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Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach

World Journal of Gastroenterology 2008年第20期14卷 3269-3272页

作者： Yasumitsu Hirano Takuo Hara Hiroshi Nozawa Kaeko Oyama Naohiro Ohta kenji omura Go Watanabe Hideki Niwa Department of General and Cardiothoracic Surgery Kanazawa University Graduate school of Medical Science 13-1 Takara-machi Kanazawa 920-8641 Japan Department of Surgery Kouseiren Takaoka Hospital5-10 Eiraku-chou Takaoka 933-8555 Japan Department of Pathology Kouseiren Takaoka Hospital 5-10 Eiraku-chou Takaoka 933-8555 Japan

We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin （B-hCG） and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous loci contained cells positive for synaptophysin, neuron-specific enolase （NSE）, and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.

关键词： Gastric cancer Choriocarcinoma Neuroen-docrine cell carcinoma Tubular adenocarcinoma Combined carcinoma

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Quantification of Thymidylate Synthase Gene Expression in human gastrointestinal carcinoma tissues using Competitive PCR

Quantification of Thymidylate Synthase Gene Expression in hu...

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2000全国肿瘤学术大会

作者： kenji omura Kazuyuki Kawakami Minoru Morishita Eiji Kanehira Yoshinori Ishida Kazuya Maeda Go Watanabe Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN Department of Surgery（1） Kanazawa University School of MedicineFaculty of Medicine13-1 TakaramachiKanazawa920-8641 JAPAN

＜正＞Thymidylate synthase（TS）is a target enzyme for fluoropyrimidine cytotoxic drugs,including 5-fluorouracil（5- FUra）.The cytotoxic effect of 5-FUra is generally shown by inhibition of TS by FdUMP,a metabolite of 5-FUra, forming an inactive ternary complex with ***,it is useful to determine the TS expression level in tumor tissue for predicting the effect of 5-FUra-based ***,current widely used assays of TS re-

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