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Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

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Journal of Molecular Cell Biology 2021年第1期13卷 41-58页

作者： Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee kenneth D.Poss Tao P.Zhong State Key Laboratory of Genetic Engineering School of Life SciencesZhong Shan HospitalFudan UniversityShanghai 200438China Shanghai Key Laboratory of Regulatory Biology Institute of Molecular MedicineEast China Normal University School of Life SciencesShanghai 200241China Department of Cell Biology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Pathology and Laboratory Medicine McAllister Heart InstituteUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Developmental and Cell Biology Vanderbilt University School of MedicineNashvilleTN 37232USA T These authors share first authorship.

Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely ***,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury *** blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and *** Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound *** analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled ***-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to ***,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation.

关键词： heart regeneration Wnt signaling PAK2 kinase cardiomyocyte proliferation cardiomyocyte dedifferentiation zebrafish

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Low Prevalence of Carbapenem Resistance in Clinical Isolates of Extended Spectrum Beta Lactamase (ESBL) Producing <i>Escherichia coli</i>in North Central, Nigeria

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Advances in Infectious Diseases 2018年第3期8卷 109-120页

作者： kenneth I. Onyedibe Emmanuel O. Shobowale mark O. Okolo Michael O. Iroezindu Tolulope O. Afolaranmi Francisca O. Nwaokorie Solomon O. Opajobi Samson E. Isa Daniel Z. Egah Department of Medical Microbiology University of Jos Jos Nigeria Department of Medical Microbiology Babcock University Ilishan-Remo Nigeria Department of Medicine University of Nigeria Nsukka Nigeria Department of Epidemiology & Community Health University of Jos Jos Nigeria Division of Molecular Biology Nigerian Institute of Medical Research Lagos Nigeria Department of Medicine University of Jos Jos Nigeria

Extended Spectrum Beta Lactamase (ESBL) producing Escherichia coli is a global cause of life threatening infections. We determined the presence of ESBL and carbapenemase production in clinical isolates of E. coli and their antibiotic susceptibility. Clinical isolates of community and hospital acquired E. coli from 220 patients seen at a tertiary hospital were evaluated. Antibiotic susceptibility testing was by the modified Kirby-Bauer protocol while ESBL production was determined by the Double Disk Synergy Test (DDST). Carbapenem resistance was confirmed by the Modified Hodge Test. Of the 220 isolates, 122 (55.5%) were from females;41 (18.6%) were ESBL positive. About 90% of the ESBL producing isolates were resistant to nine of the 15 antimicrobial agents tested. However, only one (2.4%) of the 41 ESBL producing isolates exhibited carbapenem resistance. The ESBL negative isolates were susceptible to Meropenem (100%), Cefepime (97.8%), Ceftriaxone (96.6%) and Cefotaxime (96.6%). All the ESBL producing isolates harbored detectable plasmids with sizes ranging from 2322 to 23,130 base pairs. Our findings show that although multidrug resistant ESBL producing E. coli are prevalent in both the hospital and the community in this environment, carbapenem resistance is still low. We recommend that institutions develop guidelines for the early phenotypic detection of ESBLs and carbapenem resistance.

关键词： E. coli ESBL Plasmids Carbapenem Resistance Nigeria

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Particulate flow analysis in inclined pipes and transfer chutes using tomography imaging,discrete element simulations and continuum modeling approaches

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Baosteel Technical Research 2010年第S1期4卷 108-页

作者： kenneth WILLIAMS Timothy DONOHUE Alan ROBERTS mark JONES Dusan ILIC TUNRA Bulk Solids University of Newcastle Callaghan 2308Australia

In particulate material transfer systems,traditional shear test based steady state analysis can provide some insight into the strength of the bulk material and subsequent resistive frictional forces during *** fast flowing transfer points,dynamic flow conditions dominate and additional modelling techniques are required to improve design *** research presented shows the evolution of a design solution which utilises two distinct processes;a continuum method and a discrete element method(DEM). Initially,the internal structure of dense granular flow,down vertical and inclined pipes was investigated using a twin sensor,12 electrode electrical capacitance tomography ***,DEM simulations were conducted using the commercial software,***,two particle types and their flow behaviours were analysed:plastic pellets and *** pipe angle was varied between 0°and 45°to the *** both the plastic pellets and the sand,good qualitative agreement was found with the spatial particle concentration ***,the flow had a dense particle region at its core with the particle concentration reducing away from this *** expected,at 0°, the core was centrally located within the pipe for both the plastic pellets and *** pipe angles 5°or greater,the dense core of particles was located on or near the pipe *** flow velocity analysis was also conducted using the results of wall friction test *** velocity comparisons also showed good agreement between the ECT image analysis and the DEM simulations. Subsequently,the DEM method was used to analyse a complex transfer system(or chute) with the continuum method providing comparative flow analysis with the DEM flow analysis.

关键词： bulk solids transfer chutes applications of DEM analysis

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1D AND 2D CIRCUIT-CODE MODELING OF THE REFURBISHED Z ACCELERATOR

1D AND 2D CIRCUIT-CODE MODELING OF THE REFURBISHED Z ACCELER...

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The 17th International Conference on High-Power Particle Beams

作者： kenneth W.Struve Lawrence F.Bennett Jean-Paul Davis mark E.Savage David L.Smith William A.Stygar Timothy F.Chavez David D.Hinshelwood Tim C.Wagoner Sandia National Laboratories P.O.Box 5800AlbuquerqueNM 87185-1194USA EG&G 2420 Comanche Rd.NEAlbuquerqueNM87107 USA Naval Research Laboratory WashingtonDCUSA Ktech Corporation 10800 Gibson Blvd.SEAlbuquerqueNM87123USA

＜正＞Now that the refurbishment of the Z machine at Sandia is complete we are routinely operating with currents over 26 MA into various *** routine operation we are able to measure current and voltage throughout the machine and compare with circuit code predictions. These measurements have motivated improvements to the original model to include two-dimensional （2D） and three-dimensional （3D） *** this paper we describe a full-machine （36 module）,one-dimensional （1D） circuit model of Z using the Bertha code developed at the Naval Research *** also describe a model that uses 2D *** addition,we discuss plans for implementing a 3D circuit model to allow investigating azimuthal effects that can be important for tailoring the rise time,shape,and length of the Z output *** tailoring on Z is achieved by staggering the timing of the various pulsed-forming modules,and by operating individual modules in either long or short-pulse *** the individual lines combine at a large diameter and are separated azimuthally, transit-time effects can be important for determining transient field enhancements at the vacuum insulator and in the vacuum transmission lines,as well as pulse "shape. Finally,we compare the 1D and 2D models with data, and provide predictions for both short and long pulse modes for various load configurations.

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以人群为基础的生物监测:纽约市有机磷和拟除虫菊酯类杀虫剂暴露

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环境与职业医学 2014年第4期31卷 329-329页

作者： Wendy McKelvey J.Bryan Jacobson Daniel Kass Dana Boyd Barr mark Davis Antonia M.Calafat kenneth M.Aldous

[背景]有机磷类和拟除虫菊酯类是两类美国最常见的杀虫剂。这些杀虫剂广泛用于控制纽约市建筑物里的虫害,所导致的杀虫剂暴露可能比比在欠城市化的环境中更高。[目的]估计纽约市杀虫剂暴露的参考值,并确定人口学特征和行为特征以预测暴... 详细信息

[背景]有机磷类和拟除虫菊酯类是两类美国最常见的杀虫剂。这些杀虫剂广泛用于控制纽约市建筑物里的虫害,所导致的杀虫剂暴露可能比比在欠城市化的环境中更高。[目的]估计纽约市杀虫剂暴露的参考值,并确定人口学特征和行为特征以预测暴露。[方法]2004年纽约市健康与营养调查是一项在人群基础上的横断面研究,研究对像为≥20岁的成年人。检测883名参加者的尿中有机磷代谢产物[二甲基磷酸酯(DMP)、二甲基硫代磷酸酯(DMTP)、二甲基二硫代磷酸酯、二乙基磷酸酯、二乙基硫代磷酸酯和二乙基二硫代磷酸酯]的浓度,以及1 452名参加者的尿中拟除虫菊酯类代谢产物[3-苯氧基苯甲酸(3-PBA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(反式DCCA)、4-氟-3-苯氧基苯甲酸和顺式-3-(2,2-二溴乙烯基)-2,2-二甲基环丙烷-1-羧酸]的浓度。使用多元线性回归在不同的预测因子类别中估计总二烃基磷酸盐(ΣDAP)的最小二乘几何平均值和3-PBA浓度。[结果]二甲基有机磷代谢产物的第95百分位浓度最高(DMP和DMTP分别为87.4μg/L和74.7μg/L)。拟除虫菊酯类代谢物中测得的最高第95百分位浓度分别为3-PBA和反式-DCCA(分别为5.23μg/L和5.94μg/L)。ΣDAP浓度随着年龄增加而增加,在非西班牙裔白人或黑人中较西班牙裔/族裔高,在专业使用杀虫剂者中较高,也随水果的消费频率增加而增加;ΣDAP浓度随非绿色蔬菜消费增加而下降。在各预测因子类别中尿3-PBA浓度几何均数的绝对差值都太小而无意义。[结论]纽约市拟除虫菊酯类和有机磷二甲酯类暴露水平估值均高于美国的整体水平,因此在制定杀虫剂的使用法规时,一定要考虑城市中虫害与杀虫剂负荷。

关键词：拟除虫菊酯类杀虫剂有机磷类纽约市生物监测人群硫代磷酸酯人口学特征行为特征

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回归十周年对香港特区法院制度的回顾

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中国法律（中英文版） 2007年第3期 47-48,138-141页

作者：鄒燦基香港大律师

光阴荏苒，岁月如飞。自香港在1997年7月1日回归祖国以来，在不知不觉之间，十年又已经成为过去。我们身处能够安居乐业的今天，回顾着风起云涌的昨日，抚今追昔，缅怀往事。实在不能不引起无限的感想，和无尽的追忆。

关键词：香港特区回归祖国法院制度

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新加坡时刻:批判地域主义、殖民根基和深远的后续发展

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装饰 2023年第8期 56-69页

作者： [英]马克·克林森孙志健伦敦大学伯贝克学院新加坡国立大学

肯尼斯·弗兰姆普敦的批判地域主义理论提出一种介于“普世文明”和“民族文化”之间的辩证关系,但同时将他选取的建筑案例的政治背景压平为一种否定的形式。弗兰姆普敦提出的这种对立源自保罗·利科,利科直接指出反殖民解放运动面临的... 详细信息

肯尼斯·弗兰姆普敦的批判地域主义理论提出一种介于“普世文明”和“民族文化”之间的辩证关系,但同时将他选取的建筑案例的政治背景压平为一种否定的形式。弗兰姆普敦提出的这种对立源自保罗·利科,利科直接指出反殖民解放运动面临的文化问题。本文将批判地域主义拉回20世纪60年代初新加坡的后殖民时期语境,将新加坡大会堂和工会大厦(马来建筑事务所Co-Partnership,1962—1965)选为当时的代表作品。这座建筑介于殖民主义和60年代后期飞速现代化发展之间,通过现代主义在独特的地域形式和理性主义的普世形式之间取得了平衡,同时另一种脆弱的协商也与这对平衡密切相关:这座建筑也是象征工人组织与李光耀人民行动党政府形成短暂联盟的产物。本文提出对这些语境下的建筑的更深理解,不仅能揭示与批判地域主义理论相关的政治条件(尤其是后殖民),同时也能反思库哈斯对新加坡在这段时期城市发展的批判。

关键词：新加坡批判地域主义后殖民城市发展现代主义

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2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Lee A Fleisher Joshua A Beckman kenneth A Brown Hugh Calkins Elliott Chaikof Kirsten E Fleischmann William K Freeman James B Froehlich Edward K Kasper Judy R Kersten Barbara Riegel John F Robb Sidney C Smith Alice K Jacobs Cynthia D Adams Jeffrey L Anderson Elliott M Antman Christopher E Buller mark A Creager Steven M Ettinger David P Faxon Valentin Fuster Jonathan L Halperin Loren F Hiratzka Sharon A Hunt Bruce W Lytle Rick Nishimura Joseph P Ornato Richard L Page Lynn G Tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

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