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Effects of soil nutrient availability and ozone on container-grown Japanese larch seedlings and role of soil microbes

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Journal of Forestry Research 2020年第6期31卷 2295-2311页

作者： Evgenios Agathokleous Mitsutoshi Kitao Masabumi Komatsu Yutaka Tamai Hideyuki Saito Hisanori Harayama Akira uemura Hiroyuki Tobita Takayoshi Koike Institute of Ecology Key Laboratory of Agrometeorology of Jiangsu ProvinceSchool of Applied MeteorologyNanjing University of Information Science and Technology(NUIST)Nanjing 210044JiangsuPeople’s Republic of China Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Forest Research and Management Organization7 HitsujigaokaSapporoHokkaido 062-8516Japan Department of Mushroom Science and Forest Microbiology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan Department of Plant Ecology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan

The interactive eff ects of ozone,soil nutrient availability and root microorganisms on physiological,growth,and productivity traits were studied for the fi rst time for Japanese larch(Larix kaempferi)seedlings grown in containers over a growing season,using a free air ozoneconcentration enrichment exposure *** nutrient availability altered leaf and root nutrient dynamics and enhanced plant growth;however,it also enhanced seedling susceptibility to damping-off disease compared to low nutrient *** eff ects of elevated ozone,as compared with ambient ozone,on leaf gas exchange and plant stem form were neither off set nor exacerbated by soil nutrient availability and root *** negative eff ects suggest that elevated ozone may have implications for ecological health even when plant vigor is limited by factors other than *** of roots with ectomycorrhizae had negligible infl uence on the eff ects of either soil nutrient availability or ***,this lack of eff ect may be upon impeded formation of complete mycorrhizal root tips due to factors other than the manipulated variables.B and Na appeared to have an important role in stress responses,so further studies to examine their link with physiological mechanisms as a function of *** study provides an important perspective for designing forestry practices to enhance seedling health.

关键词： Ectomycorrhizae Fertilizer Oxidative stress Plant-fungi interaction

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Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model

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World Journal of Gastroenterology 2008年第39期14卷 6036-6043页

作者： Tatsuhiro Tsujimoto Hideto Kawaratani Toshiyuki Kitazawa Toshiko Hirai Hajime Ohishi Mitsuteru Kitade Hitoshi Yoshiji Masahito uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan Department of Endoscopy and Ultrasound Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan

AIM: To investigate Kupffer cell dynamics and phagocytic activity,using a rat nonalcoholic steatohepatitis (NASH) model. METHODS: Male F344 rats were fed either a control diet or a choline-deficient L-amino acid-defined (CDAA) diet,followed by contrast enhanced ultrasonography (CEUS) using Levovist. The uptake of latex beads by the Kupffer cells was determined by fluorescent microscopy. The status of the Kupffer cells was compared between the two groups,using the immunohistochemical staining technique. RESULTS: After 4 or more wk of the CDAA diet,CEUS examination revealed a decrease in the signal intensity,20 min after intravenous Levovist. Fluorescent microscopic examination showed that the uptake of latex beads by the Kupffer cells was reduced at week 1 and 2 in the study group,compared with the controls,with no further reduction after 3 wk. Immunohistochemical staining revealed no significant difference in the Kupffer cell counts between the control group and the CDAA group. CONCLUSION: CEUS examination using Levovist demonstrated reduced contrast effect and phagocytic activity in the liver parenchymal phase,although the Kupffer cell numbers were unchanged,indicating reduced phagocytic function of the Kupffer cells in the rat NASH model. We believe that CEUS examination using Levovist is a useful screening modality,which can detect NASH in fatty liver patients.

关键词： Nonalcoholic steatohepatitis Kupffer cells Contrast enhanced ultrasonography Levovist Ultrasound contrast agent Phagocytic activity

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aflak:Visual programming environment enabling end-to-end provenance management for the analysis of astronomical datasets

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Visual Informatics 2019年第1期3卷 1-8页

作者： Malik Olivier Boussejra Rikuo Uchiki Yuriko Takeshima Kazuya Matsubayashi Shunya Takekawa Makoto uemura Issei Fujishiro Keio University 3-14-1 HiyoshiKouhoku-kuYokohamaKanagawaJapan Tokyo University of Technology 1404-1 KatakuramachiHachi¯ojiTokyoJapan Kyoto University 3037-5 HonjoKamogataAsakuchiOkayamaJapan Nobeyama Radio Observatory National Astronomical Observatory of Japan462-2 NobeyamaMinamimakiMinamisaku-gunNaganoJapan Hiroshima University 1-3-2 KagamiyamaHigashi-HiroshimaHiroshimaJapan

This paper describes an extendable graphical framework,aflak,which provides a visualization and provenance management environment for the analysis of multi-spectral astronomical *** its node editor interface,aflak allows the astronomer to compose transforms on input datasets queryable from public astronomical data repositories,then to export the results of the analysis as Flexible Image Transport System(FITS)files,in a manner such that the full provenance of the output data be preserved and reviewable,and that the exported file be usable by other common astronomical analysis *** is the standard of data interchange in *** embedding aflak’s provenance data into FITS files,we both achieve interoperability with existing software and full reproducibility of the process by which astronomers make discoveries.

关键词： Astronomy Provenance Visual programming Visualization

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Diagnostic value of antigenemia assay for cytomegalovirus gastrointestinal disease in immunocompromised patients

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World Journal of Gastroenterology 2011年第9期17卷 1185-1191页

作者： Naoyoshi Nagata Masao Kobayakawa Takuro Shimbo Kazufusa Hoshimoto Tomoyuki Yada Takuji Gotoda Junichi Akiyama Shinichi Oka Naomi uemura Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Department of Clinical Research and Informatics International Clinical Research Center Research Institute National Center for Global Health and Medicine Department of Clinical Laboratory Pathological Division National Center for Global Health and Medicine Department of Gastroenterology and Hepatology National Center for Global Health and MedicineKohnodai Hospital Division of Aids Clinical Center National Center for Global Health and Medicine

AIM:To investigate the utility of the cytomegalovirus(CMV)antigenemia assay for the diagnosis of CMV gastrointestinal disease(GID). METHODS:One hundred and thirty immunocompromised patients were enrolled in this *** with a history of anti-CMV treatment and who had not undergone examination using the antigenemia assay were ***-GID was defined as the detection of large cells with intranuclear inclusions alone or associated with granular cytoplasmic inclusions by *** sections were stained with hematoxylin and eosin and immunohistochemically stained with *** evaluated the association between CMV-GID and patient characteristics(symptoms,underlying disease,medication,leukocyte counts,and antigenemia assay).All patients were checked with an human immunodeficiency virus(HIV)antibody test before endoscopic *** blood cell(WBC)counts were obtained from medical records within 1 wk of *** was defined as a total WBC count<5000 cells/mm 3 . For HIV patients,we also checked CD4+counts from medical records. RESULTS:A total of 99 patients were retrospectively selected for *** the immunocompromised patients,19 had malignant disease,18 had autoimmune disease,19 had disorders of biochemical homeostasis, three had undergone transplantation,and 45 had HIV infection.A total of 50 patients had received immunosuppressive *** patients had inflammatory bowel ***-five patients were diagnosed as having *** analysis indicated an association between HIV infection,leukopenia,and positive antigenemia and CMV-GID(P<0.05).Multivariate analysis using logistic regression revealed that HIV infection and positive antigenemia were the only independent factors related to CMV-GID(P<0.01).The sensitivity,specificity,positive predictive value,and negative predictive value of antigenemia for CMV-GID were 65.4%,93.6%, 91.9%,and 71.0%,*** a subgroup analy-sis,patients with leukopenia displayed

关键词： Cytomegalovirus Gastrointestinal disease Antigenemia assay Real-time polymerase chain reaction Human immunodeficiency virus infection

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Crystal Structure of cis-[PtCl2(PyCN)2] (PyCN = 4-Cyanopyridine) Showing Temperature Dependent Single-Crystal-to-Single-Crystal Transformation

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Advances in Materials Physics and Chemistry 2013年第1期3卷 36-40页

作者： Kazuhiro uemura Department of Chemistry Faculty of Engineering Gifu University Gifu Japan

Platinum mononuclear complex, cis-[PtCl2(PyCN)2] (1, PyCN = 4-cyanopyridine), has been synthesized and characterized by single-crystal X-ray analysis. Compound 1 crystallizes as yellow plates from the reaction of a mixture of K2PtCl4 and PyCN (=1:2) in H2O, that was left to stand at room temperature with the addition of Me2CO. Compound 1 forms the square-planar coordination geometry around the Pt atom coordinated to two Cl– ions and two pyridines of PyCN ligands in cis position. Single crystal of 1 shows the temperature dependent phase transition around 140 K, where the crystal space groups change from P21/c (high temperature) to (low temperature), which is caused by the stabilization of intermolecular interaction.

关键词： Platinum Complex X-Ray Analysis Crystal Structure Phase Transition

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Appropriate Heart Rate in a Patient with Repaired Tetralogy of Fallot

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Congenital Heart Disease 2022年第6期17卷 647-652页

作者： Aya Miyazaki Hideki uemura Yasuyo Takeuchi Junya Tomida Yasuo Ono Yoshifumi Fujimoto Norie Mitsushita Akio Ikai Department of Transitional Medicine Division of Congenital Heart DiseaseShizuoka General HospitalShizuokaJapan Congenital Heart Disease Center Nara Medical UniversityKashiharaJapan Department of Cardiology Shizuoka General HospitalShizuokaJapan Department of Clinical Engineering Shizuoka General HospitalShizuokaJapan

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart diseasewith unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinusnode dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changingthe pacemaker’s lower rate from 60 to 75 bpm, New York Heart Association classification improved from III to II,and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart ratecould be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioningLV.

关键词： Heart rate repaired tetralogy of Fallot failing right ventricle pacemaker lower rate the right-left ventricular interaction

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Recent advances in artificial intelligence for pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2021年第43期27卷 7480-7496页

作者： Hiromitsu Hayashi Norio uemura Kazuki Matsumura Liu Zhao Hiroki Sato Yuta Shiraishi Yo-ichi Yamashita Hideo Baba Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

Pancreatic ductal adenocarcinoma(PDAC)remains the most lethal type of *** 5-year survival rate for patients with early-stage diagnosis can be as high as 20%,suggesting that early diagnosis plays a pivotal role in the prognostic improvement of PDAC *** the medical field,the broad availability of biomedical data has led to the advent of the“big data”*** overcome this deadly disease,how to fully exploit big data is a new challenge in the era of precision *** intelligence(AI)is the ability of a machine to learn and display intelligence to solve *** can help to transform big data into clinically actionable insights more efficiently,reduce inevitable errors to improve diagnostic accuracy,and make real-time ***-based omics analyses will become the next alterative approach to overcome this poor-prognostic disease by discovering biomarkers for early detection,providing molecular/genomic subtyping,offering treatment guidance,and predicting recurrence and *** in AI may therefore improve PDAC survival outcomes in the near *** present review mainly focuses on recent advances of AI in PDAC for *** believe that breakthroughs will soon emerge to fight this deadly disease using AI-navigated precision medicine.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Artificial intelligence Machine learning Precision medicine

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Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1337-1343页

作者： Yuka Koga Noriaki Maeshige Hiroto Tabuchi Mikiko uemura Michiko Aoyama-Ishikawa Makoto Miyoshi Chikako Katakami Makoto Usami Division of Nutrition and Metabolism Department ofBiophysicsKobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Rehabilitation Science Kobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Ophthalmology Saneikai Tsukazaki HospitalWaku 68-1Aboshi-kuHimejiJapan Department of Nutrition Kobe University HospitalKobe University School of MedicineKusunoki-cho 7-5-2Chuo-kuKobeJapan

AIM：To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium ***：Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or phenylbutyrate for *** ofα-smooth muscle actin,collagen I,collagen III and matrix metalloproteinase-1m RNA was measured by quantitative real-time reverse transcription polymerase chain reaction,and acetylated histone was evaluated by Western ***：Butyrate inhibitedα-smooth muscle actin,type III collagen and matrix metalloproteinase-1 expressions,and phenylbutyrate inhibited types I and III collagen and matrix metalloproteinase-1 expressions without changing cell viability as well as both of these increased histone *** results suggested that butyrate and phenylbutyrate suppress fibrosis through a mechanism involving histone deacetylase ***：This indicates that butyrate or phenylbutyrate have antifibrogenic effects in human pterygium fibroblasts and could be novel types of prophylactic and/or therapeutic drugs for pterygium,especially phenylbutyrate,which does not have the unpleasant smell associated with butyrate.

关键词： butyrate phenylbutymte pterygium fibroblasts antifibrogenic effect

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Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma

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Cancer Biology & Medicine 2020年第3期17卷 555-568页

作者： Shaoping Shen Ling Chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi uemura Qiyan Wu Xinguang Yu Tianyi Liu Department of Neurosurgery Chinese PLA General HospitalBeijing 100853China Pediatric Center Chinese PLA General HospitalBeijing 100853China Key Laboratory of Cancer Center Chinese PLA General HospitalBeijing 100853China Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial CenterNational Cancer CenterKashiwa 277-8577Japan

In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are *** checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on *** date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some ***,glioblastoma(GBM)still lacks an effective ***,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to ***,the use of immune checkpoints in the treatment of GBM still faces many ***,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be ***,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be *** of these concerns require extensive basic research and clinical *** this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM.

关键词： Immunotherapy glioblastoma co-inhibitory immune checkpoint checkpoint inhibitors combination therapy

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Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants

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World Journal of Gastroenterology 2018年第14期24卷 1540-1549页

作者： Naohiro Yanagisawa Naoyoshi Nagata Kazuhiro Watanabe Tatsuhiro Iida Mariko Hamada Sakurako Kobayashi Takuro Shimbo Junichi Akiyama Naomi uemura Department of Gastroenterology and Hepatology National Center for Global Health and MedicineTokyo 162-8655Japan Ohta Nishinouchi Hospital Fukushima 963-8022Japan Department of Gastroenterology and Hepatology National Center for Global Health and MedicineKohnodai HospitalChiba 272-8516Japan

AIM To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants(DOAC).METHODS We collected data from 218 patients receiving oral anticoagulants(73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics(age-and sexmatched controls) who underwent polypectomy.(1) We evaluated post-polypectomy bleeding(PPB) risk in patients receiving warfarin or DOAC compared with controls;(2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge(HPB)(endoscopy guideline recommendation), continuing AC, and discontinuing AC without *** PPB rate was significantly higher in warfarin users and DOAC users compared with controls(13.7% and 13.7% vs 0.9%, P < 0.001), but was not significantly different between rivaroxaban(13.2%), dabigatran(11.1%), and apixaban(13.3%) users. Two thromboembolic events occurred in warfarin users, but none in DOAC users. Compared with the continuing anticoagulant group, the discontinuing anticoagulant with HPB group(guideline recommendation) had a higher PPB rate(10.8% vs 19.6%, P = 0.087). These findings were significantly evident in warfarin but not DOAC users. One thrombotic event occurred in the discontinuing anticoagulant with HPB group and the discontinuing anticoagulant without HPB group; none occurred in the continuing anticoagulant *** PPB risk was similar between patients taking warfarin and DOAC. Thromboembolism was observed in warfarin users only. The guideline recommendations for HPB should be re-considered.

关键词： High-risk endoscopic procedures Novel oral anticoagulants Endoscopic guideline validation Postprocedure gastrointestinal bleeding

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