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儿童常见实体肿瘤分子学进展

临床与实验病理学杂志 2024年第7期40卷 673-679页

作者：殷敏智 kenneth Tou en Chang 上海交通大学医学院附属上海儿童医学中心病理科 200127 Departm.nt of Pathology and Laboratory m.dicine KK Women’s and Children’s HospitalSingapore 229899 Duke-NUS m.dical School Singapore 169857

儿童肿瘤包含一大类罕见肿瘤,虽然只占全年龄段肿瘤患者的极小比例,但却是儿童患者致死的主要原因。成人恶性肿瘤主要起源于上皮,儿童肿瘤通常来源于中胚层或神经外胚层,在肿瘤的发生、发展、治疗和预后等均与成人肿瘤明显不同,WHO(2023... 详细信息

儿童肿瘤包含一大类罕见肿瘤,虽然只占全年龄段肿瘤患者的极小比例,但却是儿童患者致死的主要原因。成人恶性肿瘤主要起源于上皮,儿童肿瘤通常来源于中胚层或神经外胚层,在肿瘤的发生、发展、治疗和预后等均与成人肿瘤明显不同,WHO(2023)肿瘤分类中首次将儿童肿瘤进行独立归类。研究者认为肿瘤的本质是一种基因病,2018年有文献从基因层面指出儿童肿瘤和成人肿瘤有诸多不同[1-2]:成人由于后天环境等因素的影响,使细胞长期连续遭遇“打击”(大部分为基因突变),最终发展为肿瘤。

关键词：肿瘤儿童分子学

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Well-Posedness of Stochastic Continuity Equations on Riem.nnian m.nifolds

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Chinese Annals of m.them.tics,Series B 2024年第1期45卷 81-122页

作者： Luca GALIm.ERTI kenneth H.KARLSen Departm.nt of m.them.tical Sciences NTNU Norwegian University of Science and TechnologyN-7491 TrondheimNorway Departm.nt of m.them.tics University of OsloP.O.Box 1053BlindernN-0316 OsloNorway

The authors analyze continuity equations with Stratonovich stochasticity,■ρ+divh[ρo(u(t,x)+∑_(i=1)^(N)a_(i)(x)w_(i)(t))]=0defined on a sm.oth closed Riem.nnian m.nifold m.with m.tric *** velocity field u is perturbed by Gaussian noise term. Wi(t),:WN(t)driven by sm.oth spatially dependent vector fields a1(x),...,aN(x)on *** velocity u belongs to L_(t)^(1)W_(x)^(1,2)with divh u bounded in Lf,for p>d+2,where d is the dim.nsion of m.they do not assum. div_(h) u∈L_(t,x)^(∞)).For carefully chosen noise vector fields ai(and the num.er N of them.,they show that the initial-value problem.is well-posed in the class of weak L^(2) solutions,although the problem.can be ill-posed in the determ.nistic case because of concentration *** proof of this“regularization by noise”result is based on a L^(2) estim.te,which is obtained by a duality m.thod,and a weak com.actness argum.nt.

关键词： Stochastic continuity equation Riem.nnian m.nifold Hyperbolic equa-tion Non-sm.oth velocity field Weak solution Existence Uniqueness

Predictive value of preoperative routine exam.nation for the prognosis of patients with pT2N0m. or pT3N0m. colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin Chen en-Da Yu Chao-Yu m.ao Departm.nt of Colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.nt of endocrinology and m.tabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.nt of Pharm.cology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been *** the popularization of endoscopic technology,a num.er of early CRC has been ***,despite current treatm.nt m.thods,som. patients with early CRC still experience postoperative recurrence and *** To search for indicators associated with early CRC recurrence and m.tastasis to identify high-risk *** A total of 513 patients with pT2N0m. or pT3N0m. CRC were retrospectively enrolled in this *** of blood routine test,liver and kidney function tests and tum.r m.rkers were collected before *** were followed up through disease-specific database and telephone *** recurrence,m.tastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and *** We com.rehensively com.ared the predictive value of preoperative blood routine,blood biochem.stry and tum.r m.rkers for disease-free survival(DFS)and overall survival(OS)of *** m.ltivariate analysis dem.nstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum.carcinoem.ryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum.total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for *** cutoff value of serum.CEA level for predicting OS was 2.74 ng/*** the OS of CRC patients with serum.CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0m. or T3N0m. CRC,preoperative platelet count was a protective factor for DFS,while serum.CEA level was an independent risk factor for *** that these m.asures are easier to detect and m.re acceptable to patients,they m.y have broader applications.

关键词： Colorectal cancer Platelet count Serum.carcinoem.ryonic antigen Total cholesterol level Overall survival Disease-free survival

Exogenous testosterone therapy on choroid in androgen deficiency

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International Journal of Ophthalm.logy(english edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak m.rve Kalyoncu Ram.zan Aşçi Nurşen Aritürk Departm.nt of Ophthalm.logy Ondokuz Mayıs UniversitySamsun 55139Turkey Departm.nt of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIm.To investigate the effects of exogenous testosterone treatm.nt on the choroidal param.ters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstrom.l area(C-SA),choroid-lum.nal area(C-LA),choroidstrom.l to lum.nal area ratio(CSLR),and the choroidal param.ters within central 1500μm.of the m.cula(CVI1500,C-LA1500,C-SA1500,and CSLR1500)by enhanced-depth im.ging optical coherence tom.graphy(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The m.an SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm.P=0.8).However,CVI,C-SA,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all Penous testosterone treatm.nt,SFCT,CVI,C-LA,and C-SA were significantly decreased,and these param.ters returned to baseline levels at the 18th-week visit(all P>0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(Pen-deficient patients than in healthy *** alterations in the choroid during the testosterone peak are transient in the treatm.nt of patients with androgen ***,the increase in CVI within the central 1500μm.of the m.cula persists even after 4m..

关键词： testosterone androgen deficiency choroid vascularity index

Unequal Distribution of Innovation Efforts for Neglected Tropical Diseases: The Role of Funding Evaluation Criteria

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Health 2024年第5期16卷 490-520页

作者： Anne m. G. Neevel kenneth D. S. Fernald Linda H. m. van de Burgwal Athena Institute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background: International research and innovation efforts for neglected tropical diseases have increased in recent decades due to disparities in overall health research funding in relation to global burden of disease. However, within the field of neglected tropical diseases som. seem.far m.re neglected than others. In this research the aim.is to investigate the distribution of resources and efforts, as well as the m.chanism. that underpin funding allocation for neglected tropical diseases. m.thodology: A system.tic literature review was conducted to establish a com.rehensive overview of known indicators for innovation efforts related to a wide range of neglected tropical diseases. Articles were selected based on a subjective evaluation of their relevance, the presence of original data, and the breadth of their scope. This was followed by thirteen in-depth open-ended interviews with representatives of private, public and philanthropic funding organizations, concerning evaluation criteria for funding research proposals. Results: The findings reveal a large difference in the extent to which the individual diseases are neglected with notable differences between absolute and relative efforts. Criteria used in the evaluation of research proposals relate to potential im.act, the probability of success and strategic fit. Private organizations prioritize strategic fit and econom.c im.act;philanthropic organizations prioritize short-term.societal im.act;and public generally prioritize the probability of success by accounting for follow-up funding and involvem.nt of industry. Funding decisions of different types of organizations are highly interrelated. Conclusions: This study shows that the evaluation of funding proposals introduces and retains unequal funding distribution, reinforcing the relative neglect of diseases. Societal im.act is the prim.ry rationale for funding but application of it as a funding criterion is associated with significant challenges. Furtherm.re, curre

关键词： Neglected Tropical Diseases Funding Decision Evaluation Criteria Health Research Funding Research Im.act

New Opportunities for Neutrons in environm.ntal and Biological Sciences

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Frontiers of environm.ntal Science & engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton Coates Brian H.Davison Jam.s G.Elkins Xin Gu Jennifer m.rrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron m.thods in environm.ntal and biological sciences is rapidly em.rging and accelerating with the developm.nt of new instrum.nts at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environm.ntal and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynam.cs,plant-m.crobe interactions,structure and dynam.cs of biological system.,applications in synthetic biology and enzym. engineering,next-generation bioproducts,biom.terials and bioenergy,nanoscale structure,and fluid dynam.cs of porous m.terials in *** provide an outlook on em.rging opportunities with an em.hasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** m.ssion of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim.to encourage researchers in the environm.ntal and biological research com.unity to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons environm.nt Biology Neutron im.ging Neutron scattering Second Target Station(STS)

腹腔内伴EWSR1/FUS-CREm.排恶性上皮样肿瘤1例

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中华病理学杂志 2024年第3期53卷 299-302页

作者：吴佳慧许淑霞徐曼沈萍陈洁枫金晓婷 Chik Hong Kuick kenneth Tou en Chang 殷敏智上海交通大学医学院附属上海儿童医学中心病理科上海200127 福建省儿童医院(上海儿童医学中心福建医院)病理科福州350011 重庆医科大学附属儿童医院病理科重庆400000 Departm.nt of Pathology and Laboratory m.dicine KK Women′s and Children′s HospitalSingapore 229899Singapore

腹腔内伴EWSR1/FUS-CREm.排恶性上皮样肿瘤是新近发现、分化不明的恶性肿瘤,形态学及免疫表型显示上皮分化,具有恶性潜能及转移倾向。本文报道1例多次复发伴肺转移的病例。镜下肿瘤界限尚清,有纤维性假包膜,肿瘤周边及细胞巢间隔见较... 详细信息

腹腔内伴EWSR1/FUS-CREm.排恶性上皮样肿瘤是新近发现、分化不明的恶性肿瘤,形态学及免疫表型显示上皮分化,具有恶性潜能及转移倾向。本文报道1例多次复发伴肺转移的病例。镜下肿瘤界限尚清,有纤维性假包膜,肿瘤周边及细胞巢间隔见较多炎性细胞浸润,肿瘤细胞呈上皮样、多边形,胞质丰富,呈嗜酸性,核呈圆形或卵圆形,可见小核仁。肿瘤细胞上皮细胞膜抗原弥漫强阳性,广谱细胞角蛋白局灶强阳性,波形蛋白、WT1、突触素、Calretinin等阴性。分子检测示EWSR1-ATF1融合。

关键词：腹腔内转移倾向假包膜免疫表型波形蛋白肺转移纤维性恶性肿瘤

Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang Ting Fei Xiong-Hua Xiang Quan Wang en-Cheng Zhou Departm.nt of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Am.ulatory Surgery Center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach com.ined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatm.nt of inguinal *** A total of 152 SIL-TPP surgeries were perform.d at the First Affiliated Hospital of Ningbo University from.February 2019 to Novem.er 2022.A single-port,nam.d Iconport,and standard laparoscopic instrum.nts were used during the *** data,intraoperative param.ters and short-term.postoperative outcom.s were collected and retrospectively *** The dem.graphic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from.21 to 81 years).The average body m.ss index was 27.7 kg/m.(2)(range from.17.7 kg/m.(2) to 35.6 kg/m.(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdom.nal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** m.an operative tim. was 64.5 m.nutes(range:36.0-110.0 m.nutes)for unilateral direct and fem.ral hernias and 81.6 m.nutes for indirect hernias(range:40.0-150.0 m.nutes).The m.an postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdom.nal wall ***,doctors should be encouraged to actively apply the TPP approach com.ined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

m.thionine sources and genotype affect em.ryonic intestinal developm.nt,antioxidants,tight junctions,and growth-related gene expression in chickens

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Anim.l Nutrition 2024年第1期16卷 218-230页

作者： Jam.s K.Lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János oláh Zoltán m.szár Rita Varga Brigitta Csernus Csaba Szabó Departm.nt of Anim.l Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Departm.nt of Anim.l Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and environm.ntal m.nagem.nt Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Departm.nt of Anatom. Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Departm.nt of Evolutionary Zoology and Hum.n Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

m.thionine(m.t)is an essential and first lim.ting am.no acid in the poultry diet that plays a significant role in chicken em.ryonic developm.nt and *** present study exam.ned the effect of in ovo injection of DL-m.t and L-m.t sources and genotypes on chicken em.ryonic-intestinal developm.nt and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—com.ercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were random.y distributed into four treatm.nts for each *** treatm.nt groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-m.t injected(DLm.;and 4)L-m.t injected(Lm..The in ovo injection was carried out on 17.5 d of em.ryonic developm.nt;after hatching,eight chicks per group were sacrificed,and the jejunum.was extracted for *** results showed that both DLm.and Lm.groups had enhanced intestinal developm.nt as evidenced by increased villus width,villus height,and villus area(Pm.ared to the *** DLm.group had significantly reduced crypt depth,glutathione(GSH)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the Lm.group(Penotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(m.2),occludin(OCLN),superoxide dism.tase 1(SOD1),and GST3 genes than the TSL genotype(Pm.t enhanced intestinal developm.nt,and function,with genotypes responding differently under norm.l *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-m.thionine L-m.thionine In ovo injection Intestinal developm.nt Poultry

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