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Giant vesical diverticulum:A rare cause of defecation disturbance

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World Journal of Gastroenterology 2009年第31期15卷 3957-3959页

作者： Sami Akbulut Bahri Cakabay Arsenal Sezgin kenan Isen Ayhan Senol Department of Surgery Diyarbakir Education and Research Hospital Department of Pathology Diyarbakir Education and Research Hospital Department of Urology Diyarbakir Education and Research Hospital Department of Radiology Diyarbakir Education and Research Hospital

Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-yearold man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation.

关键词： Colonic obstruction Defecation Diverticulectomy Urinary bladder Vesical diverticulum

Crossover from 2D metal to 3D Dirac semimetal in metallic PtTe2 films with local Rashba effect

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Science Bulletin 2019年第15期64卷 1044-1048页

作者： Ke Deng Mingzhe Yan Chu-Ping Yu Jiaheng Li Xue Zhou kenan Zhang Yuxin Zhao Koji Miyamoto Taichi Okuda Wenhui Duan yang Wu Xiaoyan Zhong Shuyun Zhou State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China National Center for Electron Microscopy in Beijing Key Laboratory of Advanced Materials(MOE)State Key Laboratory of New Ceramics and Fine ProcessingSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China Hiroshima Synchrotron Radiation Center Hiroshima UniversityHigashi-Hiroshima739-0046Japan Collaborative Innovation Center of Quantum Matter Beijing100084China Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing100084China

PtTe2 and PtSe2 with trigonal structure have attracted extensive research interests since the discovery of type-II Dirac fermions in the bulk crystals. The evolution of the electronic structure from bulk 3D topological semimetal to 2D atomic thin films is an important scientific question. While a transition from 3D type-II Dirac semimetal in the bulk to 2D semiconductor in monolayer(ML) film has been reported for PtSe2, so far the evolution of electronic structure of atomically thin PtTe2 films still remains *** we report a systematic angle-resolved photoemission spectroscopy(ARPES) study of the electronic structure of high quality PtTe2 films grown by molecular beam epitaxy with thickness from 2 ML to 6 *** measurements show that PtTe2 films still remain metallic even down to 2 ML thickness, which is in sharp contrast to the semiconducting property of few layer PtSe2 films. Moreover, a transition from 2D metal to 3D type-II Dirac semimetal occurs at film thickness of 4–6 ML. In addition, Spin-ARPES measurements reveal helical spin textures induced by local Rashba effect in the bulk PtTe2 crystal, suggesting that similar hidden spin is also expected in few monolayer PtTe2 films. Our work reveals the transition from2D metal to 3D topological semimetal and provides new opportunities for investigating metallic 2D films with local Rashba effect.

关键词： PtTe2 Dirac semimetal Local Rashba effect Topological semimetal Topological superconductivity

Growth of large scale PtTe,PtTe_(2) and PtSe_(2) films on a wide range of substrates

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Nano Research 2021年第6期14卷 1663-1667页

作者： kenan Zhang Meng Wang Xue Zhou Yuan Wang Shengchun Shen Ke Deng Huining Peng Jiaheng Li Xubo Lai Liuwan Zhang yang Wu Wenhui Duan Pu Yu Shuyun Zhou State key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Department of Mechanical Engineering and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing100084China Collaborative Innovation Center of Quantum Matter Beijing100084China

1T phase of transition metal dichalcogenides(TMDCs)formed by group 10 transition metals(***,Pd)have attracted increasing interests due to their novel properties and potential device *** of large scale thin films with controlled phase is critical especially considering that these materials have relatively strong interlayer interaction and are difficult to *** we report the growth of centimeter-scale PtTe,1T-PtTe2 and 1T-PtSe2 films via direct deposition of Pt metals followed by tellurization or *** find that by controlling the Te flux,a hitherto-unexplored PtTe phase can also be obtained,which can be further tuned into PtTe2 by high temperature annealing under Te *** films with different thickness can be grown on a wide range of substrates,including NaCl which can be further dissolved to obtain free-standing PtTe2 or PtSe2 ***,a systematic thickness dependent resistivity and Hall conductivity measurements show that distinguished from the semiconducting PtSe2 with hole carriers,PtTe2 and PtTe films are *** work opens new opportunities for investigating the physical properties and potential applications of group 10 TMDC films and the new monochalcogenide PtTe film.

关键词： transition metal dichalcogenides(TMDCs) selenization tellurization PtSe2 PtTe2 PtTe

Intrabiliary rupture: An algorithm in the treatment of controversial complication of hepatic hydatidosis

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World Journal of Gastroenterology 2005年第16期11卷 2472-2476页

作者： kenan Erzurumlu Adem Dervisoglu Cafer Polat Gokhan Senyurek Ibrahim Yetim Murat Hokelek Department of Surgery Medical School Ondokuz Mayis UniversityKurupelitSamsunTurkey

AIM: Intrabiliary rupture (IBR) is a common and serious compli-cation of hepatic hydatid cyst. The incidence varies from 1% to 25%. The treatment of IBR is still controversial. We aimed to design an algorithm for the treatment of hepatic hydatidosis with IBR by reviewing our ***: Eight cases of IBR were analyzed *** were evaluated according to age, sex, clinical findings, cyst number and stage, abdominal ultrasonography and CT-scan, surgical methods, complica-tions, results and coincidental ***: Female/male ratio was 1/7. Mean age was 52.12±18.26 years (range 24-69 years). Right upper quadrant pain, flatulence, palpable hepatic mass were symptoms common in all patients. Cholestatic jaundice was found in four cases. In all patients, cyst evacuation and omento-plasty were performed, followed by either choledochod-uodenostomy, T-tube drainage, intracavitary suturing of the orifice, two cases in each. Whereas in two patients diagnosed post-operatively percutaneous drainage of biliary collection or ERCP and sphincteroplasty were added. Morbidity and hospital stay were higher in these ***: When the diagnosis of IBR can be done pre-or intra-operatively, morbidity decreases. If a biliary fistula is seen post-operatively, endoscopic procedures such as ERCP, sphincteroplasty or nasobiliary drainage can be applied.

关键词： Intrabiliary rupture Hepatic hydatidcyst

Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis

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Burns & Trauma 2023年第1期11卷 709-721页

作者： Ruzhen Zhang Sheng Chen Zhifan yang Ning Zhang kenan Guo Keyi Lv Zimo Zhou Meijiao Gao Xiancheng Hu Yongping Su Jianming He Fengchao Wang State Key Laboratory of Trauma Burns and Combined InjuryInstitute of Combined InjuryChongqing Engineering Research Center for NanomedicineCollege of Preventive MedicineThird Military Medical UniversityChongqing 400038China College of Life Sciences Chongqing Normal UniversityChongqing401331 China Department of Laboratory Animal Science College of Basic Medical SciencesArmy Medical UniversityThird Military Medical UniversityChongqing 400038China Department of Military Cognitive Psychology School of PsychologyThird Military Medical UniversityChongqing400038China Department of Radiotherapy Hebei Province Hospital of Chinese MedicineHebei University of Chinese MedicineKey Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research(Hebei)Shijiazhuang050011

Background:The rapid turnover of the intestinal epithelium is driven by the proliferation and differentiation of intestinal stem cells(ISCs).The dynamics of the F-actin cytoskeleton are critical for maintaining intercellular force and the signal transduction ***,it remains unclear how direct interference with actin polymerization impacts ISC *** study aims to reveal the regulatory effects of the F-actin cytoskeleton on the homeostasis of intestinal epithelium,as well as the potential risks of benproperine(BPP)as an anti-tumor ***:Phalloidin fluorescence staining was utilized to test F-actin *** cytom-etry and IHC staining were employed to discriminate different types of intestinal epithelial *** proliferation was assessed through bromo-deoxyuridine(BrdU)and 5-ethynyl-2-deoxyuridine(EdU)incorporation *** proliferation and differentiation of intestinal stem cells were replicated in vitro through organoid *** migrationwas evaluated through BrdU pulse labeling and chasing in ***:The F-actin content was observed to significantly increase as crypt cells migrated into the villus ***,actin polymerization in secretory cells,especially in Paneth cells(PCs),was much higher than that in neighboring *** with the newly identified actin-related protein 2/3 complex subunit 2(ARPC2)inhibitor BPP led to a dose-dependent increase or inhibition of intestinal organoid growth in vitro and crypt cell proliferation in *** with the vehicle group,BPP treatment decreased the expression of Lgr5 ISC feature genes in vivo and in organoid ***,PC differentiation derived from ISCs and progenitors was decreased by inhibition of F-actin ***,BPP-induced actin polymerization inhibition may activate the Yes1-associated transcriptional regulator pathway,which affects ISC proliferation and ***,BPP treatment affected i

关键词： F-actin Benproperine ARPC2 Intestinal stem cell YAP

An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 258-270页

作者： Qiyan Wang Jian Bai Amir Abliz Ying Liu kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai yang Ke Changqing Zeng MOE Key Laboratory of Carcinogenesis and Translational Research Laboratory of Genetics Peking UniversityCancer Hospital & Institute Beijing University of Chinese Medicine CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Anyang Cancer Hospital

Esophageal squamous cell carcinoma （ESCC） has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional sam- ples using Sanger sequencing. Whole-genomc SNP arrays were employed to detect copy number alteration （CNA） and loss of heterozygosity （LOH） in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations （NSSMs） in 102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology （GO） analysis. Tumor genomes with TP53 mutations were signifi- cantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B （30.9%）, amplification of 1 1q13.3 covering CCND1 （30.9%）, and TP53 point mutation （50.9%） occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC. Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p 11.2, and 3p 12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes. These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting.

关键词： Esophageal squamous cell carcinoma Genomic subtype somatic mutation Copy number alteration Cell cycle deregulation

Measuring County Resilience After the 2008 Wenchuan Earthquake

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International Journal of Disaster Risk Science 2016年第4期7卷 393-412页

作者： Xiaolu Li Nina Lam Yi Qiang kenan Li Lirong Yin Shan Liu Wenfeng Zheng School of Automation University of Electronic Science and Technology of China Department of Environmental Sciences Louisiana State University The Earth Lab University of Colorado Boulder Geographical & Sustainability Sciences Department University of Iowa

The catastrophic earthquake that struck Sichuan Province,China,in 2008 caused serious damage to Wenchuan County and surrounding areas in southwestern *** recent years,great attention has been paid to the resilience of the affected *** study applied the resilience inference measurement(RIM) model to quantify and validate the community resilience of 105 counties in the impacted *** RIM model uses cluster analysis to classify counties into four resilience levels according to the exposure,damage,and recovery *** model then applies discriminant analysis to quantify the influence of socioeconomic characteristics on the county's *** results show that counties located at the epicenter had the lowest resilience,but counties immediately adjacent to the epicenter had the highest resilience *** that were farther away from the epicenter returned to normal resiliency *** variables—including sex ratio,per capita GDP,percent of ethnic minority,and medical facilities—were identified as the most influential characteristics influencing *** study provides useful information to improve county resilience to earthquakes and support decision making for sustainable development.

关键词： China Resilience Resilience inference measurement(RIM) model Vulnerability Wenchuan earthquake

Reaching proficiency in laparoscopic splenectomy

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World Journal of Gastroenterology 2009年第32期15卷 4005-4008页

作者： Tarik Zafer Nursal Ali Ezer Sedat Belli Alper Parlakgumus kenan Caliskan Turgut Noyan Department of General Surgery University of BaskentDadaloglu Mah.01200Serin Evler 39.Sk.No.6 Yüregir/AdanaTurkey

AIM:To investigate the proficiency level reached in laparoscopic splenectomy using the learning curve ***:All patients in need of splenectomy for benign causes in whom laparoscopic splenectomy was attempted by a single surgeon during a time period of 6 years were included in the study (n=33). Besides demographics, operation-related variables and the response to surgery were recorded. The patients were allocated to groups of five, ranked according to the date of the operation. Operation duration, complications, postoperative length of stay, conversion to laparotomy and splenic weight were then compared between these ***: There was a significant difference regarding operation times between the groups (P = 0.001). An improvement was observed after the first 5 cases. The learning curve was flat up to the 25th case. Following the 25th case the operation times decreased still further. There was no difference between the groups regarding the other ***: Unlike the widely accepted "L" shape, the learning curve for laparoscopic splenectomy is a horizontal lazy "S" with two distinct slopes. Privileges may be granted after the first 5 cases. However proficiency seems to require 25 cases.

关键词： Laparoscopic splenectomy Education Learning curve Hematology Proficiency

Intracolonic multiple pebbles in young adults:Radiographic imaging and conventional approach to a case

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World Journal of Gastroenterology 2006年第37期12卷 6074-6076页

作者： Mehmet Eryilmaz Orkun Ozturk Oner Mentes kenan Soylu Murat Durusu Kksal Oner Gulhane Military Medical Academy Department of Emergency Medicine Ankara Turkey Gulhane Military Medical Academy Department of General Surgery Ankara Turkey

Most of the foreign bodies detected in adult gastroin- testinal systems are accidentally swallowed pins. In this study, we presented a case with intracolonic multiple pebbles. A 20-year-old man was admitted to emergency surgery policlinic for abdominal pain for 2 d without any alleviation or aggravation. His upright plain abdominal radiographic imaging revealed about 30-40 overt dense opacities in lumen of colonic segments, with oval and well shaped contours, each approximately 1 cm × 1 cm in size. The multiplanar reconstructions and three- dimensional images combined with sectional screening showed that all pebbles had passed completely into the colon and no foreign bodies had remained in the ileal segments. On psychiatric assessment, he was found to have immature personality features, difficulty in over- coming stressors and adaptation disorder. He recovered by conservative management and radiographic monitoring applied during his follow-up. Thus, it can be concluded that, in differential diagnosis of abdominal pain in adult ages, though less frequently seen than in children, gastrointestinal system foreign bodies should always be kept in mind and it should be considered that ingestion of pebbles may be one of the factors contributing to abdominal pain particularly in young adults with psychiatric problems. In such cases suspected of having foreign bodies which cannot be detected by plain films, abdominal tomography can be an alternative for diagnostic imaging.

关键词： Intracolonic multiple pebbles Current approach Radiographic imaging