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Anillin actin-binding protein expression correlates with poor prognosis for prostate cancer patients

Asian Journal of Urology 2024年第4期11卷 569-574页

作者： Shinichiro Yamamoto Daisuke Obinata kenichi takayama Daigo Funakoshi Kyoko Fujiwara Makoto Hara Satoru Takahashi Satoshi Inoue Department of Systems Aging Science and Medicine Tokyo Metropolitan Institute for Geriatrics and Gerontology35-2 Sakae-choItabashi-kuTokyoJapan Department of Urology Nihon University School of Medicine30-1OoyaguchikamichoItabashi-kuTokyoJapan Department of Anatomy Nihon University School of Dentistry1-8-13Kanda SurugadaiChiyoda-kuTokyoJapan Division of Neurology Department of MedicineNihon University School of Medicine30-1OoyaguchikamichoItabashi-kuTokyoJapan Research Center for Genomic Medicine Saitama Medical University1397-1 YamaneHidaka-shiSaitamaJapan

ObjectiveOctamer transcription factor 1(OCT1),a transcription factor that interacts with androgen receptor,is involved in prostate cancer(PCa)*** OCT1 target gene,Anillin actin-binding protein(ANLN),is highly expressed in castration-resistant PCa tissue;however,it remains unclear whether ANLN expression in hormone-sensitive PCa tissue could be used as a predictive biomarker for poor prognosis of *** aimed to investigate ANLN expression in PCa tissue obtained via radical prostatectomy and its correlation with clinical *** staining for ANLN was performed on 86 PCa specimens,followed by evaluation using immunoreactivity(IR)*** was analyzed by the log-rank test using the Kaplan–Meier method to generate a cancer-specific survival *** correlations between ANLN IR and clinical parameters as well as OCT1 IR were analyzed using the Chi-squared *** median IR score was 0 for ***,given the low median IR score,an IR score of≥3 was defined as *** were 17(19.8%)ANLN-positive cases,and these cases had a significantly poorer *** analysis revealed that the Gleason score,pathological tumor and lymph node stages,and positive ANLN expression were significant predictors of poor ***,patients with both positive ANLN and high OCT1 expression had a significantly decreased overall survival(p=0.001).ConclusionANLN,which is a OCT1 target gene especially in castration-resistant PCa,is expressed in a small number of hormone-sensitive PCa *** positive ANLN expression and high OCT1 expression are significantly correlated with poor prognosis for PCa patients.

关键词： Prostatecancer Androgenreceptor Octamer transcriptionfactor1 Anillin actin-binding protein

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Surgical treatment of hepatocellular carcinoma: Evidence-based outcomes

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World Journal of Gastroenterology 2008年第5期14卷 685-692页

作者： Shintaro Yamazaki Tadatoshi takayama Department of Digestive Surgery Nihon University School of Medicine Tokyo 173-8610 Japan

Surgeons may be severely criticized from the perspective of evidence-based medicine because the majority of surgical publications appear not to be convincing. In the top nine surgical journals in 1996, half of the 175 publications refer to pilot studies lacking a control group, 18% to animal experiments, and only 5% to randomized controlled trials (RCT). There are five levels of clinical evidence:level 1 (randomized controlled trial), level 2 (prospective concurrent cohort study), level 3 (retrospective historical cohort study), level 4 (pre-post study), and level 5 (case report). Recently, a Japanese evidence-based guideline for the surgical treatment of hepatocellular carcinoma (HCC) was made by a committee (Chairman, Professor Makuuchi and five members). We searched the literature using the Medline Dialog System with four Keywords:HCC, surgery, English papers, in the last 20 years. A total of 915 publications were identified systematically reviewed. At the first selection (in which surgery-dominant papers were selected), 478 papers survived. In the second selection (clearly concluded papers), 181 papers survived. In the final selection (clinically significant papers), 100 papers survived. The evidence level of the 100 surviving papers is shown here:level-1 papers (13%), level-2 papers (11%), level-3 papers (52%), and level-4 papers (24%);therefore, there were 24% prospective papers and 76% retrospective papers. Here, we present a part of the guideline on the five main surgical issues:indication to operation, operative procedure, peri-operative care, prognostic factor, and post-operative adjuvant therapy.

关键词： Indication to operation Hepatocellular carcinoma Operative procedure Peri-operative care Prognostic factors

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2-D localization system utilizing M-sequence encoded laser beam scanning

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仪器仪表学报 2007年第3期28卷 408-413页

作者： Shinji Ohyama Kiyoshi Tanaka Junya takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan

In this paper, as the active position measurement system, a novel method for a two-dimensional localization system using M-sequence signal is proposed. The feature of this system is to realize a position measurement only by scanning the encoded laser beams from fixing points to a measurement field, and by observing it. First, both the system configuration and encoding method were practically considered, and an order and an initial value of M-sequence signal were selected for encoding. This method is based on discrete angle measurement therefore the resolution has its own limitation. To overcome this limitation, analogue phase shift detecting method was introduced. System design was performed and applied to position measurement experiments. The experimental results show that the measurement error of the analogue method is 1/3 of that of the discrete method.

关键词：激光电子束扫描位置测量二维定位系统 M序列离散法

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Suppression of Wave-Excited Vibration of Offshore Platform by Use of Tuned Liquid Dampers

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China Ocean Engineering 2001年第2期16卷 165-176页

作者：董胜李华军 Tomotsuka takayama College of Engineering Ocean University of Qingdao Qingdao 266003 China Disaster Prevention Research Institute Kyoto University Gokasho Uji Kyoto 611-0011 Japan

This paper describes experimental and theoretical investigations of Tuned Liquid Damper (TLD) characteristics for suppressing the wave-excited structural vibration. The structural model for the experiments is scaled according to a full size offshore platform by matching their dynamic properties. Rectangular TLDs of different sizes with partially filled liquid are examined. By observing the performance and behavior of TLDs through laboratory experiments, the Study investigates the influence of a number of parameters, including container size, container shape, frequency ratio, and incident wave characteristics. In an analytical study, a mathematical model that describes the nonlinear behavior of liquid in TLD and the interaction of TLD and structure is prerequisite. The validity of the model is evaluated and simulating results can reasonably match the corresponding experimental results.

关键词： numerical simulation offshore platform tuned liquid damper structural vibration rectangular container shallow water wave theory

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Study on fragmentation behavior of taxoids by tandem mass spectrometry

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Chinese Science Bulletin 2000年第8期45卷 688-698页

作者： Zeper Abliz Mitsuo takayama Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeiging 100050.ChinaFaculty of Pharmaceutical SciencesToho University2-2-1 MiyamaFunabashiChiba 274Japan

We have studied the fragmentation behavior of positive and negative ions of taxoi and 6/8/6 type taxoids, the influence of different substituents on fragmentation, and the correlativity between fragmentation patterns and structure by MS/MS technique with different ionization methods such as FAB-MS, ESI-MS, ete. We have also investigated in detail the fragmentation of various molecular-related ions, such as [M+H]+, [M+Na]+ and [M-H] ions, and the formation pathways of characteristic fragment ions. It has been found that there exists some competing reaction between the loss of C-13 side chain and decomposition by loss of acetic acid. In addition, by comparing CID spectra obtained with low- and high-energy collision, it is seen that CID-MS/MS with low-energy collision is more suitable for the study of the structural analysis of small molecules and drug metabolites. The experimental results demonstrate that MS/MS spectra can reflect more effectively the slight difference of structure between the related

关键词： taxol taxoids tandem mass spectrometry fragmentation behavior.

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The Optimal Design of TMD for Offshore Structures

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China Ocean Engineering 1999年第2期14卷 133-144页

作者： Sau Lon James HU Tomotsuka takayama Dept. of Ocean Engrg. University of Rhode Island RI02881 Professor Professor Disaster Prevention Res. Inst. Kyoto Univ. Gokasho Uji Kyoto 611-0011 Japan.

This paper presents the optimal design procedure of Tuned Mass Damper (TMD) for reducing vibration of an actual steel jacket offshore platform excited by random wave loading. In this study, a frequency domain is taken. The force on the structure is determined by use of the linearized Morison equation for an input Power Spectral Density (PSD) of wave elevation. The sensitivity of optimum values of TMD to characteristic parameters of random wave spectrum is analyzed. An optimized TMD design for the modeled platform is given based on design conditions and the findings of the study.

关键词： tuned mass damper design Morison equation power spectral density offshore structures

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ADCP application for long-term monitoring of coastal water

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Acta Oceanologica Sinica 2005年第1期24卷 95-100页

作者： YOSHIOKA Hiroshi takayama Tomotsuka SERIZAWA Shigeatsu Faculty of Information Science and Technology Aichi Prefectural University Aichi 480-1198 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 Japan

Three kind of application of ADCP is reported for long-term monitoring in coastal sea.(1)The routine monitoring of water qualities. The water quality and ADCP echo data (600 kHz) observed in the long-term are analgzed at MT (Marine Tower) Station of Kansai International Airport in the Osaka Bay, Japan. The correlation between the turbidity and echo intensity in the surface layer is not good because air bubbles generated by breaking wave are not detected by the turbidity meter, but detected well by ADCP. When estimating the turbidity consists of plankton population from echo intensity, the effect of bubbles have to be eliminated. (2) Monitoring stirring up of bottom sediment. The special observation was carried out by using following two ADCP in the Osaka Bay, One ADCP was installed upward on the sea. The other ADCP was hanged downward at the gate type stand about 3 m above from the bottom. At the spring tide, high echo intensities indicating the stirring up of bottom sediment were observed. (3) The monitoring for the boundary condition of water mixing at an estuary. In summer season, the ADCP was set at the mouth of Tanabe Bay in Wakayama Prefecture, Japan. During the observation, water temperature near the bottom showed remarkable falls with interval of about 5-7 d. When the bottom temperature fell, the inflow current with low echo intensity water appears at the bottom layer in the ADCP record. It is concluded that when occasional weak northeast wind makes weak coastal upwelling at the mouth of the bay, the combination of upwelling with internal tidal flow causes remarkable water exchange and dispels the red tide.

关键词： ADCP echo intensity monitoring coastal water red tide stirring up

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Acoustic CT system for temperature distribution measurement

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仪器仪表学报 2008年第5期29卷 897-902页

作者： Shinji Ohyama Toyofumi Oga Kazuo Oshima Junya takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan Research and Development Headquarters NTT FACILITIES INC. Minato-ku Tokyo Japan

In this paper, a measurement method for cross-sectional temperature distribution is addressed. A novel method based on an acoustic CT technique is proposed. Specifically, the temperature distributions are estimated using the time of flight data of several ultrasonic propagation paths. The times of the flight data contain both temperature and wind effect, and the method to select only temperature component is introduced. A filtered back projection method is applied to reconstruct the temperature distributions from the time of flight data. An experimental system was designed and fabricated to realize simultaneous temperature and wind velocity distribution measurements. Through this system, the effectiveness of the proposed measurement method is confirmed.

关键词：声波CT技术温度分布测量方法超声波

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Engaging with the More-Than-Human and Decolonial Turns in the Land of Shinto Cosmologies: “Negative” Comparative Education in Practice

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ECNU Review of Education 2020年第1期3卷 46-65页

作者： Keita takayama Kyoto University

Purpose:In this explorative,self-reflective article,I attempt to extend the methodological discussion of a“negative”approach to comparative education that I have recently articulated ***,I demonstrate how I attempted to put in practice negative comparative education by drawing on my experience at the Shanghai workshop,Beyond the Western Horizon in Educational Research,organized by Iveta Silova,Jeremy Rappleye,and Yun You at the East China Normal ***/Approach/Methods:I conceive my participation in the Shanghai workshop as a disruptive moment wherein my previous forms of knowing and being were *** specifically,I discuss how my attempt to situate the ecofeminist and decolonial literature,the two of the three main bodies of literature introduced through the workshop,within the context of Japanese education triggered me to reconsider the role of Shinto in Japanese education and question my own firm identification with the liberal–left politics within ***:I reflect upon how the initial sense of discomfort and the remaining sense of ambivalence took me on a journey of unlearning and relearning about the limits of my knowing,my own political subjectivities,and the place of Shinto cosmologies in Japanese ***/Value:I conclude the discussion with a few provisional thoughts that point us to an approach to comparative education that makes our research“a matter of concern”across multiple linguistically bounded,national and regional scholarly communities.

关键词： Comparative education decolonial ecofeminism negative education Shinto

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A regression model-based method for indoor positioning with compound location fingerprints

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Geo-Spatial Information Science 2019年第2期22卷 107-113,I0003页

作者： Tomofumi takayama Takeshi Umezawa Nobuyoshi Komuro Noritaka Osawa Hewlett-Packard Japan LtdTokyoJapan Graduate School of Engineering Chiba UniversityChibaJapan

This paper proposed and evaluated an estimation method for indoor *** method combines location fingerprinting and dead reckoning differently from the conventional *** uses compound location fingerprints,which are composed of radio fingerprints at multiple points of time,that is,at multiple positions,and displacements between them estimated by dead *** avoid errors accumulated from dead reckoning,the method uses short-range dead *** method was evaluated using 16 Bluetooth beacons installed in a student room with the dimensions of 11×5 m with furniture *** Received Signal Strength Indicator(RSSI)values of the beacons were collected at 30 measuring points,which were points at the intersections on a 1×1 m grid with no obstacles.A compound location fingerprint is composed of RSSI vectors at two points and a displacement vector between *** Forests(RF)was used to build regression models to estimate positions from location *** root mean square error of position estimation was 0.87 m using 16 Bluetooth *** error is lower than that received with a single-point baseline model,where a feature vector is composed of only RSSI values at one *** results suggest that the proposed method is effective for indoor positioning.

关键词： Indoor positioning integrated estimation radio fingerprinting dead reckoning machine learning non-linear regression

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