the combustion of lignite, if the temperature-dependences of distinct mineral transformations or reactions are known. Here, we report results of a sintering study (to ?1100℃) with samples containing anhydrite, quartz, and gehlenite, which are typical components of Rhenish lignite ashes. Thermal decompositions and solid-state reactions were analyzed (1) in situ and (2) both in situ and after quenching using confocal hyperspectral Raman imaging. This novel application of confocal Raman spectroscopy provides temperature-and time-resolved, 2-dimensional information about sintering processes with a micrometer-scale resolution. In the course of the sintering experiments with anhydrite and quartz with a weight ratio of 2:1 both polymorphs wollastonite and pseudowollastonite were identified in situ at about 920 and 1000℃, respectively. The formation of pseudowollastonite was thus observed about 120℃ below the phase transition temperature, demonstrating that it can form metastably. In addition,α′L-Ca2SiO4 was identified at about 1100℃. In samples containing equal weight fractions of anhydrite and quartz that were quenched after firing for 9h at about 1100℃,β-Ca2SiO4 (larnite) crystallized as rims around anhydrite grains and in direct contact to wollastonite. We furthermore observed that, depending on the ratio between quartz and anhydrite, wollastonite replaced quartz grains between 920 and 1100℃., i.e., the higher the quartz content, the lower the formation temperature of wollastonite.

关键词： Ash deposition Calcium silicate Calcium sulfate High-temperature Raman imaging

Efficiency of sample-based indices for spatial pattern recognition of wild pistachio(Pistacia atlantica) trees in semi-arid woodlands

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Journal of Forestry Research 2016年第3期27卷 583-594页

作者： Yousef Erfanifard Joachim Saborowski kerstin Wiegand Katrin M.Meyer Department of Natural Resources and Environment College of Agriculture Shiraz University Department of Ecosystem Modelling University of Goettingen

The efficiency of sample-based indices proposed to quantify the spatial distribution of trees is influenced by the structure of tree stands, environmental heterogeneity and degree of aggregation. We evaluated 10 commonly used distance-based and 10 density-based indices using two structurally different stands of wild pistachio trees in the Zagros woodlands, Iran, to assess the reliability of each in revealing stand structure in woodlands. All trees were completely stem-mapped in a nearly pure（40 ha） and a mixed（45 ha） stand. First, the inhomogeneous pair correlation function [g（r）] and the Clark-Evans index（CEI） were used as references to reveal the true spatial arrangement of all trees in these stands. The sampled data were then evaluated using the 20 *** was undertaken in a grid based on a square lattice using square plots（30 m 9 30 m） and nearest neighbor distances at the sample points. The g（r） and CEI statistics showed that the wild pistachio trees were aggregated in both stands, although the degree of aggregation was markedly higher in the pure stand. Three distance- and six density-based indices statistically verified that the wild pistachio trees were aggregated in both stands. The distance-based Hines and Hines statistic（ht） and the densitybased standardised Morisita（Ip）, patchiness（IP） and Cassie（CA） indices revealed aggregation of the trees in the two structurally different stands in the Zagros woodlands and the higher clumping in the pure stand, whereas the other indices were not sensitive enough.

关键词： Density-based indices Distance-basedindices Pattern recognition Wild pistachio Woodland

Prognostic value of serum microRNA-122 in hepatocellular carcinoma is dependent on coexisting clinical and laboratory factors

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World Journal of Gastroenterology 2020年第1期26卷 86-96页

作者： Martin Franck kerstin Schütte Peter Malfertheiner Alexander Link Department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University MagdeburgMagdeburg 39120Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Department of Internal Medicine and Gastroenterology Niels-Stensen-Kliniken MarienhospitalOsnabrück 49074Germany

BACKGROUND There is ongoing search for new noninvasive biomarkers to improve management of patients with hepatocellular carcinoma(HCC).Studies,mostly from the Asian-Pacific region,demonstrated differential expression of liverspecific microRNA-122(miR-122)in tissue as well as in sera of patients with hepatitis B virus-and hepatitis C virus-induced *** To evaluate prognostic value of miR-122 in patients with HCC in a European population and determine potential factors related to alteration of miR-122 in *** Patients with confirmed HCC(n=91)were included in the study over a two-year *** were characterized according to Child-Pugh score,Barcelona clinic liver cancer(BCLC)staging system,etiology of liver disease,laboratory parameters and overall ***-122 was measured in sera using TaqMan assay normalized to spiked-in *** serum miR-122 quantity was independent of the Child-Pugh score,the BCLC stage or the underlying *** positive correlation was found between miR-122 and alanine aminotransferase(Pse(P=0.0001),alpha-fetoprotein(AFP)(P=0.0034)and hemoglobin concentration(P=0.076).Negative correlation was observed between miR-122 level and creatinine concentration(P=0.0028).AFP,Child-Pugh score and BCLC staging system were associated with survival *** overall cohort low miR-122 in sera was only associated with a trend for a better overall survival without reaching statistical *** analysis revealed that low miR-122 was significantly associated with better prognosis in patients with advanced cirrhosis(Child-Pugh class B/C),advanced tumor stage(BCLC B/C/D)and normal AFP(<7 ng/mL).CONCLUSION Our results strongly support the value of miR-122 as potential biomarker of liver injury and probably ***,the value of miR-122 in prediction of prognosis of HCC patients was limited to certain patients’*** circulating miR-122 may be influ

关键词： Hepatocellular carcinoma MicroRNA Prognosis MicroRNA-122 Influencing factors

FAIR Geoscientific Samples and Data Need International Collaboration

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Acta Geologica Sinica(English Edition) 2019年第S1期93卷 32-33页

作者： kerstin LEHNERT Lesley WYBORN Jens KLUMP Lamont-Doherty Earth Observatory Columbia UniversityPalisadesNY10964USA National Computational Infrastructure Facility and Research School of Earth Sciences Australian National UniversityCanberra2600ACTAustralia CSIRO ARRC KensingtonWA 6151Australia

1 Introduction The primary goal of the Deep-time Digital Earth project is to develop an open collaboration and data sharing platform that enables the transition of deep-time geoscientific research to a Big Data driven *** an open platform will require the ability to effectively and efficiently access and integrate a wide variety of digital Earth data.

关键词： FAIR findable accessible interoperable reusable data standards samples IGSN

Endogenously increased n-3 PUFA levels in fat-1 transgenic mice do not protect from non-alcoholic steatohepatitis

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 447-458页

作者： Marie Liebig Dirk Dannenberger Brigitte Vollmar kerstin Abshagen Rudolf-Zenker-Institute for Experimental Surgery University Medicine Rostock18057 RostockGermany Institute of Muscle Biology and Growth Leibniz Institute for Farm Animal Biology(FBN)18196 DummerstorfGermany

Background:Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver diseaseworldwide,ranging from simple steatosis to non-alcoholic steatohepatitis(NASH)and *** for the NAFLD epidemic in industrialized countries are the high intake of pro-inflammatory n-6polyunsaturated fatty acids(n-6 PUFAs)and low consumption of healthy n-3 *** to their antiinflammatoryproperties,n-3 PUFAs may have the potential to alleviate chronic liver ***,weexamined the therapeutic effect of increased n-3 PUFA tissue levels in fat-1 transgenic mice on ***:Disease was induced in mice by streptozotocin and high fat diet(STZ/HFD)resulting in *** in 6 and 8 weeks old wild type and fat-1 transgenic STZ/HFD treated mice was *** other mammals,fat-1 transgenic mice ubiquitously express an n-3 fatty acid desaturase,which converts n-6to n-3 PUFAs,leading to increased n-3 and decreased n-6 PUFA tissue ***:Liver damage,NAFLD activity score(NAS),hepatic lipid accumulation and inflammation weresignificantly reduced in fat-1 transgenic STZ/HFD treated mice in the early(6 weeks)but not late(8 weeks)phase of ***,mRNA expression of genes involved in fatty acid uptake and storage(Cd36and Plin3,respectively)was significantly down-regulated in 6 week old but not 8 week old fat-1 transgenicSTZ/HFD treated ***:Endogenously elevated n-3 PUFA levels in fat-1 transgenic mice transiently delay the onsetof STZ/HFD induced NASH but failed to efficiently protect from NASH development.

关键词： Non-alcoholic fatty liver disease(NAFLD) non-alcoholic steatohepatitis(NASH) n-6/n-3 fat-1 steatosis