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Complete genome sequence of methicillin-sensitive Staphylococcus aureus containing a heterogeneic staphylococcal cassette chromosome element

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Science China(Life Sciences) 2013年第3期56卷 268-274页

作者： LI deZhi CHU YaNan REN LuFeng LI XinGang YUAN Lina KANG Yu ZHANG Wei YANG Yu WANG XuMin BAILLIE J.kenneth YU Jun GAO ZhanCheng department of Respiratory and Critical Care Medicine Peking University People's Hospital department of Respiratory Medicine Shandong Provincial HospitalShandong University CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences The dNA Sequencing Technologies R&d Center Beijing Institute of GenomicsChinese Academy of Sciences department of Respiratory Medicine First Affiliated Hospital of Nanchang University Chinese Academy of Inspection and Quarantine division of Genetics and Genomics The Roslin InstituteUniversity of EdinburghRoslinEH25 9RGUK department of Critical Care Medicine University of EdinburghEdinburghEH16 4TJUK

Staphylococcus aureus is a common human bacterium that sometimes becomes pathogenic,causing serious infections.A key feature of *** is its ability to acquire resistance to *** presence of the staphylococcal cassette chromosome(SCC) element in serotypes of *** has been confirmed using multiplex PCR *** SCC element is the only vector known to carry the mecA gene,which encodes methicillin resistance in *** ***,we report the genome sequence of a novel methicillin-sensitive ***(MSSA) strain:SCC-like *** strain was originally erroneously serotyped as methicillin-resistant *** in a clinical laboratory using multiplex PCR *** sequenced the genome of SCC-like MSSA463 using pyrosequencing techniques and compared it with known genome sequences of other *** *** open reading frame(CZ049;AB037671) was identified downstream of attL and attR inverted repeat *** results suggest that a lateral gene transfer occurred between *** and other organisms,partially changing *** *** propose that attL and attR inverted repeats in *** serve as frequent insertion sites for exogenous genes.

关键词： Staphylococcus aureus staphylococcal cassette chromosome mec (SCC-mec) genomics pyrosequeneing

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使用正弦实验数椐的系统识别

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世界地震工程 1984年第5期 65-70页

作者： kenneth d.Blakely Michael W.dobbs 刘达

系统识别是把系统的数学模型与实际系统的实验结果联系起来。线弹性结构体系的系统识别分四个步骤:(1)实验前数学模型的建立;(2)结构的动力试验; (3)通过实验数据的处理识别结构的特征参数(共振频率、振型、模态阻尼比); (4)用结构参数... 详细信息

系统识别是把系统的数学模型与实际系统的实验结果联系起来。线弹性结构体系的系统识别分四个步骤:(1)实验前数学模型的建立;(2)结构的动力试验; (3)通过实验数据的处理识别结构的特征参数(共振频率、振型、模态阻尼比); (4)用结构参数估算方法进行实验后模型的修改。

关键词：起振机阻尼比振型特征参数估值强迫振动实验共振频率正弦系统辨识系统识别

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内华达山脉风化花岗闪长岩的岩土力学性质

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人民长江 1985年第6期 62-68页

作者： kenneth d Krank Robert J.Watters 李吉贵

内华达山脉花岗闪长岩风化的主因是黑云母接触地下水引起的膨胀,但只有在地下水长期作用下才能发生。黑云母的膨胀引起了岩石微破裂,这种微破裂的发展使原岩逐渐破坏成砂土。风化等级的划分是按照岩石被破坏的不同程度而定。微破裂是造... 详细信息

内华达山脉花岗闪长岩风化的主因是黑云母接触地下水引起的膨胀,但只有在地下水长期作用下才能发生。黑云母的膨胀引起了岩石微破裂,这种微破裂的发展使原岩逐渐破坏成砂土。风化等级的划分是按照岩石被破坏的不同程度而定。微破裂是造成岩石工程性质变化的最初原因。用这些不同性质的关系,来论证风化对岩石工程性能的影响。这些影响是:(1)使块体容重、抗压强度、压缩波速、剪切波速、静力块体弹性模量和动力块体弹性模量等数值减小;(2)使孔隙度增大;(3)颗粒比重、静力泊松比和动力泊松比与风化无关;(4)摩擦角和凝聚力的变化呈非线性的;(5)风化土的无侧限抗压强度实际为零。应用上述这些关系,就有可能根据简易测定的物理性质(如容重、抗压强度或压缩波速)用以预测花岗闪长岩工程力学特性和岩石的工程性状。

关键词：微破裂岩石工程不连续面间断面花岗闪长岩酸性岩压缩波速纵波速度内华达山脉风化等级

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利用eXtended Performance(XP)色谱柱改进美国药典(USP)噻康唑有机杂质分析方法

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环境化学 2013年第2期32卷 258-258页

作者： kenneth d Berthelette Mia Summers kenneth J Fountain 沃特世公司

全世界的制药企业在日常工作中都需要对仿制药中的有机杂质进行分析.使用较为陈旧的仪器和色谱柱技术进行有机杂质分析,需要长时间并消耗大量的溶剂,既耗时又增加成本.

关键词： eXtended 杂质分析色谱柱美国药典噻康唑制药企业有机杂质日常工作

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仙人掌果提取液对卵巢癌的抑制作用

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广西医学院学报 2008年第2期18卷 181-184页

作者：邹大明刘华钢 Molly Brewer Jean M Feugang 梁秋云 kenneth d. Hatch Changping Zou 康州大学医学中心美国康州06032 广西医科大学中国广西南宁530021

目的:研究仙人掌果提取液在动物体内和体外对卵巢癌的抑制作用。方法:用Crystalviolet方法测定、细胞周期分析及细胞凋亡TUNEL分析观察仙人掌果提取液在体外对卵巢癌细胞生长的抑制作用;仙人掌果提取液对人卵巢癌的动物模型的治疗效果... 详细信息

目的:研究仙人掌果提取液在动物体内和体外对卵巢癌的抑制作用。方法:用Crystalviolet方法测定、细胞周期分析及细胞凋亡TUNEL分析观察仙人掌果提取液在体外对卵巢癌细胞生长的抑制作用;仙人掌果提取液对人卵巢癌的动物模型的治疗效果。结果:2种卵巢癌细胞(OVCA420和SKOV3)对于不同浓度仙人掌果提取液反应敏感程度不同,IC50分别是0·8%和8%,正常卵巢上皮细胞(IOSE)的IC50为2%;仙人掌果提取液可以有效的抑制卵巢癌在动物体内的生长(Pdroxyphernyl)retinamide(4HPR)作用相似(P>0·05)。结论:仙人掌果提取液对体外卵巢癌细胞生长和动物体内的卵巢癌生长均有明显抑制作用。

关键词：仙人掌果卵巢癌抑制作用

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A More Precise determination of Gear Oil Viscosity at Low Temperatures

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润滑油 2012年第1期27卷 45-49页

作者： kenneth O.Henderson Joseph T.Mastropierro McEinri Associates LLC Cannon Instrument Company

Low temperature fluidity of gear oils is an important fluid property as it directly impacts the useful life of a gear *** paper compares low temperature fluidity measurement precision of ASTM d6821 and ASTM *** tests are identical in the way they thermally condition the sample prior to viscosity *** ASTM d2983 is cited in many current specifications,ASTM d6821 offers users and formulators a more accurate estimate of gear oil low temperature *** primary benefit in using ASTM d6821 is better *** d6821 accomplishes this by automating the steps from prior to preheat through to viscosity measurement at end of test.

关键词： dynamic viscosity low temperature viscosity gear oil viscosity ASTM d2983 ASTM d6821

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Evaluation of doppler Radar data for Assessing depth-Area Reduction Factors for the Arid Region of San Bernardino County

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Journal of Water Resource and Protection 2019年第2期11卷 217-232页

作者： Theodore V. Hromadka II Rene A. Perez Prasada Rao kenneth C. Eke Hany F. Peters Col Howard d. McInvale department of Mathematical Sciences United States Military Academy West Point NY USA Hromadka & Associates Rancho Santa Margarita CA USA department of Civil and Environmental Engineering California State University Fullerton CA USA Flood Control Planning/Water Resources division San Bernardino County Department of Public Works San Bernardino CA USA

The doppler Radar derived rainfall data for over 150 candidate storms during 1997-2015 period, for the County of San Bernardino, California, was assessed. Eleven most significant storms were identified for detailed analysis. For these significant storms, depth-Area Reduction Factors (“dARF”) curves were developed and compared with the published curves developed and adapted by several flood control agencies for this study area. More rainfall data need to be pursued and analyzed before any correlation hypothesis is proposed.

关键词： Rainfall Radar dARF

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Understanding that Addiction Is a Brain disorder Offers Help and Hope

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Health 2022年第6期14卷 684-695页

作者： kenneth Blum Abdalla Bowirrat david Baron Rajendra d. Badgaiyan Panayotis K. Thanos Igor Elman Eric R. Braverman Mark S. Gold division of Addiction Research & Education Center for Psychiatry Medicine & Primary Care (Office of the Provost) Western University Health Sciences Pomona USA department of Molecular Biology and Adelson School of Medicine Ariel University Ariel Israel department of Psychiatry South Texas Veteran Health Care System Audie L. Murphy Memorial VA Hospital and Long School of Medicine University of Texas Health Science Center San Antonio USA department of Psychiatry MT. Sinai School of Medicine New York USA department of Psychology & Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA) Research Institute on Addictions University at Buffalo Buffalo USA department of Psychiatry Harvard School of Medicine Cambridge USA division of Personalized Medicine The Kenneth Blum Behavioral & Neurogenetic Institute (Division of iVitalize Inc.) Austin USA department of Psychiatry Washington University School of Medicine St. Louis USA

We refute the controversial statement that addiction is not a brain disorder. Extensive peer-reviewed studies support the underlying neurobiological and neurogenetic basis of addiction’s “disease model”. In the 70s and 80s, a few clinical scientists suggested that it is possible to use behavioral training to teach controlled drinking. However, this controversial model failed drastically and increased labeling and stigmatization. Additionally, it was unhelpful in the search for treatment. Instead, we assert that addiction is a neuropsychiatric disorder characterized by a recurring desire to continue taking substances despite harmful physical and mental consequences. Work from our laboratory in 1995 supported the Reward deficiency Syndrome (RdS) concept based on a common neurogenetic mechanism (hypodopaminergia) that underlies all substance and non-substance addictions. Non-substance addictions include behaviors like pathological gambling, internet addiction, and mobile phone addiction. Certain impulsive and compulsive behaviors or the acute intake of psychoactive substances result in heightened dopaminergic activity, while the opposite, hypodopaminergia, occurs following chronic abuse. Patients with Substance Use disorder (SUd) can have a genetic predisposition compounded by stress or other epigenetic insults that can impact recovery. Relapse will occur post-short-term recovery if dopaminergic dysfunction remains untreated. Addiction, a brain disorder, requires treatment with dNA-directed pro-dopamine regulation and rehabilitation.

关键词： Reward deficiency Syndrome Abstinence Controlled drinking Neurogenetic Brain disorder

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： kenneth E Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks Jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 division of digestive diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health department of Gastroenterology Virginia Commonwealth University division of Infectious disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAId-division of AIdS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PEG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. METHOdSA prospective, multicenter, phase 3, open-label, single-arm study of PEG-IFN alfa, weight-based RBV, and boceprevir, with a PEG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (TE) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PEG-IFN plus RBV) rates in sustained viral response (SVR). RESULTSA total of 257 enrolled participants were analyzed (135 TN and 122 TE). In the TN group, 81.5% were male and 54.1% were black. In the TE group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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Mesh-Free Interpolant Observables for Continuous data Assimilation

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Annals of Applied Mathematics 2022年第3期38卷 296-355页

作者： Animikh Biswas kenneth R.Brown Vincent R.Martinez department of Mathematics & Statistics University of Maryland-Baltimore County1000 Hilltop CircleBaltimoreMD 21250USA department of Mathematics University of California-DavisOne Shields AvenueDavisCA 95616USA department of Mathematics & Statistics CUNY Hunter College695 ParkAveNewYorkNY10065USA department of Mathematics CUNY Graduate Center3655th AveNew YorkNY10016USA

This paper is dedicated to the expansion of the framework of general interpolant observables introduced by Azouani,Olson,and Titi for continuous data assimilation of nonlinear partial differential *** main feature of this expanded framework is its mesh-free aspect,which allows the observational data itself to dictate the subdivision of the domain via partition of unity in the spirit of the so-called Partition of Unity Method by Babuska and *** an application of this framework,we consider a nudging-based scheme for data assimilation applied to the context of the two-dimensional Navier-Stokes equations as a paradigmatic example and establish convergence to the reference solution in all higher-order Sobolev topologies in a periodic,mean-free *** convergence analysis also makes use of absorbing ball bounds in higherorder Sobolev norms,for which explicit bounds appear to be available in the literature only up to H^(2);such bounds are additionally proved for all integer levels of Sobolev regularity above H^(2).

关键词： Continuous data assimilation nudging 2d Navier-Stokes equations general interpolant observables synchronization higher-order convergence partition of unity mesh-free Azounai-Olson-Titi algorithm

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