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Amelanotic malignant melanoma of the esophagus:Report of two cases with immunohistochemical and molecular genetic study of KIT and PDGFRA

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World Journal of Gastroenterology 2009年第21期15卷 2679-2683页

作者： Tadashi terada Department of Pathology Shizuoka City Shimizu Hospital

The author reports herein two cases of amelanotic malignant melanoma of the esophagus. Case 1 is an 87-year-old woman who was admitted to our hospital because of nausea and vomiting. Endoscopic examination revealed an ulcerated tumor of the distal esophagus, and a biopsy was taken. The biopsy showed malignant polygonal and spindle cells. No melanin pigment was recognized. Immunohistochemically, the tumor cells were positive for melanosome （HMB45）, S100 protein, KIT and Platelet derived growth factor receptor-α （PDG- FRA）. The patient was treated by chemotherapy and radiation, but died of systemic metastasis 12 mo after the presentation. Case 2 is a 56-year-old man presenting with dysphagia. Endoscopic examination revealed a polypoid tumor in the middle esophagus, and a biopsy was obtained. The biopsy showed malignant spindle cells without melanin pigment. Immunohistochemically, the tumor cells were positively labeled for melanosome,S100 protein, KIT and PDGFRA. The patient refused operation, and was treated by palliative chemotherapy and radiation. He died of metastasis 7 mo aEer the admission. In both cases, molecular genetic analyses of gene （exons 9, 11, 13 and 17） and PDGFRA gene （exons 12 and 18） were performed by the PCR direct sequencing method, which showed no mutations of KIT and PDGFRA genes. This is the first report of esophageal malignant melanoma with an examination of the expression of KIT and PDGFRA and the mutational status of K/T and PDGFRA genes.

关键词： Esophagus Amelanotic melanoma KIT Platelet derived growth factor receptor-c~

Schistosomal appendicitis:Incidence in Japan and a case report

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World Journal of Gastroenterology 2009年第13期15卷 1648-1649页

作者： Tadashi terada Department of Pathology Shizuoka City Shimizu Hospital

Schistosomal appendicitis is very rare in developed countries like the USA,Europe,and *** author reviewed 311 pathologic archival specimens of vermiform appendix over the past 10 *** case of schistosomal appendicitis was ***,the incidence of this disease was 0.32% in all appendices surgically resected in our *** patient was a 41-year-old woman presenting with lower abdominal *** was a sailor traveling to many countries including endemic *** examination,laboratory data,and imaging modalities suggested an acute appendicitis,and appendectomy was performed under the diagnosis of ordinary ***,numerous schistosomal eggs were present in the vasculatures throughout the appendiceal *** of the eggs were *** foreign body reaction was also *** appendicitis was phlegmonous consisting of severe infiltrations of neutrophils and *** serositis was also *** of feces revealed numerous eggs of Schistosoma *** should be aware of schistosomal appendicitis.

关键词： Appendix Histopathology Pathologicarchival specimens Schistosomiasis Acute appendicitis

Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene

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World Journal of Gastroenterology 2008年第47期14卷 7256-7259页

作者： Tadashi terada Department of Pathology Shizuoka Municipal Shimizu HospitalMiyakami 1231Shimizu-Ku424-8636ShizuokaJapan

The author reports a very rare case of sporadic primary multiple extragastrointestinal stromal tumors (EGISTs) of the omentum associated with different mutations of the exon 11 of the c-kit gene in a 75-year-old man with gastric cancer. During an operation for the cancer, two solid tumors (10 mm and 8 mm) were found in the omentum. Both tumors consisted of cellular spindle cells. Mitotic figures were two and three per 50 high power fields. The tumor cells were positive for KIT, CD34 and vimentin, but negative for desmin, S100 protein, α-smooth muscle actin and p53 protein. Ki67 labeling was 2% and 3%. The larger EGIST showed a deletion of codons 552-558 of exon 11 of the c-kit gene, while the smaller EGIST had a point mutation at codon 559 (GTT←GAT) in exon 11 of the c-kit gene. Exons 9, 13, and 17 of the c-kit gene, and exons 12 and 18 of the platelet derived growth factor receptor α genes showed no mutations. The case shows that sporadic multiple EGISTs can occur in the omentum.

关键词： Omentum Extragastrointestinal stromal tumors c-kit Platelet derived growth factor receptor CD34

Silent microscopy to explore a brain that hears butterflies'wings

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Light(Science & Applications) 2022年第6期11卷 1026-1028页

作者： Shin-Ichiro terada Masanori Matsuzaki Department of Physiology Graduate School of MedicineThe University of TokyoTokyoJapan Brain Functional Dynamics Collaboration Laboratory RIKEN Center for Brain ScienceSaitamaJapan International Research Center for Neurointelligence(WPI-IRCN) The University of Tokyo Institutes for Advanced StudyTokyoJapan

A silent two-photon laser-scanning microscopy system,which eliminates mechanical vibrations in the audible range,has enabled the detection of auditory cortical neurons with responses at sound pressure levels as low as... 详细信息

关键词： eliminate system sound

Histopathological study using computer database of 10000 consecutive gastric specimens:(2)malignant lesions

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Gastroenterology Report 2016年第1期4卷 54-58,I0003页

作者： Tadashi terada Department of Pathology Shizuoka City Shimizu HospitalShizuokaJapan

Using a computer database,the author investigated the histopathology of 10000 consecutive gastric specimens collected in the last 12 years 2002–2013 at his pathology laboratory in a relatively large hospital in *** of histological sections was done when *** gastric specimens were made up of 8579 benign conditions and 1421 malignant *** latter comprised gastric carcinoma in 1342 cases(94.4%),gastrointestinal stromal tumor(GIST)in 34(2.4%),mucosal-associated lymphoid tissue(MALT)lymphoma in 25(1.8%),non-Hodgkin’s malignant lymphoma in 19(1.3%),and metastatic carcinoma in 1 case(0.1%).Of the 1342 cases of gastric carcinoma,the histological type was as follows:tubular adenocarcinoma in 755 cases,papillary adenocarcinoma in 176,mucinous adenocarcinoma in 147,signet ring cell carcinoma in 145,poorly differentiated adenocarcinoma in 114,adenosquamous carcinoma in 4,and metastatic small cell carcinoma from the lung in *** surgically resected cases,the number of early gastric carcinomas was 258 and of advanced carcinoma,521 *** GIST(n=34),there were 2 cases of the epithelioid type and 32 of the spindle cell *** size of GIST ranged from 1–15 cm,with a mean of 5.6 ***(CD117)was positive in 34/34 cases,CD34 in 31/34,desmin 2/34,and S1004/34.A genetic analysis was performed in 6 cases of GIST,all of which showed point mutation of KIT and/or PDGFRA *** MALT lymphoma(n=25),centrocyte-like cells and lymphoepithelial lesions were seen in every *** pylori infection was noted in 92%.In non-Hodgkin’s lymphoma(n=19),17 cases were of diffuse large B-cell lymphoma,and 1 was peripheral T-cell lymphoma,while 1 was NK-cell lymphoma.

关键词： stomach malignant lesions histopathology

Esophageal combined carcinomas:Immunohoistochemical and molecular genetic studies

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World Journal of Gastroenterology 2012年第13期18卷 1545-1551页

作者： Tadashi terada Hirotoshi Maruo Department of Pathology Shizuoka City Shimizu HospitalShizuoka 424-8636Japan Department of Surgery Shizuoka City Shimizu Hospital424-8636 izuokaJapan

Primary esophageal combined carcinoma is very rare. The authors herein report 2 cases. Case 1 was a com- bined squamous cell carcinoma and small cell carci- noma, and case 2 was a combined squamous cell carci- noma, adenocarcinoma, and small cell carcinoma. Case 1 was a 67-year-old man with complaints of dysphagia. Endoscopic examination revealed an ulcerated tumor in the middle esophagus, and 6 biopsies were obtained. All 6 biopsies revealed a mixture of squamous cell car- cinoma and small cell carcinoma. Both elements were positive for cytokeratin, epithelial membrane antigen, and p53 protein, and had high Ki-67 labeling. The small cell carcinoma element was positive for synaptophysin, CD56, KIT, and platelet-derived growth factor-~ （PDG- FRA）, while the squamous cell carcinoma element was not. Genetically, no mutations of K/Tand PDGFRA were recognized. The patient died of systemic carcinomato- sis 15 mo after presentation. Case 2 was a 74-year-old man presenting with dysplasia. Endoscopy revealed a polypoid tumor in the distal esophagus. Seven biopsies were taken, and 6 showed a mixture of squamous cell carcinoma, small cell carcinoma, and adenocarcinoma. The 3 elements were positive for cytokeratins, epithe-lial membrane antigen, and p53 protein, and had high Ki-67 labeling. The adenocarcinoma element was posi- tive for mucins. The small cell carcinoma element was positive for CD56, synaptophysin, KIT, and PDGFRA, but the other elements were not. Mutations of KIT and PDGFRA were not recognized. The patient died of sys- temic carcinomatosis 7 mo after presentation. These combined carcinomas may arise from enterochromaf- fin cells or totipotential stem cell in the esophagus or transdifferentiation of one element to another. A review of the literature was performed.

关键词： Esophagus Combined carcinoma Histopath-ology Immunohistochemistry Molecular genetics

Histopathological study using computer database of 10000 consecutive gastric specimens:(1)benign conditions

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Gastroenterology Report 2015年第3期3卷 238-242页

作者： Tadashi terada Department of Pathology Shizuoka City Shimizu HospitalShizuokaJapan

Using a computer database,the author investigated the histopathology of 10000 consecutive gastric specimens,taken in the last 12 years(2002-2013)at the pathology laboratory of a Japanese ***-observation of the already examined histological sections was done when the histological diagnosis and findings on the computer data base were not very *** gastric specimens were identified as 8579 benign conditions and 1421 malignant *** 8579 benign conditions were comprised almost normal stomach in 74 cases(0.9%),chronic gastritis in 4374(51.0%),benign gastric peptic ulcer in 2195(25.6%),foveolar hyperplastic polyp in 1004(11.7%),fundic gland polyp in 421(4.9%),adenoma in 487(5.6%),heterotopic pancreas in 9(0.1%),pancreatic acinar metaplasia(PAM)in 8(0.1%),and amyloidosis in 7(0.1%).Chronic gastritis showed lymphocytic infiltration and frequently showed erosions and intestinal *** peptic ulcer showed exudate,necrosis,active inflammation,and regenerative atypia of the *** hyperplastic polyp revealed 23 malignant changes and frequently showed dysplastic glands and intestinal *** gland polyp demonstrated cystic dilations of fundic gland *** adenoma showed adenomatous proliferation in the superficial mucosa and cystic dilation of the epitheliumunder the *** pancreas was located in the submucosa and consisted of acinar cells,ducts,and occasionally *** was a tiny lesion in the mucosa and consisted of only pancreatic acinar *** was primary amyloidosis with positive reaction with Congo-red stain.

关键词： stomach benign lesions histopathology

Simultaneous large cell neuroendocrine carcinoma and adenocarcinoma of the stomach

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World Journal of Gastroenterology 2011年第43期17卷 4831-4834页

作者： Tadashi terada Hirotoshi Maruo Department of Pathology Shizuoka City Shimizu Hospital Department of Surgery Shizuoka City Shimizu Hospital

A large cell neuroendocrine carcinoma(LCNEC) of the stomach is very rare.A 76-year-old Japanese man was admitted to our hospital because of epigastralgia and *** revealed 2 large tumors in the *** did not have multiple endocrine neoplasia typeⅠor Zollinger-Ellison *** modalities,including computed tomography and magnetic resonance imaging,revealed no other ***,cholecystectomy,and lymph node dissection were *** resected stomach had 2 tumors:one was an antral ulcerated type 3 tumor measuring 5 cm x 5 cm,and the other was a polypoid type 1 tumor measuring 6 cm x 6 cm x 3 cm in the ***,the antral ulcerated tumor was a well differentiated adenocarcinoma with deep *** fundus polypoid tumor was a LCNEC,being composed of malignant large cells arranged in trabecular and nested *** tumor cells were large and the nuclei were *** were frequently present,and there were many mitotic figures,apoptotic bodies,and necrotic *** lymphovascular permeation was *** out of 29 dissected lymph nodes showed metastatic foci;6 were from the LCNEC and 1 from *** intravascular tumor emboli of LCNEC were seen in the peritoneum around the lymph *** were present in the adenocarcinoma but not in the ***,the LCNEC tumor cells were positive for pancytokeratins,synaptophysin(50%positive) ,chromogranin A(10% positive) ,Ki-67(90%labeled) ,and platelet-derived growth factor-α(80%positive) .They were negative for KIT,p53,CD56,and neuron-specific *** non-cancerous stomach showed a normal number of endocrine *** patient is now treated with adjuvant chemotherapy.

关键词： Stomach Carcinomas

Determination of Ring-OSF Position in Czochralski Silicon Single Crystals by Numerical Analysis of Distribution of Grown-in Defects

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Journal of Rare Earths 2006年第Z1期24卷 213-216页

作者： Sunao Abe Takahiro terada Yasutada Nakagawa Kazuhiko Kashima Silicon Company Toshiba Ceramics Co.Ltd. 6-861-5 Higashikou Seirou-machi Niigata 957-0197 Japan Corporate Manufacturing Engineering Center Toshiba Corp. 33 Shin-isogo Isogo-ku Yokohama Kanagawa 235-0017 Japan Corporate Manufacturing Engineering Center Toshiba Corp. 33 Shin-isogo Isogo-ku Yokohama Kanagawa 235-0017 Japan New Business Creation Division Toshiba Ceramics Co.Ltd. 1-6-3 Osaki Shinagawa-ku Tokyo 141-0032 Japan

A numerical analysis technique that incorporates Voronkov's model were examined and used to estimate the distribution of defects during crystal growth. By comparisons of the distribution of the density of LSTD and the position of R-OSF in non-nitrogen-doped (non-N-doped) and nitrogen-doped (N-doped) silicon crystals, it is found that the results of the numerical analyses agree with practically evaluated data. The observations suggest that the R-OSF nucleus is a VO2 complex that is formed by bonds between oxygen atoms and residual vacancies consumed during the formation of void defects. This suggests that Voronkov's model can be used to accurately predict the generation and growth of defects in silicon crystals. This numerical analysis technique was also found to be an effective method of estimating the distribution of defects in silicon crystals during crystal growth.

关键词： computer simulation nucleation point defects volume defect semiconducting silicon