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The Influence of Iron on Ammonium Ion Generation from Nitrate Ion in Liquid Phase

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Plasma Science and Technology 2005年第1期7卷 2673-2677页

作者： Youhei Kinoshita Naoki okumura Kazunori Takashima Shinji Katsura Akira Mizuno Department of Ecological Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 JapanDepartment of Ecological Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 JapanDepartment of Ecological Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 JapanDepartment of Ecological Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 JapanDepartment of Ecological Engineering Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 Japan

Flue gas cleaning in discharge plasma process has been studied intensivelyand we have tried to remove the NO_x and SO_2 using the wet-type plasma reactor. In this system, NOis oxidized to NO_2 and absorbed as NO_3^-, and SO_2 is absorbed as SO_3^(2-) and oxidized in theliquid to SO_4^(2-). But the concentration of NO_3^- was saturated and the absorption of NO_x andSO_2 was inhibited. Then, the reduction of NO_3^- in the liquid is required. We examined thereductive reaction of NO_3^- to NH_4^+ using discharge above the liquid surface then the pH value ofthe liquid was changed to alkaline slightly. When the Fe plate was used as a ground electrode inthe liquid, NH_4^+ was generated. Then, the relation between the generation of NH_4^+ and Fe ions(Fe^(2+) and Fe^(3+)) was studied. When Fe^(2+) was presented in the liquid, NH_4^+ was generatedand Fe^(2+) was oxidized to Fe^(3+). Fe^(2+) is required to generate NH_4^+ from NO_3^-. When NH_4^+was generated from NO_3^-, both the calculated pH value from NH_4^+ concentration and the measuredpH value indicated a similar value. From these results, the discharge above the liquid surface waseffective to convert NO_3^- to NH_4^+ and the reductive reaction leads to more absorption of NO_3^-.These results showed that the wet-type plasma reactor is effective for NO_x and SO_2 removalsystem.

关键词： discharge plasma reduction nitric acid ammonium

Gastrojejunostomy followed by induction chemotherapy for incurable gastric cancer with outlet obstruction

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World Journal of Gastroenterology 2010年第34期16卷 4367-4370页

作者： Yasuhiro okumura Manabu Ohashi Souya Nunobe Tomohiro Iwanaga Tatsuo Kanda Yoshiaki Iwasaki Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Gastrointestinal Surgery Tokyo University Hospital Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

A 72-year-old male gastric cancer patient with outlet obstruction underwent laparoscopic exploration. The examination disclosed intraperitoneal free cancer cells with no overt peritoneal, lymphatic, or hepatic metastasis. The patient underwent laparoscopy-assisted gastroje-junostomy (LAGJ) and started chemotherapy with S-1 plus cisplatin on postoperative day 13. Three course of the chemotherapy shrank the tumor markedly. Then, the patient underwent gastrectomy with a curative intent. Laparotomy revealed no intraperitoneal free cancer cells, and microscopically complete resection was achieved. The patient received S-1 chemotherapy as postoperative adjuvant treatment for 1 year, and is still alive with no evidence of peritoneal recurrence. LAGJ followed by S-1 plus cisplatin is one of the optional treatments that should be considered for patients with outlet obstruction as it may widen opportunities for potentially curative resection.

关键词： Gastric cancer Outlet obstruction CY1 Laparoscopy-assisted gastrojejunostomy S-1 plus cisplatin

Influence of pulsed electric field on enzymes, bacteria and volatile flavor compounds of unpasteurized sake

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Plasma Science and Technology 2018年第4期20卷 51-56页

作者： Takamasa okumura Taro YAEGASHI Takahiro FUJIWARA Katsuyuki TAKAHASHI Koichi TAKAKI Tomo KUDO Institute of Fluid Science Tohoku University Department of Systems Innovation Engineering Iwate University Washinoo Co. Ltd

A pulsed electric field(PEF) was applied to unpasteurized sake at constant temperatures, at which α-amylase was not inactivated. We adjusted the input energy to be identical for the temperatures by changing the number of PEF application, because the current significantly increased with the temperature, even the amplitude of the applied voltage was identical. As a result, the α-amylase was seemed to be inactivated by PEF application, not due to thermal *** glucoamylase was significantly inactivated by PEF. Moreover, the acid carboxypeptidase was inactivated by PEF at 4 °C but significantly activated at 25 °C. These results show that the sensitivity of enzyme to PEF application differs depending on the types of enzyme and treatment temperature. On the other hand, the colony number of bacteria was remarkably decreased, but the amount of the volatile flavor compounds was not decreased by PEF application.

关键词： pulsed electric field enzyme activity bacteria inactivation vulnerable molecules unpasteurized sake electroporation

Tegafur-uracil-induced rapid development of advanced hepatic fibrosis

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World Journal of Gastroenterology 2017年第31期23卷 5823-5828页

作者： shuya honda koji sawada takumu hasebe shunsuke nakajima mikihiro fujiya toshikatsu okumura division of gastroenterology and hematology/oncology department of medicine asahikawa medical university

Tegafur-uracil has been reported to have only minor adverse effects and is associated with liver injury in 1.79% of Japanese patients. The development of tegafur-uracil-induced hepatic fibrosis with portal hypertension is rare. Here, we report a case of a 74-year-old woman with rapidly developing tegafururacil-induced hepatic fibrosis. The patient had no history of liver disease and had been treated with tegafur-uracil for 8 mo after breast cancer surgery. The patient was admitted to our hospital for abdominal distension and leg edema associated with liver dysfunction. Computed tomography imaging revealed massive ascites and splenomegaly, and a non-invasive assessment of liver fibrosis indicated advanced fibrosis. The histopathological findings revealed periportal fibrosis and bridging fibrosis with septation. The massive ascites resolved after discontinuing tegafururacil. These findings suggest that advanced hepatic fibrosis can develop from a relatively short-term administration of tegafur-uracil and that non-invasive assessment is useful for predicting hepatic fibrosis.

关键词： Tegafur-uracil Drug-induced liver injury Hepatic fibrosis Portal hypertension Non-invasive assessment

Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy

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Case Reports in Clinical Medicine 2021年第4期10卷 108-116页

作者： kenji Niwa Kentaro Nagata Takefumi Nakagami Ryuichiro Shimaoka Kentaro Niwa Motoki Takenaka Takuji Tanaka Nobuo okumura Department of Obstetrics & Gynecology Gujo City Hospital Gujo Japan Section of Laboratory Medicine and Obstetrics & Gynecology Gujo City Hospital Gujo Japan Department of Obstetrics & Gynecology Gifu University School of Medicine Gifu Japan Department of Obstetrics & Gynecology University of Fukui Hospital Fukui Prefecture Japan Department of Diagnostic Pathology & Research Center of Diagnostic Pathology Gifu Municipal Hospital Gifu Japan Department of Clinical Laboratory Sciences School of Health Sciences Shinshu University Matsumoto Japan

Congenital dysfibrinogenemia (CD) is a qualitative congenital fibrinogen (Fbg) disorder characterized by normal antigen levels of dysfunctional Fbg. A 41-year-old Japanese woman visited the emergent room of our hospital due to acute and severe abdominal pain. Catheterization of the full bladder released her abdominal pain. Magnetic resonance imaging showed a huge pelvic mass, suggesting an intra-mural giant myoma. Before the removal operation of myoma, screening tests showed no abnormalities, including prothrombin time and activated partial thromboplastin time. However, Fbg level was not determined. The patient wanted to receive early surgical treatment, and an abdominal hysterectomy was performed as usual and the intra-operative blood loss was 100 g (ml). However, we found subcutaneous and pelvic hematomas, although active bleeding was not recognized on an emergent computed tomography examination. At that time, we noticed a low level of plasma Fbg (47 mg/dl). We performed a re-laparotomy to remove hematomas. All ligated blood vessels were re-ligated, and oozing points were vaporized. Around the re-operation, six units of fresh frozen plasma and twelve units of red blood cell suspension were transfused. The clinical course after the 2nd operation was uneventful except for the low level of Fbg. An additional study showed that the value of the Fbg activity and antigen was dissociated, and the patient was diagnosed CD with γ275 Arg to His (CGC to CAC) mutation.

关键词： Dysfibrinogenemia Asymptomatic Major Bleeding Event γ275 Arg to His Mutation

Nanotechnology and Nanomedicine: A Promising Avenue for Lung Cancer Diagnosis and Therapy

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Engineering 2021年第11期7卷 1577-1585页

作者： Wei Yin Feng Pan Junjie Zhu Junwu Xu Diego Gonzalez-Rivas Meinoshin okumura Zhiyong Tang Yang Yang Key Laboratory of Oral Biomedical Engineering(Wuhan University) Ministry of EducationHospital of StomatologySchool of StomatologyWuhan UniversityWuhan 430079China Department of Biomedical Data Science Geisel School of MedicineDartmouth CollegeHanoverNH 03756USA Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Tus-Medical Health Technology Investment(Jiaxing)Co. Ltd.Jiaxing 314033China Minimally Invasive Thoracic Surgery Unit(UCTMI) Hospital San RafaelCoruña 15006Spain Osaka Toneyama Medical Center Osaka 560-8552Japan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190China

Lung cancer is a leading cause of cancer-related death worldwide,with a very poor overall five-year survival *** intrinsic limitations associated with the conventional diagnosis and therapeutic strategies used for lung cancer have motivated the development of nanotechnology and nanomedicine approaches,in order to improve early diagnosis rate and develop more effective and safer therapeutic options for lung *** nanomedicines aim to individualize drug delivery,diagnosis,and therapy by tailoring them to each patient’s unique physiology and pathological features—on both the genomic and proteomic levels—and have attracted widespread attention in this *** the successful application of nanomedicine techniques in lung cancer research,the clinical translation of nanomedicine approaches remains challenging due to the limited understanding of the interactions that occur between nanotechnology and biology,and the challenges posed by the toxicology,pharmacology,immunology,and largescale manufacturing of *** this review,we highlight the progress and opportunities associated with nanomedicine use for lung cancer treatment and discuss the prospects of this field,together with the challenges associated with clinical translation.

关键词： Nanomedicine Lung cancer Diagnosis Therapy

Rare case of fecal impaction caused by a fecalith originating in a large colonic diverticulum: A case report

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World Journal of Clinical Cases 2021年第2期9卷 416-421页

作者： Hiroki Tanabe Kazuyuki Tanaka Mitsuru Goto Tomonobu Sato Keisuke Sato Mikihiro Fujiya Toshikatsu okumura Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan Department of Pathology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Fecal impaction is defined as a large mass of compacted feces in the colon and has the potential to induce a serious medical condition in elderly *** impaction is generally preventable,and early recognition of the typical radiological findings is important for making an early *** factors that lead to fecal impaction are usually similar to those causing *** cases with fecal impaction associated with a diverticulum have been *** SUMMARY We present the case of a 62-year-old woman who suffered from abdominal pain and vomiting,had a medical history of repeated acute abdomen and was diagnosed with fecal impaction in the descending colon based on X-ray and computed tomography(CT)*** examination by gastrografinenhanced colonography following colonoscopy and CT colonography,the fecalith was suspected to have been produced at the site of a large diverticulum in the transverse *** fecalith was surgically resected,and a histological diagnosis of pseudodiverticulum was *** was no recurrence during 33 mo of *** This case highlights the importance of accurate identification and treatment of a fecal *** case indicated that the endoscopic evacuation and subsequent colonography were effective for identifying a diverticulum that might have caused fecal impaction.A fecal impaction was associated with the ***,the planned diverticulectomy was *** emergency medical treatment and maintenance treatments should be selected in such cases to prevent recurrence.

关键词： Colonic ileus Constipation Acute abdomen Computed tomography colonography Case report Colonoscopy

Laparoscopic right hemicolectomy for ascending colon cancer with persistent mesocolon

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World Journal of Gastroenterology 2014年第18期20卷 5557-5560页

作者： Atsushi Tsuruta Akimasa Kawai Yasuo Oka Hideo okumura Hideo Matsumoto Toshihiro Hirai Masafumi Nakamura Department of Digestive Surgery Kawasaki Medical SchoolOkayama 701-0192Japan

Persistent ascending or descending mesocolon is an embryological anomaly that occurs during the final process of intestinal development in ***,the primitive dorsal mesocolon fails to fuse with the parietal peritoneum in the fifth month of ***,we describe a case of ascending colon cancer with persistent ascending and descending mesocolon treated by laparoscopic right *** computed tomography imaging of the abdomen demonstrated that the descending colon shifted at the midline of the abdomen and the sigmoid colon was located under the ascending *** detailed preoperative imaging examination revealed malpositioning of the large intestine and aided in the procedural *** persistent mesocolon may result in the formation of abnormal adhesions,an accurate preoperative diagnosis is *** propose that it is important to consider this anomaly when making the preoperative imaging diagnosis to ensure a safe operation.

关键词： Laparoscopic surgery Colon cancer Persistent descending mesocolon Persistent ascending mesocolon Mobile cecum

Development of beta ray scanner for imaging foliar uptake of radiocesium

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Radiation Detection Technology and Methods 2017年第2期1卷 76-80页

作者： Fuminobu Sato Tomonori okumura Yushi Kato Isao Murata Toshiyuki Iida Graduate School of Engineering Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Large quantities of radionuclides were released from the Fukushima Daiichi Nuclear Power Plant(FDNPP)into the atmosphere,which then contaminated the soil and vegetation surrounding the *** research on radiocesium contamination of agricultural products and wild plants is ***,we developed a simple beta ray scanner to obtain radiographs of the transport and foliar uptake of *** simple beta ray scanner comprised a beta ray detector,a motorized sample stage,a shielding box,and a personal *** rays released from radiocesium were detected effectively using a plastic scintillator plate coupled to multipixel photon counter *** spatial resolving power was approximately 6 mm×4 mm(FWHM).In a preliminary experiment,a drop of radiocesium solution was placed on the upper surface of a radish ***-lapse images of radiocesium in the leaf were obtained by the beta ray *** of isotope transport in the leaf were successfully obtained with the beta ray *** beta ray scanner will be used in our future research on the mechanism of the foliar uptake of radiocesium.

关键词： Beta ray scanner Multipixel photon counter Foliar uptake of radiocesium Artificial climate germination box