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辐射防护 2020年第6期40卷 540-544页

作者： Sho Imai kenichi watanabe Astushi Yamazaki Sachiko Yoshihashi Akira Uritani Seiji Tasaki Setsuo Satoh Nagoya University Furo-choChikusa-kuNagoya464-8603Japan Kyoto University YoshidahonmachiSakyo-kuKyoto606-8501Japan High Energy Accelerator Research Organization Oh-hoTsukuba305-0801Japan

We fabricated the spheroid neutron diffractometer with 79 neutron detector rings using the transparent rubber sheet type Eu:LiCaAlF6 scintillators and wavelength-shifting *** confirmed that the fabricated detector shows a clear neutron peak and can discriminate neutron and gamma-ray events in a signal pulse *** additionally checked that the fabricated diffractometer can detect a neutron diffraction peak of ferrite powder at Kyoto University Accelerator-driven Neutron ***,it can be expected that crystal structural analysis will be possible even by small accelerator neutron sources.

关键词： TRUST Eu:LiCAF scintillator neutron diffractometer neutron detector time-of-flight KUANS LiTA12

Evaluation of sorafenib for hepatocellular carcinoma by contrast-enhanced ultrasonography:A pilot study

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World Journal of Gastroenterology 2012年第40期18卷 5753-5758页

作者： Kazue Shiozawa Manabu watanabe Yoshinori Kikuchi Takahide Kudo kenichi Maruyama Yasukiyo Sumino Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Medical CenterOmori HospitalTokyo 143-8541Japan Department of Clinical Functional Physiology Toho University Medical CenterOmori HospitalTokyo 143-8541Japan

AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:Fourteen advanced HCC patients who received sorafenib 400/800 mg/d for at least 4 wk and were followed up by CEUS were enrolled in this *** was performed before treatment and 2 and 4 wk after treatment,and images of the target lesion in the arterial phase were recorded for each *** images were analyzed by *** mapping(CM) images obtained by AtPI were compared before and after the *** these CM images,the mean arrival time of the contrast agent in the region of interest from the starting point [mean time(MT)] was *** each patient,differences between MT before and MT 2 and 4 wk after the treatment were compared with responses evaluated 4-8 wk after the treatment by dynamic computed tomography(CT),and statistical analysis was *** response evaluation criteria in solid tumors was used for the response ***:In CM images both 2 and 4 wk after the treatment,delays in the arrival time of the contrast agent were noted in 8 of the 14 *** the other 6 patients,no color changes were observed in the tumor,or red and/or yellow increase,suggesting a decrease in blood flow velocity between images 2 and 4 wk after the treatment and those before the *** CT could be performed 4-8 wk after the treatment in 13 of the 14 *** differences in the MT were 1.13 s and 1.015 s,2 and 4 wk after the treatment,respectively,in the 8 patients who showed stable disease(SD)/partial response(PR) on dynamic *** differences in the MT were-0.39 s and-0.95 s,2 and 4 wk after the treatment,respectively,in the 5 patients who showed progressive disease(PD).Differences in the median MT between SD/PR and PD groups were significant 2 and 4 wk after the treatment with P = 0.019 and P = 0.028,resp

关键词： Sorafenib Sonazoid Contrast-enhanced ul-trasonography Hepatocellular carcinoma Therapeutic response

Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance

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World Journal of Gastroenterology 2012年第35期18卷 4811-4822页

作者： Tetsuo Arakawa Toshio watanabe Tetsuya Tanigawa Kazunari Tominaga Yasuhiro Fujiwara kenichi Morimoto Department of Gastroenterology Osaka City University Graduate School of Medicine

In this paper, we review the concept of quality of ulcer healing （QOUH） in the gastrointestinal tract and its role in the ulcer recurrence. In the past, peptic ulcer disease （PUD） has been a chronic disease with a cycle of repeated healing/remission and recurrence. The main etiological factor of PUD is Helicobacter pylori （H. pylorl~, which is also the cause of ulcer recur- rence. However, H. pylori-negative ulcers are pres- ent in 12%-20% of patients; they also recur and are on occasion intractable. QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated. Within the scars of healed ulcers, regenerated tissue is immature and with distorted architecture, suggesting poor QOUH. The abnormalities in mucosal regeneration can be the basis for ulcer recurrence. Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence. Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macro- phages, which in turn produce increased amounts of cytokines and chemokines, which attract neutrophils to the regenerated area. Neutrophils release proteolytic enzymes that destroy the tissue, resulting in ulcer re- currence. Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a defi- ciency and/or an imbalance of endogenous growth fac- tors. Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar. In addition to PUD, the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn＇s disease and ulcer- ative colitis.

关键词： Quality of ulcer healing Peptic ulcer dis-ease Recurrence Prostaglandin Cytokines Growthfactors

Transcriptional regulation of human polo-like kinases and early mitotic inhibitors

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Journal of Genetics and Genomics 2008年第4期35卷 215-224页

作者： Moe Tategu Hiroki Nakagawa Kaori Sasaki Rieko Yamauchi Sota Sekimachi Yuka Suita Naoko watanabe kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture 1-1-1 Higashimita Tama-ku Kawasaki Kanagawa 214-8571 Japan

Human polo-like kinases （PLK1-PLK4） have been implicated in mitotic regulation and carcinogenesis. PLK1 phosphorylates early mitotic inhibitor 1 （Emil） to ensure mitosis entry, whereas Emi2 plays a key role during the meiotic cell cycle. Transcription factor E2F is primarily considered to regulate the G1/S transition of the cell cycle but its involvement in the regulation of mitosis has also been recently suggested. A gap still exists between the molecular basis of E2F and mitotic regulation. The present study was designed to characterize the transcriptional regulation of human PLK and Emi genes. Adenoviral overexpression of E2F1 increased PLK1 and PLK3 mRNA levels in A549 cells. A reporter gene assay revealed that the putative promoter regions of PLK1, PLK3, and PLK4 genes were responsive to activators E2F, E2F1-E2F3. We further characterized the putative promoter regions of Emil and Emi2 genes, and these could be regulated by activators E2F and E2F1-E2F4, respectively. Finally, PLK1-PLK4, Emil, and Emi2 mRNA expression levels in human adult, fetal tissues, and several cell lines indicated that each gene has a unique expression pattern but is uniquely expressed in common tissues and cells such as the testes and thymus. Collectively, these results indicate that E2F can integrate G1/S and G2/M to oscillate the cell cycle by regulating mitotic genes PLK and Emi, leading to determination of the cell fate.

关键词： polo-like kinase early mitotic inhibitor cell cycle E2F promoter gene regulation

Retroperitoneal cavernous hemangioma resected by a pylorus preserving pancreaticoduodenectomy

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World Journal of Gastroenterology 2013年第28期19卷 4624-4629页

作者： Marie Hanaoka Masaji Hashimoto Kazunari Sasaki Masamichi Matsuda Takeshi Fujii kenichi Ohashi Goro watanabe Department of Digestive Surgery Toranomon Hospital Tokyo 105-8470 Japan Department of Pathology Toranomon Hospital Tokyo 105-8470 Japan Department of Pathology Yokohama City University Graduate School of Medicine Kanagawa 236-0004 Japan

A retroperitoneal hemangioma is a rare disease. We report on the diagnosis and treatment of a retroperitoneal hemangioma which had uncommonly invaded into both the pancreas and duodenum, thus requiring a pylorus preserving pancreaticoduodenectomy (PpPD). A 36-year-old man presented to our hospital with abdominal pain. An enhanced computed tomography scan without contrast enhancement revealed a 12 cm × 9 cm mass between the pancreas head and right kidney. Given the high rate of malignancy associated with retroperitoneal tumors, surgical resection was performed. Intraoperatively, the tumor was inseparable from both the duodenum and pancreas and PpPD was performed due to the invasive behavior. Although malignancy was suspected, pathological diagnosis identified the tumor as a retroperitoneal cavernous hemangioma for which surgical resection was the proper diagnostic and therapeutic procedure. Reteoperitoneal cavernous hemangioma is unique in that it is typically separated from the surrounding organs. However, clinicians need to be aware of the possibility of a case, such as this, which has invaded into the surrounding organs despite its benign etiology. From this case, we recommend that combined resection of inseparable organs should be performed if the mass has invaded into other tissues due to the hazardous nature of local recurrence. In summary, this report is the first to describe a case of retroperitoneal hemangioma that had uniquely invaded into surrounding organs and was treated with PpPD.

关键词： Retroperitoneal tumor Retroperitoneal cavernous hemangioma Cavernous hemangioma Pancreaticoduodenectomy Pylorus preserving pancreaticoduodenectomy

Chenguodaite (Ag_9FeTe_2S_4):a new tellurosulfide mineral from the gold district of East Shandong Peninsula,China

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Chinese Science Bulletin 2008年第22期53卷 3567-3573页

作者： GU XiangPing Makoto watanabe XIE XianDe PENG ShengLin Yoshihiro NAKAMUTA Makio OHKAWA kenichi HOSHINO Kazumasa OHSUMI Yasuhiro SHIBATA Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Department of Earth & Planetary Sciences Hiroshima University Higashi Hiroshima City Hiroshima 739-8526 Japan Department of Earth Sciences and Environmental Engineering Central South University Changsha 410083 China The Kyushu University Museum Kyushu University Kakozaki Fukuoka 812-8581 Japan Photon Factory National Laboratory for High Energy Physics (KEK) Oho 1-1 Tsukuba Ibaraki 305 Japan

Chenguodaite, approved by IMA-CNMMN (2004-042a), was discovered in the Bunan quartz vein-type gold deposit in the gold district of East Shandong Peninsula. The mineral occurs in high grade Au-Ag-Cu ores, coexisting with galena, chalcopyrite, hessite, electrum, unnamed Ag6TeS2 and Ag16FeBiTe3S8, enclosed and replaced by native silver and acanthite. In the reflected light microscope, the mineral has light gray color, indistinguishable anistropism and hardness around 2―3. The color indices of chenguodaite relative to ICE C illuminator are: x=0.3027, y=0.3076, Y=25.78%, λd=474 nm, Pe=3.68%, similar to those of canfieldite. The average chemical composition from 16 microprobe analyses is Ag8.97Fe1.00Te1.99S4.04, idealized to Ag9FeTe2S4. The polycrystalline X-ray diffraction of chenguodaite by Gandolfi camera and synchrotron oscillation photography results in 67 reflections with the 12 strongest being (relative intensity in bracket): 6.742(69), 6.416(39), 5.951(33), 3.265(100), 2.981(24), 2.649(22), 2.25(24), 2.188(71), 2.142(22), 2.123(31), 2.044(23), 1.949(33), which are indexed to a primitive orthorhombic cell with a=12.769 (2) , b= 14.814(2), c= 16.233 (1) , V= 3070.63, Z = 9, Dcal.=6.85 g/cm3. The name is for the late Prof. Chen Guoda, a famous Chinese geologist and the founder of Diwa-Geodepression theory of tectonics.

关键词： Ag9FeTe2S4 新矿石硫化亚碲山东东部

A New Evaluation Method for Antibiotic-Resistant Bacterial Groups in Environment

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Advances in Microbiology 2016年第3期6卷 133-151页

作者： Katsuji watanabe Naoto Horinishi Kunimasa Matsumoto Akihiro Tanaka kenichi Yakushido Department of Life Environment and Materials Science Fukuoka Institute of technology Fukuoka Japan National Agricultural Research Center for Kyushu-Okinawa Region National Agriculture and Food Research Organization Kumamoto Japan National Agricultural Research Center National Agriculture and Food Research Organization Tsukuba Japan

In the present manuscript it was presented whether spreading of antibiotic resistant bacterial groups in environment could be monitored by our newly developed method by enumerating antibiotic resistant bacterial groups in various biological wastes and composts. Although the numbers were not so high, diverse kinds of colistin resistant bacteria (25 mg·L-1) were included in row cattle feces (1.78 × 104 MPN g-1) and cattle feces manure (>3.84 × 104 MPN g-1). Compost originated from leftover food (>44.8 × 104 MPN g-1) and shochu lee (>320 × 104 MPN g-1) included higher numbers of chlortetracycline resistant Pseudomonas sp., (25 mg·L-1), and row cattle feces included higher numbers of chlortetracycline resistant Enterobacteriacea (15.7 × 104 MPN g-1), which mostly consisted from Pantoea sp. or Xenorhobdus doucetiae. Numbers of multi drug resistant bacteria, resistant to 25 mg·L-1 of ciprofloxacin, streptomycin, chloramphenicol, and ampicillin, were the highest in row cattle feces (>143.6 × 104 MPN g-1), followed by cattle feces manure (4.19 × 104 MPN g-1), and shochu lee (0.36 × 104 MPN g-1), which included diverse kinds of bacterial group. The present results indicated that higher numbers of multi drug resistant bacteria were typically found in row cattle feces, and the method was found suitable to enumerate and identify them. These results suggested that the method might become their environmental risk evaluation method.

关键词： Colistin Resistant Bacteria Chlortetracycline Resistant Bacteria Multi Drug Resistant Bacteria Multiple Enzyme Restriction Fragment Length Polymorphism Analysis The Most Probable Number Method Microchip Electrophoresis System

Overview of genetic and epigenetic alterations in the pathogenesis of esophagogastric junctional adenocarcinoma and esophageal adenocarcinoma: recent fi ndings by next generation sequencing

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 123-129页

作者： Yu Imamura Ryuma Tokunaga kenichi Nakamura Hideo Baba Masayuki watanabe Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityKumamoto 860-8555Japan.

Esophagogastric junctional adenocarcinoma is commonly treated as esophageal adenocarcinoma(EAC)and has dramatically increased in Western countries for several *** similar trend has been observed in Asian countries(not in China).Barrett’s esophagus(BE)is a widely accepted precursor of *** advances of next-generation sequencing could provide researchers with a better understanding of genetic and epigenetic alterations in the carcinogenesis of *** this review,we have summarized the recently reported major genetic and epigenetic alterations in both BE and *** hedgehog/bone morphogenetic protein axis,which is a key signaling for esophageal development,plays an important role in BE intestinal *** nucleotide polymorphisms related to esophageal organogenesis,such as FOXF1 and FOXP3,are frequently detected in BE *** the progression of BE to adenocarcinoma,lacking of normal function of TP53 and CDKN2A by loss of heterozygosity(LOH),mutation,or promoter methylation has been frequently *** at 9p(coding CDKN2A)is an earlier event to EAC carcinogenesis compared to that at 17q(coding TP53)*** order to further elucidate the pathogenesis of BE and EAC,it will be necessary to analyze these genetic/epigenetic alterations in combination with clinical data in a large-scale cohort.

关键词： Barrett’s esophagus carcinogenesis epigenetic esophageal adenocarcinoma esophagogastric junctional adenocarcinoma genetic intestinal metaplasia

Bacterial Groups Concerned with Maturing Process in Manure Production Analyzed by a Method Based on Restriction Fragment Length Polymorphism Analysis

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Advances in Microbiology 2015年第13期5卷 832-841页

作者： Katsuji watanabe Naoto Horinishi Kunimasa Matumoto Akihiro Tanaka kenichi Yakushido Department of Life Environment and Materials Science Fukuoka Institute of Technology Fukuoka Japan National Agricultural Research Center for Kyushu-Okinawa Region National Agriculture and Food Research Organization Koshi Japan National Agricultural Research Center National Agriculture and Food Research Organization Tsukuba Japan

Composting is a biological aerobic decomposition process consisted from different phases. Although the Japanese Standards for manure recommended that it took at least 6 months to complete the maturing phase, there was no reliable ground. In order to find out shortening method of the maturing phase, the microorganisms concerned with a progress of the maturing was determined by using the most probable number method (MPN) and PCR-RFLP of the 16S rDNA, which was found effective to provide numbers and taxonomy of polymyxin B resistant bacterial groups in the former paper [1]. Compared to the numbers after thermophilic phase, those of Actinobacteria, δ-proteobacteria, and the other gram negative bacteria increased to 50 times, 20 times, and 105 times, respectively, after maturing phase, while those of Bacillus spp., and α and β-proteobacteria decreased to 1/10, and 1/105 after maturing phase. Numbers of the other Fumicutes, and γ-proteobacteria remained in the same revel. Actinobacteria, δ-proteobacteria, and the other gram negative bacteria might be concerned with a progress of the maturing phase, because these bacterial groups were detected and enumerated due to their proliferation ability. Although number of Acitinobacteria might be underestimated because of a PCR bias, the method was found effective for the purpose to monitor bacteria actively proliferated in culture medium.

关键词： Maturing Phase Manure Production Microchip Electrophoresis Multiple Enzyme Restriction Fragment Length Polymorphism Analysis The Most Probable Number Method

Spatial variability of chemical tracers in surface snow along the traverse route from the coast to 1000 km inland at east Dronning Maud Land, Antarctica

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Chinese Journal of Polar Science 2003年第1期14卷 48-56页

作者： Toshitaka Suzuki Yoshinori Iizuka Teruo Furukawa kenichi Matsuoka Kokichi Kamiyama Okitsugu watanabe Yamagata University Kojirakawa cho 1-chomeNational Institute of Polar ResearchKaga 1-chomeNational Institute of Polar ResearchKaga 1-chomeInstitute of Low Temperature Science Hokkaido UniversityNational Institute of Polar ResearchKaga 1-chomeNational Institute of Polar ResearchKaga 1-chome Yamagata 990-8560 Itabashi kuTokyo 173-8515 Itabashi kuTokyo 173-8515 Kita-19 Nishi-8 Kita-ku Sapporo 060-0819Itabashi kuTokyo 173-8515 Itabashi kuTokyo 173-8515

We measured the spatial variability of Cl -, Na +, SO 2- 4, NO - 3 and 7Be concentrations in snow cover along the traverse route from S16 to Dome Fuji station in east Dronning Maud Land, Antarctica. The concentrations of Cl - and Na + at the coast exponentially decreased with distance from the coast up to 200 km inland. Between 200 1000 km inland, the concentrations of Na + were nearly constant. On the other hand, the concentrations of Cl - increased with distance beyond 750 km inland. Furthermore, the contribution factors between Cl - and Na + decreased and the Cl -/Na + ratio and the nssCl -/Cl - ratio increased toward the interior of the continent. These results indicate that sea salt aerosols are transported from the coastal region toward the inland region of the Antarctic continent, and that a source of Cl - other than sea salt exists in the inland plateau of Antarctica. The concentrations of SO 2- 4, NO - 3 and 7Be in snow were relatively high in the coastal region and the inland plateau region compared with those in the katabatic wind region.

关键词： Antarctica snow chemistry spatial variability atmospheric transport.