检索结果-南通市图书馆

OTX2 signaling in retinal dysfunction,degeneration and regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第10期16卷 2002-2003页

作者： kenneth.L.Moya Raoul Torero Ibad Centre for Interdisciplinary Research in Biology(CIRB) Collège de FranceCNRS UMR 7241INSERM U1050Labex MemoLifePSL Research UniversityParisFrance(Moya KLIbad RT)Univ.LilleCNRSUMR 8523-PhLAM-Physique des Lasers Atomes et MoléculesF-59000 LilleFrance(Ibad RT)

The protein OTX2 in the retina is necessary for the maintenance of normal physiologic processes,and may be a promising therapeutic agent for some ophthalmic *** this Perspective,we first shortly introduce the organization of the retina and the importance of OTX2 *** then present an example of reduced OTX2 activity in the developed retina associated with structural and functional *** next show that homeoproteins can have neuroprotective *** finally review several clear examples of OTX2 non-cell autonomous activity in the retina and the effects of diminishing or providing extracellular OTX2.

关键词： expression. functions. agent

Rethinking the Histories of War in Modern China

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of History in China 2018年第1期13卷 2-27页

作者： kenneth Pomeranz Department of History University of Chicago Chicago IL 60637 USA

War creates intense experiences, and can be a powerful engine of social transformation. Yet it can also epitomize ＂sound and fury, signifying nothing＂： either pure destruction that contributed to no large project, or a stage which merely displayed the inevitable outcome of a balance of forces already determined by social, economic, or political processes unfolding elsewhere.

关键词：

Large-scale distribution of elements in Chinese aerosol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Particuology 2007年第6期5卷 395-400页

作者： Jinghua Guo kenneth A. Rahn Guoshun Zhuang Shuifeng Wang Analysis and Testing Center Beijing Normal University Beijing 100875 China Center for Atmospheric Chemistry Studies Graduate School of Oceanography University of Rhode Island Narragansett R1 02882-1197 USA The Center for Atmospheric Chemistry Study Department of Environmental Science & Engineering Fudan University Shanghai 200433 China

In spite of increasing attention on Chinese aerosol, there has never been a country-wide survey of its general characteristics. This paper presents elemental data for aerosol at 23 sites in and around China, mostly drawn from the literature, and shows some of the large-scale patterns. Al, Na, and Se are used to represent the crustal, marine, and pollution components, respectively. Most of the patterns are aligned in SW-Ne. Al and Na are highest to the NW and the Se, respectively, and their ratio changes rapidly near the coast. Se has a broad maximum over Central China, and the Se/Al ratio （an indicator of pollution vs. crustal aerosol） increases progressively from the NW to the Se. A simple index for simulating pollution aerosol, which uses population density, annual precipitation, and mean wind speed, adequately reproduces the large-scale pattern of pollution aerosol and shows how crustal Al in the NW gradually gives way to flyash Al toward the Se.

关键词： Chinese aerosol elemental concentration Distribution Pollution index

Dendritic cells in cancer immunology

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第1期19卷 3-13页

作者： Theresa L.Murphy kenneth M.Murphy Department of Pathology and Immunology Washington University in St.LouisSchool of MedicineSt.LouisMO 63110USA

The clinical success of immune checkpoint therapy(ICT)has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune *** of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTLA4 or PD1/PD-L1 blockade and are solidly developed on the basis of currently accepted *** these principles through continuous basic research may help broaden translational *** this mindset,we focused this review on three threads of basic research directly relating to mechanisms underlying ***,this review covers three aspects of dendritic cell(DC)biology connected with antitumor immune responses but are not specifically oriented toward therapeutic ***,we review recent advances in the development of the cDC1 subset of DCs,identifying important features distinguishing these cells from other types of ***,we review the antigen-processing pathway called cross-presentation,which was discovered in the mid-1970s and remains an *** pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic ***,we review the longstanding field of helper cells and the related area of DC licensing,in which CD4 T cells influence the strength or quality of CD8 T cell *** topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.

关键词： Dendritic cells transcription factors cross-presentation tumor rejection CD4 help

Understanding voltage hysteresis and decay during anionic redox reaction in layered transition metal oxide cathodes:A critical review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第3期16卷 3766-3780页

作者： Wei Zheng Gemeng Liang Shilin Zhang kenneth Davey Zaiping Guo School of Chemical engineering&Advanced Materials The University of AdelaideAdelaideSA 5005Australia

The emergence of anionic redox reactions in layered transition metal oxide cathodes provides practical opportunity to boost the energy density of rechargeable ***,the activation of anionic redox reaction in layered oxides has significant voltage hysteresis and decay that reduce battery performance and limit ***,we critically review the up-todate development of anionic redox reaction in layered oxide cathodes,summarize the proposed reaction mechanism,and unveil their connection to voltage hysteresis and decay based on the state-of-the-art *** addition,advances associated with various modification approaches to mitigate the voltage hysteresis/decay in layered transition metal oxide cathodes are also ***,we conclude with an appraisal of further research directions including rational design of high-performance layered oxide cathodes with reversible anionic redox reactions and suppressed voltage hysteresis/*** will be of immediate benefit to the development of layered oxide cathodes for high performance rechargeable batteries.

关键词： anionic redox reaction voltage hysteresis voltage decay layered transition metal oxides Li-ion battery Na-ion battery

enhancing plastic deformability of Mg and its alloys—A review of traditional and nascent developments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2017年第4期5卷 460-475页

作者： kenneth Kanayo Alaneme eloho Anita Okotete Department of Metallurgical and Materials engineering Federal University of TechnologyAkureNigeria African Materials Science engineering Network AMSEN(A Carnegie-IAS RISE Network)AkureNigeria

Mg and its alloys have continued to attract interest for several structural and super-sensitive applications because of their light weight and good combination of engineering *** for some of these applications,high plastic deformability is required to achieve desired component shapes and configurations;unfortunately,Mg and its alloys have low ***,the plastic behaviour of Mg and its alloys ranks among the most complex and difficult to reconcile in metallic material *** basically,the HCP crystal structure coupled with low stacking fault energies(SFe)are largely linked to the poor ductility exhibited by Mg *** innate material characteristics have regrettably limited wide spread applicability of Mg and its *** research efforts aimed at exploring processing strategies to make these alloys more amenable for high formability–mediated engineering use have been reported and still *** paper reviews the structural metallurgy of Mg alloys and its influence on mechanical behaviour,specifically,plasticity *** also concisely presents various processing routes(Alloying,Traditional Forming and Severe Plastic Deformation(SPD))which have been explored to enhance plastic deformability in Mg and its *** refinement and homogenising of phases,reducing CRSS between slip modes,twinning suppression to activate non-basal slip,and weakening and randomisation of the basal texture were observed as the formability enhancing strategies explored in the reviewed *** identifying the limitations of these strategies,further areas to be explored for enhancing plasticity of Mg alloys are highlighted.

关键词： Mg alloys HCP crystal structure Basal texture Severe plastic deformation Formability

editorial for the Special Issue on High-end Measuring Instruments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

engineering 2022年第9期16卷 1-2页

作者： Jiubin Tan kenneth Thomas Victor Grattan Key Laboratory of Ultra-Precision Intelligent Instrumentation Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150080China School of Science&Technology City University of LondonLondon EC1V 0HBUK

In recent years, two major challenges have arisen in the field of measurement and instrument technology. One is the redefinition of the seven basic units in the international system of units(Système International d’Unités or SI). The SI is now based on fundamental physical constants, with full implementation having occurred in 2019.

关键词： technology. instrument arise

Characterization of Baram and Tanjung sands as potential proppants

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

energy Geoscience 2021年第3期2卷 175-180页

作者： Henry elochukwu kenneth Kho Khai Kiat Department of Petroleum engineering Curtin UniversityCDT25098009MiriSarawakMalaysia

Baram and Tanjung sands were evaluated for potential use as *** was conducted on Baram and Tanjung sands following ISO and ASTM recommended *** showed that Baram and Tanjung sand mineralogy is predominantly quartz with presence of metal *** descriptors of both sands for sphericity and roundness were above *** sand was retained by 20/40 mesh size with mean size of 448.2 mm,bulk density of 1.32 g/cc,acid solubility of 1.5%and crush resistance of 4000 *** Tanjung sand was retained by 30/50 mesh size with mean size of 383.2 mm,bulk density of 1.30 g/cc,acid solubility of 1.20%and crush resistance of 8000 *** indicates that Baram sand has larger grain size that supports high permeability at low closure stress,making this sand suitable for shallow depth hydraulic fracturing operations,whereas Tanjung sand is more suitable for deeper domains with high closure *** results and economic comparison with commercial frac sand and other proppant types support using Baram and Tanjung sands as potential proppants.

关键词： Baram sand Tanjung sand Crush resistance Proppant Hydraulic fracturing

Intraocular lens power calculation in eyes with previous corneal refractive surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

eye and Vision 2018年第1期5卷 172-181页

作者： Giacomo Savini kenneth J.Hoffer G.B.Bietti eye Foundation RomeItaly. Stein eye Institute University of CaliforniaLos AngelesCAUSA.3 St.Mary’s Eye CenterSanta MonicaCAUSA

Background:This review aims to explain the reasons why intraocular lens(IOL)power calculation is challenging in eyes with previous corneal refractive surgery and what solutions are currently available to obtain more accurate ***:After IOL implantation in eyes with previous LASIK,PRK or RK,a refractive surprise can occur because (i)the altered ratio between the anterior and posterior corneal surface makes the keratometric index invalid;(ii)the corneal curvature radius is measured out of the optical zone;and (iii)the effective lens position is erroneously predicted if such a prediction is based on the post-refractive surgery corneal *** methods are currently available to obtain the best refractive outcomes in these eyes,even when the perioperative data(*** corneal power and surgically induced refractive change)are not *** this review,we describe the most accurate methods based on our clinical ***:IOL power calculation after myopic corneal refractive surgery can be calculated with a variety of methods that lead to relatively accurate outcomes,with 60 to 70%of eyes showing a prediction error within 0.50 diopters.

关键词： Cataract Intraocular lens power LASIK PRK excimer laser Corneal surgery Keratometry