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Integrated in-process chatter monitoring and automatic suppression with adaptive pitch control in parallel turning

Advances in Manufacturing 2018年第3期6卷 291-300页

作者： Shuntaro Yamato Yuki Yamada kenichi nakanishi Norikazu Suzuki Hayato Yoshioka Yasuhiro Kakinuma Department of System Design Engineering Keio University3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Nakamura-Tome Precision Industry Co. Ltd. 15 NetsunoHakusan Ishikawa 920-2195 Japan Department of Mechanical Science and Engineering Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan Precision and Intelligent Laboratory Tokyo Institute of Technology 4259-G2-19 Nagatsuta Midori-kuYokohama 226-8503 Japan

Simultaneous processes such as parallel turningor milling offer great opportunities for more efficientmanufacturing because of their higher material removalrates. To maximize their advantages, chatter suppressiontechnologies for simultaneous processes must be devel-oped. In this study, we constructed an automatic chattersuppression system with optimal pitch control for shared-surface parallel turning with rigid tools and a flexibleworkpiece, integrating in-process chatter monitoring basedon the cutting force estimation. The pitch angle betweentwo tools is tuned adaptively in a position control system inaccordance with the chatter frequency at a certain spindlespeed, in a similar manner as the design methodology forvariable-pitch cutters. The cutting force is estimatedwithout using an additional external sensor by employing amulti-encoder-based disturbance observer. In addition, thechatter frequency is measured during the process by per-forming a low-computational-load spectrum analysis at acertain frequency range, which makes it possible to cal-culate the power spectrum density in the control system ofthe machine tool. Thus, the constructed system for automatic chatter suppression does not require any addi-tional equipment.

关键词： Chatter Multitasking machine tool Parall elturning Adaptive control Sensorless Disturbance observer

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Recent traction methods for endoscopic submucosal dissection

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World Journal of Gastroenterology 2016年第26期22卷 5917-5926页

作者： Kunihiro Tsuji Naohiro Yoshida Hiroyoshi nakanishi kenichi Takemura Shinya Yamada Hisashi Doyama Department of Gastroenterology Ishikawa Prefectural Central Hospital

Endoscopic mucosal resection(EMR) is problematic with regard to en bloc and curable resection *** in endoscopic techniques have enabled novel endoscopic approaches such as endoscopic submucosal dissection(ESD), which has overcome some EMR problems, and has become the standard treatment for gastrointestinal tumors. However, ESD is technically difficult. Procedure time is longer and complications such as intraoperative perforation and bleeding occur more frequently than in EMR. Recently various traction methods have been introduced to facilitate ESD procedures, such as clip with line, external forceps, clip and snare, internal traction, double scope, and magnetic anchor. Each method must be used appropriately according to the anatomical characteristics. In this review we discuss recently proposed traction methods for ESD based on the characteristics of various anatomical sites.

关键词： Endoscopic submucosal dissection Traction Pharyngeal cancer Esophageal cancer Gastric cancer Colorectal cancer

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Estimating effects from trapped magnetic fluxes in superconducting magnetic levitation measurement

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仪器仪表学报 2008年第3期29卷 449-452页

作者： Masakazu nakanishi Metrology Institute of Japan National Institute of Advanced Industrial Science and Technology 1-1-1 Umezono Tsukuba-shi Ibaraki 305-8563 Japan

Superconducting magnetic levitation measurement is one of the most promising approaches to define mass standard based on the fundamental physical constants. However, the present system has unknown factors causing error larger than 50 ppm. We examined the effects of magnetic fluxes trapped in the superconducting coil and the superconducting floating body. When fluxes were trapped in either coil or floating body, their effects were able to be cancelled by reversing polarities of current and magnetic field, as had been believed. However, fluxes trapped in both coil and body induced an attractive force between them and caused error. In order to reduce the fluxes, the coil and the floating body should be cooled in low magnetic field in magnetic and electromagnetic shields.

关键词：截留磁通量超导电磁飘浮测量基本物理常量

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Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging

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Neural Regeneration Research 2020年第1期15卷 25-29页

作者： Hiroshi nakanishi Department of Pharmacology Faculty of Pharmacy Yasuda Women’s University

Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent *** microglia are the main cellular source of interleukin-1βin the *** B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the *** leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial ***,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain *** active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.

关键词： brain aging caspase-1 cathepsin B inflammatory brain diseases interleukin-1β microglia mitochondrial transcription factor A neuroinflammation nuclear factor-κB oxidative stress

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Hierarchically porous monoliths based on low-valence transition metal (Cu, Co, Mn) oxides:gelation and phase separation

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National Science Review 2020年第11期7卷 1656-1666页

作者： Xuanming Lu Kazuyoshi Kanamori Kazuki nakanishi Department of Chemistry Graduate School of ScienceKyoto University Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto University Division aof Materials Research Institute of Materials and Systems for Sustainability Nagoya University

Hierarchically porous monoliths based on copper (Cu), cobalt (Co) and manganese (Mn) oxides with three-dimensionally (3D) interconnected macropores and open nanopores were prepared using metal bromides as precursors via a sol–gel process accompanied by phase separation. The difficulty of gelation for low-valence metal cation was overcome by introducing a highly electronegative Br atom near to the metal atom to control the rates of hydrolysis and polycondensation. The 3D interconnected macropores were obtained using appropriate polymers to induce phase separation. The domain sizes of macropores and skeletons can be controlled by reaction parameters such as concentration and/or average molecular weight of polymers, and the amount of hydrochloric acid. The crystalline metal oxide monoliths with their 3D interconnected macroporous structure preserved were obtained after heat treatment in air.

关键词： hierarchically porous monolith low-valence transition metal oxide 3D interconnected macropore sol–gel process phase separation

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Molecular Basis of Neuroimmune Interaction in an In Vitro Coculture Approach

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Cellular & Molecular Immunology 2008年第4期5卷 249-259页

作者： Mamoru nakanishi Tadahide Furuno School of Pharmacy Aichi Gakuin University 1-100 Kusumoto-choChikusa-kuNagoya 464-8650Japan

A team of researchers from Nagoya, Tokyo and Hamilton developed a unique technique for studying neuroimmune interaction with confocal laser scanning fluorescence microscopy several years ago. It relies on guiding immune and nerve cell interaction by creating an adhesive environment using an in vitro coculture dish. With their technique, they are able to study details of the mechanism of how nerve cells communicate with immune cells （mast cells and T lymphocytes） and vice versa. They showed that nerve-mast cell communication could occur in the absence of an intermediary transducing cell and that the neuropeptide substance P, operating v/a NK-1 receptors, was a soluble factor of this communication. In addition, recently, they showed that ATP which was released from activated mast cells mediated the activation of nerve cells. Further, with their technique, Nagoya＇s group was able to study details of the molecular mechanism of nerve-mast cell interaction. N-cadherin and CADM1 （cell adhesion molecule 1） appeared to mediate attachment and promoted the communication between mast cells and nerves predominantly. It would lead to new therapeutic modalities for diseases based on neuroimmune interaction such as neurogenic inflammation, intestinal bowel diseases, asthma, and autoimmune disorders. Cellular ＆ Molecular Immunology. 2008;5（4）：249-259.

关键词： neuro-immunology coculture confocal microscopy soluble factor adhesion molecule

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Sintering Formation of Low Temperature Phase MnBi and Its Disordering in Mechanical Milling

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Journal of Materials Science & Technology 1996年第5期12卷 335-341页

作者： Yin, FX Gu, NJ Shigematsu, T nakanishi, N KONAN UNIV FAC SCIDEPT CHEMKOBE 658JAPAN

With X-ray diffraction and DSC analysis, it is found that 4 cycles of sintering at 593 K are necessary for the complete production of the low-temperature phase (LTP) MnBi. The c/a of the fabricated LTP MnBi is 1.4286. Metastable phase MnBip formed in primary sintering stage of LTP MnBi has the similar crystal structure and lattice constant with the quenched high-temperature phase (HTP) Mn1.08Bi. The structural differences between MnBip phase and Mn1.08Bi phase are discussed. The LTP MnBi phase is unstable for strong mechanical milling as Bi appears after milling over 7200 s in the present milling condition. Strains caused by the mechanical attrition are difficult to accumulate in the MnBi crystals, and the crystal size of the milled MnBi is only 30 nm before the presence of grains coalescence. The whole milling process can be classified into 3 stages indicated by the structural changes. Based on the structural parameter calculation, the changes of atomic configurations in every stage have been discussed. The existence of Bi equivalent vacancy site is considered to play an important role in the disordering processes of Mn and Bi atoms.

关键词： Binary alloys

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Breast cancer resistance protein(BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression

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Chinese Journal of Cancer 2012年第2期31卷 73-99页

作者： Takeo nakanishi Douglas D.Ross Department of Membrane Transport and Biopharmaceutics Kanazawa University School of Pharmaceutical SciencesKanazawa 920-1192Japan University of Maryland Greenebaum Cancer Center the Departments of Medicine Pathology and Pharmacology and Experimental TherapeuticsUniversity of Maryland School of Medicineand the Baltimore VA Medical CenterBaltimoreMaryland 21201USA

Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily G member 2(ABCG2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer *** physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis *** recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical ***,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer *** BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor ***,blocking BCRP-mediated active efflux may provide a therapeutic benefit for *** the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated *** evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated ***,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer ***,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of *** biological events seem involved in a complicated *** the events would be an essential first step to developing a method to modulate BCRP function to aid patients with *** review will present a sy

关键词：多重耐药性基因表达调控组蛋白修饰乳腺癌过氧化物酶体增殖物激活受体分子机制多药耐药肿瘤细胞

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Awake thoracoscopic surgery under epidural anesthesia: is it really safe?

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Chinese Journal of Cancer Research 2014年第4期26卷 368-370页

作者： Ryoichi nakanishi Manabu Yasuda Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations

Thoracoscopic surgeries usually require single-lung ventilation under general anesthesia because of the need to obtain a sufficient working *** patients with impaired pulmonary function,if the patient can undergo general anesthesia,a more selected collapse of the lung is considered to be beneficial for intraoperative *** selective bronchial blockade of the lobe to be resected has been reported by several investigators （1-3）.Mukaida and coworkers first reported thoracoscopic surgery for pnenmothorax under local and epidural anesthesia in 1998 in high-risk patients contraindicated for general anesthesia （4）.

关键词： is it really safe lung Awake thoracoscopic surgery under epidural anesthesia

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Non-Contact Measurements of Water Jet Spreading Width with a Laser Instrument

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Journal of Thermal Science 2016年第4期25卷 349-354页

作者： Yuki Funami Ryo Hasuya Kotaro Tanabe Yuji nakanishi Kanagawa University: 3-27-1 Rokkakubashi Kanagawa-ku Yokohama Kanagawa 221-8686 Japan

Jet spreading width is one of the important characteristics of water jets discharging into the *** researchers have dealt with measuring this width,and contact measuring methods on the water jet surface were employed in a lot of the *** order to avoid undesirable effects caused by the contact on the jet surface,we introduce non-contact measuring methods with a laser instrument to the measurements of jet spreading *** measurements,a transmitter emits sheet-like laser beam to a *** water jet between the transmitter and the receiver interrupts the laser beam and makes a *** minimum and maximum values of the shadow width are *** addition,pictures of the water jet are taken with a scale,and the shadow width is measured from the *** experiments on various needle strokes were *** kinds of width consistent with the jet structure were *** the results,it can be concluded that our non-contact measuring methods are *** data of jet spreading widths and jet taper were obtained and are useful for future applications.

关键词： Water jet Jet spreading width Jet taper Non-contact measurement Laser instrument

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