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Patient prompting of their physician resulted in increased colon cancer screening referrals

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World journal of Gastrointestinal Oncology 2014年第7期6卷 257-262页

作者： Vu Le Saqib Syed kenneth j Vega Tushar Sharma Mohammad F Madhoun Nakumar Srinivasan Courtney W Houchen Division of Digestive Disease and Nutrition Univer-sity of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States College of Public Health University of Okla-homa Health Sciences Center Oklahoma City OK 73104 United States

AIM:To determine whether a communication instru-ment provided to patients prior to their primary carephysician(PCP)visit initiates a conversation with theirPCP about colorectal cancer screening(CRC-S),impact-ing screening referral rates in fully insured and underin-sured ***:A prospective randomized control studywas performed at a single academic center outpatient internal medicine(IRMC,underinsured)and fam-ily medicine(FMRC,insured)resident clinics prior to scheduled *** the intervention group,a pamphlet about the benefit of CRC-S and a reminder card were given to patients before the scheduled visit for prompt-ing of CRC-S referral by their *** main outcome measured was frequency of CRC-S referral in each clinic after ***:In the IRMC,148 patients participated,a control group of 72 patients(40F and 32M)and 76 patients(48F and 28M)in the intervention ***-ferrals for CRC-S occurred in 45/72(63%)of control vs 70/76(92%)in the intervention group(P≤0.001).In the FMRC,126 patients participated,66(39F:27M)con-trol and 60(33F:27M)in the intervention ***-S referrals occurred in 47/66(71%)of controls vs 56/60(98%)in the intervention group(P≤0.001).CONCLUSION:Patient initiated physician prompting produced a significant referral increase for CRC-S in un-derinsured and insured patient *** investigation aimed at increasing CRC-S acceptance is warranted.

关键词： Colon cancer Screening Primary care Physician patient relationship Referral

A Large Therizinosauroid(Dinosauria:Theropoda) from the Early Cretaceous of Northwestern China

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Acta Geologica Sinica(English Edition) 2007年第4期81卷 539-549页

作者： LI Daqing PENG Cuo YOU Hailu Matthew C. LAMANNA jerald D. HARRIS kenneth j. LACOVARA ZHANG jianping China University of Geosciences School of Earth Sciences and Resources Beijing 100083 P. R. China Fossil Research and Development Center of the Third Geology and Mineral Resources Exploration Academy of Gansu Province Lanzhou Gansu Province 730050 P. R. China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 P. R. China Section of Vertebrate Paleontology Carnegie Museum of Natural History Pittsburgh Pennsylvania 15213 USA Dixie State College Science Building Utah 84770 USA Paleontology and Geology Program Department of Bioscience and Biotechnology Drexel University Philadelphia Pennsylvania 19104 USA

We herein describe an associated partial postcranial skeleton of a theropod dinosaur discovered in the Lower Cretaceous Xinminpu Group of the Yujingzi Basin, in the jiuquan area of Gausu Province, northwestern China. Features of its humerus, such as strongly expanded proximal and distal ends, a well developed medial tuberosity, distal condyles expressed on the humeral cranial surface, and a hypertrophied entepicondyle, definitively establish the therizinosauroid affinities of the specimen. It differs from other therizinosauroids in having a shallow, poorly demarcated glenoid fossa with a prominent rounded and striated tumescence on the dorsomedial surface of its scapular portion, and a pubis with a strongly concave cranial margin. It represents a new taxon, Suzhousaurus megatherioides gen. et sp. nov. Cladistic analysis recovers Suzhousaurus as the sister taxon of Nothronychus mckinleyi from the mid-Cretaceous of western North America; together, they are basal members of the Therizinosauroidea, more derived than the Early Cretaceous Falcarius and Beipiaosaurus but less derived than Alxasaurus and the Therizinosauridae. Along with ＂Nanshiungosaurus＂ bohlini from possibly coeval beds in the Mazongshan area of northern-most Gansu, Suzhousaurus represents one of the largest-known Early Cretaceous therizinosauroids, demonstrating that this clade attained considerable body size early in its evolutionary history.

关键词： Dinosauria Theropoda Therizinosauroidea Yujingzi Basin Early Cretaceous jiuquan area Gansu Province China

Tsc2 mutation induces renal tubular cell nonautonomous disease

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Genes & Diseases 2022年第1期9卷 187-200页

作者： Prashant Kumar Fahad Zadjali Ying Yao Daniel johnson Brian Siroky Aristotelis Astrinidis Peter Vogel kenneth W.Gross john j.Bissler Department of Pediatrics University of Tennessee Health Science Center and Le Bonheur Children's HospitalMemphisTN 38103USA Children's Foundation Research Institute(CFRI) Le Bonheur Children's HospitalMemphisTN 38105USA Department of Clinical Biochemistry College of Medicine&Health SciencesSultan Qaboos UniversityMuscat 123Oman Molecular Bioinformatics Center University of Tennessee Health Science CenterMemphisTN 38163USA Department of Veterinary Pathology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Molecular and Cellular Biology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Pediatric Medicine Department St.Jude Children's Research HospitalMemphisTN 38105USA

TSC renal cystic disease is poorly understood and has no approved *** a new principal cell-targeted murine model of Tsc cystic disease,the renal cystic epithelium is mostly composed of type A intercalated cells with an intact Tsc2 gene confirmed by sequencing,although these cells exhibit a Tsc-mutant disease *** used a newly derived targeted murine model in lineage tracing and extracellular vesicle(EV)characterization experiments and a cell culture model in EV characterization and cellular induction experiments to understand TSC *** lineage tracing experiments,we found principal cells undergo clonal expansion but contribute very few cells to the *** determined that cystic kidneys contain more interstitial EVs than noncystic kidneys,excrete fewer EVs in urine,and contain EVs in cyst ***,the loss of Tsc2 gene in EV-producing cells greatly changes the effect of EVs on renal tubular epithelium,such that the epithelium develops increased secretory and proliferative pathway *** demonstate that the mTORC1 pathway activity is independent form the EV production,and that the EV effects for a single cell line can vary *** cystogenesis involves significant contribution from genetically intact cells conscripted to the mutant phenotype by mutant cell derived EVs.

关键词： Cell nonautonomous trait Polycystic kidney disease Renalcystogenesis Tuberous sclerosis complex

胶东区域成矿断裂带蚀变年龄研究及其矿床学意义

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地学前缘 2017年第2期24卷 140-150页

作者：吕承训 Norbert H.MAERZ kenneth j.BOYKO 吕古贤邵鹤森密苏里科技大学地质科学与石油及地质工程学院美国密苏里州罗拉65401 中国地质科学院地质力学研究所北京100081 中国地质大学(北京)地球科学与资源学院北京100083

胶东金矿是中生代构造岩浆活化区岩浆期后中温热液蚀变脉状矿床。前人曾认为该类金矿属于壳源深融花岗岩-热液石英脉-蚀变岩型金矿。近期研究表明,胶东金矿围岩蚀变年龄的测定,对于矿床成因的研究有重要意义。为解决胶东区域断裂热液蚀... 详细信息

胶东金矿是中生代构造岩浆活化区岩浆期后中温热液蚀变脉状矿床。前人曾认为该类金矿属于壳源深融花岗岩-热液石英脉-蚀变岩型金矿。近期研究表明,胶东金矿围岩蚀变年龄的测定,对于矿床成因的研究有重要意义。为解决胶东区域断裂热液蚀变年龄问题,对胶东半岛主要断裂矿化蚀变带开展如下相关研究:(1)选择胶东地区各蚀变岩带普遍发育的黄铁绢英岩化蚀变岩带和强钾长石化蚀变岩带作为取样目标,进行区域对比;(2)该两类岩石中的蚀变矿物受到脆性断裂影响较小,能够得到蚀变阶段的稳定化学成分;(3)该两类岩石中的蚀变矿物发育有与蚀变同期的韧性变形,能够揭示蚀变阶段的构造应力应变状态。对样品中的钾长石和斜长石颗粒进行K-Ar法同位素年龄测试,获得蚀变岩同位素年龄数据。测试结果显示,胶东区域构造热液蚀变作用时期为(148.3±4.3)^(52.03±0.70)Ma,即早白垩世燕山晚期;同位素年龄自西向东逐渐变小,证明胶东西部地区的热液蚀变作用早于东部地区。通过分析已有的构造、热液成分和成矿物理化学参数等资料,结合本研究的最新成果,总结出区域成矿时代与成矿规律:胶东区域断裂蚀变系统中的构造附加静水压力、流体温度压力条件和成矿元素的分布与变化控制了热液蚀变成矿规律。上述地质特征显示,胶东金矿床是复成构造热液作用下的一种新型矿床类型。

关键词：胶东金矿 K-Ar同位素年龄黄铁绢英质蚀变岩带钾长石化蚀变岩带复成构造热液作用

Light field on a chip: metasurface-based multicolor holograms

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Advanced Photonics 2021年第2期3卷 1-14页

作者： Dandan Wen jasper j.Cadusch jiajun Meng kenneth B.Crozier University of Melbourne Department of Electrical and Electronic EngineeringVictoriaAustralia University of Melbourne School of PhysicsVictoriaAustralia University of Melbourne Australian Research CouncilCentre of Excellence for Transformative Meta-Optical SystemsVictoriaAustralia

Multicolor holography can faithfully record the color,depth,parallax,and other properties of scenes and have thus found numerous applications,for example,in optical document security,nonvolatile data storage,and virtual or augmented reality *** metasurfaces present multiple degrees of freedom to manipulate the properties of optical fields at visible *** in turn provide opportunities for metasurface-based multicolor *** describe recent developments in multicolor metasurface *** are categorized based on their color-separating mechanisms rather than their structural properties,such as whether they are plasmonic or *** hope this review will provide readers with new insights and thus help extend applications of metasurface-based multicolor holography to other fields.

关键词： multicolor hologram metasurface

The Roles of Different CLE Domains in Arabidopsis CLE Polypeptide Activity and Functional Specificity

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Molecular Plant 2010年第4期3卷 760-772页

作者： Ling Meng kenneth C. Ruth jennifer C. Fletcher Lewis Feldman Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Plant Gene Expression Center USDA-UC Berkeley 800 Buchanan Street Albany CA 94710 USA

The CLE （CLVATA3/ESR-related） family of plant polypeptide signaling molecules shares a conserved 14-aminoacid （aa） motif, designated the CLE motif, which recent studies suggest is sufficient for CLE function in vitro. In this study, we report that Arabidopsis CLE proteins can function in a tissue-specific manner and confirm some CLE factors can act through different receptors. Using domain swapping, we show for the first time that the CLE motif likely determines much of the functional tissue-specificity of the proteins in planta. However, we also provide evidence in support of the new view that sequences outside the CLE motif （14 aa） contribute to CLE function and functional specificity in vivo. Additionally, we report that deletion of the putative signal peptide from different CLE proteins completely inactivates CLE function in vivo, whereas exchanging the CLE signal peptides with a conventional signal peptide from a rice glycine-rich cell wall protein also influences CLE function. We thus propose that the CLE motif itself determines its functional tissue-specificity by dic- tating the direct recognition and interaction of each CLE peptide with its optimal receptor（s）, whereas the receptor（s） may be available in a tissue-specific manner. On the other hand, the sequences outside the CLE motif may influence CLE function by affecting the processing of CLE peptides, resulting in a change in the availability and/or abundance of CLE peptides in specific tissues and/or cells.

关键词： Arabidopsis cell signaling CLE meristem polypeptide protein domain.

A High-throughput Genomic Tool： Diversity Array Technology Complementary for Rice Genotyping

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journal of Integrative Plant Biology 2006年第9期48卷 1069-1076页

作者： Yong Xie kenneth McNally Cheng-Yun Li Hei Leung You-Yong Zhu National Center for Agro-biodiversity Yunnan Agricultural University Kunming 650201 China Genetic Resources Center International Rice Research Institute DAPO P.O. Box 7777 Metro Manila Philippines Entomology and Plant Pathology Division International Rice Research Institute DAPO P.O. Box 7777 Metro Manila Philippines

Diversity array technology （DART^TM） was a genotyping tool characterized gel-independent and high throughput. The main purpose of present study is to validate DArT for rice （Oryza sativa L.）genotyping in a high throughput manner. Technically, the main objective was to generate a rice general purpose gene pool, and optimize this genomic tool in order to evaluate rice germplasm genetic diversity. To achieve this, firstly, a generalpurpose DArT array was developed. Ten representatives from 24 varieties were hybridized with the general-purpose array to determine the informativeness of the clones printed on the array. The informative 1 152 clones were re-arrayed on a slide and used to fingerprint 17 of 24 germplasms. Hybridizing targets prepared from the germplasm to be assayed to the DNA array gave DNA fingerprints of germplasms. Raw data were normalized and transformed into binary data, which were then analyzed by using NTSYSpc （Numerical taxonomy system for cluster and ordination analysis, v. 2.02j） software package. The graphically displayed dendrogram derived from the array experimental data was matched with simple sequence repeats genotyping outline and varieties＇ pedigree deviation of the different varieties. Considering DArT is a sequence-independent genotyping approach, it will be applied in studies of the genetic diversity and the gene mapping of diverse of organisms, especially for those crops with less-developed molecular markers.

关键词： amplified fragment length polymorphisms diversity array technology genome complexity reduction microarray rice genotyping

The Fossils in Shangxi Group and Its Implication for Tectonics, Southern Anhui, China

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Science China Chemistry 1994年第3期37卷 366-376页

作者：徐树桐陈冠宝陶正石永红孙枢 kenneth j.Hsu 尹磊明欧阳舒廖卓庭 Anhui Institute of Geology Hefei 230001 PRC Institute of Geology Academia Sinica Beijing 100029 PRC Swiss Federal Institute of Technology CH-8092 Zurich Switzerland Nanjing Institute of Geology and Palaeontolgy Academia Sinica Nanjing 210008 PRC

The Shangxi Group is the local name in southern Anhui Province and it is believed to be the equivalence of the well-known Banxi Group in Hunan Province, southern China. So the area occupied by the Shangxi Group was regarded as a part of the 'jiangnan old land' of Presinian till it was challenged by the present authors years ago. After we postulated that there may be some strata of Palaeozoic Era in Shangxi Group, some microfossils and then macrofossils of Palaeozoic were found in some part of it. The macrof os-sils, Lingula sp. , Conulariid and the microfossils indicate that most units of the Shangxi Group are Palaeozoic strata. Based on the discovery of these fossils and the recognition of the tectonic-setting of the different tectono-petrologic units in the Shangxi Group, three different stratigraphic sequences (island-arc volcanics, back-arc sediments and the cover of passive margin of Yangtze Continental Plate) are established and the tectonic evolution of them is postulated in the present paper. All the evidences obtained recently from the Shangxi Group indicate that there is no 'Old Land' over the discussed area, but a subduction followed by a collision zone between the island-arc and Yangtze Continental Plate; all these metamorphosed strata were originally island-arc, back-arc basin sediments during the Sinian-late Paleozoic, except the Presinian sandstone distributed in a narrow belt on the northmost margin of the metamorphic terrane.

关键词： jiangnan old land fossil tectono-petrolagic unit.

Compression behavior of Sm)2Ti_2O_7-pyrochlore up to 50 GPa:single-crystal X-ray diffraction and density functional theory calculations

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Chinese Science Bulletin 2014年第36期59卷 5278-5282页

作者： Bjrn Winkler Alexandra Friedrich Wolfgang Morgenroth Eiken Hausshl Victor Milman Chris R.Stanek kenneth j.Mc Clellan Geowissenschaften Goethe-Universitt Altenh ferallee 160438 Frankfurt am Main Germany Dassault Syste`mes BIOVIA 334 Science ParkCambridge CB4 0WN UK Los Alamos National Laboratory Los Alamos NM 87545 USA

Single-crystal X-ray diffraction at pressures up to 50 GPa has been employed to study the compression behavior of Sm2Ti2O7-pyrochlore. In contrast to earlier reports, we observed no pressure-induced amorphization or pressure-induced anion disorder up to 50 GPa. The experimental study has been complemented by density functional theory-based calculations. A combination of the theoretical and experimental data yields a bulk modulus of 185 GPa, significantly higher than a value which had been reported earlier. In comparison to earlier work, the current study provides more reliable data due to the use of neon as a pressure medium, which provides a more hydrostatic pressure than the aluminum, which had been employed as a pressure medium in the earlier studies. An analysis of the compressibility of Al2B2O7 pyrochlores shows an approximately linear dependence of the bulk modulus on the unit cell volume.

关键词：密度泛函理论压缩行为单晶X射线衍射烧绿石计算单晶X-射线衍射压力诱导体积弹性模量