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Maize Gene Regulatory Network for Phenolic Metabolism

Molecular Plant 2017年第3期10卷 498-515页

作者： Fan Yang Wei Li Nan Jiang Haidong Yu kengo morohashi Wilberforce Zachary Oumal Daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis Daniel Prada-Salcedo Roberto Alers Velazquez Jasmin Valentin Maria Katherine Mejia-Guerra John Gray Andrea I. Doseff Erich Grotewold Center for Applied Sciences (CAPS) Department of Molecular Genetics Department of Physiology and Cell Biology Heart and Lung Research Institute Molecular Cellular and Developmental Biology (MCDB) Graduate Program Success in Graduate Education (SiGuE) Program The Ohio State University Columbus OH 43210 USA Department of Biological Sciences University of Toledo Toledo OH 43560 USA

The translation of the genotype into phenotype, represented for example by the expression of genes encod- ing enzymes required for the biosynthesis of phytochemicals that are important for interaction of plants with the environment, is largely carried out by transcription factors （TFs） that recognize specific cis-regulatory elements in the genes that they control. TFs and their target genes are organized in gene regulatory net- works （GRNs）, and thus uncovering GRN architecture presents an important biological challenge necessary to explain gene regulation. Linking TFs to the genes they control, central to understanding GRNs, can be car- ried out using gene- or TF-centered approaches. In this study, we employed a gene-centered approach uti- lizing the yeast one-hybrid assay to generate a network of protein-DNA interactions that participate in the transcriptional control of genes involved in the biosynthesis of maize phenolic compounds including gen- eral phenylpropanoids, lignins, and flavonoids. We identified 1100 protein-DNA interactions involving 54 phenolic gene promoters and 568 TFs. A set of 11 TFs recognized 10 or more promoters, suggesting a role in coordinating pathway gene expression. The integration of the gene-centered network with informa- tion derived from TF-centered approaches provides a foundation for a phenolics GRN characterized by in- terlaced feed-forward loops that link developmental regulators with biosynthetic genes.

关键词： phenylpropanoid flavonoid yeast one-hybrid chromatin immunoprecipitation

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