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The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre

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Asian Journal of Urology 2018年第2期5卷 122-126页

作者： kenneth Chen Allen Sim Alex Ford Kan Department of Urology Singapore General HospitalSingapore Department of Anaesthesiology Singapore General HospitalSingapore

Objective:Caudal block provides satisfactory postoperative pain relief in lower abdominal *** pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy(RARP).Methods:From 2013 to 2014,40 consecutive patients were randomized into two groups d one received caudal block using ropivacaine immediately after operation,the other received standard *** outcome measure was pain score based on 11-point Likert scale(0e10)recorded at recovery room,and at 6,12,24,48,and 72 h after *** analgesic requirements,opioid-related adverse events and time to passage of flatus were ***:Mean age of the two groups was similar(60.4 vs.62.3 years,p Z 0.33),as was American Society of Anaesthesiologists(ASA)class,body mass index(BMI)and operation *** significant difference in median pain scores was reported in recovery room(2 vs.3,p Z 0.34),and at 6 h(2 vs.2,p Z 0.94),12 h(0 vs.0,p Z 0.62),24 h(1 vs.0,p Z 0.58),48 h(1 vs.0,p Z 0.36)and 72 h(0 vs.0,p Z 0.78)postoperatively between control and caudal block groups,*** was a higher mean opioid usage in the caudal block group which was not statistically *** this was statistically insignificant while no significant difference in mean paracetamol usage was observed *** time to passage of flatus was similar(2.0 vs.2.0 days,p Z 0.97).There was one case of superficial wound infection and no opioid-related adverse events *** stay was similar in both groups(2.5 vs.2.5 days,p Z 0.96).

关键词： Caudal block Robotic radical prostatectomy Post-operative pain Analgesia Opioid

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離散數學及其應用

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2006年

作者： kenneth h.Rosen

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Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery

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Nano Research 2018年第10期11卷 5584-5595页

作者： Jonathan Wang Christopher Poon Deborah Chin Sarah Milkowski Vivian Lu kenneth R. hallows Eun Ji Chung Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA Division of Nephrology and hypertension Department of Medicine Keck School of Medicine University of Southern California Los Angeles CA 90033 USA USC/UKRO Kidney Research Center Keck School of Medicine University of Southern California Los Angeles CA 90033 USA Norris Comprehensive Cancer Center University of Southern California Los Angeles CA 90033 USA Department of Stem Cell Biology and Regenerative Medicine University of Southern California Los Angeles CA 90033 USA Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los Angeles CA 90089 USA

One in three Americans is at risk for developing chronic kidney disease （CKD） and end-stage renal disease （ESRD）, leading to the need for dialysis or a kidney transplant. Small-molecule drugs have been proposed as therapies to manage kidney diseases, but high dosages are often required to achieve therapeutic efficacy, generating off-target side effects, some of which are lethal. To address these limitations, we developed a novel kidney-targeting multimodal micelle （KM） system for drug delivery applications. SpecificaU~ we incorporated the kidney-targeting peptide （Lysine-Lysine-Glutamic acid-Glutamic acid-Glutamic acid）3-Lysine）（（KKEEE）3K） into micelles. This peptide binds to megalin, a multi-ligand cell surface receptor present on renal tubule cells. When incubated with human kidney proximal tubule cells, KMs were found to be biocompatible in vitro. In vivo, KMs showed higher accumulation in the kidneys as compared to a non-targeted （NT） control upon intravenous injection in wild-type C57BL/6J mice. histological evaluation showed no signs of tissue damage, while blood urea nitrogen （BUN） and creatinine levels were within normal ranges, validating the preservation of kidney health upon micelle administration. To our knowledge, this is the first utilization of （KKEEE）BK in a nanoparticle formulation, and our study offers strong evidence that this novel nanoparticle platform can be used as a candidate drug delivery carrier to direct therapeutics to diseased tissue in CKD.

关键词： micelle kidney disease renal targeting biodistribution nanoparticle

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Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle

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Journal of Animal Science and Biotechnology 2019年第4期10卷 1101-1107页

作者： Ibukun M.Ogunade Jerusha Lay kenneth Andries Christina J.Mc Manus Frederick Bebe College of Agriculture Communities and the Environment Kentucky State University

Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, ***, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as Megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate he DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate bindi

关键词： Functional potential Live yeast Rumen

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Data Collection and Processing on Siemens X-200B Area Detector

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Progress in Natural Science:Materials International 1994年第4期4卷 92-97页

作者： kenneth A.Satyshur,徐英博,张添志,常文瑞 National Laboratory of Biomacromolecules Institute of Biophysics Academia Sinica Beijing 100101 PRC National Laboratory of Biomacromolecules Institute of Biophysics Academia Sinica Beijing 100101 PRC National Laboratory of Biomacromolecules Institute of Biophysics Academia Sinica Beijing 100101 PRC National Laboratory of Biomacromolecules Institute of Biophysics Academia Sinica Beijing 100101 PRC

Since the first set X-ray area detector system of China was installed in the National Laboratory of Biomacromolecules in 1990, it has been used to collect more than twenty data sets on crystals of biomacromolecules from laboratories in China. The data sets include Rsym from 2.18% for the native insulin to 8.69% for glucose isomerase. A complete data set for a medium resolution can be collected in 24-40 h. Compared with a four-cycle diffractometer, the area detector has more obvious advantages on the speed of collection, saving crystals and quality of data. The basic principles of the area detector, the analysis of data quality and the problems of processing data for R3 space group are introduced and discussed.

关键词： area detector system biomacromolecules diffraction data.

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中国和西方儿童的社会行为及其社会接受性研究

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心理科学 1992年第2期15卷 1-7页

作者：陈欣银 kenneth h.Rubin 李丹李正云李伯黍加拿大滑铁卢大学心理学系上海师范大学教管系

612名中国儿童和296名加拿大儿童经“班级戏剧”量表测量获得的数据进行因素分析,得到三个在中,加样本中含义相同的变量:亲社会性、攻击性和羞怯-敏感性。在加拿大样本中,羞怯-敏感性项目和孤立性项目聚合在一起,与同伴接受成显著负相... 详细信息

612名中国儿童和296名加拿大儿童经“班级戏剧”量表测量获得的数据进行因素分析,得到三个在中,加样本中含义相同的变量:亲社会性、攻击性和羞怯-敏感性。在加拿大样本中,羞怯-敏感性项目和孤立性项目聚合在一起,与同伴接受成显著负相关。与此相反,中国儿童的羞怯-敏感行为被认为是一种积极的品质,它与社会孤立性分离开来,而与亲社会行为及同伴接受成显著正相关。

关键词：中国西方儿童社会行为

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Fluorescence Intensity Decay Shape Analysis Microscopy （FIDSAM） for Quantitative and Sensitive Live-Cell Imaging： A Novel Technique for Fluorescence Microscopy of Endogenously Expressed Fusion-Proteins

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Molecular Plant 2010年第3期3卷 555-562页

作者： Frank Schleifenbaum Kirstin Elgass Marcus Sackrow Katharina Caesar kenneth Berendzen Alfred J. Meixner Klaus hatter Center for Plant Molecular Biology Department of Plant Physiology University of Tubingen Auf der Morgenstelle 1 72076 Tubingen Germany Institute of Physical and Theoretical Chemistry University of Tubingen Auf der Morgenstelle 8 72076 Tubingen Germany

Fluorescent studies of living plant cells such as confocal microscopy and fluorescence lifetime imaging often suffer from a strong autofluorescent background contribution that significantly reduces the dynamic image contrast and the quantitative access to sub-cellular processes at high spatial resolution. here, we present a novel technique--fluorescence intensity decay shape analysis microscopy （FIDSAM） to enhance the dynamic contrast of a fluorescence image of at least one order of magnitude. The method is based on the analysis of the shape of the fluorescence intensity decay （fluorescence lifetime curve） and benefits from the fact that the decay patterns of typical fluorescence label dyes strongly differ from emission decay curves of autofluorescent sample areas. Using FIDSAM, we investigated Arabidopsis thaliana hypocotyl cells in their tissue environment, which accumulate an eGFP fusion of the plasma membrane marker protein LTI6b （LTI6b-eGFP） to low level. Whereas in conventional confocal fluorescence images, the membranes of neighboring cells can hardly be optically resolved due to the strong autofluorescence of the cell wall, FIDSAM allows for imaging of single, isolated membranes at high spatial resolution. Thus, FIDSAM will enable the sub-cellular analysis of even low-expressed fluorophoretagged proteins in living plant cells. Furthermore, the combination of FIDSAM with fluorescence lifetime imaging provides the basis to study the local physico-chemical environment of fluorophore-tagged biomolecules in living plant cells.

关键词： Cell structure cell walls membrane proteins high-resolution fluorescence microscopy.

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Earths dynamic systems 10th ed.

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2004年

作者： W. kenneth hamblin, Eric h. Christiansen

The book maintains its solid coverage of the two major energy systems of earth: the plate tectonic system and the hydrologic cycle.

ISBN: (纸本)0131420666

The book maintains its solid coverage of the two major energy systems of earth: the plate tectonic system and the hydrologic cycle.

关键词： Physical geology.

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胶东断裂蚀变带构造-流体成矿规律研究

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地质论评 2016年第B11期62卷 317-318页

作者：吕承训吴淦国 Norbert h. MAERZ kenneth J. BOYKO Missouri University of Science and Technology MO USA 65401 中国地质大学(北京) 中国北京100083

胶东是目前中国最大的金矿集中区，矿床位于花岗岩与老地层之间的区域剪切断裂带，围岩是在花岗岩区段的断裂破碎蚀变岩带，成矿作用与岩浆期后热液交代直接有关。区域构造-流体研究的一个难题是：如何选择既能保证流体包裹体分析质量... 详细信息

胶东是目前中国最大的金矿集中区，矿床位于花岗岩与老地层之间的区域剪切断裂带，围岩是在花岗岩区段的断裂破碎蚀变岩带，成矿作用与岩浆期后热液交代直接有关。区域构造-流体研究的一个难题是：如何选择既能保证流体包裹体分析质量，又可以观测交代蚀变阶段构造应力应变的岩石样品。

关键词：胶东构造流体成矿规律

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钩藤碱对多巴胺诱导的NT2细胞凋亡的影响(英文)

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Acta Pharmacologica Sinica 2002年第5期23卷 63-67页

作者：石京山,haglid G kenneth 遵义医学院药理学教研室歌德堡大学解剖与细胞生物学系遵义中国 563003 歌德堡大学解剖与细胞生物学系歌德堡瑞典 41390 歌德堡瑞典 41390

目的:观察钩藤碱(rhnchophylline,Rhy)对多巴胺(dopamine,DA)诱导NT2细胞凋亡的防护作用.方法:以LDh的漏出率反映细胞的生存率;用TUNEL染色法和DNA琼脂糖凝胶电泳法观察NT2神经元凋亡情况;用Western blotting法测定Bcl-2蛋白表达.结果:... 详细信息

目的:观察钩藤碱(rhnchophylline,Rhy)对多巴胺(dopamine,DA)诱导NT2细胞凋亡的防护作用.方法:以LDh的漏出率反映细胞的生存率;用TUNEL染色法和DNA琼脂糖凝胶电泳法观察NT2神经元凋亡情况;用Western blotting法测定Bcl-2蛋白表达.结果:Rhy在5和50μmol/L的浓度下能显著地抑制由DA所致的乳酸脱氢酶的漏出,以及明显地提高以PMS试剂转化为指标的生存率(Phy使DA诱导的转染bcl-2基因神经元和未转染bcl-2基因神经元的凋亡率均明显减少;Rhy能抑制DA所致的DNA降解,但Phy对NT2细胞Bcl-2蛋白表达无明显影响.结论:Rhy能对抗DA诱导的NT2细胞的损伤.

关键词：多巴胺钩藤碱 NT2细胞细胞凋亡

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