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Current and Future Research Trends of Environmental Nanomaterials

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Current and Future Research Trends of Environmental Nanomate...

全国环境纳米技术及生物效应学术研讨会

作者： kelvin sze-yin leung Department of Chemistry Faculty of Science Hong Kong Baptist University

The role of nanomaterials（NMs） in environmental application becomes important. Removal of emerging contaminant and pollutant from wastewater by NMs is promising. The negative impact of NMs to environment raise big concern these days. Different type of NMs and their mechanism to remove pollutant is summarized. The current progress of toxicity of NMs, green technique on NMs and further development on NMs will be discussed briefly.

关键词： Nanomaterials Toxicity Water treatment Environmental implication

Developmental toxicity evaluation of Rhizoma Atractylodis Macrocephalae:in-vivo and in-vitro studies

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Developmental toxicity evaluation of Rhizoma Atractylodis Ma...

中国毒理学会第五次全国学术大会

作者： kelvin sze-yin leung Kingfai Cheng Chan Wing leung Hong Kong Baptist UniversityL The Chinese University of Hong Kong

＜正＞Backgroud Rhizoma Atractylodis Macrocephalae （RAM）is the dried rhizome of Atractylodes macrocephala Koidz in the Compositae *** is a commonly used tonic herb in China in the treatment of diarrhea,lack of appetite, anorexia,mental fatigue and other *** herb has also been used for thousands of years to treat pregnant disorders for preventing abortion during early ***, there is no sufficient evidence so far to identify its embryotoxicity and teratogenicity.

关键词： Rhizoma Atractylodis Macrocephalae developmental toxicity mouse embryonic stem cell

Modified method of single cell analysis by Quadrupole ICP-MS

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Modified method of single cell analysis by Quadrupole ICP-MS

第五届全国原子光谱及相关技术学术会议

作者： Judy Tsz-Shan Lum kelvin sze-yin leung Department of Chemistry Hong Kong Baptist University Partner State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist University

Single cell-ICP-MS or single particle-ICP-MS is an emerging technique for the analysis of nanoparticles or cells.[1,2] It is well known that conventional ICP-MS with a quadrupole mass analyzer has limitation in such analysis,due to the one mass measurement at a *** contrasts with the simultaneous multi-elemental analysis performed by ICP-TOF-MS,in which a broad range of isotopes can be *** this project,a modified method of single cell analysis using ICP-QMS was *** masses were monitored（2-mass mode） during the analysis in comparison to that of single mass in the conventional approach in single particle-ICP-MS *** such as particle size,number of particles and the size distribution profile obtained by the two modes were *** proposed method was proved successful in mixtures of AgNP and AuNP with different particle *** sizes determined by the two analysis modes were in a good agreement with each *** percentage difference of the evaluated parameters of the two modes are within the acceptable range,demonstrating the potential of 2-mass mode in comparing two elements in cells or ***,the developed method was used in the analysis of single-cell algae treated with nanoparticles,to study the nanoparticle uptake of the cells after ***-TOFMS was also employed to supplement the information obtained by the *** the amount of information retrieved is not comparable to that by ICP-TOF-MS,the success of the current approach can extend the capability of ICP-QMS for multi-elemental detection in single cell level,offering useful information for single particle/cell analysis.

关键词： Single cell-ICP-MS nanoparticles inductively coupled plasma-quadrupole-mass spectrometry inductively coupled plasma time-of-flight mass spectrometry

Determination of plasma cholesterol sulfate by LC–APCI-MS/MS in the context of pediatric autism

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Determination of plasma cholesterol sulfate by LC–APCI-MS/M...

中国化学会第十九届全国有机分析及生物分析学术研讨会

作者： Bonnie Mei-Wah Fong Sidney Tam kelvin sze-yin leung Department of Chemistry Hong Kong Baptist University Department of Clinical Biochemistry Queen Mary Hospital

＜正＞Cholesterol sulfate （CS） has various biological ***,plasma CS was measured primarily as a means to diagnose X-linked ichthyosis;however,a recent hypothesis suggests that CS deficiency might be related to *** such,an assay capable of measuring both very high （in the case of X-linked ichthyosis）and very low （in the case of autism） plasma CS levels is *** we describe a novel LC–APCI-MS/MS

关键词： Plasma cholesterol sulfate LC–APCI-MS/MS Chinese pediatric reference interval Autism

Bioimaging of platinum complexes by laser ablation-inductively coupled plasma-mass spectrometry

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Bioimaging of platinum complexes by laser ablation-inductive...

中国化学会第二届全国质谱分析学术报告会

作者： kelvin sze-yin leung Tsz Shan Lum Yeuk Ki Tsoi Department of Chemistry Hong Kong Baptist University

Emerging applications of elemental imaging have been found in the biomedical and clinical *** are several examples of bioimaging using laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS),such as brain,liver and kidney[1].The spatial distribution of biologically essential elements(Cu,Zn,Fe)and other metals(Pt,Gd)can provide valuable information for understanding the accumulation and metabolism of the *** this project,we have successfully performed bioimaging using LA-ICP-MS in mice liver,kidney,as well as mice whisker after drug administration,demonstrating the potential use of LA-ICP-MS in drug development study and ***-platin is the first line anti-cancer drug and it is known to be *** the first part of this project,the anti-cancer potential of some metal containing complexes were *** platinum complexes were chosen and administered to ICR mice by intraperitoneal *** distribution of metal in brain,lung,heart,liver,kidney and testis were determined by ICP-MS bulk ***,the spatial distribution of platinum for these complexes in formalin fixed-paraffin embedded liver and kidney sections were studied by *** to the biomaps of liver and kidney,the trend of Pt accumulation for different complexes was consistent with that obtained in the ICP-MS bulk analysis,in the following order,Pt-4is-platin>*** addition,differential accumulation of platinum was observed in kidney for the chemically distinct complexes,***-2 and Pt-4 shown a higher deposition at the rim of kidney,while in the case of cis-platin,the platinum were found more evenly distributed over the *** difference in spatial distribution of the metal complexes can only be obtained by the imaging of LA-ICP-MS but not the standalone ICP-MS analysis,with this additional information,more insights about the binding of the complexes with other biomolecules will be obtained,which can help in studying the tox

关键词： bioimaging laser ablation ICP-MS

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang kelvin sze-yin leung Martin Elsner ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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HPLC测定川木通中齐墩果酸的含量

华西药学杂志 2006年第3期21卷 273-274页

作者：青琳森张浩吕光华陈金泉梁士贤陈雏四川大学华西药学院四川成都610041 Department of Pharmacy School of Applied SciencesUniversity of WolverhamptomWolverhamptomUnited Kingdom 香港浸会大学中医药学院研究与开发部

目的建立测定水解后的川木通药材中齐墩果酸含量的方法。方法采用HPIE法。Alltima C18色谱柱（250mm×4．6mm，5μm）；流动相为甲醇-水-冰醋酸-三乙胺（89：11：0．04：0．02）；检测波长207nm；流速1．0ml·min^-1；柱温45℃。结果齐... 详细信息

目的建立测定水解后的川木通药材中齐墩果酸含量的方法。方法采用HPIE法。Alltima C18色谱柱（250mm×4．6mm，5μm）；流动相为甲醇-水-冰醋酸-三乙胺（89：11：0．04：0．02）；检测波长207nm；流速1．0ml·min^-1；柱温45℃。结果齐墩果酸色谱峰分离度良好，线性范围为0．1003—8．024μg（r=0．9999，n=5），方法的检测限和定量限分别为0．3μg·ml^-1和1．0μg·ml^-1。平均回收率为96．1％，RSD=2.8％（n=5）。结论所用结果准确，重复性好，专属性强，可为川木通药材质量控制提供科学的依据。

关键词：川木通齐墩果酸高效液相色谱法

Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing yin Peng yin Chunhui Zhang Wing-leung Wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

冻干鲜鱼腥草超临界CO_2流体萃取工艺和提取物GC-MS分析

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中国中药杂志 2007年第3期32卷 215-217页

作者：孟江董小萍周毅生姜志宏梁士贤赵中振香港浸会大学中医药学院成都中医药大学药学院四川成都610081 广东药学院中药学院广东广州510000

目的:优选超临界CO2流体萃取冻干鲜鱼腥草提取物的工艺,分析冻干鲜鱼腥草提取物的组成。方法:以甲基正壬酮含量为指标,采用正交试验法对超临界CO2流体萃取冻干鲜鱼腥草提取物的条件进行了优选,并用GC-MS法对提取物成分进行分析。结果:... 详细信息

目的:优选超临界CO2流体萃取冻干鲜鱼腥草提取物的工艺,分析冻干鲜鱼腥草提取物的组成。方法:以甲基正壬酮含量为指标,采用正交试验法对超临界CO2流体萃取冻干鲜鱼腥草提取物的条件进行了优选,并用GC-MS法对提取物成分进行分析。结果:最佳萃取工艺:萃取压力15 000kPa,萃取温度35℃,萃取时间20 min。鉴定了冻干鲜鱼腥草提取物中出38种成分,并测定了其相对含量。结论:该工艺合理,能够有效保证提取物的质量。

关键词：超临界CO2 流体萃取冻干鲜鱼腥草正交实验 GC—MS分析