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Evaluation of CA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation

Journal of Geriatric Cardiology 2015年第2期12卷 100-106页

作者： Huseyin Ayhan Haca Ahmet Kasapkara Tahir Durmaz Telat Keles Cenk San Serdal Bastug kemal esref erdogan Nihal Akar Bayram Emine Bilen Murat Akgay Engin Bozkurt Faculty of Medicine Department of Cardiology Ytldtrtm Beyaztt University Ankara 06800 Turkey Department of Cardiology Ankara Ataturk Education and Research Hospital Ankara 06800 Turkey Faculty of Medicine Department of Cardiovascular Surgery Yddtrtm Beyaztt University Ankara 06800 Turkey

Background Transcatheter aortic valve implantation （TAVI） is a minimally invasive, emerging therapy in surgically high risk, or in- operable patients. Parameters used for risk classification have some deficiencies in the selection of patients. The objective of this study is to evaluate the impact of TAVI on carbohydrate antigen 125 （CA125） and N-terminal pro brain-type natriuretic peptide （NT-proBNP） as biomarkers that have been used frequently in recent years, and also the relationship of these biomarkers to prognosis. Methods ＆ Results Transcatheter aortic valve implantation was practiced on 31 patients in this study. Then, CA125 and NT-proBNP levels studied in patients prior to and after the TAVI were evaluated. The patients were also grouped in accordance with their left ventrieular ejection fraction （LVEF） and CA125 levels （LVEF 〉 40% and 〈 40%; CA125 ≤ 35 U/L and 〉 35 U/L）. The TAVI operation was successfully performed in all patients. There was no in-hospital mortality and substantial improvement in functional capacity was detected at follow ups. In addition, a statistically significant decrease was detected in post-TAVI CA 125 and NT-proBNP levels of all patients （CA 125 83.8 ± 18.1 U/L vs. 64.3 ±14.2 U/L, P = 0.008; NT-proBNP： 4633.6± 627.6 pg/mL vs. 2866.3±536.8 pg/mL, P 〈 0.001）. In groups divided according to the CA125 levels, there was also statistically significant post-TAVI decline in CA125 levels. Within CA125 〉 35 U/L and LVEF 〈 40% groups, the permanent need for a pacemaker was required in one （3.2%） patient and mortality was observed in two （6.4%） patients after TAVI at follow up. Conclusions The results show that TAVI can be performed effectively and reliably in patients with high baseline levels of CA125 and NT-proBNP. These biomarkers are reduced substantially with TAVI, while high biomarker levels are associated with undesired events, and certainly, these biomarkers can be used for risk classifications in patient selection for TAVI.

关键词： B-type natriuretic peptide Biomarker Carbohydrate antigen Heart failure Transcatheter aortic valve implantation Risk score

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Persistent currents of ultrarelativistic plasma-encased endofullerene molecules entrapping a H atom

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Communications in Theoretical Physics 2024年第6期76卷 148-164页

作者： Mustafa kemal Bahar Department of Physics Faculty of ScienceSivas Cumhuriyet University58140SivasTurkey

In this work,for the first time in the relevant literature,the persistent currents(PC)and induced magnetic fields(IMF)of an endofullerene molecule entrapping a hydrogen atom,under spherical confinement,are *** endofullerene molecule is enclosed within a spherical region and embedded in a plasma *** plasma environment is depicted with the more general exponential cosine screened Coulomb potential,and its relevant effects are analyzed by considering plasma screening *** relevant model for endohedral confinement is the Woods-Saxon confinement potential,which is compatible with experimental *** effects of various forms of Cn are thoroughly elucidated via the analysis of the confinement depth,spherical shell thickness,the inner radius,and the smoothing *** find the bound states in the spherically confined endofullerene,the decoupling of the second-order Dirac equation for the large and small components of the radial atomic wave functions is *** Dirac equation with the interaction potential is solved numerically by using the Runge-Kutta-Fehlberg method via the decoupling *** influence of spin orientations on the PC and IMF is also *** effects of spherical confinement,plasma shielding,and the structural properties of the fullerene on the PC and IMF are thoroughly ***,under given physical conditions,the optimal ranges of these effects are determined.

关键词： quantum plasma endohedral fullerene persistent current ultrarelativistic interaction induced magnetic field

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Complementary comments on metastatic liver lesions with exceptional and rare cases

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World Journal of Gastroenterology 2024年第7期30卷 770-773页

作者： kemal Bugra Memis Sonay Aydin Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24000Turkey

Liver metastases can appear in different forms in magnetic resonance *** to popular belief,while radiologists report hypovascular or hypervascular metastatic lesions,exceptional examples may be detected in various *** aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis,as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.

关键词： Hepatic lesions Magnetic resonance imaging Liver metastases Echinococcus alveolaris Prostate adenocarcinoma Appendix neuroendocrine tumor

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Knowledge, attitudes, and practices regarding Covid-19 and their relationship with Covid-19 booster vaccination status among women with infertility

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Asian pacific Journal of Reproduction 2024年第2期13卷 68-75页

作者： Gita Pratama Mila Maidarti Kanadi Sumapradja Achmad kemal Harzif Natasha Talya Kevin Ezekia Irfan Arieqal Hatta Ampri Reproductive Immunoendocrinology Division Department of Obstetrics and GynecologyFaculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia Yasmin IVF Clinic dr.Cipto Mangunkusumo General Hospital JakartaIndonesia Human Reproduction Infertilityand Family Planning ClusterIndonesia Reproductive Medicine Research and Training CenterFaculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia

Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with ***:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,*** assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic ***:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 *** the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination *** significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding *** participants had poor knowledge about the relationship between infertility and the Covid-19 *** general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.

关键词： Covid-19 Booster vaccine Infertility Knowledge Attitude Practice Human reproduction Pandemic

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Imaging features and management of focal liver lesions

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World Journal of Radiology 2024年第6期16卷 139-167页

作者： Gökhan Kahraman kemal Murat Haberal Osman Nuri Dilek Department of Radiology Suluova State HospitalAmasya 05500Türkiye Department of Radiology Başkent University Faculty of MedicineAnkara 06490Türkiye Department of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye

Notably,the number of incidentally detected focal liver lesions(FLLs)has increa-sed dramatically in recent years due to the increased use of radiological *** diagnosis of FLLs can be made through a well-documented medical history,physical examination,laboratory tests,and appropriate imaging *** benign FLLs are more common than malignant ones in adults,even in patients with primary malignancy,accurate diagnosis of incidental FLLs is of utmost clinical *** clinical practice,FLLs are frequently evaluated non-invasively using ultrasound(US),computed tomography(CT),and magnetic resonance imaging(MRI).Although US is a cost-effective and widely used imaging method,its diagnostic specificity and sensitivity for FLL characterization are *** are primarily characterized by obtaining enhancement patterns through dynamic contrast-enhanced CT and *** is a problem-solving method with high specificity and sensitivity,commonly used for the evaluation of FLLs that cannot be characterized by US or *** technical advancements in MRI,along with the use of hepatobiliary-specific MRI contrast agents,have significantly improved the success of FLL characterization and reduced unnece-ssary *** American College of Radiology(ACR)appropriateness criteria are evidence-based recommendations intended to assist clinicians in selecting the optimal imaging or treatment option for their *** Appropriateness Criteria Liver Lesion-Initial Characterization guideline provides recommend-ations for the imaging methods that should be used for the characterization of incidentally detected FLLs in various clinical *** American College of Gastroenterology(ACG)Clinical Guideline offers evidence-based recommend-ations for both the diagnosis and management of *** Association for the Study of Liver Diseases(AASLD)Practice Guidance provides an approach to the diagnosis and management of patients with hepatocellular *** th

关键词： Focal liver lesions Imaging Ultrasonography Computed tomography Magnetic resonance imaging Management

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Characteristics of the imaging diagnosis of alveolar echinococcosis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2748-2754页

作者： Sonay Aydin Baris Irgul kemal Bugra Memis Volkan Kızılgoz Mecit Kantarci Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Erzurum Ataturk UniversityErzurum 25000Türkiye

Alveolar echinococcosis(AE)primarily manifests in the liver and exhibits charac-teristics resembling those of slow-growing malignant *** Echino-coccus multilocularis infection can be *** infiltrating the vascular systems,biliary tracts,and the hilum of the liver,it might lead to various *** to its ability to infiltrate neighbouring tissues or metastasize to distant organs,AE can often be mistaken for *** present a concise overview of the epi-demiological and pathophysiological characteristics of AE,as well as the clinical manifestations of the *** article primarily examines the imaging charac-teristics of AE using various imaging techniques such as ultrasonography,com-puted tomography(CT),magnetic resonance imaging,diffusion-weighted ima-ging,and virtual non-enhanced dual-energy *** additionally examined the contribution of radiography in the diagnosis,treatment,and monitoring of the condition.

关键词： Alveolar echinococcosis Echinococcus multilocularis Virtual non-enhanced dual-energy computed tomography Percutaneous cyst drainage Cyst infection Interven-tional radiology

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Deep neck infections mortal complications:Intrathoracic complications and necrotising fasciitis

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World Journal of Clinical Cases 2024年第30期12卷 6383-6390页

作者： kemal Koray Bal Can Aslan Harun Gür Seda Turk Bal Recep Okan Ustun Murat Unal Department of Otorhinolaryngology Mersin UniversityMersin 33160Türkiye Department of Emergency Medicine Tarsus State HospitalMersin 33460Türkiye Department of Aestetic Division of Plastic and Reconstructive SurgeryUniversity of Health Sciences Mersin City HospitalMersin 33230Türkiye

BACKGROUND We planned this study considering that complications of deep neck infections can be seriously life *** To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and *** This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1,*** the patient files were retrospectively examined,16 of 188 patients(8.5%)were included in the study because they were observed to have necrotizing fasciitis and/or intrathoracic *** There were a total of 16 patients in this study,9 males(56.25%)and 7 females(43.75%).All patients were adults(>18 years)and the mean age was 50.37 years±15.37 *** patients had a mean age of 40.42 years±13.38 years,whereas for male patients was 58.11 years±12.44 *** Patients with necrotizing fasciitis and/or intrathoracic complications require more complicated and serious surgeries,intensive care unit monitoring,and mechanical ventilator *** rates of morbidity and mortality should be expected in Bal KK et *** neck infections mortal complications WJCC https://*** 6384 October 26,2024 Volume 12 Issue 30 these patients who are hospitalized for longer periods of time.

关键词： Deep neck infection Necrotising fasciitis Mediastinitis Complications Mortality

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Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 190-194页

作者： Haydar erdogan Ayse Vural Ozec Cengiz Caner Mustafa Ilker Toker Mustafa kemal Arici Aysen Topalkara Departments of Ophthalmology School of MedicineUniversity of Cumhuriyet

·AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.·METHODS:This study is a prospective,randomized,double-masked and *** study included 90 eyes of 90 patients which were scheduled to have phacoemulsification *** were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients).Two hour before surgery,the patients received one drop latanoprost/timolol (group 1),dorzolamide/timolol (group 2) and placebo (group 3,control group).The IOPs were measured at preoperative and postoperative 4,8,and 24 hours.·RESULTS:The preoperative mean intraocular pressure was not statistically significant between both drug groups and control *** group 1 and 2,the postoperative mean IOP [group1:(14.03?à3.15)mmHg and group 2:(14.16?à4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93?à3.70)mmHg,(P 0.05).·CONCLUSION:When compared with placebo,the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery,but did not completely prevent IOP spikes.·

关键词： dorzolamide/timolol latanoprost/timolol intraocular pressure phacoemulsification cataract surgery

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Behavior of a Nonlinear Difference Equation xn＋1=1-2n/A＋∑k i=1xn-i

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Journal of Life Sciences 2016年第4期10卷 215-220页

作者： Mehmet Emre erdogan kemal Uslu Huglu Vocational High School Selcuk University Konya Turkey Department of Science Selcuk University Konya Turkey

In this paper, we investigate the global behavior of the difference equation xn＋1=1-2n/A＋∑k i=1xn-iwith the A ∈ （-∞,-1） is a real number, k is a positive integer and the initial conditions x_k x0 ∈ （-∞, 0].

关键词： Recursive sequences global asymptotic stability period-two solution invariant interval.

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Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 448-451页

作者： Ayhan Dursun Mustafa kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar erdogan Aysen Topalkara Department of Ophthalmology School of MedicineCumhuriyet UniversitySivasTurkey

·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.

关键词： corneal neovascularisation bevacizumab ranibizumab

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