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Ch＇en Tu-hsiu： A Powerful Voice for Modern China

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Journal of Literature and Art Studies 2017年第10期7卷 1365-1370页

作者： kenneth lee California State University Northridge USA

Ch＇en Tu-hsiu （1879-1942）, co-founder of the Chinese Communist Party （CCP）, was one of the major intellectual figures who strongly advocated anti-Confucianism during the May Fourth Movement in 1919 on the basis that in order for China to survive in the modem world, it was necessary for China to reject the totally outdated tradition of Confucianism and adopt wholeheartedly Western methods and ideas, such as individualism and even Christianity. While the hard-line conservatives viewed that the way to reform China was in upholding Confucianism as unifying factor, Ch＇en viewed Confucianism as a formless philosophy that kept China back from the process of modernization.

关键词： Ch'en Tu-hsiu Chen Duxiu Chen Qingtong Zongfu Shi'an Chinese Communist Party

eco-mindfulness in Buddhism

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Journal of Literature and Art Studies 2017年第12期7卷 1645-1650页

作者： kenneth lee California State University Northridge USA

Many of those involved in the ecological movement have found inspiration and parallels within the Buddhist tradition. The Buddhist philosophy of karmic causality and dependent origination （pratitya-samutpada） convey the notion of interdependence of humans and nature. Today, especially in the United States, there are many movements, such as the Buddhist Peace Fellowship, to promote eco-living and sustainable communities, which call for humans to be mindful of the environment and make conscientious choices for the benefit of all sentient beings and non-sentient entities. Just as humans have been the cause of the gradual deterioration of Nature, we can also be the solution towards an coo-conscious living, which not only fosters a healthy environment, but also enables us to build good merit. The core Buddhist teaching, which must be embraced by all eco-minded practitioners is the notion of interdependence, which has been expounded by notable Japanese Buddhist figures in the eighth century, such as Kukai （774-835） of the Shingon School and Dogen （1200-1253） of the Soto Zen sect, who both viewed that non-living life forms--trees, plants, and the earth--could also achieve enlightenment. Their view is based on the ontological notions of Buddha-nature （tathagata-garbha） and Indra＇s Jewel Net, which is a powerful image found in Huayen＇s （Jpn. Kegon） Avatamsaka Sutra. This paper examines Buddhist teachings and sutras, which support eco-friendly and sustainable movements in our society and world today.

关键词： mindfulness Buddhism nature environment dependent origination eco-living Indra's Net

Tribological Performance of Coated Surfaces

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材料热处理学报 2004年第5期25卷 20-27页

作者： kenneth Holmberg Anssi Laukkanen VTT Technical Research Centre of Finland Espoo FinlandVTT Technical Research Centre of Finland Espoo Finland

The fundamentals of coating tribology is presented in a generalised holistic approach to friction and wear mechanisms of coated surfaces in dry sliding contacts. It is based on a classification of the tribological contact process into macromechanical, micromechanical, tribochemical contact mechanisms and material transfer. The tribological contact process is dominated by the macromechanical mechanisms, which have been systematically analysed by using four main parameters: the coating-to-substrate hardness relationship, the film thickness, the surface roughness and the debris in the contact. In this paper special attention is given to the microlevel mechanisms, and in particular new techniques for modelling the elastic, plastic and brittle behaviour of the surface by finite element (FeM) computer simulations. The contact condition with a sphere sliding over a plate coated with a very thin hard coating is analysed. A three dimensional FeM model has been developed for calculating the first principal stress distribution in the scratch tester contact of a diamond spherical tip moving with increased load on a 2 thick titanium nitride (TiN) coated steel surface. The model is comprehensive in that sense that it considers elastic, plastic and fracture behaviour of the contact surfaces. By identifying from a scratch experiment the location of the first crack and using this as input data can the fracture toughness of the coating be determined.

关键词：硬敷层 FeM 应力模拟断口摩擦性能贴合表面

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Texas Helimak

Plasma Science and Technology 2008年第3期10卷 284-289页

作者： kenneth W.GeNTLe Fusion Research Center University of Texas at Austin Texas USA

Helimak is an experimental approximation to the ideal cylindrical slab, a onedimensional magnetized plasma with magnetic curvature and shear. The Texas Helimak realizes this approximation to a large degree; the finite size of the device can be neglected for many phenomena. Specifically, the drift-wave turbulence characteristic of a slab is observed with scale lengths small compared with the device size. The device and the general features of its behavior are described here. The device is capable of studying drift-wave turbulence, scrape-off layer （SOL） turbulence, and the stabilization of turbulence by imposing velocity shear.

关键词： plasma turbulence drift waves particle transport turbulence suppression

Driving neural regeneration through the mammalian target of rapamycin

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Neural Regeneration Research 2014年第15期9卷 1413-1417页

作者： kenneth Maiese Cellular and Molecular Signaling Newark NJUSA

Neurodegenerative disorders affect more than 30 million individuals throughout the world and lead to significant disability as well as death. These statistics will increase almost exponentially as the lifespan and age of individuals increase globally and individuals become more susceptible to acute disorders such as stroke as well as chronic diseases that involve cognitive loss, Alzheimer＇s disease, and Parkinson＇s disease. Current therapies for such disorders are effective only for a small subset of individuals or provide symptomatic relief but do not alter disease progression. One exciting therapeutic approach that may turn the tide for addressing neurodegenerative disorders involves the mammalian target of rapamycin （mTOR）. mTOR is a component of the protein complexes roTOR Complex 1 （mTORC1） and mTOR Complex 2 （mTORC2） that are ubiquitous throughout the body and control multiple functions such as gene transcription, metabolism, cell survival, and cell senescence, roTOR through its relationship with phosphoinositide 3-kinas e （PI 3-K） and protein kinase B （Akt） and multiple downstream signaling pathways such as p70 ribosomal $6 kinase （p70S6K） and proline rich Akt substrate 40 kDa （PRAS40） promotes neuro- nal cell regeneration through stem cell renewal and oversees critical pathways such as apoptosis, autophagy, and necroptosis to foster protection against neurodegenerative disorders. Targeting by mTOR of specific pathways that drive long-term potentiation, synaptic plasticity, and [3-amyl old toxicity may offer new strategies for disorders such as stroke and Alzheimer＇s disease. Overall, mTOR is an essential neuroprotective pathway but must be carefully targeted to maximize clini- cal efficacy and eliminate any clinical toxic side effects.

关键词： Alzheimer's disease apoptosis autophagy mTOR necroptosis rapamycin stem cells stroke

Impacting dementia and cognitive loss with innovative strategies: mechanistic target of rapamycin, clock genes, circular non-coding ribonucleic acids, and Rho/Rock

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Neural Regeneration Research 2019年第5期14卷 773-774页

作者： kenneth Maiese Cellular and Molecular Signaling

A significant global impact from dementia:According to the World Health Organization(Dua et al.,2017),the current numbers for the prevalence and treatment costs for dementia worldwide are *** 50 million individuals suffer from *** is now considered to be the 7^th leading cause of ***,at least five percent of the world’s elderly population,equal to approximately 47 million individuals,have ***,at least sixty percent reside in low and middle income *** seventy-five percent of these new cases are to occur in these *** number of new cases each year throughout the globe is increasing at approximately 10 million per *** the year 2030,82 million people are expected to have dementia and by the year 2050,152 million are expected to have the disease.

关键词： Impacting dementia cognitive loss innovative strategies

Recent progress in α1-adrenergic receptor research

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Acta Pharmacologica Sinica 2005年第11期26卷 1281-1287页

作者： kenneth P MINNeMAN Atlanta Department of Pharmacology school of Medicine emory University GA 30322 UsA

αt-Adrenergic receptors (AR) play an important role in the regulation of physiological responses mediated by norepinephrine and epinephrine, particularly in the cardiovascular system. The three cloned oc,-AR subtypes (α1Aα1Band α1D) are G protein-coupled receptors that signal through the Gq/11signaling pathway, each showing distinct pharmacological properties and tissue distributions. However, due to the lack of highly subtype-selective drugs, the functional roles of individual subtypes are still not clear. Development of new subtype-specific drugs will greatly facilitate the identification of the functions of each subtype. Conopeptide TIA has been found to be a new α1B-AR selective antagonist with different modes of inhibition at α1-AR subtypes. In addition, recent studies using genetically engineered mice have shed some light on α1AR functions in vivo, especially in the cardiovascular system and brain. Several proteins have been shown to interact directly with particular α1-AR, and may be important in regulating receptor function. Receptor heterodimerization has been shown to be important for cell surface expression, signaling and internalization. These new observations are likely to help elucidate the functional roles of individual a,-AR subtypes.

关键词： alphal-adrenergic receptor noncompetitive drug protein-protein interaction dimerization cell surface expression

endoderm contributes to endocardial composition during cardiogenesis

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Chinese Science Bulletin 2014年第22期59卷 2749-2755页

作者： Yan Li Xiaoyu Wang Zhenglai Ma Manli Chuai Andrea Münsterberg kenneth KaHo lee Xuesong Yang Key Laboratory for Regenerative Medicine Ministry of Education Medical College Jinan University Division of Cell and Developmental Biology University of Dundee Dundee DD1 5EH UK School of Biological Sciences University of East AngliaNorwich NR4 7TJ UK Stem Cell and Regeneration Thematic Research Programme School of Biomedical Sciences Chinese University of Hong Kong

Heart formation commences from a single heart tube,which fuses from bilateral primordial heart *** developing heart tube is composed of outer-layer myocardial cells and inner-layer endocardial *** distinct populations of precardiac cells contribute to cardiac ***,it still remains not very clear about the lineage of endocardium at gastrulation ***,this study focused on ascertaining the correlation between the hypoblast in gastrulation and endocardium during ***,the fusing heart tube morphologically is closed to endoderm-derived pharynx floor,implying the possibility that pharynx floor might be wrapped into the formation of ***,HNK1 is expressed in hypoblast strongly at gastrula stage and subsequently appeared in endocardium of ***,fate map data displayed that DiI labeled hypoblast was also present in endocardium later *** more evidence is chick-quail chimera of hypoblast transplantation,in which quail-hypoblast derivative could be identified inendocardium of cardiogenesis by QCPN *** sum,our current data suggests that endoderm in gastrula contribute at least partly to the formation of endocardium of cardiogenesis.

关键词：心内膜心脏胚层原肠胚期组成心肌细胞数据显示膜细胞

AI,the internet of legal things,and lawyers

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Journal of Management Analytics 2019年第4期6卷 390-403页

作者： kenneth Tung In-Gear Legalytics Limited Hong KongChina

A great deal of has been written about the challenges of a legal profession that resists change and sub-optimizes clients’benefits,and even more ink has been spilled on the opportunities and threats of *** laws are falling further behind an accelerating,dynamic world,the gap between businesses and opaque legal functions widens with the latter being perceived often as fire-fighting cost *** article calls out the opportunity of AI,specifically machine learning,and its impact on decision making as an opportunity for business leaders to elevate lawyers to contribute further to corporate strategies and *** the implications of machine learning through the lens of each element of decision making,the article aims to bring the relevance of today’s ubiquitous transformations to the legal *** also reminds business leaders that the legal function will need some help,such as corporate legal strategists,to drive and sustain change that resides in the intersection of law,business and technology.

关键词： artificial intelligence machine learning corporate legal strategy change management strategic business functions