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Light field on a chip: metasurface-based multicolor holograms

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Advanced Photonics 2021年第2期3卷 1-14页

作者： Dandan Wen Jasper J.Cadusch Jiajun Meng kenneth b.crozier University of Melbourne Department of Electrical and Electronic EngineeringVictoriaAustralia University of Melbourne School of PhysicsVictoriaAustralia University of Melbourne Australian Research CouncilCentre of Excellence for Transformative Meta-Optical SystemsVictoriaAustralia

Multicolor holography can faithfully record the color,depth,parallax,and other properties of scenes and have thus found numerous applications,for example,in optical document security,nonvolatile data storage,and virtual or augmented reality *** metasurfaces present multiple degrees of freedom to manipulate the properties of optical fields at visible *** in turn provide opportunities for metasurface-based multicolor *** describe recent developments in multicolor metasurface *** are categorized based on their color-separating mechanisms rather than their structural properties,such as whether they are plasmonic or *** hope this review will provide readers with new insights and thus help extend applications of metasurface-based multicolor holography to other fields.

关键词： multicolor hologram metasurface

Quo vadis,plasmonic optical tweezers?

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Light(Science & Applications) 2019年第1期8卷 878-883页

作者： kenneth b.crozier School of Physics and Department of Electrical and Electronic EngineeringThe University of MelbourneMelbourneVictoria 3010Australia

Conventional optical tweezers based on traditional optical microscopes are subject to the diffraction limit,making the precise trapping and manipulation of very small particles *** optical tweezers can surpass this constraint,but many potential applications would benefit from further enhanced performance and/or expanded *** this Perspective,we discuss trends in plasmonic tweezers and describe important opportunities presented by its interdisciplinary combination with other techniques in *** furthermore highlight several open questions concerning fundamentals that are likely to be important for many potential applications.

关键词： optical furthermore precise

Well-Posedness of Stochastic Continuity Equations on Riemannian Manifolds

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Chinese Annals of Mathematics,Series b 2024年第1期45卷 81-122页

作者： Luca GALIMbERTI kenneth H.KARLSEN Department of Mathematical Sciences NTNU Norwegian University of Science and TechnologyN-7491 TrondheimNorway Department of mathematics University of OsloP.O.Box 1053BlindernN-0316 OsloNorway

The authors analyze continuity equations with Stratonovich stochasticity,■ρ+divh[ρo(u(t,x)+∑_(i=1)^(N)a_(i)(x)w_(i)(t))]=0defined on a smooth closed Riemannian manifold M with metric *** velocity field u is perturbed by Gaussian noise terms Wi(t),:WN(t)driven by smooth spatially dependent vector fields a1(x),...,aN(x)on *** velocity u belongs to L_(t)^(1)W_(x)^(1,2)with divh u bounded in Lf,for p>d+2,where d is the dimension of M(they do not assume div_(h) u∈L_(t,x)^(∞)).For carefully chosen noise vector fields ai(and the number N of them),they show that the initial-value problem is well-posed in the class of weak L^(2) solutions,although the problem can be ill-posed in the deterministic case because of concentration *** proof of this“regularization by noise”result is based on a L^(2) estimate,which is obtained by a duality method,and a weak compactness argument.

关键词： Stochastic continuity equation Riemannian manifold Hyperbolic equa-tion Non-smooth velocity field Weak solution Existence Uniqueness

Surviving winter on the Qinghai-Xizang Plateau:Extensive reversible protein phosphorylation plays a dominant role in regulating hypometabolism in hibernating Nanorana parkeri

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Zoological Research 2024年第1期45卷 1-12页

作者： Yong-Gang Niu Deng-bang Wei Xue-Jing Zhang Ti-Sen Xu Xiang-Yong Li Hai-Ying Zhang Zhi-Fang An kenneth b.Storey Qiang Chen Department of Life Sciences Dezhou UniversityDezhouShandong 253023China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXiningQinghai 810016China School of Life Sciences Lanzhou UniversityLanzhouGansu 730000China Department of biology Carleton UniversityOttawaON K1S 5B6Canada

Changes in protein abundance and reversible protein phosphorylation(RPP)play important roles in regulating hypometabolism but have never been documented in overwintering frogs at high *** test the hypothesis that protein abundance and phosphorylation change in response to winter hibernation,we conducted a comprehensive and quantitative proteomic and phosphoproteomic analysis of the liver of the Xizang plateau frog,Nanorana parkeri,living on the Qinghai-Xizang *** total,5170 proteins and 5695 phosphorylation sites in 1938 proteins were *** on proteomic analysis,674 differentially expressed proteins(438 up-regulated,236 down-regulated)were screened in hibernating *** versus summer *** enrichment analysis revealed that higher expressed proteins in winter were significantly enriched in immune-related signaling pathways,whereas lower expressed proteins were mainly involved in metabolic processes.A total of 4251 modified sites(4147 up-regulated,104 down-regulated)belonging to 1638 phosphoproteins(1555 up-regulated,83 down-regulated)were significantly changed in the *** hibernation,RPP regulated a diverse array of proteins involved in multiple functions,including metabolic enzymatic activity,ion transport,protein turnover,signal transduction,and alternative *** changes contribute to enhancing protection,suppressing energy-consuming processes,and inducing metabolic ***,the activities of phosphofructokinase,glutamate dehydrogenase,and ATPase were all significantly lower in winter compared to *** conclusion,our results support the hypothesis and demonstrate the importance of RPP as a regulatory mechanism when animals transition into a hypometabolic state.

关键词： Nanorana parkeri Proteomic Phosphoproteomic Hibernation Reversible protein phosphorylation Metabolism

Exciton-polaritons in a 2D hybrid organic-inorganic perovskite microcavity with the presence of optical Stark effect

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Chinese Physics b 2024年第3期33卷 551-555页

作者： kenneth Coker 郑楚媛 Joseph Roger Arhin Kwame Opuni-boachie Obour Agyekum 张伟利 School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and Electronic Engineering Ho Technical UniversityHo 00233Ghana Telecommunication Engineering Department Kwame Nkrumah University of Science and TechnologyKumasi 00233Ghana

This study investigates the properties of exciton-polaritons in a two-dimensional(2D)hybrid organic-inorganic perovskite microcavity in the presence of optical Stark *** both steady and dynamic state analyses,strong coupling between excitons of perovskite and cavity photons is revealed,indicating the formation of polaritons in the perovskite ***,it is found that an external optical Stark pulse can induce energy shifts of excitons proportional to the pulse intensity,which modifies the dispersion characteristics of the polaritons.

关键词： exciton-polaritons perovskite microcavity optical Stark effect

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2114-2131页

作者： Chuan Yang Xueping Wang kenneth K.W.To Caimei Cui Min Luo Shaocong Wu Lamei Huang Kai Fu Can Pan Zeyu Liu Teng Fan Caibo Yang Fang Wang Liwu Fu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China School of Pharmacy Faculty of MedicineThe Chinese University of Hong KongHong KongChina LAbVIV Technology(Shenzhen)Co. LtdShenzhen 518057China

Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer *** remains elusive how CTCs evade immune surveillance and elimination by immune *** this study,we unequivocally identified a subpopulation of CTCs shielded with extracellular vesicle(EVs)-derived CD45(termed as CD45^(+)CTCs)that resisted T cell attack.A higher percentage of CD45^(+)CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer ***,CD45^(+)tumor cells orchestrated an immunosuppressive milieu and CD45^(+)CTCs exhibited remarkably stronger metastatic potential than CD45−CTCs in ***,CD45 expressing on tumor surfaces was shown to form intercellular CD45-CD45 homophilic interactions with CD45 on T cells,thereby preventing CD45 exclusion from TCR-pMHC synapse and leading to diminished TCR signaling transduction and suppressed immune ***,these results pointed to an underappreciated capability of EVs-derived CD45-dressed CTCs in immune evasion and metastasis,providing a rationale for targeting EVs-derived CD45 internalization by CTCs to prevent cancer metastasis.

关键词： CD45 metastasis prevention

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica b 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li Yu Lu kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell biology&Institute of biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

Ultra-resolution scalable microprinting

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微系统与纳米工程(英文) 2023年第3期9卷 195-207页

作者： Callum Vidler kenneth crozier David Collins Department of biomedical Engineering University of MelbourneMelbourneVICAustralia School of Physics University of MelbourneVictoria 3010Australia Department of Electrical and Electronic Engineering University of MelbourneVictoria 3010Australia Australian Research Council(ARC)Centre of Excellence for Transformative Meta-Optical Systems University of MelbourneVictoria 3010Australia The Graeme Clark Institute The University of MelbourneParkville 3052 VICAustralia

Projection micro stereolithography(PµSL)is a digital light processing(DLP)based printing technique for producing structured *** this approach there is often a tradeoff between the largest object that can be printed and the minimum feature size,with higher resolution generally reducing the overall extent of the *** ability to produce structures with high spatial resolution and large overall volume,however,is immensely important for the creation of hierarchical materials,microfluidic devices and bioinspired *** this work,we report a low-cost system with 1µm optical resolution,representing the highest resolution system yet developed for the creation of micro-structured parts whose overall dimensions are nevertheless on the order of *** do so,we examine the limits at which PµSL can be applied at scale as a function of energy dosage,resin composition,cure depth and in-plane feature *** doing so we develop a unique exposure composition approach that allows us to greatly improve the resolution of printed *** ability to construct high-resolution scalable microstructures has the potential to accelerate advances in emerging areas,including 3D metamaterials,tissue engineering and bioinspired constructs.

关键词： lithography resolution printing

The emerging roles of microRNAs in the molecular responses of metabolic rate depression

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分子细胞生物学报:英文版 2011年第3期3卷 167-175页

作者： Kyle K.biggar kenneth b.Storey Institute of biochemistry and Department of biology Carleton University1125 Colonel By DriveOttawaONCanada K1S 5B6

Metabolic rate depression is an important survival strategy for many animal species and a common element of hibernation,torpor,estivation,anoxia and *** of the molecular mechanisms that regulate reversible transitions to and from hypometabolic states have identified principles of regulatory *** control mechanisms are conserved among biologically diverse organisms and include the coordinated reduction of specific groups of key regulatory enzymes or proteins in the cell,a process likely driven by microRNA target repression/*** present review focuses on a growing area of research in hypometabolism and mechanisms involving the rapid and reversible control of translation facilitated by *** analysis draws primarily from current research on three animal models:hibernating mammals,anoxic turtles and freeze-tolerant frogs(with selected examples from multiple other sources).Here,we demonstrate a link between metabolic rate depression,a well-documented response to periods of environmental stress,and microRNA ***-based expression profiles and PCR-driven studies have revealed that specific microRNAs are induced in response to environmental *** members of this group decrease pro-apoptotic signaling,reduce muscle wasting and reduce protein translation,whereas other members contribute to cell cycle arrest and mitogen-activated protein kinase *** of the same microRNAs are frequently deregulated in numerous disease pathologies and,hence,the hypometabolism model could provide a novel approach for the treatment of stroke and heart attack in humans.

关键词： microRNA metabolism metabolic rate depression protein translation muscle atrophy cell cycle apoptosis