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Hepatitis C virus antigens enzyme immunoassay for one-step diagnosis of hepatitis C virus coinfection in human immunodeficiency virus infected individuals

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World Journal of Hepatology 2019年第5期11卷 442-449页

作者： Ke-Qin Hu Wei Cui Susan D Rouster kenneth e sherman Division of GI/Hepatology University of CaliforniaIrvineSchool of MedicineOrangeCA 92868United States Division of Digestive Diseases University of Cincinnati College of MedicineCincinnatiOH 45267United States

BACKGROUND Current diagnosis of hepatitis C virus(HCV)infection requires two sequential steps:testing for anti-HCV followed by HCV RNA PCR to confirm *** have developed a highly sensitive and specific HCV-antigens enzyme immunoassay(HCV-Ags eIA)for one-step diagnosis of viremic HCV *** To assess the clinical application of the HCV-Ags eIA in one-step diagnosis of viremic HCV infection in human immunodeficiency virus(HIV)-coinfected *** The study blindly tested HCV-Ags eIA for its performance in one-step diagnosing viremic HCV infection in 147 sera:10 without HCV or HIV infection;54 with viremic HCV monoinfection;38 with viremic HCV/HIV coinfection;and 45 with viremic HCV and non-viremic HIV *** Upon decoding,it was 100%accordance of HCV-Ags eIA to HCV infection status by HCV RNA PCR *** five sera with HCV infection,HCV RNA was as low as 50-59 IU/mL,and four out of five tested positive for HCV-Ags ***,it was also 100%accordance of HCV-Ags eIA to HCV infection status by HCV RNA PCR in 83 sera with HCV and HIV coinfection,regardless if HIV infection was active or *** The modified HCV-Ags eIA has a lower detection limit equivalent to serum HCV RNA levels of approximately 100 IU/*** is highly sensitive and specific in the setting of HIV coinfection,regardless of HIV infection status and CD4 *** data support the clinical application of the HCV-Ags eIA in one-step diagnosis of HCV infection in HIV-infected individuals.

关键词： Hepatitis C virus Hepatitis C virus antigens Hepatitis C virus core antigen Hepatitis C virus diagnostic test Diagnostic assay enzyme immunoassay

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： kenneth e sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks Jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAID-Division of AIDS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PeG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. MeTHODSA prospective, multicenter, phase 3, open-label, single-arm study of PeG-IFN alfa, weight-based RBV, and boceprevir, with a PeG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (Te) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PeG-IFN plus RBV) rates in sustained viral response (SVR). ReSULTSA total of 257 enrolled participants were analyzed (135 TN and 122 Te). In the TN group, 81.5% were male and 54.1% were black. In the Te group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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大规模商品生产病毒杀虫剂的可能性

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世界农药 1986年第6期 29-34+38页

作者： kenneth e.sherman 晓岚美国George Washington大学医学院

本文是评论替代传统害虫防治技术的病毒杀虫剂的大规模商品生产必需考虑的种种因素和问题,对于工业生产过程进行专门详细介绍的有许多出色的论文和技术报告,本文调查和评价病毒杀虫剂生产的方法,重点是一些有关安全和质量控制关键的地... 详细信息

本文是评论替代传统害虫防治技术的病毒杀虫剂的大规模商品生产必需考虑的种种因素和问题,对于工业生产过程进行专门详细介绍的有许多出色的论文和技术报告,本文调查和评价病毒杀虫剂生产的方法,重点是一些有关安全和质量控制关键的地方。最近有几种病毒杀虫剂被美国环境保护局(ePA)批准,而有大量其他品种正处于不同的评价阶段,有关病毒制剂的文献资料为评价目前应用的品种提供了充足的材料。

关键词：病毒杀虫剂致病病毒害虫 NPV 多角体包涵体寄主昆虫粉纹夜蛾商品生产

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2024 Wheelchair Compendium of Physical Activities:An update of activity codes and energy expenditure values

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Journal of Sport and Health Science 2024年第1期13卷 18-23页

作者： Scott A.Conger Stephen D.Herrmann erik A.Willis Tom e.Nightingale Joseph R.sherman Barbara e.Ainsworth Department of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of exercise and Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an update of the 2011 Wheelchair Compendium of Physical Activities designed for wheelchair users and is referred to as the 2024 Wheelchair *** Wheelchair Compendium aims to curate existing knowledge of the energy expenditure for wheelchair physical activities(PAs).Methods:A systematic review of the published energy expenditure of PA for wheelchair users was completed between 2011 and May *** added these data to the 2011 Wheelchair Compendium data that was compiled previously in a systematic review through ***:A total of 47 studies were included,and 124 different wheelchair PA reported energy expenditure values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nordic sit skiing).Conclusion:In introducing the updated 2024 Wheelchair Compendium,we hope to bridge the resource gap and challenge the prevailing narratives that inadvertently exclude wheelchair users from physical fitness and health PAs.

关键词： Disability exercise MeT Mobility

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Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson Magnus ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren eva Lindberg kenneth Nystrom emanuele Papucci Patrik Ulvdal Hans OleØrka erik Næsset Zhengyang Hou Håkan Olsson Ronald e.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

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Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal endoscopy 2024年第6期16卷 335-342页

作者： kenneth W Chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H Hsu Viktor e eysselein Neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

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Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn kenneth P. Vogel Terry J. Klopfenstein Galen erickson P. Stephen Baenziger Bruce e. Anderson Mary e. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, Ne, USA. each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

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DeSIGN OF ReCONFIGURABLe MANUFACTURING SYSTeMS WITH STRONGLY COUPLeD NATURe

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Chinese Journal of Mechanical engineering 2007年第1期20卷 91-95页

作者： LANG sherman Y T Integrated Manufacturing Technologies Institute National Research Council Canada N6G 4X8 ON Canada

Today＇s manufacturing cnvironmem forces manufacturing companies to make as many product variations as possible at affordable costs within a short time. Mass customisation is one of most important technologies for companies to achieve their objectives. efforts to mass customisation should be made on two aspects：（1） To modularize products and make them as less differences as possible; （2） To design manufacturing resources and make them provide as many processes variations as possible. This paper reports our recent work on aspect （2）, i.e. how to design a reconfignrable manufacturing system （RMS） so that it can be competent to accomplish various processes optimally; Reconfignrable robot system （RRS） is taken as an example. RMS design involves architecture design and configuration design, and configuration design is further divided in design analysis and design synthesis. Axiomatic design theory （ADT） is applied to architecture design, the features and issues of RRS configuration design are discussed, automatic modelling method is developed for design analysis, and concurrent design methodology is presented for design synthesis.

关键词： Mass customisation Reconfignrable manufacturing systems Reconfignrable robotic system Analysis Synthesis Architecture Adaptability Reconfignrability Configuration design

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Overview of the Global electricity System in Oman Considering energy Demand Model Forecast

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energy engineering 2023年第2期120卷 409-423页

作者： Ahmed Al-Abri kenneth e.Okedu Department of electrical and Communication engineering National University of Science and TechnologyPC 111MuscatSultanate of Oman Department of electrical and electronic engineering Nisantasi UniversityIstanbulTurkey

Lately,in modern smart power grids,energy demand for accurate forecast of electricity is gaining attention,with increased interest of *** is due to the fact that a good energy demand forecast would lead to proper responses for electricity *** addition,proper energy demand forecast would ensure efficient planning of the electricity industry and is critical in the scheduling of the power grid capacity and management of the entire power *** most power systems are been deregulated and with the rapid introduction and development of smart-metering technologies in Oman,new opportunities may arise considering the efficiency and reliability of the power system;like price-based demand response *** programs could either be a large scale for household,commercial or industrial ***,excellent demand forecasting models are crucial for the deployment of these smart metering in the power grid based on good knowledge of the electricity market ***,in this paper,an overview of the Oman regulatory regime,financial mechanism,price control,and distribution system security standard were *** so,the energy demand forecast in Oman was analysed,using the econometric model to forecasts its energy peak *** energy econometric analysis in this study describes the relationship between the growth of historical electricity consumption and macro-economic parameters(by region,and by tariff),considering a case study of Mazoon electricity Distribution Company(MZeC),which is one of the major power distribution companies in Oman,for effective energy demand in the power grid.

关键词： energy forecast energy demand load demand power grids electricity sector

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Synchrophasor-based real-time state estimation and situational awareness system for power system operation

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Journal of Modern Power Systems and Clean energy 2016年第3期4卷 370-382页

作者： Heng CHeN Lin ZHANG Jianzhong MO kenneth e.MARTIN electric Power Group Pasadena CA 91101 USA

State estimation is a critical functionality of energy management system(eMS) to provide power system states in real-time operations. However, problems such as failure to converge, prone to failure during contingencies,and biased estimates while system is under stressed condition occur so that state estimation results may not be *** unreliable results further impact downstream network and market applications, such as contingency analysis,voltage stability analysis, transient stability analysis, system alarming, and unit commitment. Thus, operators may lose the awareness of system condition in eMS. This paper proposes a fully independent and one-of-a-kind system by integrating linear state estimator into situational awareness applications based on real-time synchrophasor data. With guaranteed and accurate state estimation solution and advanced real-time data analytic and monitoring functionalities, the system is capable of assisting operators to assess and diagnose current system conditions for proactive and necessary corrective actions. The architecture, building components, and implementation of the proposed system are explored in detail. Two case studies with simulated data from the subsystems of electric Reliability Council of Texas(eRCOT) and Los Angeles Department of Water and Power(LADWP) are presented. The test results show the effectiveness and reliability of the system, and its value for realtime power system operations.

关键词： Synchrophasor Linear state estimator Situational awareness Power system operation

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