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Combination of genetic analysis and ancient literature survey reveals the diverge nee of traditional Brassica rapa varieties from Kyoto, Japan

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Horticulture Research 2021年第1期8卷 1877-1886页

作者： Yaichi Kawakatsu Tomoaki Sakamoto Hokuto Nakayama Kaori Kaminoyama Kaori Igarashi Masaki Yasugi Hiroshi Kudoh Atsushi JNagano kentaro yano Nakao Kubo Michitaka Notaguchi Seisuke Kimura Faculty of Life Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 603-8555Japan Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Center for Plant Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 6038555Japan Graduate School of Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan School of Agriculture Meiji University1-1-1Higashi-MitaTama-kuKawasakiKanagawa 214-8571Japan Faculty of Engineering Utsunomiya University7-1-2 YotoUtsunomiyaTochigi 321-8585Japan Center for Ecological Research Kyoto UniversityHirano 2-509-3OtsuShiga 520-2113Japan Faculty of Agriculture Ryukoku University1-5 YokotaniSeta Oe-choOtsuShiga 520-2194Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural University1-5 Hangi-choShimogamoSakyo-kuKyoto 606-8522Japan Biotechnology Research Department Kyoto Prefectural AgricultureForestry and Fisheries Technology Center74 OjiKitainayazumaSeika-choSoraku-gunKyoto 6190244Japan Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Institute of Transformative Bio-Molecules Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Since ancient times,humans have bred several plants that we rely on ***,little is known about the divergence of most of these *** the present study,we investigated the divergence of Mibuna(Brassica rapa *** ***),a traditional leafy vegetable in Kyoto(Japan),by combining genetic analysis and a survey of ancient *** is considered to have been bred 200 years ago from Mizuna,another traditional leafy vegetable in *** has simple spatulate leaves,whereas Mizuna has characteristic serrated *** quantitative trait loci(QTL)and gene expression analyses suggested that the downregulation of BrTCP15 expression contributed to the change in the leaf shape from serrated to simple ***,the SNP analysis indicated that the genomic region containing the BrTCP15 locus was transferred to Mibuna by ***,we conducted a survey of ancient literature to reveal the divergence of Mibuna and found that hybridization between Mizuna and a simple-leaved turnip might have occurred in the ***,the genomic analysis of multiple turnip cultivars showed that one of the cultivars,Murasakihime,has almost the same sequence in the BrTCP15 region as *** results suggest that the hybridization between Mizuna and turnip has resulted in the establishment of Mibuna.

关键词： cultivar survey analysis

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A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato Koichi Kato Hisao Hayashi kentaro Yoshioka Kazuhiko Hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome

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Mutations in carboxy-terminal part of E2 including PKR/eIF2αphosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b:Their correlation with response to interferon monotherapy and viral load

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World Journal of Gastroenterology 2006年第23期12卷 3722-3728页

作者： Koji Ukai Masatoshi Ishigami kentaro Yoshioka Naoto Kawabe Yoshiaki Katano Kazuhiko Hayashi Takashi Honda Motoyoshi yano Hidemi Goto Division of Gastroenterology Department of Internal MedicineNagoya University Graduate School of MedicineNagoyaJapan Division of Liver and Biliary Diseases Department of Internal MedicineFujita Health University School of MedicineAichiJapan

AIM： To study the amino acid substitutions in the carboxy （C）-terminal part of E2 protein and in the interferon （IFN） sensitivity determining region （ISDR） and their correlation with response to IFN and viral load in 85 hepatitis C virus （HCV）-lb-infected patients treated with IFN. METHODS： The C-terminal part of E2 （codons 617-711） including PKR/eIF2α phosphorylation homology domain （PePHD） and ISDR was sequenced in 85 HCV-1b-infected patients treated by IFN monotherapy. RESULTS： The amino acid substitutions in PePHD detected only in 4 of 85 patients were not correlated either with response to iFN or with viral load. The presence of substitutions in a N-terminal variable region （codons 617-641） in the C-terminal part of E2 was significantly correlated with both small viral load （33.9% vs 13.8%, P = 0.0394） and sustained response to iFN （25.0% vs 6.9 %, P = 0.0429）. Four or more substitutions in ISDR were significantly correlated with both small viral load （78.6% vs 16.2%, P 〈 0.0001） and sustained response to iFN （85.7% vs 2.9%, P 〈 0.0001）. In multivariate analysis, ISDR in nonstructural （NS） 5A （OR = 0.39, P 〈 0.0001） and N-terminal variable region （OR = 0.51, P = 0.039） was selected as the independentpredictors for small viral load, and ISDR （OR = 39.0, P 〈 0.0001） was selected as the only independent predictor for sustained response. CONCLUSION： The N-terminal variable region in the C-terminal part of E2 correlates with both response to IFN monotherapy and viral load and is one of the factors independently associated with a small viral load.

关键词： E2 Genotype HCV Interferon ISDR NS5A PePHD PKR SVR

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Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine

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World Journal of Gastroenterology 2005年第7期11卷 1087-1089页

作者： Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido kentaro Sugano Department of Internal Medicine

AIM:To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine. METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, 3apan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis. RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3 out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm. CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel.

关键词： Double-balloon enteroscopy Strictures Small intestine

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Efficacy of subcutaneous penrose drains for surgical site infections in colorectal surgery

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 110-114页

作者： Shinya Imada Shingo Noura Masayuki Ohue Tatsushi Shingai Toshinori Sueda kentaro Kishi Terumasa Yamada Hiroaki Ohigashi Masahiko yano Osamu Ishikawa Department of Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases

AIM: To investigate whether a subcutaneous penrose drain would decrease the superficial surgical site infection (s-SSI) rate in elective colorectal surgery. METHODS: This is a comparative study of the historical control type. Intervention consisted of the use of penrose drain in elective open colorectal surgical wounds. The outcome was an incidence of s-SSI. The patients were risk stratified according to the depth of subcutaneous ***: There were 131 patients (40 patients with high s-SSI risk) in the prior period (from July 2008 to June 2009, when no penrose drains were inserted) and 151 patients (75 patients with high s-SSI risk) in the latter period (from June 2010 to November 2011, when penrose drains were inserted). The overall s-SSI rate was 6.1% and 5.3% during the two periods (P = 0.770), and the s-SSI rate in the high s-SSI risk group was 15.0% and 8.0% (P = 0.242).CONCLUSION: Although penrose drain was not observed to significantly reduce s-SSI, there tended to be a reduced risk of s-SSI in the high s-SSI risk group.

关键词： Surgical site infections Subcutaneous penrose drains Colorectal surgery Open surgery Subcutaneous tissue

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Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy

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World Journal of Gastroenterology 2005年第31期11卷 4861-4864页

作者： Yoshikazu Hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido kentaro Sugano Department of Internal Medicine

AIM： To clarify clinical features of the NSAID-induced sma bowel lesions using a new method of endoscopy. METHODS： This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at .lichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient. RESULTS： Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively. The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug. CONCLUSION： NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon.

关键词： Double-balloon endoscopy NSAIDS-inducedsmall bowel injuries

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Solitary mediastinal lymph node recurrence after curative resection of colon cancer

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World Journal of Gastrointestinal Surgery 2014年第8期6卷 164-168页

作者： Yasuhiro Matsuda Masahiko yano Norikatsu Miyoshi Shingo Noura Masayuki Ohue Keijiro Sugimura Masaaki Motoori kentaro Kishi Yoshiyuki Fujiwara Kunihito Gotoh Shigeru Marubashi Hirofumi Akita Hidenori Takahashi Masato Sakon Department of Surgery Osaka Medical Center for Cancer and Cardiovascular Disease

We report two cases of solitary mediastinal lymph node recurrence after colon cancer resection. Both cases had para-aortic lymph node metastasis at the time of initial surgery and received adjuvant chemotherapy for 4 years in case 1 and 18 mo in case 2. The time to recurrence was more than 8 years in both cases. After resection of the recurrent tumor, the patient is doing well with no recurrence for 6 years in case 1 and 4 mo in case 2. Patients should be followed up after colon cancer surgery considering the possibility of solitary mediastinal lymph node recurrence if they had para-aortic node metastasis at the time of initial surgery.

关键词： Solitary mediastinal lymph node recurrence Colon cance

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