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Acute kidney injury and the compensation of kidney function after nephrectomy in living donation

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World Journal of Transplantation 2022年第8期12卷 223-230页

作者： kenji okumura Holly Grace Hiroshi Sogawa Shigeyoshi Yamanaga Department of Surgery Westchester Medical Center/New York Medical CollegeValhallaNY 10595United States Department of Surgery New York Medical CollegeValhallaNY 10595United States Department of Surgery Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan

Acute kidney injury(AKI)incidence is growing rapidly,and AKI is one of the predictors of inpatient *** nephrectomy,all the patients have decreased kidney function with AKI and recover from ***,the characteristic and behavior of AKI is different from usual AKI and compensatory kidney function has been well known in the postoperative setting,especially in living *** this review,we have focused on the compensation of kidney function after nephrectomy in living *** discuss factors that have been identified as being associated with kidney recovery in donors including age,sex,body mass index,remnant kidney volume,estimated glomerular filtration rate,and various comorbidities.

关键词： Acute kidney injury Kidney transplant donor Compensation Kidney function

Inferior outcomes of liver transplantation for hepatocellular carcinoma during early-COVID-19 pandemic in the United States

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World Journal of Hepatology 2023年第4期15卷 554-563页

作者： Inkyu S Lee kenji okumura Ryosuke Misawa Hiroshi Sogawa Gregory Veillette Devon John Thomas Diflo Seigo Nishida Abhay Dhand Department of Surgery Westchester Medical CenterValhallaNY 10595United States Department of Medicine Westchester Medical CenterValhallaNY 10595United States

BACKGROUND Early in the coronavirus disease 2019(COVID-19)pandemic,there was a significant impact on routine medical care in the United States,including in fields of transplantation and *** To analyze the impact and outcomes of early COVID-19 pandemic on liver transplantation(LT)for hepatocellular carcinoma(HCC)in the United *** WHO declared COVID-19 as a pandemic on March 11,*** retrospectively analyzed data from the United Network for Organ Sharing(UNOS)database regarding adult LT with confirmed HCC on explant in 2019 and *** defined pre-COVID period from March 11 to September 11,2019,and early-COVID period as from March 11 to September 11,*** Overall,23.5%fewer LT for HCC were performed during the COVID period(518 vs 675,P<0.05).This decrease was most pronounced in the months of March-April 2020 with a rebound in numbers seen from May-July *** LT recipients for HCC,concurrent diagnosis of non-alcoholic steatohepatitis significantly increased(23 vs 16%)and alcoholic liver disease(ALD)significantly decreased(18 vs 22%)during the COVID *** age,gender,BMI,and MELD score were statistically similar between two groups,while waiting list time decreased during the COVID period(279 days vs 300 days,P=0.041).Among pathological characteristics of HCC,vascular invasion was more prominent during COVID period(P<0.01),while other features were the *** the donor age and other characteristics remained same,the distance between donor and recipient hospitals was significantly increased(P<0.01)and donor risk index was significantly higher(1.68 vs 1.59,P<0.01)during COVID *** outcomes,90-day overall and graft survival were the same,but 180-day overall and graft were significantly inferior during COVID period(94.7 vs 97.0%,P=0.048).On multivariable Coxhazard regression analysis,COVID period emerged as a significant risk factor of post-transplant mortality(Hazard ratio 1.85;95%CI:1.28-2.68,P=0.001).CONCLUSION Durin

关键词： Liver transplantation Hepatocellular carcinoma COVID-19 Mortality Graft failure United Network for Organ Sharing database

Trends and outcomes of liver transplantation among older recipients in the United States

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World Journal of Transplantation 2022年第8期12卷 259-267页

作者： kenji okumura Joon Sub Lee Abhay Dhand Hiroshi Sogawa Gregory Veillette Devon John Ryosuke Misawa Roxana Bodin David C Wolf Thomas Diflo Seigo Nishida Department of Surgery Westchester Medical Center/New York Medical CollegeValhallaNY 10595United States

BACKGROUND The average age of recipients and donors of liver transplantation(LT)is *** there has been a change in the indications for LT over the years,data regarding the trends and outcomes of LT in the older population is *** To assess the clinical characteristics,age-related trends,and outcomes of LT among the older population in the United *** We analyzed data from the United Network for Organ Sharing database between *** sample was split into younger group(18-64 years old)and older group(≥65 years old).RESULTS Between 1987-2019,155758 LT were performed in the United *** this period there was a rise in median age of the recipients and percentage of LT recipients who were older than 65 years increased(P<0.05)with the highest incidence of LT among older population seen in 2019(1920,23%).Common primary etiologies of liver disease leading to LT in older patients when compared to the younger group,were non-alcoholic steatohepatitis(16.4%vs 5.9%),hepatocellular carcinoma(14.9%vs 6.9%),acute liver failure(2.5%vs 5.2%),hepatitis C cirrhosis(HCV)(19.2%vs 25.6%)and acute alcoholic hepatitis(0.13%vs 0.35%).In older recipient group female sex and Asian race were higher,while model for end-stage liver disease(MELD)score and rates of preoperative mechanical ventilation were lower(P<0.01).Median age of donor,female sex,body mass index(BMI),donor HCV positive status,and donor risk index(DRI)were significantly higher in older group(P<0.01).In univariable analysis,there was no difference in post-transplant length of hospitalization,one-year,three-year and five-year graft survivals between the two *** multivariable Cox-Hazard regression analysis,older group had an increased risk of graft failure during the five-year post-transplant period(hazard ratio:1.27,P<0.001).Other risk factors for graft failure among recipients were male sex,African American race,re-transplantation,presence of diabetes,mechanical ventilation at th

关键词： Liver transplant Elderly Outcomes Hepatocellular carcinoma Nonalcohol steatohepatitis

Preventing pancreatic fistula after distal pancreatectomy: An invagination method

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World Journal of Gastroenterology 2017年第8期23卷 1507-1512页

作者： Nagato Katsura Yasuhiro Kawai Takashi Gomi kenji okumura Takahiko Hoashi Seijun Fukuda Katsushi Takebayashi kenji Shimizu Masugi Satoh Department of Surgery Misugikai Otokoyama Hospital Department of Surgery Misugikai Satoh HospitalYobuhigashimachi Hirakata

Following an increase in the use of the GIA stapler for treating a pancreatic stump, more techniques to prevent postoperative pancreatic juice leakage have been required. We describe one successful case using our new technique of invaginating the cut end of the pancreas into the stomach to prevent a pancrea-tic fistula(PF) from occurring. A 50-year-old woman with pancreatic cancer in the tail of the pancreas underwent distal pancreatectomy, causing a grade A PF. We resected the distal pancreas without additional reinforcement to invaginate the stump into the gastric posterior wall with single layer anastomosis using a 3-0 absorbable suture. The drain tubes were removed on the third postoperative day. Although a grade A PF was noted, the patient was discharged on foot on the eleventh postoperative day. Our technique may be a suitable method for patients with a pancreatic body and tail tumor.

关键词：淀粉酶 Pancreatectomy 胰腺的管胰液瘤

An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient:A case report

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World Journal of Gastroenterology 2012年第19期18卷 2434-2437页

作者： kenji okumura Masahiko Ikebe Tatsuro Shimokama Morishige Takeshita Nao Kinjo Keishi Sugimachi Hidefumi Higashi Department of Surgery Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology Nippon Steel Yawata Memorial HospitalKitakyushu 805-8508Japan Department of Pathology School of MedicineFukuoka UniversityFukuoka 814-0180Japan

Enteropathy-associated T-cell lymphoma(EATL) is a rare peripheral T-cell lymphoma classified into 2 types,with or without celiac disease,based on *** 2 EATL is less commonly associated with celiac disease,in which cells are characterized by being monomorphic and small-to *** are characterized by CD8 and CD56 expression and c-MYC oncogene locus *** present an atypical case of type 2 EATL in the jejunum,with human T-lymphotropic virus-1 that was CD4-CD8+ CD56-CD30-CD25-TIA-1+ and granzyme B+ on immunohistological *** also displayed translocation of chromosome 8p24(c-MYC),as determined by fluorescent in situ *** spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal *** lymphoma may be derived from intraepithelial CD8+ T cells,similar to celiac disease.

关键词： C-MYC 易位染色体 T细胞淋巴瘤病例报告空肠 C基因免疫组织化学染色

Gallbladder cancer:Historical treatment and new management options

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1317-1335页

作者： kenji okumura Shekhar Gogna Mahir Gachabayov Daniel Moritz Felsenreich Matthew McGuirk AramRojas Luis Quintero Ramanathan Seshadri Katie Gu Xiang Da Dong Department of Surgery Westchester Medical CenterValhallaNY 10595United States Division of General Surgery Department of SurgeryVienna Medical UniversityVienna 1090Austria Department of Surgery New York Medical CollegeValhallaNY 10595United States Division of Surgical Oncology Nuvance HealthNorwalkCT 06856United States

Gallbladder cancer is a rare,aggressive malignancy that has a poor overall *** treatment consists of early detection and surgical *** the wide spread treatment of gallbladder disease with minimally invasive techniques,the rate of incidental gallbladder cancer has seen an equitable rise along with stage migration towards earlier *** the treatment remains mostly surgical,newer modalities such as regional therapy as well as directed therapy based on molecular medicine has led to improved outcomes in patients with advanced *** aim to summarize the management of gallbladder cancer along with the newer developments in this formidable disease process.

关键词： Gallbladder cancer Radical cholecystectomy Cholangiocarcinoma Epide�miology Gallbladder disease

Emphysematous cholecystitis associated with constipation: A case report

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Case Reports in Clinical Medicine 2013年第1期2卷 9-10页

作者： kenji okumura Alan T. Lefor Takafumi Maeda Yoshiharu Takenaka Toshiyuki Suganuma Department of Surgery Tokyo-Bay Urayasu Ichikawa Medical Center Chiba Japan Department of Surgery Uwamachi General Hospital Yokosuka Japan

Constipation is one of the most common complaints in the general population, with a wide variety of causes. We present the case of a man with a four-week history of constipation who developed signs and symptoms of acute cholecystitis. Computed tomography scan of the abdomen revealed emphysematous cholecystitis and pericholecystic inflammatory changes extending to the adjacent colon. Emergent cholecystectomy was performed, and bowel function improved after surgery. Chronic inflammation of the gallbladder might be associated with constipation in this patient.

关键词： Constipation Emphysematous Cholecystitis

应用体细胞胚进行苜蓿无性系繁殖和保存的研究

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国外畜牧学（草原与牧草） 1997年第3期 44-45页

作者： kenji okumura 李威

研究应用组织培养技术产生体细胞胚,以达到苜蓿(Medicago sativa L.)无性系繁殖和保存的目的。首先,为建立更有效的培养方法并确定具有较高再生力外植体源,改进培养系统。第二,分析体细胞胚再生和生产性能间的关系,以获得具有较高生产... 详细信息

研究应用组织培养技术产生体细胞胚,以达到苜蓿(Medicago sativa L.)无性系繁殖和保存的目的。首先,为建立更有效的培养方法并确定具有较高再生力外植体源,改进培养系统。第二,分析体细胞胚再生和生产性能间的关系,以获得具有较高生产性能的体细胞胚植株。第三,将体细胞无性系的变异效果作为重要性状来研究。第四,用脱水体细胞胚进行无性系保存。最后,就无性系的繁殖和保存在苜蓿育种中的应用进行探讨。

关键词：苜蓿无性系繁殖组织培养体细胞胚

Unilateral branch retinal artery occlusion in association with COVID-19:a case report

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 777-782页

作者： Kunihiko Hirosawa Takenori Inomata Jaemyoung Sung Yuki Morooka Tianxiang Huang Yasutsugu Akasaki Yuichi okumura Ken Nagino Kaho Omori Shintaro Nakao Department of Ophthalmology Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Telemedicine and Mobile Health Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan AI Incubation Farm Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology Tulane University School of MedicineNew OrleansLA 70112USA

Dear Editor,I am Kunihiko Hirosawa of the Department of Ophthalmology at Juntendo University Hospital.I am writing to present a case of concomitant Coronavirus Disease 2019(COVID-19)with branch retinal artery occlusion(BRAO).BRAO presents as a sudden,painless loss of vision on the afflicted side and is most often focal in nature[1].

关键词： branch COV occlusion