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Strategy to differentiate autoimmune pancreatitis from pancreas cancer

World Journal of Gastroenterology 2012年第10期18卷 1015-1020页

作者： kensuke Takuma Terumi Kamisawa Rajesh Gopalakrishna Seiichi Hara Taku Tabata Yoshihiko Inaba Naoto Egawa Yoshinori Igarashi Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Department of Gastroenterology and Hepatology Omori Medical Center Toho University School of Medicine

Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. findings suggesting AIP rather than pancreatic cancer include:fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed en- hancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection.

关键词：自身免疫性胰腺炎胰腺癌肿瘤标志物磁共振图像表观扩散系数 AIP 病理检查

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Single-cell analysis for identification of T-cell clonotypes associated with IgG4 production of autoimmune pancreatitis

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Gastroenterology Report 2023年第1期11卷 590-592页

作者： kensuke Shibata Nao fujimori Takamasa Oono Daisuke Motooka Daisuke Okuzaki Koh-Hei Sonoda Yoshihiro Ogawa Sho Yamasaki Department of Microbiology and Immunology Graduate School of MedicineYamaguchi UniversityUbeJapan Department of Ophthalmology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Molecular Immunology Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Single Cell Genomics Human ImmunologyWorld Premier International Research Center Initiative Immunology Frontier Research CenterOsaka UniversitySuitaJapan Genome Information Research Center Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Laboratory of Molecular Immunology Immunology Frontier Research CenterOsaka UniversitySuitaJapan Division of Molecular Immunology Medical Mycology Research CenterChiba UniversityChibaJapan

Introduction Autoimmune pancreatitis(AIP)is one of the recently established immunoglobulin G4-related diseases(IgG4-RD)[1].The detailed pathogenic mechanisms have been an intensive research area for prophylactic and therapeutic purposes because aberrant immune activation and tissue fibrosis in AIP are the major factors that worsen the disease outcomes in these patients.

关键词： IgG4 pancreatitis diseases

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Solitary peritoneal metastasis of gastrointestinal stromal tumor: A case report

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World Journal of Gastroenterology 2020年第36期26卷 5527-5533页

作者： Yoichi Sugiyama kensuke Shimbara Masaru Sasaki Mohei Kouyama Tatsuya Tazaki Shinya Takahashi Atsushi Nakamitsu Department of Gastrointestinal Surgery JA Hiroshima General HospitalHatsukaichi 738-8503Japan Department of Surgery Institute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the *** of GISTs mostly occurs in the liver or peritoneum,and in most cases,multiple metastases *** a solitary peritoneal metastasis is rare,an appropriate treatment strategy has not been ***,we report a case of solitary peritoneal metastasis after complete resection of gastric *** SUMMARY A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET *** the recurrence risk was intermediate,adjuvant imatinib therapy was not *** years after surgery,routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right *** imaging tests did not reveal any *** observation showed that the tumor was located at the retroperitoneum,and intraperitoneal dissemination was not ***,we performed laparoscopic tumor ***,the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling *** administered adjuvant imatinib *** was no evidence of recurrence 3 years after the *** This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection.

关键词： Gastrointestinal stromal tumor Peritoneal metastasis Laparoscopic resection Solitary metastasis Imatinib Case report

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Chyawanprash,a formulation of traditional Ayurvedic medicine,shows a protective effect on skin photoaging in hairless mice

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Journal of Integrative Medicine 2016年第6期14卷 473-479页

作者： Yuki Takauji Kyoko Morino kensuke Miki Mohammad Hossain Dai Ayusawa Michihiko fujii Graduate School of Nanobioscience Yokohama City UniversityKanagawa 236-0027Japan Department of Biochemistry Primeasia UniversityDhaka 1213Bangladesh Ichiban Life Corporation 1-1-7 Horai-choNaka-kuYokohama 231-0048Japan

OBJECTIVE： Chronic exposure to ultraviolet （UV） radiation induces skin photoaging （premature skin aging）. UV irradiation generates reactive oxygen species （ROS）, which are shown to play a pivotal role in skin photoaging. Ayurveda is a holistic traditional medical system, and Chyawanprash is one of the most popular formulations in Ayurveda. Since maintenance of the function and appearance of skin is important, we examined whether Chyawanprash has a protective effect on skin photoaging. METHODS： To examine the effect of Chyawanprash on skin photoaging, hairless mice were administered with Chyawanprash in drinking water for 3 weeks, and then repeatedly exposed to ultraviolet light B （UVB） irradiation （225 or 450 mJ/cm2） to induce skin photoaging. To further examine the function of Chyawanprash, its effects were examined in cells cultured in vitro. Chyawanprash was added in culture medium, and examined for the effect on the growth of human keratinocytes, and for the ability to eliminate ROS which generated by paraquat （50 μmol/L） in HeLa cells. RESULTS： UVB irradiation caused symptoms such as rough skin, erythema, and edema on the skin in hairless mice, but administration of Chyawanprash relieved these symptoms. further, Chyawanprash significantly suppressed epidermal thickening, a typical marker of skin photoaging, in mice. We then analyzed the effect of Chyawanprash in human cells in culture, and found that Chyawanprash enhanced the growth of human keratinocytes, and efficiently eliminated ROS, which are causally involved in skin photoaging, in HeLa cells. CONCLUSION： These findings suggested that Chyawanprash may have beneficial effects on slowing skin photoaging.

关键词： medicine, Ayurvedic Chyawanprash photoaging of skin reactive oxygen species

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Extract of Emblica officinalis enhances the growth of human keratinocytes in culture

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Journal of Integrative Medicine 2019年第2期17卷 141-146页

作者： Yoshimi Yamakami Kyoko Morino Yuki Takauji Ryuichiro Kasukabe kensuke Miki Mohammad Nazir Hossain Dai Ayusawa Michihiko fujii Graduate School of Nanobioscience Yokohama City University Ichiban Life Corporation Department of Biochemistry Primeasia University

Objective: Keratinocytes are the predominant cell type in the epidermis and play key roles in epidermal function. Thus, identification of the compounds that regulate the growth of keratinocytes is of importance. Here we searched for such compounds from the herbs used in traditional medicine ***: Human keratinocytes were cultured in the presence or absence of the herbal extracts for 2 weeks; the effect of the extracts on cell growth was determined by staining the cells with Coomassie brilliant blue. To detect the compounds that regulate the growth of keratinocytes, the herbal extracts were subjected to high-performance liquid chromatography(HPLC).Results: We found that the extract of Emblica officinalis enhanced the growth of keratinocytes in ***, we fractionated the extract of E. officinalis using HPLC and identified the fractions responsible for the enhanced growth of ***: The extract of E. officinalis enhanced the growth of human keratinocytes in culture.E. officinalis contains the compounds that would be beneficial for human skin health because enhanced growth of keratinocytes would promote wound healing.

关键词： Keratinocyte Cell growth Ayurveda Emblica officinalis

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S-1 induced secondary acute erythroid leukemia with a chromosome inv(12)(p13;q13)

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World Journal of Gastroenterology 2011年第41期17卷 4632-4634页

作者： kensuke Matsumoto Akira Kitanaka Makiko Uemura fusako Waki Tetsuya fukumoto Hiroaki Ohnishi Yoshitsugu Kubota Toshihiko Ishida first Department of Internal Medicine Faculty of MedicineKagawa Univesity Hematology Faculty of MedicineKagawa Univesity Department of Transfusion Medicine Kagawa University

Adjuvant chemotherapy by S-1 following gastrectomy is considered standard treatment in *** of follow-up data have proved the effi cacy of S-1 admin-istration,and that hematological adverse events were relatively *** anti-metabolites,including S-1,have shown relatively lower risks for secondary hematological malignancies in comparison to alkylat-ing agents and topoisomerase-Ⅱ *** here report a case of therapy-related leukemia after S-1 administration.A patient who had received S-1as the sole adjuvant chemotherapy was diagnosed with acute erythroid *** the best of our knowledge,our patient represents the fi rst report of S-1 induced acute leukemia.

关键词：急性白血病红白血病 S-1 染色体继发性诱导恶性血液病拓扑异构酶

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Selection of Hammering Sound Collection Devices for the Development of Total Hip Arthroplasty Support Systems

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Journal of Biomedical Science and Engineering 2022年第7期15卷 179-186页

作者： Rina Sakai Katsufumi Uchiyama Shun Nishizawa Tomomi Mizuhashi Takeaki Yamamoto Kazuhiro Yoshida kensuke fukushima Naonobu Takahira Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Kanagawa Japan Kitasato University Graduate School of Medical Sciences Kanagawa Japan Department of Orthopedic Surgery Kitasato University School of Medicine Kanagawa Japan Department of Clinical Engineering St. Luke’s International Hospital Tokyo Japan Department of Orthopedic Surgery St. Marianna University School of Medicine Kanagawa Japan

In total hip arthroplasty, intraoperative femoral fractures can be avoided by analyzing the hammering sounds from the stem inserted into the femur. This procedure is based on a hammering test that makes use of the fact that sound depends on the stability of the object. This technique is generally used in engineering. A system designed to avoid excessive stem hammering by predicting the intraoperative fracture risk based on this technique and software for real-time spectra analysis has been developed with repetitive improvements. The remaining technical challenge lies in selecting an appropriate sound collection device and building a compact and easy unit for use. This study reviewed the types of directional microphones suitable for the sound collection system to develop a practical THA support system. four types of microphones based on selected methods were used to collect and compare the peak frequencies of the hammering sounds and make comparisons between them, and the built system was used to conduct clinical trials. for miniaturization and operational ease of the unit, plug-in unidirectional microphones are appropriate. However, no laboratory-level data has been collected, and thus, further data accumulation is necessary.

关键词： Intraoperative fractures Total Hip Arthroplasty Hammering Sound fourier Analysis Peak frequency

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通过水溶液还原法用抗坏血酸制备纳米铜颗粒(英文)

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Transactions of Nonferrous Metals Society of China 2012年第9期22卷 2198-2203页

作者：刘清明 Takehiro YASUNAMI kensuke KURUDA Masazumi OKIDO 名古屋大学工学部材料科学系日本4648603 中南大学化学化工学院长沙410083

通过水溶液还原法用抗坏血酸还原Cu2+制备纳米铜颗粒,并研究溶液pH和Cu2O平均粒径对纳米铜颗粒制备的影响。在溶液pH值为3、5和7时,可制得铜颗粒,并且在pH=7时制得的铜颗粒粒径最小。在溶液pH为9和11时无法制得铜颗粒。Cu2O的平均粒径... 详细信息

通过水溶液还原法用抗坏血酸还原Cu2+制备纳米铜颗粒,并研究溶液pH和Cu2O平均粒径对纳米铜颗粒制备的影响。在溶液pH值为3、5和7时,可制得铜颗粒,并且在pH=7时制得的铜颗粒粒径最小。在溶液pH为9和11时无法制得铜颗粒。Cu2O的平均粒径能影响铜粉的粒径。Cu2O的平均粒径越大,得到的铜颗粒越大。通过对反应过程中不同时间点收集的样品进行XRD分析,可探索出反应的进程。在反应过程中,Cu(OH)2首先作为前驱体出现,然后被还原为Cu2O,最后被还原为铜颗粒。

关键词：纳米铜颗粒水溶液还原法抗坏血酸中间产物

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Osteoconductivity Control Based on the Chemical Properties of the Implant Surface

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Journal of Biomaterials and Nanobiotechnology 2018年第1期9卷 26-40页

作者： kensuke Kuroda Masazumi Okido Institute of Materials and Systems for Sustainability (IMaSS) Nagoya University Nagoya Japan

Metallic materials, such as Ti, Zr, Nb, Ta, and their alloys, and also stainless steels are widely attractive as osteoconductive materials in the dental and orthopedic fields. Ceramics and polymers are also commonly used as biomaterials. However, they do not have high osteoconductivity in their pure form, and surface coatings with bioactive substances, such as hydroxyapatite or TiO2, are needed before implantation into the bone. Many reports claim that the surface chemical properties of implants, in particular, hydrophilicity and hydrophobicity, strongly affect the biological reactions. However, the effect of surface properties on osteoconductivity is not clear. In this review, we focus on the relationship between the surface hydrophilicity of metallic implants and osteoconductivity using in vivo evaluation, and the control of the osteoconductivity is discussed from the viewpoint of protein adsorption in implants.

关键词： Hydrophilicity Hydrophobicity Osteoconductivity Protein Adsorption Surface Modification

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Multinomial Logistic Regression Model for Predicting Driver＇s Drowsiness Using Only Behavioral Measures

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Journal of Traffic and Transportation Engineering 2015年第2期3卷 80-90页

作者： Atsuo Murata kensuke Naitoh Department of Intelligent Mechanical Systems Okayama University Okayama 700-8530 Japan

The aim of this study was to explore the effectiveness of behavioral evaluation measures for predicting drivers" subjective drowsiness. Behavioral measures included neck bending angle, back pressure, foot pressure, COP (center of pressure) movement on sitting surface and tracking error in driving simulator task. Drowsy states were predicted by means of the multinomial logistic regression model where behavioral measures and subjective evaluation of drowsiness corresponded to independent variables and a dependent variable, respectively. first, we compared the effectiveness of two methods (correlation coefficient-based method and odds ratio-based method) for determining the order of entering behavioral measures into the prediction model. It was found that the prediction accuracy did not differ between both methods. Second, the prediction accuracy was compared among the numbers of behavioral measures. The prediction accuracy did not differ among four, five and six behavioral measures and it was concluded that entering at least four behavioral measures into the prediction model is enough to achieve higher prediction accuracy. Third, the prediction accuracy was compared between the strongly drowsy and the weakly drowsy groups. The prediction accuracy differed between the two groups and the proposed method was effective under the condition where drowsiness was induced to a larger extent.

关键词：交通工程运输工程综合运输运输体制

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