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Effects of sclerostin antibody on bone healing

World Journal of Orthopedics 2021年第9期12卷 651-659页

作者： Atsushi Mihara Kiminori Yukata Toshihiro Seki Ryuta Iwanaga Norihiro Nishida kenzo fujii Yuji Nagao Takashi Sakai Department of Orthopedic Surgery Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Promoting bone healing after a fracture has been a frequent subject of ***,sclerostin antibody(Scl-Ab)has been introduced as a new anabolic agent for the treatment of ***-Ab activates the canonical Wnt(cWnt)-β-catenin pathway,leading to an increase in bone formation and decrease in bone *** of its rich osteogenic effects,preclinically,Scl-Ab has shown positive effects on bone healing in rodent models;researchers have reported an increase in bone mass,mechanical strength,histological bone formation,total mineralized callus volume,bone mineral density,neovascularization,proliferating cell nuclear antigen score,and bone morphogenic protein expression at the fracture site after Scl-Ab *** addition,in a rat critical-size femoral-defect model,the Scl-Ab-treated group demonstrated a higher bone healing *** the other hand,two clinical reports have researched Scl-Ab in bone healing and failed to show positive effects in the femur and *** review discusses why Scl-Ab appears to be effective in animal models of fracture healing and not in clinical cases.

关键词： Canonical Wnt-β-catenin pathway Fracture healing Osteoporosis Romosozumab Sclerostin antibody

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Electric Field Enhancement of Nano Gap of Silver Prisms

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Chinese Physics Letters 2007年第10期24卷 2934-2937页

作者： kenzo Yamaguchi TOMOHIRO Inoue MASAMITSU fujii MASANOBU Haraguchi TOSHIHIRO Okamoto MASUO Fukui SHU Seki SEIICHI Tagawa Department of Optical Science and Engineering Faculty and School of Engineering The University of Tokushima 2-1 Minamijosanjima-cho Tokushima-city Tokushima 770-8506 Japan Department of Electronics and Mechanics Toba National College of Maritime Technology 1-1 Ikegami-cho Toba-city Mie 517-8501 Japan Institute of Scientific and Industrial Research Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Using numerical calculation, we examine the effects of gap distance of a pair of nano gap silver prisms with rounded corners on the local light intensity enhancement. Two peaks due to localized surface plasmon （LSP） excitation are observed in a wavelength range from 900nm to 300nm. The results demonstrate that peaks at a longer and a shorter wavelength corresponded to dipole-like and quadrupole-like LSP resonances, respectively. It is found that a gap distance up to 20 nm provides larger light intensity enhancement than that of a single silver nano prism with rounded corners. Furthermore, nano gap silver prisms are fabricated by direct focused ion beam processing, and we measure the scattering light spectrum of a pair of nano prisms by a confocal optical system. However, the two LSP peaks are not observed in visible range because the sizes of the nano gap and prisms are too large.

关键词： SURFACE-PLASMON RESONANCE AG NANOPARTICLES NEAR-FIELD NANOANTENNAS SCATTERING

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