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Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib:a case report and literature review

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Hepatoma Research 2015年第1期1卷 104-106页

作者： kenneth Siu Ho Chok Ian Yu Hong wong See Ching Chan Ronnie Tung Ping Poon Chung Mau Lo Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)with inferior vena cava(IVC)invasion and metastatic lymph node metastases has a poor prognosis,and surgical resection is seldom *** report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor thrombosis in the IVC was successfully downstaged and ultimately resected together with the *** the disease had been downstaged,curative resection of the tumor and IVC was conducted with immediate reconstruction of the *** patient has survived for more than 2 years after the *** conclusion,tumor and IVC resection can cure metastatic HCC after downstaging treatment combining sorafenib and transarterial chemoembolization.

关键词： Downstaging hepatocellular carcinoma lymph node metastases sorafenib vascular resection

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中国航天计划加大对美挑战

航天员 2012年第1期 32-33页

作者： Edward wong kenneth Chang 肖志军（编译）

2011年12月29日，国务院新闻办公室发布了《2011年中国的航天》白皮书，对2006年以来中国航天的主要进展与未来5年的主要任务做了介绍和说明。白皮书发表当天，《纽约时报》刊登解读文章，中国航天务实而持续的进步让美国人嫉妒，但不... 详细信息

2011年12月29日，国务院新闻办公室发布了《2011年中国的航天》白皮书，对2006年以来中国航天的主要进展与未来5年的主要任务做了介绍和说明。白皮书发表当天，《纽约时报》刊登解读文章，中国航天务实而持续的进步让美国人嫉妒，但不得不承认中国是出于和平目的开发利用外太空。虽然本刊并不完全赞同文章的某些观点，但为了让读者全面了解西方看法，还是进行了全文翻译，以飨读者。

关键词：中国航天航天计划国务院新闻办公室《纽约时报》开发利用全文翻译白皮书美国人

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如何培养员工的工作主动性、敬业精神?

程序员 2009年第9期 80-80,81页

作者： kenneth wong 王速瑜唐海群楼飞宝轩辕互动公司腾讯R&D 尚瑞薪才信息技术有限公司爱可信公司

本期话题来自CSDN网站的CTO俱乐部(http://***/)。在这里,来自各个公司的CTO会提出很多现实工作环境中遇到的问题。本期的问题来自于北京普照天星科技有限公司研发中心总监李天泉先生,他提出:如何培养员工的工作主动性、敬业精神?

关键词：敬业精神员工培养 CSDN 研发中心 CTO 俱乐部

Disappearance and appearance of an indigestible marker in feces from growing pigs as affected by previous-and currentdiet composition

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Journal of Animal Science and Biotechnology 2017年第3期8卷 643-651页

作者： Brandy M.Jacobs John F.Patience Merlin D.Lindemann kenneth J.Stalder Brian J.Kerr Department of Animal Science Iowa State UniversityAmes 50010USA Department of Animal and Food Sciences University of KentuckyLexington 40546KYUSA USDA-ARS-National Laboratory for Agricultural and the Environment Ames 50010IAUSA

Background： Indigestible markers are commonly utilized in digestion studies, but the complete disappearance or maximum appearance of a marker in feces can be affected by diet composition, feed intake, or an animal＇s *** objectives of this study were to determine the impact of previous（Phase 1, P1） and current-（Phase 2, P2）diet composition on marker disappearance（Cr） and appearance（Ti） in pigs fed 3 diets differing in NDF ***： When pigs were maintained on the 25.1, 72.5, and 125.0 g/kg NDF diets, it took 5.1, 4.1, and 2.5 d, respectively,for Cr levels to decrease below the limit of quantitation; or 4.6, 3.7, or 2.8 d, respectively, for Ti to be maximized. These effects were not, however, independent of the previous diet as indicated by the interaction between P1 and P2 diets on fecal marker concentrations（P 〈 0.01）. When dietary NDF increased from P1 to P2, it took less time for fecal Cr to decrease or fecal Ti to be maximized（an average of 2.5 d）, than if NDF decreased from P1 to P2 where it took longer for fecal Cr to decrease or fecal Ti to be maximized（an average of 3.4 d）.Conclusions： Because of the wide range in excretion times reported in the literature and improved laboratory methods for elemental detection, the data suggests that caution must be taken in considering dietary fiber concentrations of the past and currently fed diets so that no previous dietary marker addition remains in the digestive tract or feces such that a smal amount of maker is present to confound subsequent experimental results, and that marker concentration have stabilized when these samples are col ected.

关键词： Adaptation Digestibility Fiber Indigestible marker Pig

The effect of the magnetic fields from three different configurations of the MRIgRT systems on the dose deposition from lateral opposing photon beams in a laryngeal geometry–A Monte Carlo study

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Radiation Medicine and Protection 2021年第3期2卷 103-111页

作者： Vivien W.S.Chu Monica W.K.Kan Louis K.Y.Lee kenneth C.W.wong Macy Tong Anthony T.C.Chan Department of Clinical Oncology Prince of Wales HospitalHong KongChina Department of Clinical Oncology The Chinese University of Hong KongHong KongChina Medical Center The Chinese University of Hong KongChina State Key Laboratory of Translational Oncology Sir YK Pao Center for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Objective:To investigate the impact of different magnetic field strengths and orientations on the dose deposition from lateral opposing photon beams irradiating a laryngeal geometry,with particular attention focused on the dose homogeneity of the area around the air cavity inside the ***:Geant4 simulation toolkit was used to perform Monte Carlo simulations on a phantom resembling the *** energy spectrum of a 6 MV photon beam from a Varian Clinac iX machine was used to provide the source of *** configurations of the Magnetic Resonance Image-Guided Radiation Therapy(MRIgRT)system were simulated:the Fixed Cylindrical(FC)geometry,the Longitudinal Rotating Biplanar(LRBP)geometry,and the Transverse Rotating Biplanar(TRBP)*** magnetic fields of different field strengths were *** relative dose maps and the homogeneity index(HI)were obtained for ***:The LRBP geometry together with a magnetic field strength of 0.5 T produced the most homogeneous dose distribution with a HI of 0.139 for the region of interest around the air cavity,compared with a HI of 0.180 when the magnetic field was *** TRBP geometry,the dose distribution shifted towards the cranial direction,leading to a region of hot spots at the superior edge and a region of cold spots at the inferior edge of the irradiated *** HI around the air cavity was therefore *** addition,strong electron streaming effect(ESE)was *** the FC geometry,hot and cold spots were formed around the air cavity which increased the ***:Out of the three configurations of the MRIgRT systems,the LRBP geometry produced the most clinically beneficial dose distribution in which it provided a higher dose to the treatment area and a boost in dose to the tissue immediately adjacent to the air cavity.

关键词： Monte Carlo MRIgRT MR-Linac Magnetic field Air cavity

Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation

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Hepatoma Research 2018年第9期4卷 159-170页

作者： James Fung Danny Ka-Ho wong Yasuhito Tanaka Regina Lo Tiffany wong kenneth Siu-Ho Chok AIbert Chi-Yan Chan Tan-To Cheung Wing-Chiu Dai KeIvin Ng Kevin Ng Man Kwan Irene Ng Wai-Kay Seto Ching-Lung Lai Man-Fung Yuen Chung-Mau Lo The Liver Transplant Center Queen Mary HospitalHong KongChina Department of Medicine the University of Hong KongHong KongChina State Key Laboratory for Liver Research the University of Hong KongHong KongChina Department of Virology and Liver Unit Graduate School of Medical sciencesNagoya City UniversityNagoya 467-8601Japan Department of Pathology the University of Hong KongHong KongChina Department of Surgery the University of Hong KongHong KongChina

Aim:Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for chronic hepatitis B (CHB) can be associated with reappearance of hepatitis B surface antigen (HBsAg). The current study determined the significance of HBsAg qualitatively and quantitatively using a highly sensitive assay in recurrent HCC after transplantation. Methods:Consecutive patients with HBV-related HCC with LT were included. Oral nucleos(t)ide analogues without hepatitis B immune globulin were used as hepatitis B virus (HBV) prophylaxis. Quantitative HBsAg levels were performed at time of transplant, at 1 month, 3 and 6 months post transplant using a highly sensitive (hs)-HBsAg assay. Results:One hundred and fourteen patients were included, with a median follow-up of 80 months, with 24 cases of HCC recurrence, and a cumulative rate of 20.7% at 5 years. There was significant correlation between time of tumor recurrence and time of HBsAg reappearance (r = 0.551,P = 0.027). Early HCC recurrence was associated with higher median level of hs-HBsAg at the time of transplant (72.85vs. 69.70 IU/mL,P = 0.018). Using a hs-HBsAg cut-off level of 0.0005 IU/mL, patients with levels above this threshold at 3 and 6 months were associated with higher rate of early HCC recurrence (28.6%vs. 3.0% and 26.9%vs. 2.9% respectively, bothP =0.0006). There was no significant difference in HCC recurrence between positive and negative HBsAg using the conventional qualitative HBsAg assay. Conclusion:Serum hs-HBsAg levels of≥ 0.0005 IU/mL at 3 to 6 months after LT is associated with higher rates of early HCC recurrence, and may be useful as an early tumor marker.

关键词： Hepatitis B hepatocellular carcinoma transplantation hepatitis B surface antigen recurrence

Effects of a Single-Dose of Mind-Body Practice on the Heart Rate Variability, Brain Activity and Shooting Performance in Archers: A Pilot Study

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Yangtze Medicine 2019年第2期3卷 124-134页

作者： Peter X. L. Li Chung S. C. Chan kenneth K. Y. Lai Jennifer P. C. wong William W. N. Tsang Medical School Yangtze University Jingzhou China Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hong Kong China

Objective: Factors affecting performance of archery are categorized into psychological, skill, and fitness perspectives. Increase in attention, relaxation and parasympathetic system activity is believed to enhance the shooting performance of archers during competition. This pilot study aims to investigate the effects of single-dose of Tai Chi practice on archer’s performance and the feasibility of an investigation protocol under a competition scenario. Methods: This was a randomized controlled trial (RCT) with a crossover study design. Pre- and post-intervention measurements were conducted to evaluate the effects of Tai Chi practice on the archer’s autonomic nervous system activity, attention and relaxation through electroencephalography investigation, and shooting performance when compared with stretching as control. Results: The protocol of the study was found to be feasible during a competition setting. No significant difference was detected in the outcome measures under the two intervention conditions. Participants after practicing Tai Chi were found to improve significantly in their shooting performance (p = 0.021). Conclusion: This pilot study showed that a real-time measurement of autonomic nervous system and brain wave activities in the competition field was feasible and it did not hinder the archers’ performance. There was a significant improvement observed in the shooting performance of archers after Tai Chi practice when compared with baseline. The findings of this pilot study provide the basis for the conduction of a larger RCT study to examine the potential beneficial effects of Tai Chi practice on archers.

关键词： Mind-Body Autonomic Nervous System Brain Waves Archery

Factors Affecting Mesenchymal Stromal Cells Yield from Bone Marrow Aspiration

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Chinese Journal of Cancer Research 2011年第1期23卷 43-48页

作者： Jing Li Wilfred Hing-Sang wong Shing Chan James Chor-San Chim kenneth Man-Chee Cheung Tsz-Leung Lee Wing-Yan Au Shau-Yin Ha Albert Kwok-Wei Lie Yu-Lung Lau Raymond Hin-Suen Liang Godfrey Chi-Fung Chan China Oxford Centre for International Health Research Cardiovascular Institute ＆ Fuwai HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100037China Department of Paediatrics and Adolescent Medicine Department of Medicine Department of Orthopaedics ＆Traumatology the University of Hong KongHKSARChina

Objective：This study was to investigate the variables in bone marrow harvesting procedure and individual donor factors which can potentially affect the yield of mesenchymal stromal cells（MSC）.Methods：We determined the yield of MSC from bone marrow under different clinical conditions by comparing the MSC colony numbers from：（1） donors of different ages;（2） healthy donors and patients with leukemia;（3） bone marrow aspirated at different time points during marrow harvesting;（4） bone marrow harvested by different ***：During the process of harvesting,the number of MSC significantly decreased with increase number of aspiration,from 675/ml at the initial decreased to 60/ml after 100 ml bone marrow aspirated,and 50/ml after 200 ml bone marrow *** number of MSC retrieved from leukemia patients（99/ml bone marrow） was significantly lower than that of healthy donors（708/ml bone marrow）.However,there was no significant difference in growth *** was no significant age-related difference of MSC yielded from donors 55 *** there was no significant difference in MSC number between the samples from single end-holed needle and those from multiple-side-hole ***：The optimal bone marrow samples for MSC collection should be obtained earlier in the process of harvesting *** marrow from donors 55 years was equally good as MSC *** autologous MSC from leukemia patients can be utilized for in-vitro MSC expansion.

关键词： Mesenchymal stromal cell CFU-F Bone marrow aspiration Leukemia

Forage and breed effects on behavior and temperament of pregnant beef heifers

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Journal of Animal Science and Biotechnology 2013年第3期4卷 165-169页

作者： Angela R Mays Michael L Looper Benjamin C Williamson kenneth P Coffey Wayne K Coblentz Glen E Aiken Charles F Rosenkrans Jr Department of Animal Science University of ArkansasFayetteville AR 72701 USA Department of Agricultural Sciences Morehead StateUniversity327 Reed Hall Morehead KY 40351 USA USDA-ARS US Dairy Forage Research CenterMarshfield WI 54449 USA USDA-ARS Forage Animal Production Research UnitLexingtonKY 40546 USA

Background： Integration of behavioral observations with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle production ***-influenced（BR;n = 64） and Gelbvieh × Angus（GA;n = 64） heifers consumed either toxic endophyte-infected tall fescue（E＋） or one of two nontoxic endophyte-infected tall fescue（NT） cultivars during two *** were weighed at midpoint and termination of *** behavior（grazing,resting in the shade,lying,or standing without grazing） was recorded（n = 13 visual observations per yr in June and July） for each *** yr 2,exit velocity（EV） and serum prolactin（PRL） were ***： Grazing behavior was influenced（P 0.05） by an interaction between fescue cultivar and breed *** × Angus heifers assigned to E＋ pastures had the lowest percentage of animals grazing and the largest percentage of animals resting in the ***-influenced heifers had faster EV（P 0.001） than GA heifers（0.52 vs.0.74 ± 0.04 s/m,respectively）.Body weight（BW） was affected（P 0.01） by an interaction of tall fescue cultivar and d,and an interaction of tall fescue cultivar and breed *** grazing NT pastures were heavier（P 0.01） than heifers grazing E＋ pastures at midpoint and *** × Angus heifers grazing NT pastures were heavier（P 0.01） than GA and BR heifers grazing E＋ and BR heifers grazing NT *** interaction of forage cultivar and breed type occurred on serum PRL（P 0.01）.Conclusion： Collectively fescue cultivar,EV,and concentrations of serum PRL were associated with grazing *** grazing NT pastures were observed to be grazing more than heifers assigned to E＋ pastures,regardless of breed type,which may have contributed to changes in BW and average daily gain（ADG） in *** of behavioral observations along with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle prod

关键词： Cattle Endophyte-infected tall fescue Grazing behavior Prolactin Temperament