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The Interventional Capacity of Community Health Volunteers for Screening and Linkages of Non-Communicable Diseases in Nyeri County, Kenya

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Open Journal of Preventive Medicine 2024年第4期14卷 61-78页

作者： kenneth Mugambi Jackline Nyaberi Elizabeth Echoka Kemri Graduate School Nairobi Kenya Jomo Kenyatta University of Science & Technology Nairobi Kenya

Non-communicable diseases (NCDs) account for 63% of mortalities. Approximately 80% of these NCD-related deaths occur in LMICs. A quasi-experimental study utilizing a non-equivalent pre-and post-test was conducted from May 2022 to March 2023 with 370 study participants. Multistage cluster and random sampling were used to select ten community units, and therefore, 150 CHVs were chosen for the control unit, and 150 were used to form the interventional group. Data was collected from the KOBO app. Six (6) homogenous FGDs comprised ten members, and 10 KII were conducted across study sites. Quantitative data was analyzed using SPSS version 28.0, and qualitative data was audio-recorded, transcribed, and analyzed via N-Vivo 12. The study shows that 59.3% of respondents have minimal information, and 92.7% (n = 139) have no clear understanding of NCDs, with a pre-intervention capacity of 48.8%. Independent sample t-test showed a significant difference in capacity from a pre-intervention average of 48.75 (SD ± 5.7)%, which increased to 68.28 (SD ± 7.6)%, p < 0.001. A well-designed community interventional model plays a pivotal role in grassroots healthcare delivery but requires optimization for NCD management.

关键词： Intervention Community Health Volunteers Non-Communicable Disease Screening Linkages

Assessment of Barriers and Challenges to the Screening and Linkages of Non-Communicable Diseases by Community Health Volunteers in Nyeri County, Kenya

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Open Journal of Preventive Medicine 2024年第5期14卷 90-109页

作者： kenneth Mugambi Jackline Nyaberi Elizabeth Echoka Kemri Graduate School NRB Nairobi Kenya Jomo Kenyatta University of Science & Technology Nairobi Kenya

Non-communicable diseases (NCDs) are a significant global health challenge, contributing to 50% of worldwide morbidity and 63% of mortality. The burden is particularly substantial in low—and middle-income countries (LMICs), where 80% of NCD-related deaths occur. A quasi-experimental study addressed this challenge from May 2022 to March 2023. This study utilized a non-equivalent pre-and post-test design, with 300 participants in the quantitative and 70 in the qualitative. The study employed multistage cluster and random sampling to select ten community units, resulting in 150 community health volunteers (CHVs) in the control unit and 150 in the intervention group. Data collection was facilitated through the KOBO app. Qualitative data analysis involved six homogeneous focus group discussions (FGDs) and ten key informant interviews (KIIs), audio-recorded, transcribed, and analyzed using N-Vivo 12. Despite efforts to implement screening programs and improve linkages to care, significant barriers persist. This article reviews these barriers, drawing on current literature and empirical evidence. Key obstacles identified include limited awareness, inadequate healthcare infrastructure, cultural beliefs, financial constraints, fragmented healthcare systems, and challenges linking individuals to appropriate care services. The article explores strategies to overcome these barriers, emphasizing the importance of collaborative approaches involving stakeholders at various levels. Addressing these challenges aims to strengthen NCD screening and linkages to care, ultimately improving health outcomes for populations globally. Several recommendations emerge from the study’s findings and literature review. Raising awareness about NCDs and preventive measures is crucial and can be achieved through targeted health education campaigns and community outreach programs. Addressing healthcare infrastructure deficiencies, such as inadequate facilities and workforce shortages, is essential to

关键词： Non-Communicable Diseases Barriers Challenges Healthcare Infrastructure Awareness Cultural Beliefs Financial Constraints

Karun and Shatt Al-Arab River System: Historic and Modern Attempts to Manage Iran’s Lifeline

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Open Journal of Soil Science 2024年第7期14卷 416-447页

作者： kenneth Ray Olson Sergey Stanislavovich Chernyanskii Department of Natural Resources and Environmental Sciences College of Agricultural Consumer and Environmental Sciences University of Illinois Urbana USA EnviSoilCons Pr. Belgrade Serbia

The Islamic Republic of Iran’s principal rivers are the Karun and Shatt al-Arab. The Karun River has a 950 km length. The Karun River starting point is the convergence of the Amand, Kuhrang, and Bazoft rivers. From their headwater sources in the mountains of eastern Iran, these rivers descend through valleys and gorges and flow into the plains of Iran. The Shatt al-Arab River drains an area of 879,790 square kilometers which includes land in Iran, Syria, Türkiye, Kuwait, and Iraq. The Karun joins Shatt al-Arab 110 km downriver from the confluence of the Euphrates and Tigris Rivers and flows 85 km into the Persian Gulf. The Karun river flows in a southwestern direction through the central plain and provides about 10 per cent of the water balance of Iran’s largest wetland, the Shadegan, which includes permanent marshes, lakes, and riparian habitats. The article summarizes a vast array of publications on the stated topic and this civilizationally important region in order to draw additional attention to its interdependent environmental, economic and political problems the successful resolution of which is only possible with the participation of the entire research community.

关键词： Shatt Al-Arab River Iraq Karun River Baghdad Sinjar Marshes Soil Tunnels

Design, Synthesis, Photophysical Studies and Electrochemistry of Carbazole-, Oxadiazole-, and Oxadiazole-Triarylamine-Containing Rhenium(Ⅰ) Diimine Alkynyl Complexes

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Chinese Journal of Chemistry 2014年第10期32卷 1015-1021页

作者： Wai-kin Chung Keith Man-Chung Wong Vivian Wing-wah Yam and Department of ChemistryThe University of Hong KongPokfulam RoadHong KongChina

A series of rhenium(I)diimine alkynyl complexes with various electron-and hole-transporting moieties has been synthesized and *** electronic absorption,emission and electrochemical properties have also been studied.

关键词： electrochemistry luminescence metal alkynyl rhenium(Ⅰ)diimine,UV/Vis spectroscopy

The Volga River Is Russia’s Lifeline and in Need of Maintenance, Mitigation and Restoration

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Open Journal of Soil Science 2024年第3期14卷 159-179页

The Volga River flows entirely through Russia and the watershed includes three of the country’s ten largest cities. The river is the longest in Europe and western Russia’s principal waterway. The Volga River basin is home to approximately half of Russia’s population and occupies almost two-fifth of European Russia. It covers much of the Volga region and stretches 3530 kilometers from its source in the Valdai Hills to the Caspian Sea, the world’s largest inland water body. Its economic, cultural, and historic importance makes it one of the world’s greatest rivers. The Volga basin makes up 8 percent of the Russian territory. Stalingrad, located on the banks of the Volga River, has been described as the site of the greatest de-feat in the history of the German Army. It is often identified as the turning point on the Eastern Front of WWII, in the war against Germany, and in the entire WWII. The meeting point of the Eurasian Civilization was historically the Volga River. The river has some of the world’s largest reservoirs and is a major source of livelihood for millions of people. Many factories and cities empty their waste including sewage, industrial waste, fertilizers, and pesticides into the Volga River. Pollutants tend to settle in the reservoirs and contain several meters of heavily contaminated muck. The primary objectives are to assess lessons learned, manage, and restore the Volga River system lifeline in Russia.

关键词： Volga River Caspian Sea Soviet Union Russia Germany WWII Stalin-grad Volgograd

CircTUBD1: A Novel Circular RNA Molecule as a Therapeutic Target in Radiation-induced Liver Fibrosis

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 571-573页

作者： Catherine Yujia Gu Terence kin wah Lee Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic UniversityHong KongChina

Citation of this article:Gu CY,Lee ***1:A Nov-el Circular RNA Molecule as a Therapeutic Target in Radiation-induced Liver Fibrosis.J Clin Transl Hepatol 2022;10(4):***:10.14218/*** liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer mortality worldwide.1 Liver transplantation and surgical resection are two curative therapeutic options for liver cancer patients at the early ***,most patients are diagnosed at advanced stages.

关键词： Liver Therapeutic cancer

Tigris, Euphrates, and Shatt Al-Arab River System: Historic and Modern Attempts to Manage and Restore Iraq’s Lifeline

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Open Journal of Soil Science 2024年第1期14卷 28-63页

作者： kenneth Ray Olson David R. Speidel College of Agricultural Consumer and Environmental Sciences University of Illinois Urbana USA US Army Iraq Mosul Iraq Foreign Agricultural Service Mahmudiyah Iraq Foreign Agricultural Service Washington D.C. USA

In Iraq, the principal rivers are the Tigris, Shatt Al-Arab and Euphrates. From their headwater sources in the mountains of eastern Türkiye, these rivers descend through valleys and gorges and flow into the uplands of Syria and northern and central alluvial plain of Iraq. The Euphrates and Tigris Rivers confluence to form the Shatt Al-Arab river at Al-Qurnah which flows into the Persian Gulf. From sources in the Zagros Mountains other tributaries join the Tigris from the east. The Tigris and Euphrates rivers flow in a southeastern direction through the central plain and discharge into the Mesopotamian Marshes, which include permanent marshes, lakes, and riparian habitat. The rivers and their tributaries drain an area of 879,790 km2 which includes almost the entire area of Iraq as well as land in Syria, Türkiye, Kuwait and Iran. The region has historical importance as part of the Fertile Crescent region and where Mesopotamian civilization first emerged. The post war reconstruction efforts in the Yusifiyah township, an important food production region for Baghdad, illustrate the importance of these water resources. In addition, the advent of soil tunnels by Iraqi insurgents within the riverine corridors will make reconstruction of this resource more complex. The primary objectives of this study are to assess lessons learned, manage, and restore the Tigris, Euphrates, and Shatt Al-Arab river system lifeline in Iraq.

关键词： Mesopotamian Shatt Al-Arab Iraq Tigris Euphrates Baghdad Soil Tunnels Yusifiyah

Detailed Analyses of Nymphea Seeds Consumed in the Senegal River Valley

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Food and Nutrition Sciences 2024年第8期15卷 695-700页

作者： Nicolas Cyrille Ayessou Michel Bakar Diop Fatou kiné Gueye César Bassène Mame Samba Mbaye Centre dEtudes sur la Scurit Alimentaire et les Molcules Fonctionnelles (CESAM-RESCIF) Universit Cheikh Anta DIOP Dakar Sngal Unit de formation et de Recherche des Sciences Agronomiques de lAquaculture et des Technologies Alimentaires Universit Gaston Berger Saint-Louis Sngal Laboratoire de Botanique-Biodiversit Biologie Vgtale Universit Cheikh Anta Diop Dakar Senegal

Physicochemical investigations were performed on seeds of Nymphea lotus and N. micrantha consumed in the Senegal River valley. They revealed a composition similar to that of cereals. In order to estimate their intrinsic quality, the determination of their amino acid, fatty acid and monosaccharids profiles was done. The results indicate that monosaccharides are represented specifically by saccharose (7%) and glucose (0.67%);a predominance of stearic acid and linoleic acid as unsaturated acids (24.86%);arachidic and palmitic acids as the only saturated acid found (11.12%);a good ratio of unsaturated/saturated acid (2.23);a lack of oleic acid, linoleic, palmitoleic, myristic, caprylic acids;a poor-quality index protein due to low quantity amino acids. Nevertheless, all essential amino acids are present in the seeds. The Nymphea sp grains consumed by the populations around the Senegal River valley offer an interesting nutritional quality linked to fatty acids and carbohydrates.

关键词： Nymphea Seeds Composition

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-Min Zhang Ken kin Lam Yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress