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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVId-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven d.m.rley Kay Samuel Katie morgan Lyndsey Boswell Timothy J kendall david A dorward Jonathan A Fallowfield Peter C Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUNd.m.tabolic dysfunction-associated steatotic liver disease(mASLd),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell d.m.ge and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVId-19),while preexisting mASLd increases the risk of LI and the development of COVId-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVId-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of mASLd and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of mASLd were determined in formalin-fixed liver tissue sections across the mASLd pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(mASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVId-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic mASH compared to healthy controls but not in the progression to mASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the mASLd *** A

关键词： metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVId-19 COVId-19-associated cholangiopathy

Viscoelastic potential flow instability theory of Rivlin-Ericksen electrified fluids of cylindrical interface

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Journal of Ocean Engineering and Science 2024年第4期9卷 311-316页

作者： d.m.mostafa department of mathematics College of ScienceQassim UniversityPO Box 6644Buraidah 51452Saudi Arabia department of mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

A linear electrohydrodynamic Kelvin-Helmholtz instability of the interface between two viscoelastic Rivlin-Ericksen fluids enclosed by two concentric horizontal cylinders has been studied via the viscoelastic potential flow *** dispersion equation of complex coefficients for asymmetric disturbance has been obtained by using normal mode *** stability criteria are analyzed theoretically and illustrated *** imaginary part of growth rate is plotted versus the wave *** influences of dynamic viscoelastic,uniform velocities,Reynolds number,electric field,dynamic viscosity,density fluids ratio,dielectric constant ratio and inner fluid fraction on the stability of the system are *** study finds its significance in Ocean pipelines to transfer oil or gas such as Eastern Siberia-Pacific Ocean oil pipeline.

关键词： Rivlin-Ericksen fluid Cylindrical flow Viscoelastic potential flow Electrohydrodynamics stability

Numerical calculation of Z-scan measurements for nonlinear media with large phase shift

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Optoelectronics Letters 2024年第3期20卷 177-182页

作者： m.d.Zidan A.Allahham department of Physics Atomic Energy Commission of SyriaP.O.Box 6091DamascusSyria

We have reported the characteristics of a Z-scan for the poly(azaneylylidene-acylene)(dAZA) polymer, as nonlinear medium with a large nonlinear phase shift using continuous-wave(CW) laser beam. It has been verified that the Fresnel diffraction model is applicable for analyses of Z-scan measurements with dAZA polymer at high laser power. It was found that Z-scan curves with peak-to-valley features appear as the applied light intensity increases in the case of a large nonlinear phase shift. The Z-scan experiments were carried out using a CW laser to verify the theoretical calculations in the case of a large nonlinear phase shift model. Our results show good agreements between the experimental data and the proposed theoretical models.

关键词： nonlinear phase media

Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.d.Hossain m.S.Sikder m.N.I.Khan m.R.Rahman Physics discipline Khulna UniversityKhulna9208Bangladesh department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh department ofComputer Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material Science division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRd),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEm),energy dispersive X-ray(EdX),vibrating sample magnetometer(VSm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRd patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EdX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： merc m.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(Ad)is the most common form of d.m.ntia-the 7th leading cause of death *** the tissue level,Ad is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset Ad and longitudinal brain-imaging studies of late-onset Ad indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan E m Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based.m.del of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is d.m.nstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

Predictor-corrector Fdm analysis of mHd darcy-Forchheimer flow of a micropolar fluid with viscous dissipation and heterogeneoushomogeneous

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Propulsion and Power Research 2024年第2期13卷 257-272页

作者： d.Thenmozhi m.Eswara Rao department of mathematics Saveetha School of EngineeringSIMATSChennaiTamilnaduIndia

This research delves into an intricate exploration ofﬂuid dynamics within heat transfer systems,with a speciﬁc focus on enhancing our understanding and improving system efﬁ*** a sophisticated.m.thematical model,the study incorporates micropolarﬂuid dynamics,micro rotational effects,laminarﬂow characterized by the darcy-Forchheimer model,inertia effects,and chemical reactions within a heat transfer system featuring boundary layer *** mathematical framework consists of partial differential equations(PdEs),and the study utilizes advanced numerical techniques,including the(PC4-Fdm)Predictor-Corrector Finite difference method and the shooting method,to solve these govern-ing *** inclusion of quantized.m.sh points and analysis of convergence using 4th orderﬁnite difference methods enhances the precision of the obtained *** param-eters are scrutinized to draw meaningful *** heterogeneous parameter reveals an increasing trend inﬂuid concentration,while the homogeneous parameter indicates a collision effect leading to a decrease inﬂuid *** Eckert number,associated with viscous dissipation,exhibits a correlation with decreasedﬂuid temperature and increasedﬂuid *** rotation parameters suggest a parallel increase inﬂuid velocity and a marginal decrease inﬂuid ***,the darcy-Forchheimer parameter,reﬂective of inertial effects,showcases an increase inﬂuid temperature and decrease in velocity in the convection *** the industrial implications,the study underscores the signiﬁcance of convection heat transfer systems in the context of ***ﬁndings offer valuable insights for optimizing heating and cooling processes in diverse industrial applications,ranging from power plants to waste heat recovery units and pharmaceutical industries.ª2024 The *** services by Elsevier *** behalf of KeAi Communications ***.

关键词： Predictor-corrector micropolarﬂuid magnetohydrodynamics(mHd) Viscous dissipation Homogeneous-heterogeneous

Radioisotope production using lasers:From basic science to applications

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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.d.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur d.Singappuli d.m.lloy d.Raffestin m.Alonzo G.G.Rapisarda d.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata S.Palmerini T.Carriere m.Cipriani G.di Giorgio G.Cristofari R.de Angelis G.A.P.Cirrone d.m.rgarone L.Giuffrida d.Batani P.Nicolai K.Batani R.Lera L.Volpe d.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Acad.m. of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Acad.m. of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

Charting the course to solid-state dual-ion batteries

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Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom d.Asfaw Antonia Kotronia Nuria Garcia-Araez Kristina Edström daniel Brandell department of Chemistry Ångström LaboratoryUppsala UniversityUppsalaSweden department of Chemistry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(dIB)must be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from anodic dissolution.A higher salt concentration is needed in the electrolyte,in comparison to typical battery electrolytes,to maximize energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have d.m.nstrated that highly concentrated organic electrolytes,ionic liquids,gel polymer electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulombic efficiency,energy density,and long-term cycle life of ***,GPEs are suited to manufacture compact dIB designs without separators by virtue of their mechanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in dIBs,with particular emphasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polymer electrolyte