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Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?

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World Journal of Hepatology 2015年第7期7卷 968-979页

作者： Akinobu Takaki Kazuhide yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Oxidative stress is becoming recognized as a key factor in the progression of chronic liver disease(CLD) and hepatocarcinogenesis. The metabolically important liver is a major reservoir of mitochondria that serve as sources of reactive oxygen species, which are apparently responsible for the initiation of necroinflammation. As a result, CLD could be a major inducer of oxidative stress. Chronic hepatitis C is a powerful generator of oxidative stress, causing a high rate of hepatocarcinogenesis among patients with cirrhosis. Non-alcoholic steatohepatitis is also associated with oxidative stress although its hepatocarcinogenic potential is lower than that of chronic hepatitis C. Analyses of serum markers and histological findings have shown that hepatocellular carcinoma correlates with oxidative stress and experimental data indicate that oxidative stress increases the likelihood of developing hepatocarcinogenesis. However, the results of antioxidant therapy have not been favorable. Physiological oxidative stress is a necessary biological response, and thus adequate control of oxidative stress and a balance between oxidative and anti-oxidative responses is important. Several agents including metformin and L-carnitine can reportedly control mechanistic oxidative stress. This study reviews the importance of oxidative stress in hepatocarcinogenesis and of control strategies for the optimal survival of patients with CLD and hepatocellular carcinoma.

关键词： Liver cancer Liver cirrhosis Hepatitis B Viral protein C Non-alcoholic steatohepatitis Reactiveoxygen species

Galling phenomena in metal forming

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Friction 2021年第4期9卷 665-685页

作者： Kuniaki DOHDA Masahito yamamoto Chengliang HU Laurent DUBAR Kornel F.EHMANN Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208-3111USA Manufacturing Engineering Center NSKLtd.Fujisawa-Shi 251-8501Japan Institute of Forming Technology and Equipment School of Materials and EngineeringShanghai Jiao Tong UniversityShanghai 200240China LAMIH UMR CNRS 8201 Universite Polytechnique Hauts-de-FranceValenciennes Cedex 959313France

Galling phenomena in metal forming not only affect the quality of the engineered surfaces but also the success or failure of the manufacturing operation *** paper reviews the different galling conditions in sheet and bulk metal forming processes along with their evolution and the effects of temperature on galling.A group of anti-galling methods employed to prevent galling defects are also presented in *** techniques for quantitatively measuring galling are introduced,and the related prediction models,including friction,wear,and galling growth models,are presented to better understand the underlying *** phenomena in other processes similar to those occurring in metal forming are also examined to suggest different ways of further studying galling in metal ***,future research directions for the study of galling in metal forming are suggested.

关键词： galling metal forming friction wear adhesion anti-galling

New Reflection Principles for Maxwell's Equations and Their Applications

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Numerical Mathematics(Theory,Methods and Applications) 2009年第1期2卷 1-17页

作者： Hongyu Liu Masahiro yamamoto Jun Zou Department of Mathematics University of Washington Box 354350 Seattle WA 98195 USA. Department of Mathematical Sciences The University of Tokyo Komaba Meguro Tokyo 153-8914 Japan. Department of Mathematics The Chinese University ofHong Kong Shatin N.T. Hong Kong.

Some new reflection principles for Maxwell's equations are first established, which are then applied to derive two novel identifiability results in inverse electromagnetic obstacle scattering problems with polyhedral ... 详细信息

关键词： Maxwell's equations reflection principles inverse electromagnetic scattering identiflability and uniqueness.

Utility of single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal inspection

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World Journal of Gastrointestinal Surgery 2017年第12期9卷 264-269页

作者： Masateru yamamoto Takashi Urushihara Toshiyuki Itamoto Department of Gastroenterological Breast and Transplant SurgeryHiroshima Prefectural Hospital Department of Gastroenterological and Transplant Surgery Applied Life ScienceInstitute of Biomedical and Health ScienceHiroshima University

AIM To study the utility of single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal *** A 2 cm transverse skin incision was made in the umbilicus, extending to the intraperitoneal cavity. Carbon dioxide was insufflated followed by insertion of laparoscope to observe the intraperitoneal cavity. The type of hernia was diagnosed and whether there was the presence of intestinal incarceration was confirmed. When an intestinal incarceration in the hernia sac was found, the forceps were inserted through the incision site and the intestine was returned to the intraperitoneal cavity without increasing the number of trocars. Once the peritoneum was closed, totally extraperitoneal inguinal hernia repair was performed, and finally, intraperitoneal observation was performed to reconfirm the *** Of the 75 hernias treated, 58 were on one side, 17 were on both sides, and 10 were recurrences. The respective median operation times for these 3 groups of patients were 100 min(range, 66 to 168), 136 min(range, 114 to 165), and 125 min(range, 108 to 156), with median bleeding amounts of 5 g(range, 1 to 26), 3 g(range, 1 to 52), and 5 g(range, 1 to 26), respectively. Intraperitoneal observation showed hernia on the opposite side in 2 cases, intestinal incarceration in 3 cases, omental adhesion into the hernia sac in 2 cases, severe postoperative intraperitoneal adhesions in 2 cases, and bladder protrusion in 1 case. There was only 1 case of *** Single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal inspection makes hernia repairs safer and reducing postoperative complications. The technique also has excellent cosmetic outcomes.

关键词： Inguinal hernia Intestinal incarceration Totally extraperitoneal inguinal hernia repair Intraperitoneal inspection Single incision

IgE PRODUCTION IS INVOLVED IN BUTYRATE- ENHANCED NK CELL ACTIVITY IN VIVO

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Chinese Medical Sciences Journal 2001年第2期16卷 76-81页

作者： Ming Zhong Akihiro Tai Itaru yamamoto Department of Immunochemistry Faculty of Pharmaceutical SciencesOkayama UniversityTsushima-naka 1-1-1Okayama 700-8530Japan

It has been demonstrated that patients with asthma have a large number of NK cells and show a stronger NK activity. These results indicate that NK cell activity may be related to total IgE level in serum in healthy subjects. Previously,we have found that sodium butyrate (NaBu) markedly enhanced the IL- 4- induced IgE production in the LPS- stimulated murine splenocytes in vitro, and inductive rat IgE production in vivo, and enhanced the NK cell activity ex vivo .We hypothesized that the IgE production might be involved in butyrate- enhanced NK cell activity in vivo. Mice were intraperitoneally treated/immunized with NaBu or/and Ascaris suum extract (ASC),and the spleen NK cell activity was evaluated. Furthermore, the effect of serum (NAS) on IL- 2- or IFN-γ- induced spleen NK cell activity was determined. The spleen NK cell activity and IL- 2- or IFN-γ- induced spleen NK cell activity of mice treated/immunized with NaBu or/and ASC were stronger than those of untreated/unimmunized mice. Although IL- 4 blocked IL- 2 (100 U/ml)- or IFN-γ (100 U/ml)- induced increase in NK cell activity,these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. IgE production showed a tendency to rise in NaBu- treated mice serum, and a synergistic effect was observed with treatment of NaBu and ASC. Moreover, the NAS significantly increased IL- 2(25 U/ml)- or IFN-γ (25 U/ml)- induced NK cell activity, and its effect was inhibited by anti- mouse IgE mAb. These data show that IgE plays an important role in NAS- enhanced IL- 2/IFN-γ- induced NK cell activity, and IL- 4 does not inhibit IgE and IL- 2/IFN-γ- induced NK cell activity in mice.

关键词： immunoglobulin E (IgE) sodium butyrate (NaBu) NK cell activity

Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis

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BIOCELL 2021年第2期45卷 395-415页

作者： XIAOYU WANG TAKESHI yamamoto MAKOTO KADOWAKI YIFU YANG Laboratory of Immunology and Virology Experiment Center for Science and TechnologyShanghai University of Traditional Chinese MedicineShanghai201203China Division of Gastrointestinal Pathophysiology Institute of Natural MedicineUniversity of ToyamaToyama9300194Japan

Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent *** purpose of the present study was to identify gene signatures with IgE/antigen(dinitrophenyl-bovine serum albumin,DNP-BSA)or calcium ionophore(A23187)on the activation of *** expressed genes between the two types of samples were identified with microarray *** ontology functional and pathway enrichment analyses of differentially expressed genes were performed using the database for annotation,visualization,and integrated discovery *** results showed that IgE/antigen and A23187 could induce degranulation,increase vacuoles,and elevate the cytosolic calcium concentration in ***,GeneChip analysis showed that the same 134 mRNAs were altered with IgE/DNP-BSA and A23187,suggesting that DNP-BSA/IgE and A23187 affect the same signal pathway partly in *** analysis showed that the data were enriched in NF-κB,TNF,MAPK,transcription factor activity,DNA binding,and nucleic acid binding,suggesting that activation of MMCs is a complex *** results provide new insights on MMCs activation.

关键词： Mucosal mast cell Antigen Calcium ion Bioinformatics analysis

Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

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World Journal of Gastroenterology 2014年第10期20卷 2641-2652页

作者： Atsuki yamamoto Tomokazu Itoh Reishi Nasu Ryuichi Nishida Pharmaceutical research laboratories Sakai Chemical Industry Co. Ltd. Kawachinagano Osaka 586-0006 Japan KATAYAMA SEIYAKUSYO Co. Ltd.Hirakata Osaka 573-1132 Japan Kaigen Pharma Co. Ltd.Doshomachi Chuo-ku Osaka 541-0045 Japan

AIM: To investigate the effects of sodium alginate (AL-Na) on indomethacin-induced small intestinal lesions in rats.

关键词： Sodium alginate Non-steroidal anti-inflammatory drugs Gastrointestinal mucosal injury Mucin Bacterial translocation

The Monotone Robin-Robin Domain Decomposition Methods for the Elliptic Problems with Stefan-Boltzmann Conditions

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Communications in Computational Physics 2010年第8期8卷 642-662页

作者： Wenbin Chen Jin Cheng Masahiro yamamoto Weili Zhang School of Mathematical Sciences and Key Laboratory of Computational Physics(MOE) Fudan UniversityShanghai200433China Shanghai Key Laboratory of Intelligent Information Processing Fudan UniversityShanghai200433China Department of Mathematical Sciences University of TokyoTokyo153-8914Japan

This paper is concerned with the elliptic problems with nonlinear StefanBoltzmann boundary *** combining with the monotone method,the RobinRobin domain decomposition methods are proposed to decouple the nonlinear interface and boundary *** monotone properties are verified for both the multiplicative and the additive domain decomposition *** numerical results confirm the theoretical analysis.

关键词： Nonlinear Stefan-Boltzmann condition monotone methods Robin-Robin domain decomposition method

Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation